Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer

Myc and cell cycle control

(2015) Gabriel Bretones et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase–Activated Leukemias

(2015) Nidal Muvarak et al.   MOLECULAR CANCER RESEARCH

MYC impairs resolution of site-specific DNA double-strand breaks repair

(2015) Susanna Ambrosio et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The ribonuclease DIS3 promotes let-7 miRNA maturation by degrading the pluripotency factor LIN28B mRNA

(2015) Simona Segalla et al.   NUCLEIC ACIDS RESEARCH

The ubiquitin ligase human TRIM71 regulates let-7 microRNA biogenesis via modulation of Lin28B protein

(2014) Seo Hyun Lee et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Principles and mechanisms of CD95 activation

(2014) Harald Wajant   BIOLOGICAL CHEMISTRY

HMGA2 induces transcription factor Slug expression to promote epithelial-to-mesenchymal transition and contributes to colon cancer progression

(2014) Yang Li et al.   CANCER LETTERS

Frequent Overexpression ofHMGA2in Human Atypical Teratoid/Rhabdoid Tumor and Its Correlation withlet-7a3/let-7bmiRNA

(2014) Keqiang Zhang et al.   CLINICAL CANCER RESEARCH

Expression of LIN28 and its regulatory microRNAs in adult adrenocortical cancer

(2014) André M. Faria et al.   CLINICAL ENDOCRINOLOGY

Epigenetic Interventions Increase the Radiation Sensitivity of Cancer Cells

(2014) Juan Ren et al.   CURRENT PHARMACEUTICAL DESIGN

From cell membrane to the nucleus: an emerging role of E-cadherin in gene transcriptional regulation

(2014) Wenjun Du et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Assessing the ceRNA Hypothesis with Quantitative Measurements of miRNA and Target Abundance

(2014) Rémy Denzler et al.   MOLECULAR CELL

LIN28 Is Involved in Glioma Carcinogenesis and Predicts Outcomes of Glioblastoma Multiforme Patients

(2014) Rong Qin et al.   PLoS One

miR-27 Negatively Regulates Pluripotency-Associated Genes in Human Embryonal Carcinoma Cells

(2014) Heiko Fuchs et al.   PLoS One

H19 promotes pancreatic cancer metastasis by derepressing let-7’s suppression on its target HMGA2-mediated EMT

(2014) Chenchao Ma et al.   TUMOR BIOLOGY

Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1

(2014) Xiaoyu Ma et al.   Nature Communications

IMP3 RNP Safe Houses Prevent miRNA-Directed HMGA2 mRNA Decay in Cancer and Development

(2014) Lars Jønson et al.   Cell Reports

c-MYC-Induced Genomic Instability

(2014) A. Kuzyk et al.   Cold Spring Harbor Perspectives in Medicine

Lin28 Promotes Growth of Prostate Cancer Cells and Activates the Androgen Receptor

(2013) Ramakumar Tummala et al.   AMERICAN JOURNAL OF PATHOLOGY

MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3

(2013) Bingtian Zhao et al.   CANCER LETTERS

Lin28: Primal Regulator of Growth and Metabolism in Stem Cells

(2013) Ng Shyh-Chang et al.   Cell Stem Cell

Molecular Pathways: Targeting MYC-induced Metabolic Reprogramming and Oncogenic Stress in Cancer

(2013) B. Li et al.   CLINICAL CANCER RESEARCH

Nuclear Death Receptor TRAIL-R2 Inhibits Maturation of Let-7 and Promotes Proliferation of Pancreatic and Other Tumor Cells

(2013) Verena Haselmann et al.   GASTROENTEROLOGY

LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7

(2013) B. B. Madison et al.   GENES & DEVELOPMENT

Mechanisms of Lin28-Mediated miRNA and mRNA Regulation—A Structural and Functional Perspective

(2013) Florian Mayr et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Wnt- -catenin pathway represses let-7 microRNA expression through transactivation of Lin28 to augment breast cancer stem cell expansion

(2013) W.-Y. Cai et al.   JOURNAL OF CELL SCIENCE

The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer

(2013) Xiaowen Hu et al.   MOLECULAR CANCER RESEARCH

The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs

(2013) Amanda N. Kallen et al.   MOLECULAR CELL

A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28–let-7 pathway

(2013) Hao-Ming Chang et al.   NATURE

HMGA2 functions as a competing endogenous RNA to promote lung cancer progression

(2013) Madhu S. Kumar et al.   NATURE

miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis

(2013) X Fu et al.   ONCOGENE

Stat3-coordinated Lin-28–let-7–HMGA2 and miR-200–ZEB1 circuits initiate and maintain oncostatin M-driven epithelial–mesenchymal transition

(2013) L Guo et al.   ONCOGENE

Lin28 Mediates Radiation Resistance of Breast Cancer Cells via Regulation of Caspase, H2A.X and Let-7 Signaling

(2013) Linbo Wang et al.   PLoS One

Loss of Let-7 MicroRNA Upregulates IL-6 in Bone Marrow-Derived Mesenchymal Stem Cells Triggering a Reactive Stromal Response to Prostate Cancer

(2013) Shian-Ying Sung et al.   PLoS One

Increased Expression of Lin28B Associates with Poor Prognosis in Patients with Oral Squamous Cell Carcinoma

(2013) Tianfu Wu et al.   PLoS One

SOX2-LIN28/let-7 pathway regulates proliferation and neurogenesis in neural precursors

(2013) F. Cimadamore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA let-7c inhibits Bcl-xl expression and regulates ox-LDL-induced endothelial apoptosis

(2012) Bing Qin et al.   BMB Reports

High expression of Lin28 is associated with tumour aggressiveness and poor prognosis of patients in oesophagus cancer

(2012) R Hamano et al.   BRITISH JOURNAL OF CANCER

LIN28A Is a Suppressor of ER-Associated Translation in Embryonic Stem Cells

(2012) Jun Cho et al.   CELL

Lin28 and HER2: Two stem cell regulators conspire to drive aggressive breast cancer

(2012) Fayaz Malik et al.   CELL CYCLE

Lin28 regulates HER2 and promotes malignancy through multiple mechanisms

(2012) Chen Feng et al.   CELL CYCLE

Let-7 Expression Is a Significant Determinant of Response to Chemotherapy through the Regulation of IL-6/STAT3 Pathway in Esophageal Squamous Cell Carcinoma

(2012) K. Sugimura et al.   CLINICAL CANCER RESEARCH

Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells

(2012) Moussa Benhamed et al.   NATURE CELL BIOLOGY

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

Ectopic over-expression of tristetraprolin in human cancer cells promotes biogenesis of let-7 by down-regulation of Lin28

(2012) Chae Won Kim et al.   NUCLEIC ACIDS RESEARCH

High Let-7a MicroRNA Levels in KRAS-Mutated Colorectal Carcinomas May Rescue Anti-EGFR Therapy Effects in Patients with Chemotherapy-Refractory Metastatic Disease

(2012) A. Ruzzo et al.   ONCOLOGIST

MicroRNA let-7c Is Downregulated in Prostate Cancer and Suppresses Prostate Cancer Growth

(2012) Nagalakshmi Nadiminty et al.   PLoS One

Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance

(2012) K. Meirelles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How does Lin28 let-7 control development and disease?

(2012) James E. Thornton et al.   TRENDS IN CELL BIOLOGY

A let-7/Fas double-negative feedback loop regulates human colon carcinoma cells sensitivity to Fas-related apoptosis

(2011) Li Geng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology

(2011) O. M. Pello et al.   BLOOD

Estrogen receptor-regulated microRNAs contribute to the BCL2/BAX imbalance in endometrial adenocarcinoma and precancerous lesions

(2011) Rong Zhang et al.   CANCER LETTERS

LIN28B Promotes Colon Cancer Progression and Metastasis

(2011) C. E. King et al.   CANCER RESEARCH

MYC and Metastasis

(2011) A. Wolfer et al.   CANCER RESEARCH

Molecular Basis for Interaction of let-7 MicroRNAs with Lin28

(2011) Yunsun Nam et al.   CELL

Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms

(2011) Elena Piskounova et al.   CELL

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

(2011) Leonardo Salmena et al.   CELL

The Lin28/let-7 Axis Regulates Glucose Metabolism

(2011) Hao Zhu et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

MiR-181 mediates cell differentiation by interrupting the Lin28 and let-7 feedback circuit

(2011) X Li et al.   CELL DEATH AND DIFFERENTIATION

Tumor microenvironment: becoming sick of Myc

(2011) Jonathan R. Whitfield et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Let-7/miR-98 regulate Fas and Fas-mediated apoptosis

(2011) S Wang et al.   GENES AND IMMUNITY

Expression analysis of stem cell-related genes reveal OCT4 as a predictor of poor clinical outcome in medulloblastoma

(2011) Carolina Oliveira Rodini et al.   JOURNAL OF NEURO-ONCOLOGY

LIN28: A regulator of tumor-suppressing activity of let-7 microRNA in human breast cancer

(2011) Minako Sakurai et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Lin-28 reactivation is required for let-7 repression and proliferation in human small cell lung cancer cells

(2011) Lin Pan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28

(2011) Fionna E Loughlin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanisms

(2011) C E King et al.   ONCOGENE

MicroRNA Let-7f Inhibits Tumor Invasion and Metastasis by Targeting MYH9 in Human Gastric Cancer

(2011) Shuli Liang et al.   PLoS One

Deregulation of MYCN, LIN28B and LET7 in a Molecular Subtype of Aggressive High-Grade Serous Ovarian Cancers

(2011) Åslaug Helland et al.   PLoS One

Cellular Stress Induced Alterations in MicroRNA let-7a and let-7b Expression Are Dependent on p53

(2011) Anthony D. Saleh et al.   PLoS One

Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs

(2011) R. J. A. Frost et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Studies Reveal That Lin28 Enhances the Translation of Genes Important for Growth and Survival of Human Embryonic Stem Cells

(2011) Shuping Peng et al.   STEM CELLS

Specific miRNA signatures are associated with metastasis and poor prognosis in clear cell renal cell carcinoma

(2011) Joana Heinzelmann et al.   WORLD JOURNAL OF UROLOGY

Double-Negative Feedback Loop between Reprogramming Factor LIN28 and microRNA let-7 Regulates Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells

(2010) X. Yang et al.   CANCER RESEARCH

Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3

(2010) Yu Wang et al.   JOURNAL OF HEPATOLOGY

Let-7g targets collagen type I α2 and inhibits cell migration in hepatocellular carcinoma

(2010) Junfang Ji et al.   JOURNAL OF HEPATOLOGY

The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma

(2010) Satoshi Shimizu et al.   JOURNAL OF HEPATOLOGY

STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer

(2010) Dimitrios Iliopoulos et al.   MOLECULAR CELL

Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer

(2010) S Peng et al.   ONCOGENE

Epithelial to Mesenchymal Transition Is Mechanistically Linked with Stem Cell Signatures in Prostate Cancer Cells

(2010) Dejuan Kong et al.   PLoS One

Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line

(2010) Keiichi Ohshima et al.   PLoS One

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation

(2009) Inha Heo et al.   CELL

H2AX: functional roles and potential applications

(2009) Jennifer S. Dickey et al.   CHROMOSOMA

Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7

(2009) Surabhi Dangi-Garimella et al.   EMBO JOURNAL

let-7 MicroRNA Transfer in Pancreatic Cancer-Derived Cells Inhibits In Vitro Cell Proliferation but Fails to Alter Tumor Progression

(2009) Jérôme Torrisani et al.   HUMAN GENE THERAPY

The NF90-NF45 Complex Functions as a Negative Regulator in the MicroRNA Processing Pathway

(2009) S. Sakamoto et al.   MOLECULAR AND CELLULAR BIOLOGY

Lin28 promotes transformation and is associated with advanced human malignancies

(2009) Srinivas R Viswanathan et al.   NATURE GENETICS

Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells

(2009) John P Hagan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

(2009) T.-C. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans

(2009) C. M. Hammell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lin28 modulates cell growth and associates with a subset of cell cycle regulator mRNAs in mouse embryonic stem cells

(2009) B. Xu et al.   RNA

Nuclear Hormone Receptor Regulation of MicroRNAs Controls Developmental Progression

(2009) Axel Bethke et al.   SCIENCE

Let-7a microRNA suppresses therapeutics-induced cancer cell death by targeting caspase-3

(2008) Wing Pui Tsang et al.   APOPTOSIS

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'

(2008) T. E. Mullen et al.   GENES & DEVELOPMENT

Determinants of MicroRNA Processing Inhibition by the Developmentally Regulated RNA-binding Protein Lin28

(2008) Elena Piskounova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MYCtranslocation-negative classical Burkitt lymphoma cases: an alternative pathogenetic mechanism involving miRNA deregulation

(2008) E Leucci et al.   JOURNAL OF PATHOLOGY

Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA

(2008) Inha Heo et al.   MOLECULAR CELL

Integrin β3 expression is regulated by let-7a miRNA in malignant melanoma

(2008) D W Müller et al.   ONCOGENE

MicroRNA Expression and Identification of Putative miRNA Targets in Ovarian Cancer

(2008) Neetu Dahiya et al.   PLoS One

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

(2008) M. A. Newman et al.   RNA

The let-7 family of microRNAs

(2008) Sarah Roush et al.   TRENDS IN CELL BIOLOGY

let-7 microRNAs in development, stem cells and cancer

(2008) Ingo Büssing et al.   TRENDS IN MOLECULAR MEDICINE