Targeting Neural Hyperactivity as a Treatment to Stem Progression of Late-Onset Alzheimer’s Disease

Heightened cortical excitability in aged rodents with memory impairment

(2017) Rebecca P. Haberman et al.   NEUROBIOLOGY OF AGING

Increased hippocampal activation in ApoE-4 carriers and non-carriers with amnestic mild cognitive impairment

(2017) Tammy T. Tran et al.   NeuroImage-Clinical

Incidence and impact of subclinical epileptiform activity in Alzheimer's disease

(2016) Keith A. Vossel et al.   ANNALS OF NEUROLOGY

Expression of A152T human tau causes age‐dependent neuronal dysfunction and loss in transgenic mice

(2016) Sumihiro Maeda et al.   EMBO REPORTS

Attenuation of  -Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity

(2016) P. Yuan et al.   JOURNAL OF NEUROSCIENCE

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

Network abnormalities and interneuron dysfunction in Alzheimer disease

(2016) Jorge J. Palop et al.   NATURE REVIEWS NEUROSCIENCE

Reelin-immunoreactive neurons in entorhinal cortex layer II selectively express intracellular amyloid in early Alzheimer's disease

(2016) Asgeir Kobro-Flatmoen et al.   NEUROBIOLOGY OF DISEASE

Tracking the flow of hippocampal computation: Pattern separation, pattern completion, and attractor dynamics

(2016) James J. Knierim et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

DREADDs for Neuroscientists

(2016) Bryan L. Roth   NEURON

Neuronal hyperactivity - A key defect in Alzheimer's disease?

(2015) Marc Aurel Busche et al.   BIOESSAYS

Amyloid-β deposition in mild cognitive impairment is associated with increased hippocampal activity, atrophy and clinical progression

(2015) Willem Huijbers et al.   BRAIN

Cascading network failure across the Alzheimer’s disease spectrum

(2015) David T. Jones et al.   BRAIN

Sleep Interacts with Aβ to Modulate Intrinsic Neuronal Excitability

(2015) Masashi Tabuchi et al.   CURRENT BIOLOGY

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

(2015) S. Wegmann et al.   EMBO JOURNAL

Combined administration of levetiracetam and valproic acid attenuates age-related hyperactivity of CA3 place cells, reduces place field area, and increases spatial information content in aged rat hippocampus

(2015) Jonathan Robitsek et al.   HIPPOCAMPUS

Tonic Inhibitory Control of Dentate Gyrus Granule Cells by α5-Containing GABA A Receptors Reduces Memory Interference

(2015) Elif Engin et al.   JOURNAL OF NEUROSCIENCE

Tau-Dependent Kv4.2 Depletion and Dendritic Hyperexcitability in a Mouse Model of Alzheimer's Disease

(2015) Alicia M. Hall et al.   JOURNAL OF NEUROSCIENCE

Memory impairment in aged primates is associated with region-specific network dysfunction

(2015) A Thomé et al.   MOLECULAR PSYCHIATRY

Rescue of long-range circuit dysfunction in Alzheimer's disease models

(2015) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

Neurocognitive Aging and the Hippocampus across Species

(2015) Stephanie L. Leal et al.   TRENDS IN NEUROSCIENCES

Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer’s disease mouse model

(2015) Haakon B Nygaard et al.   Alzheimers Research & Therapy

Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task performance

(2015) Arnold Bakker et al.   NeuroImage-Clinical

Functional MRI Assessment of Task-Induced Deactivation of the Default Mode Network in Alzheimer’s Disease and At-Risk Older Individuals

(2014) Maija Pihlajamäki et al.   BEHAVIOURAL NEUROLOGY

Genetic Heterogeneity in Alzheimer Disease and Implications for Treatment Strategies

(2014) John M. Ringman et al.   Current Neurology and Neuroscience Reports

Subclinical cognitive decline in middle-age is associated with reduced task-induced deactivation of the brain's default mode network

(2014) Naja Liv Hansen et al.   HUMAN BRAIN MAPPING

Amyloid Deposition Is Linked to Aberrant Entorhinal Activity among Cognitively Normal Older Adults

(2014) W. Huijbers et al.   JOURNAL OF NEUROSCIENCE

CA3 Retrieves Coherent Representations from Degraded Input: Direct Evidence for CA3 Pattern Completion and Dentate Gyrus Pattern Separation

(2014) Joshua P. Neunuebel et al.   NEURON

The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials

(2014) Reisa Sperling et al.   NEURON

Dendritic Structural Degeneration Is Functionally Linked to Cellular Hyperexcitability in a Mouse Model of Alzheimer’s Disease

(2014) Zuzana Šišková et al.   NEURON

Specific Disruption of Hippocampal Mossy Fiber Synapses in a Mouse Model of Familial Alzheimer's Disease

(2014) Scott A. Wilke et al.   PLoS One

Expression of SV2 isoforms during rodent brain development

(2013) Julie Crèvecœur et al.   BMC NEUROSCIENCE

Antiepileptics Topiramate and Levetiracetam Alleviate Behavioral Deficits and Reduce Neuropathology in APPswe/PS1dE9 Transgenic Mice

(2013) Jian-Quan Shi et al.   CNS Neuroscience & Therapeutics

Synaptic vesicle protein 2A: basic facts and role in synaptic function

(2013) Julieta Griselda Mendoza-Torreblanca et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mindspan: Lessons from Rat Models of Neurocognitive Aging

(2013) M. Gallagher et al.   ILAR JOURNAL

Hilar interneuron vulnerability distinguishes aged rats with memory impairment

(2013) Amy M. Spiegel et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Reduced Reelin Expression Accelerates Amyloid-  Plaque Formation and Tau Pathology in Transgenic Alzheimer's Disease Mice

(2013) S. Kocherhans et al.   JOURNAL OF NEUROSCIENCE

Visual object pattern separation varies in older adults

(2013) H. M. Holden et al.   LEARNING & MEMORY

Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

(2013) Elsa Suberbielle et al.   NATURE NEUROSCIENCE

Vulnerable Neural Systems and the Borderland of Brain Aging and Neurodegeneration

(2013) William Jagust   NEURON

A task to assess behavioral pattern separation (BPS) in humans: Data from healthy aging and mild cognitive impairment

(2013) Shauna M. Stark et al.   NEUROPSYCHOLOGIA

Inhibitory Neuron and Hippocampal Circuit Dysfunction in an Aged Mouse Model of Alzheimer's Disease

(2013) Anupam Hazra et al.   PLoS One

Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease

(2013) Keith A. Vossel et al.   JAMA Neurology

Spatial pattern separation in cognitively normal young and older adults

(2012) Heather M. Holden et al.   HIPPOCAMPUS

Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease

(2012) Nikita Rudinskiy et al.   NATURE NEUROSCIENCE

Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

(2012) Arnold Bakker et al.   NEURON

Selective GABAA α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment

(2012) Ming Teng Koh et al.   NEUROPHARMACOLOGY

Hilar GABAergic Interneuron Activity Controls Spatial Learning and Memory Retrieval

(2012) Yaisa Andrews-Zwilling et al.   PLoS One

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

(2012) P. E. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical role of soluble amyloid-  for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

(2012) M. A. Busche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease

(2012) Christine Grienberger et al.   Nature Communications

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Marilyn S. Albert et al.   Alzheimers & Dementia

A perfect storm: Converging paths of epilepsy and Alzheimer’s dementia intersect in the hippocampal formation

(2011) Jeffrey Noebels   EPILEPSIA

Levetiracetam clinical pharmacokinetics in elderly and very elderly patients with epilepsy

(2011) M. Contin et al.   EPILEPSY RESEARCH

A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of levetiracetam

(2011) Anna L. Meehan et al.   JOURNAL OF NEUROPHYSIOLOGY

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

Hippocampal Hyperactivation Associated with Cortical Thinning in Alzheimer's Disease Signature Regions in Non-Demented Elderly Adults

(2011) D. Putcha et al.   JOURNAL OF NEUROSCIENCE

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

(2011) Adam W Bero et al.   NATURE NEUROSCIENCE

The potential of functional MRI as a biomarker in early Alzheimer's disease

(2011) Reisa Sperling   NEUROBIOLOGY OF AGING

Age-related changes in the default mode network are more advanced in Alzheimer disease

(2011) D. T. Jones et al.   NEUROLOGY

Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift

(2011) Todd E. Golde et al.   NEURON

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia

(2011) Michael Ewers et al.   TRENDS IN NEUROSCIENCES

Pattern separation in the hippocampus

(2011) Michael A. Yassa et al.   TRENDS IN NEUROSCIENCES

SV2 regulates neurotransmitter release via multiple mechanisms

(2010) Amy Nowack et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cognitive Decline Is Associated with Reduced Reelin Expression in the Entorhinal Cortex of Aged Rats

(2010) Alexis M. Stranahan et al.   CEREBRAL CORTEX

Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer’s disease

(2010) Eduardo Cumbo et al.   EPILEPSY & BEHAVIOR

Apolipoprotein E4 Causes Age- and Tau-Dependent Impairment of GABAergic Interneurons, Leading to Learning and Memory Deficits in Mice

(2010) Y. Andrews-Zwilling et al.   JOURNAL OF NEUROSCIENCE

Cotrafficking of SV2 and Synaptotagmin at the Synapse

(2010) J. Yao et al.   JOURNAL OF NEUROSCIENCE

Transgenic Mouse Models of Alzheimer's Disease

(2010) Gregory A. Elder et al.   MOUNT SINAI JOURNAL OF MEDICINE

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment

(2010) Michael A. Yassa et al.   NEUROIMAGE

Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline

(2010) J. L. O'Brien et al.   NEUROLOGY

Intracellular calcium signalling in Alzheimer’s disease

(2009) Marina Hermes et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Amyloid  -Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

(2009) R. Minkeviciene et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease: progress in prediction

(2009) Ronald C Petersen   LANCET NEUROLOGY

Visual object pattern separation deficits in nondemented older adults

(2009) C. K. Toner et al.   LEARNING & MEMORY

Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain

(2009) D.L. Vogt et al.   NEUROBIOLOGY OF AGING

Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia

(2009) Reisa A. Sperling et al.   NEURON

Treatment Strategies Targeting Excess Hippocampal Activity Benefit Aged Rats with Cognitive Impairment

(2009) Ming Teng Koh et al.   NEUROPSYCHOPHARMACOLOGY

Levetiracetam has a time- and stimulation-dependent effect on synaptic transmission

(2009) Xiao-Feng Yang et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Cognitive Aging: A Common Decline of Episodic Recollection and Spatial Memory in Rats

(2008) R. J. Robitsek et al.   JOURNAL OF NEUROSCIENCE

Animal models of Alzheimer's disease and frontotemporal dementia

(2008) Jürgen Götz et al.   NATURE REVIEWS NEUROSCIENCE

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON

Levetiracetam Inhibits both ryanodine and IP3 receptor activated calcium induced calcium release in hippocampal neurons in culture

(2008) Nisha Nagarkatti et al.   NEUROSCIENCE LETTERS

Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation

(2008) S. L. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pattern Separation in the Human Hippocampal CA3 and Dentate Gyrus

(2008) A. Bakker et al.   SCIENCE

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE

Review: Is levetiracetam different from other antiepileptic drugs? Levetiracetam and its cellular mechanism of action in epilepsy revisited

(2008) Rainer Surges et al.   Therapeutic Advances in Neurological Disorders

Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: Insights from functional MRI studies

(2007) Bradford C. Dickerson et al.   NEUROPSYCHOLOGIA