Immunosenescence Induced by Plasma from Individuals with Obesity Caused Cell Signaling Dysfunction and Inflammation

Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation

(2016) Yang Wang et al.   AGING CELL

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits

(2016) Alexander Teumer et al.   AGING CELL

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Local proliferation initiates macrophage accumulation in adipose tissue during obesity

(2016) C Zheng et al.   Cell Death & Disease

The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging

(2016) Daniel Edgar et al.   Aging-US

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Changes in inflammation, oxidative stress and adipokines following bariatric surgery among adolescents with severe obesity

(2015) A S Kelly et al.   INTERNATIONAL JOURNAL OF OBESITY

A simple stochastic model for the feedback circuit between p16INK4a and p53 mediated by p38MAPK: implications for senescence and apoptosis

(2015) L. R. de Oliveira et al.   Molecular BioSystems

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Effect of obesity on telomere length: Systematic review and meta-analysis

(2015) Eduardo Mundstock et al.   Obesity

γ-oryzanol reduces caveolin-1 and PCGEM1 expression, markers of aggressiveness in prostate cancer cell lines

(2015) Gabriela E. Hirsch et al.   PROSTATE

A Model for p38MAPK-Induced Astrocyte Senescence

(2015) José C. M. Mombach et al.   PLoS One

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Assessing Cell and Organ Senescence Biomarkers

(2012) Bruno Bernardes de Jesus et al.   CIRCULATION RESEARCH

Obesity and the risk and outcome of infection

(2012) R Huttunen et al.   INTERNATIONAL JOURNAL OF OBESITY

Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model

(2012) Mitra Lavasani et al.   Nature Communications

Obesity is associated with impaired immune response to influenza vaccination in humans

(2011) P A Sheridan et al.   INTERNATIONAL JOURNAL OF OBESITY

Meta-Analysis and Dose-Response Metaregression: Circulating Insulin-Like Growth Factor I (IGF-I) and Mortality

(2011) Anne Marij G. Burgers et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Nuclear damage in peripheral lymphocytes of obese and overweight Italian children as evaluated by the γ-H2AX focus assay and micronucleus test

(2010) Roberto Scarpato et al.   FASEB JOURNAL

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Obesity Increases Vascular Senescence and Susceptibility to Ischemic Injury Through Chronic Activation of Akt and mTOR

(2009) C.-Y. Wang et al.   Science Signaling

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY