Calcium signalling links MYC to NUAK1

Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche

(2016) Fabrizio Miranda et al.   CANCER CELL

AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours

(2016) Fiona A. Ross et al.   FEBS Journal

Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model

(2016) Cristian A. Lasagna-Reeves et al.   NEURON

Calcium-dependent binding of Myc to calmodulin

(2016) Philipp Raffeiner et al.   Oncotarget

microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer

(2016) Mariko Obayashi et al.   Oncotarget

NUAK1 (ARK5) Is Associated with Poor Prognosis in Ovarian Cancer

(2016) Neil T. Phippen et al.   Frontiers in Oncology

MiR-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma

(2015) Xinkui Xiong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The BCL-2 protein family, BH3-mimetics and cancer therapy

(2015) A R D Delbridge et al.   CELL DEATH AND DIFFERENTIATION

Targeting the 5′-AMP-activated protein kinase and related metabolic pathways for the treatment of prostate cancer

(2015) Petra Popovics et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Evidence of cancer-promoting roles for AMPK and related kinases

(2015) Tiziana Monteverde et al.   FEBS Journal

Activation of ARK5/miR-1181/HOXA10 axis promotes epithelial-mesenchymal transition in ovarian cancer

(2015) HAI-YAN ZHANG et al.   ONCOLOGY REPORTS

MiR-204 inhibits human NSCLC metastasis through suppression of NUAK1

(2014) L Shi et al.   BRITISH JOURNAL OF CANCER

miR-96 functions as a tumor suppressor gene by targeting NUAK1 in pancreatic cancer

(2014) XUAN HUANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Risk Prediction for Late-Stage Ovarian Cancer by Meta-analysis of 1525 Patient Samples

(2014) Markus Riester et al.   JNCI-Journal of the National Cancer Institute

An AMPK-Independent Signaling Pathway Downstream of the LKB1 Tumor Suppressor Controls Snail1 and Metastatic Potential

(2014) Jonathan M. Goodwin et al.   MOLECULAR CELL

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

(2014) Susanne Walz et al.   NATURE

Differential effects of AMPK agonists on cell growth and metabolism

(2014) E E Vincent et al.   ONCOGENE

BIM Is the Primary Mediator of MYC-Induced Apoptosis in Multiple Solid Tissues

(2014) Nathiya Muthalagu et al.   Cell Reports

Rewiring of an Epithelial Differentiation Factor, miR-203, to Inhibit Human Squamous Cell Carcinoma Metastasis

(2014) Nathan Benaich et al.   Cell Reports

Synthetic Lethal Screens as a Means to Understand and Treat MYC-Driven Cancers

(2014) S. Cermelli et al.   Cold Spring Harbor Perspectives in Medicine

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

(2013) Sourav Banerjee et al.   BIOCHEMICAL JOURNAL

LKB1 and AMPK and the cancer-metabolism link - ten years after

(2013) D Hardie et al.   BMC BIOLOGY

Terminal Axon Branching Is Regulated by the LKB1-NUAK1 Kinase Pathway via Presynaptic Mitochondrial Capture

(2013) Julien Courchet et al.   CELL

Molecular Pathways: Targeting MYC-induced Metabolic Reprogramming and Oncogenic Stress in Cancer

(2013) B. Li et al.   CLINICAL CANCER RESEARCH

Transcription Factor/microRNA Axis Blocks Melanoma Invasion Program by miR-211 Targeting NUAK1

(2013) Rachel E. Bell et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line

(2013) Andrew Adey et al.   NATURE

Neural tube defects by NUAK1 and NUAK2 double mutation

(2012) Tomomi Ohmura et al.   DEVELOPMENTAL DYNAMICS

High NUAK1 expression correlates with poor prognosis and involved in NSCLC cells migration and invasion

(2012) Peng Chen et al.   EXPERIMENTAL LUNG RESEARCH

Muscle-specific Knock-out of NUAK Family SNF1-like Kinase 1 (NUAK1) Prevents High Fat Diet-induced Glucose Intolerance

(2012) Fumika Inazuka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deregulated MYC expression induces dependence upon AMPK-related kinase 5

(2012) Lidan Liu et al.   NATURE

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

(2012) S. A. Hawley et al.   SCIENCE

Akt, FoxO and regulation of apoptosis

(2011) Xinbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Myc-Nick: A Cytoplasmic Cleavage Product of Myc that Promotes α-Tubulin Acetylation and Cell Differentiation

(2010) Maralice Conacci-Sorrell et al.   CELL

New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion

(2010) A. Zagorska et al.   Science Signaling

Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca2+and AMP

(2009) Sarah Fogarty et al.   BIOCHEMICAL JOURNAL

Regulation of ploidy and senescence by the AMPK-related kinase NUAK1

(2009) Nicolas Humbert et al.   EMBO JOURNAL

Human obesity as a heritable disorder of the central control of energy balance

(2009) S O'Rahilly et al.   INTERNATIONAL JOURNAL OF OBESITY

Distinct Thresholds Govern Myc's Biological Output In Vivo

(2008) Daniel J. Murphy et al.   CANCER CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL