Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry

Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases

(2016) Timothy J. Miles et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Stabilization of protein–protein interaction complexes through small molecules

(2016) Barbara Zarzycka et al.   DRUG DISCOVERY TODAY

Crystal structure and stability of gyrase–fluoroquinolone cleaved complexes fromMycobacterium tuberculosis

(2016) Tim R. Blower et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a quinolone-stabilized cleavage complex of topoisomerase IV fromKlebsiella pneumoniaeand comparison with a relatedStreptococcus pneumoniaecomplex

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Effects of Olive Metabolites on DNA Cleavage Mediated by Human Type II Topoisomerases

(2015) Kendra R. Vann et al.   BIOCHEMISTRY

New Mechanistic and Functional Insights into DNA Topoisomerases

(2013) Stefanie Hartman Chen et al.   Annual Review of Biochemistry

Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases

(2013) Timothy J. Miles et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and anticancer activity of dichloroplatinum(II) complexes of podophyllotoxin

(2013) Xuan Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Therapy-related acute promyelocytic leukemia: a systematic review

(2013) Armin Rashidi et al.   MEDICAL ONCOLOGY

On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs

(2013) Chyuan-Chuan Wu et al.   NUCLEIC ACIDS RESEARCH

Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

Anthracenedione–methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profiles

(2012) Chieh-Hua Lee et al.   BIOCHEMICAL PHARMACOLOGY

Probing Conformational Changes in Human DNA Topoisomerase IIα by Pulsed Alkylation Mass Spectrometry

(2012) Yu-tsung Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage

(2012) Timothy J. Wendorff et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

Mechanism of Generation of Therapy Related Leukemia in Response to Anti-Topoisomerase II Agents

(2012) Ian G. Cowell et al.   International Journal of Environmental Research and Public Health

The resurgence of covalent drugs

(2011) Juswinder Singh et al.   NATURE REVIEWS DRUG DISCOVERY

All tangled up: how cells direct, manage and exploit topoisomerase function

(2011) Seychelle M. Vos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide

(2011) C.-C. Wu et al.   SCIENCE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

Strategies for discovering and derisking covalent, irreversible enzyme inhibitors

(2010) Douglas S Johnson et al.   Future Medicinal Chemistry

The roles of drug metabolism in the pathogenesis of T-cell-mediated drug hypersensitivity

(2009) Sidonie Nelly Lavergne et al.   Current Opinion in Allergy and Clinical Immunology

Covalent Modifiers: An Orthogonal Approach to Drug Design

(2009) Michele H. Potashman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases

(2009) Ivan Laponogov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Immune-Mediated Adverse Drug Reactions

(2008) Jack Uetrecht   CHEMICAL RESEARCH IN TOXICOLOGY

Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage

(2008) X. S. Pan et al.   NUCLEIC ACIDS RESEARCH

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

(2008) J. E. Deweese et al.   NUCLEIC ACIDS RESEARCH