A cautionary tale of sense-antisense gene pairs: independent regulation despite inverse correlation of expression

Ectopically expressed Slc34a2a sense-antisense transcripts cause a cerebellar phenotype in zebrafish embryos depending on RNA complementarity and Dicer

(2017) Monica J. Piatek et al.   PLoS One

Expanding the p53 regulatory network: LncRNAs take up the challenge

(2016) Elena Grossi et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Genome-wide identification of transcriptional start sites in the haloarchaeon Haloferax volcanii based on differential RNA-Seq (dRNA-Seq)

(2016) Julia Babski et al.   BMC GENOMICS

Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins

(2016) Sungyul Lee et al.   CELL

p53 partners with RNA in the DNA damage response

(2016) Maite Huarte   NATURE GENETICS

An inducible long noncoding RNA amplifies DNA damage signaling

(2016) Adam M Schmitt et al.   NATURE GENETICS

p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity

(2016) Carmen Adriaens et al.   NATURE MEDICINE

Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer

(2016) Youyou Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer

(2016) Angel Diaz-Lagares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions

(2016) Lovorka Stojic et al.   Nature Communications

Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer

(2016) Youyou Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein Abundance Control by Non-coding Antisense Transcription

(2016) Florian Huber et al.   Cell Reports

Strand-specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA

(2015) Kate M Broadbent et al.   BMC GENOMICS

A BRCA1-interacting lncRNA regulates homologous recombination

(2015) V. Sharma et al.   EMBO REPORTS

The landscape of antisense gene expression in human cancers

(2015) O. Alejandro Balbin et al.   GENOME RESEARCH

Neighboring Gene Regulation by Antisense Long Non-Coding RNAs

(2015) Victoria Villegas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LncRNA Khps1 Regulates Expression of the Proto-oncogene SPHK1 via Triplex-Mediated Changes in Chromatin Structure

(2015) Anna Postepska-Igielska et al.   MOLECULAR CELL

The emerging role of lncRNAs in cancer

(2015) Maite Huarte   NATURE MEDICINE

NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/β-catenin pathway

(2015) Jin-Ju Lei et al.   Oncotarget

PARTICLE, a Triplex-Forming Long ncRNA, Regulates Locus-Specific Methylation in Response to Low-Dose Irradiation

(2015) Valerie Bríd O’Leary et al.   Cell Reports

TODRA, a lncRNA at the RAD51 Locus, Is Oppositely Regulated to RAD51, and Enhances RAD51-Dependent DSB (Double Strand Break) Repair

(2015) Inbal Gazy et al.   PLoS One

Examining the condition-specific antisense transcription in S. cerevisiae and S. paradoxus

(2014) Krishna B S Swamy et al.   BMC GENOMICS

PCAT-1 , a Long Noncoding RNA, Regulates BRCA2 and Controls Homologous Recombination in Cancer

(2014) John R. Prensner et al.   CANCER RESEARCH

Genome-wide identification of long noncoding natural antisense transcripts and their responses to light in Arabidopsis

(2014) H. Wang et al.   GENOME RESEARCH

Transcriptional interference by antisense RNA is required for circadian clock function

(2014) Zhihong Xue et al.   NATURE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

A New lncRNA, APTR, Associates with and Represses the CDKN1A/p21 Promoter by Recruiting Polycomb Proteins

(2014) Masamitsu Negishi et al.   PLoS One

KAISO, a critical regulator of p53-mediated transcription ofCDKN1Aand apoptotic genes

(2014) Dong-In Koh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of antisense long noncoding RNA in small RNA-triggered gene activation

(2014) Xizhe Zhang et al.   RNA

Genome-wide analysis of the human p53 transcriptional network unveils a lncRNA tumour suppressor signature

(2014) Yolanda Sánchez et al.   Nature Communications

Gene regulation by the act of long non-coding RNA transcription

(2013) Aleksandra E Kornienko et al.   BMC BIOLOGY

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

(2013) Lei S. Qi et al.   CELL

Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

(2013) Albert W Cheng et al.   CELL RESEARCH

Cell cycle regulation by long non-coding RNAs

(2013) Masatoshi Kitagawa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway

(2013) Guohui Wan et al.   CELLULAR SIGNALLING

Chk1 Inhibits E2F6 Repressor Function in Response to Replication Stress to Maintain Cell-Cycle Transcription

(2013) Cosetta Bertoli et al.   CURRENT BIOLOGY

A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation

(2013) Guohui Wan et al.   EMBO JOURNAL

The functions of natural antisense transcripts

(2013) Megan Wight et al.   Essays in Biochemistry

The long non-coding RNA ERIC is regulated by E2F and modulates the cellular response to DNA damage

(2013) Orit Feldstein et al.   Molecular Cancer

RNA-guided gene activation by CRISPR-Cas9–based transcription factors

(2013) Pablo Perez-Pinera et al.   NATURE METHODS

CRISPR RNA–guided activation of endogenous human genes

(2013) Morgan L Maeder et al.   NATURE METHODS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Gene regulation by antisense transcription

(2013) Vicent Pelechano et al.   NATURE REVIEWS GENETICS

DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1

(2013) Anne S. Calkins et al.   NUCLEIC ACIDS RESEARCH

Promoter RNA links transcriptional regulation of inflammatory pathway genes

(2013) Masayuki Matsui et al.   NUCLEIC ACIDS RESEARCH

Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2

(2013) Oskar Marín-Béjar et al.   GENOME BIOLOGY

Expression of non-protein-coding antisense RNAs in genomic regions related to autism spectrum disorders

(2013) Dmitry Velmeshev et al.   Molecular Autism

Long Non-Coding RNAs Embedded in the Rb and p53 Pathways

(2013) Murugan Subramanian et al.   Cancers

Genome Regulation by Long Noncoding RNAs

(2012) John L. Rinn et al.   Annual Review of Biochemistry

NOP14 promotes proliferation and metastasis of pancreatic cancer cells

(2012) Bin Zhou et al.   CANCER LETTERS

The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage

(2012) Ali Zhang et al.   CELL RESEARCH

Long non-coding RNAgadd7interacts with TDP-43 and regulatesCdk6mRNA decay

(2012) Xuefeng Liu et al.   EMBO JOURNAL

E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression

(2012) L. A. Carvajal et al.   GENES & DEVELOPMENT

The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression

(2012) T. Derrien et al.   GENOME RESEARCH

Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat

(2012) Claudia Carrieri et al.   NATURE

Modular regulatory principles of large non-coding RNAs

(2012) Mitchell Guttman et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation

(2012) Farzaneh Modarresi et al.   NATURE BIOTECHNOLOGY

The hallmarks of cancer

(2012) Tony Gutschner et al.   RNA Biology

Airn Transcriptional Overlap, But Not Its lncRNA Products, Induces Imprinted Igf2r Silencing

(2012) P. A. Latos et al.   SCIENCE

Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters

(2011) Tiffany Hung et al.   NATURE GENETICS

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL

Genome-wide analysis of expression modes and DNA methylation status at sense–antisense transcript loci in mouse

(2010) Yutaka Watanabe et al.   GENOMICS

RUNX3 Modulates DNA Damage-mediated Phosphorylation of Tumor Suppressor p53 at Ser-15 and Acts as a Co-activator for p53

(2010) Chizu Yamada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a

(2010) Kyoko L. Yap et al.   MOLECULAR CELL

Wrap53, a Natural p53 Antisense Transcript Required for p53 Induction upon DNA Damage

(2009) Salah Mahmoudi et al.   MOLECULAR CELL

Regulatory roles of natural antisense transcripts

(2009) Mohammad Ali Faghihi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Antisense transcription: A critical look in both directions

(2008) T. Beiter et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition

(2008) M. Beltran et al.   GENES & DEVELOPMENT

Kcnq1ot1 Antisense Noncoding RNA Mediates Lineage-Specific Transcriptional Silencing through Chromatin-Level Regulation

(2008) Radha Raman Pandey et al.   MOLECULAR CELL

Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA

(2008) Wenqiang Yu et al.   NATURE

Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription

(2008) Xiangting Wang et al.   NATURE

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

(2008) Oliver H. Tam et al.   NATURE

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase

(2008) Mohammad Ali Faghihi et al.   NATURE MEDICINE

The Antisense Transcriptomes of Human Cells

(2008) Yiping He et al.   SCIENCE