Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats

Optimized solubilization of TRIzol-precipitated protein permits Western blotting analysis to maximize data available from brain tissue

(2017) Ashley M. Kopec et al.   JOURNAL OF NEUROSCIENCE METHODS

Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents

(2017) Nicole E Burma et al.   NATURE MEDICINE

Influence of maternal care on the developing brain: Mechanisms, temporal dynamics and sensitive periods

(2016) James P. Curley et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Cocaine-mediated induction of microglial activation involves the ER stress-TLR2 axis

(2016) Ke Liao et al.   Journal of Neuroinflammation

New insights into the multidimensional concept of macrophage ontogeny, activation and function

(2016) Florent Ginhoux et al.   NATURE IMMUNOLOGY

Opposing mechanisms mediate morphine- and cocaine-induced generation of silent synapses

(2016) Nicholas M Graziane et al.   NATURE NEUROSCIENCE

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization

(2016) Gil M. Lewitus et al.   NEURON

Toll-like Receptor 4 Mediates Morphine-Induced Neuroinflammation and Tolerance via Soluble Tumor Necrosis Factor Signaling

(2016) Lori N Eidson et al.   NEUROPSYCHOPHARMACOLOGY

Lack of Specific Involvement of (+)-Naloxone and (+)-Naltrexone on the Reinforcing and Neurochemical Effects of Cocaine and Opioids

(2016) Gianluigi Tanda et al.   NEUROPSYCHOPHARMACOLOGY

Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse

(2016) Michael J Lacagnina et al.   NEUROPSYCHOPHARMACOLOGY

Reversal of morphine-induced cell-type–specific synaptic plasticity in the nucleus accumbens shell blocks reinstatement

(2016) Matthew C. Hearing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduction of nicotine self-administration by chronic nicotine infusion with H1 histamine blockade in female rats

(2016) Edward D. Levin et al.   PSYCHOPHARMACOLOGY

Increases in Drug and Opioid Overdose Deaths — United States, 2000–2014

(2016) Rose A. Rudd et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4

(2015) Ryan Bachtell et al.   CNS & Neurological Disorders-Drug Targets

DAT isn’t all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling

(2015) A L Northcutt et al.   MOLECULAR PSYCHIATRY

The therapeutic potential of interleukin-10 in neuroimmune diseases

(2015) A.J. Kwilasz et al.   NEUROPHARMACOLOGY

Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats

(2015) Brandon J. Hall et al.   NEUROPHARMACOLOGY

Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine

(2015) Anna M W Taylor et al.   NEUROPSYCHOPHARMACOLOGY

Improvement of spinal non-viral IL-10 gene delivery by D-mannose as a transgene adjuvant to control chronic neuropathic pain

(2014) Ellen C Dengler et al.   Journal of Neuroinflammation

Contrasting forms of cocaine-evoked plasticity control components of relapse

(2014) Vincent Pascoli et al.   NATURE

Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward

(2014) Yijun Cui et al.   NATURE NEUROSCIENCE

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Toll-Like Receptor 4 Mutant and Null Mice Retain Morphine-Induced Tolerance, Hyperalgesia, and Physical Dependence

(2014) Theresa Alexandra Mattioli et al.   PLoS One

Effect of Chronic Delivery of the Toll-like Receptor 4 Antagonist (+)-Naltrexone on Incubation of Heroin Craving

(2013) Florence R. Theberge et al.   BIOLOGICAL PSYCHIATRY

National trends in pharmaceutical opioid related overdose deaths compared to other substance related overdose deaths: 1999–2009

(2013) Susan Calcaterra et al.   DRUG AND ALCOHOL DEPENDENCE

Ethanol induces TLR4/TLR2 association, triggering an inflammatory response in microglial cells

(2013) Sara Fernandez-Lizarbe et al.   JOURNAL OF NEUROCHEMISTRY

Adolescent Morphine Exposure Affects Long-Term Microglial Function and Later-Life Relapse Liability in a Model of Addiction

(2013) J. M. Schwarz et al.   JOURNAL OF NEUROSCIENCE

Negative regulation of Toll-like receptor 4 signaling by IL-10-dependent microRNA-146b

(2013) G. Curtale et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FACS analysis of neuronal–glial interactions in the nucleus accumbens following morphine administration

(2013) Jaclyn M. Schwarz et al.   PSYCHOPHARMACOLOGY

Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement

(2012) M. R. Hutchinson et al.   JOURNAL OF NEUROSCIENCE

Nucleus accumbens D2- and D1-receptor expressing medium spiny neurons are selectively activated by morphine withdrawal and acute morphine, respectively

(2012) T. Enoksson et al.   NEUROPHARMACOLOGY

Morphine activates neuroinflammation in a manner parallel to endotoxin

(2012) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animal Models of Neuropsychiatric Disorders

(2011) A.B.P. Fernando et al.   Annual Review of Clinical Psychology

The pro- and anti-inflammatory properties of the cytokine interleukin-6

(2011) Jürgen Scheller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Early-Life Experience Decreases Drug-Induced Reinstatement of Morphine CPP in Adulthood via Microglial-Specific Epigenetic Programming of Anti-Inflammatory IL-10 Expression

(2011) J. M. Schwarz et al.   JOURNAL OF NEUROSCIENCE

Microglia and Memory: Modulation by Early-Life Infection

(2011) L. L. Williamson et al.   JOURNAL OF NEUROSCIENCE

Drug-Evoked Synaptic Plasticity in Addiction: From Molecular Changes to Circuit Remodeling

(2011) Christian Lüscher et al.   NEURON

Plasticity of the stress response early in life: Mechanisms and significance

(2010) Aniko Korosi et al.   DEVELOPMENTAL PSYCHOBIOLOGY

Essential role of toll-like receptor 2 in morphine-induced microglia activation in mice

(2010) Yi Zhang et al.   NEUROSCIENCE LETTERS

The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release

(2009) Sondra T. Bland et al.   BRAIN BEHAVIOR AND IMMUNITY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE