Review
Cell Biology
Elisabetta Lauretti, Konrad Dabrowski, Domenico Pratico
Summary: Non-protein-coding RNAs have been found to play significant roles in neurodegenerative disorders such as Alzheimer's disease, affecting gene expression, amyloid-beta production, and other key mechanisms underlying disease pathology.
AGEING RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Daniele Lettieri-Barbato, Katia Aquilano, Carolina Punziano, Giuseppina Minopoli, Raffaella Faraonio
Summary: Cell senescence plays critical roles in various aspects of organism life, including tissue development, homeostasis, tumor suppression, and aging-related diseases. Oxidative stress, caused by inadequate detoxification of reactive oxygen/nitrogen species, is a major driver of senescence. Non-coding RNAs, such as microRNAs, long non-coding RNAs, and circular RNAs, are important regulators of cellular processes, including oxidative stress responses and senescence.
Review
Cell Biology
Kevina Sonawala, Satish Ramalingam, Iyappan Sellamuthu
Summary: Cancer stem cells (CSCs) have been extensively studied over the past two decades, but many questions about their regulation and characteristics remain unanswered. Understanding the signaling pathways of CSCs may provide insights into the mechanisms involved. Non-coding RNAs, especially long non-coding RNAs (lncRNAs), have recently been found to play important roles in the modulation of CSC signaling pathways and tumor properties.
Review
Cell Biology
Lina Ma, Zhang Zhang
Summary: This comment provides an overview of the types and features of lncRNA databases worldwide, and discusses their contribution to lncRNA research.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)
Review
Oncology
Mohammad Roshani, Ghazaleh Baniebrahimi, Mahboubeh Mousavi, Noushid Zare, Reza Sadeghi, Reza Salarinia, Amirhossein Sheida, Danial Molavizadeh, Sara Sadeghi, Farzaneh Moammer, Mohammad Reza Zolfaghari, Hamed Mirzaei
Summary: Exosomal lncRNAs play a crucial role in the biology of gastrointestinal cancer and can be utilized as biomarkers for diagnosis, prognosis, and potential treatment targets.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Yadong Liu, Penghao Sun, Yuhao Zhao, Bin Liu
Summary: The study of long non-coding RNAs (lncRNA) is a rapidly growing field, with potential implications for diagnosis, classification, prognosis, and therapy of leukemia. These RNAs play crucial roles in regulating cell growth, differentiation, and apoptosis, making them key factors in the development of leukemia.
HEMATOLOGICAL ONCOLOGY
(2021)
Review
Medicine, Research & Experimental
Amirhosein Maharati, Meysam Moghbeli
Summary: Breast cancer is a major global health challenge, and investigating the molecular mechanisms involved in its progression can lead to improved therapeutic and diagnostic strategies. Long non-coding RNAs (lncRNAs) play important roles in regulating cytokine and growth factor-dependent signaling pathways in breast tumor cells. This review discusses the oncogenic role of lncRNAs in promoting PI3K/AKT, MAPK, and TGF-β signaling pathways in breast cancer and suggests lncRNA inhibition as a potential therapeutic strategy to reduce tumor growth and as reliable diagnostic markers in breast cancer patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Cell Biology
Vahid Goodarzi, Shadi Nouri, Zohre Saleh Nassaj, Mansoureh Bighash, Sadegh Abbasian, Rozita adldoosti Hagh
Summary: Asthma is a chronic inflammatory disease of the airways, with unclear pathogenic mechanisms. Long noncoding RNAs have been found to play a crucial regulatory role in childhood asthma, affecting inflammation, cell proliferation, and airway remodeling. Further research is needed in this area.
JOURNAL OF MOLECULAR HISTOLOGY
(2023)
Article
Cell Biology
Fabiana Tortora, George A. Calin, Amelia Cimmino
Summary: Non-coding RNAs, especially long ncRNAs, play a crucial role in cancer progression by influencing physiological processes, particularly in genitourinary neoplasms. Their dysregulation can be significant for cancer onset and progression.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Medical Laboratory Technology
Ke Lu, Muyuan Yu, Yongchang Chen
Summary: Research has shown that non-coding RNAs may play a significant role in the progression of prostate cancer, participating in the regulatory network of AR signaling and helping identify new molecular mechanisms to promote the disease.
CLINICA CHIMICA ACTA
(2021)
Review
Biochemistry & Molecular Biology
Quanah J. Hudson, Katharina Proestling, Alexandra Perricos, Lorenz Kuessel, Heinrich Husslein, Rene Wenzl, Iveta Yotova
Summary: Studies have shown that lncRNAs play an important role in the pathogenesis of endometriosis, with SNPs and genome-wide transcriptomic studies confirming this.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Saeed Ashrafizaveh, Milad Ashrafizadeh, Ali Zarrabi, Kiavash Husmandi, Amirhossein Zabolian, Md Shahinozzaman, Amir Reza Aref, Michael R. Hamblin, Noushin Nabavi, Francesco Crea, Yuzhuo Wang, Kwang Seok Ahn
Summary: Studies have shown that long non-coding RNAs play a significant role in DOX resistance, both activating resistance pathways and increasing sensitivity of cancer cells to DOX.
Review
Pathology
Mohammad Mahdi Khanifar, Zahra Zafari, Mohsen Sheykhhasan
Summary: Colorectal cancer is a prevalent malignancy and a leading cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs) are dysregulated in colorectal cancer and have been found to modulate the expression of the p53 gene, a crucial tumor suppressor gene involved in various cellular processes. Understanding the interaction between lncRNAs and the p53 pathway in colorectal cancer has important implications for carcinogenesis, tumor progression, and therapeutic resistance.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Medicine, General & Internal
Yachen Shi, Qingyun Wang, Ruize Song, Yan Kong, Zhijun Zhang
Summary: Non-coding RNAs, such as microRNAs, circular RNAs, and long non-coding RNAs, play important roles in regulating normal biological processes and may be implicated in the pathogenesis of human diseases like depression. Clinical studies have shown that abnormal expression of ncRNAs in depressed patients compared to healthy individuals, with potential for ncRNAs to serve as biomarkers for diagnosis and treatment. Despite uncertainties regarding their precise roles, ncRNAs demonstrate promising clinical value in the management of depression.
Article
Biotechnology & Applied Microbiology
Miao Da, Hao Jiang, Yangyang Xie, Weili Jin, Shuwen Han
Summary: Exosomal lncRNAs play a crucial role in regulating cancer progression, angiogenesis, and chemotherapy resistance, with potential applications in cancer diagnosis, treatment, and prognosis. Exosomal lncRNAs can transmit different phenotypic patterns to neighboring cells, serving as a new medium for cancer behavior.
ONCOTARGETS AND THERAPY
(2021)
