Article
Neurosciences
Chaofei Bao, Xiaoyue Zhu, Joshua Moller-Mara, Jingjie Li, Sylvain Dubroqua, Jeffrey C. Erlich
Summary: This study reveals that the frontal orienting field (FOF) is a crucial node in the neural circuit for the dynamic representation of action values during decision-making under risk in rats. Silencing the FOF caused a change in the curvature of the rats' utility function and reduced lottery choices.
NATURE NEUROSCIENCE
(2023)
Article
Biology
Tarryn Balsdon, Pascal Mamassian, Valentin Wyart
Summary: This study examined neural activity associated with perceptual decision-making and confidence evaluation, revealing distinct patterns even after observers had made their decision commitments. The neural resources for confidence computation were located in specific brain regions, demonstrating a dissociation between perception and confidence evaluation.
Article
Multidisciplinary Sciences
Gwynne L. Davis, Adelaide R. Minerva, Argentina Lario, Linda D. Simmler, Carolyn Rodriguez, Lisa A. Gunaydin
Summary: Intravenous infusion of ketamine rapidly reduces obsessive-compulsive disorder symptoms. Here, the authors show in mice that ketamine acts by increasing activity in a fronto-striatal circuit that causally controls compulsive grooming behavior.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Tianye Jia, Chao Xie, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Christian Buechel, Erin Burke Quinlan, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Juliane H. Froehner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Trevor W. Robbins, Jianfeng Feng
Summary: Using neural imaging techniques, a study explored the neural network underlying alcoholism onset in adolescents. It identified a network centered on the medial orbitofrontal cortex, with evidence of inhibitory and excitatory coregulation by this region over the dorsal periaqueductal gray. Additionally, the study found significant relationships between baseline excitatory coregulation in this network and impulsivity, supporting the role of negative urgency in alcohol dependence.
Article
Neurosciences
Weikang Shi, Sebastien Ballesta, Camillo Padoa-Schioppa
Summary: A series of studies has identified different groups of neurons in the orbitofrontal cortex (OFC) that encode the value of individual options, the choice outcome, and the chosen value. Recent research showed that these neuronal responses are similar under simultaneous and sequential offers, indicating that economic choices rely on the same neural circuit regardless of presentation order.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Nathan A. Schneider, Benjamin Ballintyn, Donald Katz, John Lisman, Hyun-Jae Pi
Summary: In the classical view of economic choices, subjects often fail to reach optimal outcomes due to covert factors such as emotion and sensitivity to sunk cost. The quantification of sensitivity to sunk cost revealed it as another contributor to reduced optimality, along with the cost parameter. When certain conditions were met, the mice behaved in a more rational manner, showing that rationality is a task-specific construct even in mice.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Junneng Shao, Yujie Zhang, Li Xue, Xinyi Wang, Huan Wang, Rongxin Zhu, Zhijian Yao, Qing Lu
Summary: This study utilized a Bayesian model to examine the shared and disease-sensitive alterations in patients with depressive episodes, specifically unipolar disorder and bipolar disorder. The findings revealed three transdiagnostic alteration factors, and demonstrated a relationship between these factors and the bipolar index in patients with initial depressive episode bipolar disorder.
NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Neurosciences
Xinying Cai
Summary: Cognitive maps in rodent hippocampus have evolved from spatial representations to low-dimensional organization of information. Neuroeconomists see utility functions as constructs with neurobiological basis driving choice behavior. The emergence of distinct neuron groups in primate OFC suggests the formation of an abstract cognitive map for organizing information of goods.
Article
Cell Biology
Elise Bousseyrol, Steve Didienne, Samir Takillah, Clement Solie, Maxime Come, Tarek Ahmed Yahia, Sarah Mondoloni, Eleonore Vicq, Ludovic Tricoire, Alexandre Mourot, Jeremie Naude, Philippe Faure
Summary: We developed a task where mice self-determine their actions based on their knowledge of the outcomes and found that a sequence of oscillations and firings in the VTA, OFC, and PFC co-encodes and co-determines self-initiation and choices. Interactions between these structures varied with the reward context, particularly the uncertainty associated with the different options.
Article
Psychology, Biological
Basile Garcia, Mael Lebreton, Sacha Bourgeois-Gironde, Stefano Palminteri
Summary: Standard models assume that subjective value is associated with each option, regardless of whether it is inferred from experience or explicitly instructed. However, this study challenges the assumption of unified representation of experiential and symbolic value. Through nine experiments, participants' choices showed a systematic neglect of experiential values. This normatively irrational decision strategy persisted even when alternative explanations were considered and had an economic cost. Overall, these findings challenge the dominant models commonly used in value-based decision-making research.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Biology
Weikang Shi, Sebastien Ballesta, Camillo Padoa-Schioppa
Summary: Economic choices are influenced by various biases, including order bias and preference bias. These biases emerge at different computational stages.
Article
Multidisciplinary Sciences
Alice Newton-Fenner, Danielle Hewitt, Jessica Henderson, Hannah Roberts, Tyler Mari, Yiquan Gu, Olga Gorelkina, Timo Giesbrecht, Nicolas Fallon, Carl Roberts, Andrej Stancak
Summary: Forming and comparing subjective values (SVs) of choice options is a critical stage of decision-making. This study utilized the Becker-DeGroot-Marschak (BDM) auction to identify the core brain valuation system involved in processing SV. The results showed that willingness-to-pay (WTP) was positively correlated with BOLD activations in several brain regions.
Article
Neurosciences
Qi-Ya Xu, Hai -Long Zhang, Han Du, Yong -Chang Li, Fu-Hai Ji, Rui Li, Guang-Yin Xu
Summary: Chronic visceral pain is a major challenge for both patients and health providers. Research has found that inhibiting or activating CL glutamatergic neurons has no effect on CFA-induced inflammatory pain, but is critical for visceral pain. Further studies have demonstrated a causal link between such neuronal activity and visceral pain behaviors.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Merridee J. Lefner, Alexa P. Magnon, James M. Gutierrez, Matthew R. Lopez, Matthew J. Wanat
Summary: This study investigates the impact of temporal delays on reward preference by examining rats' preference for different flavored rewards during a free-feeding test, finding that temporal delays enhance preference for initially less desirable rewards.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Bilgehan Cavdaroglu, Sadia Riaz, Elton H. L. Yeung, Andy C. H. Lee, Rutsuko Ito
Summary: The ventral hippocampus plays a crucial role in cue-driven approach-avoidance decisions in the face of motivational conflict, with potential deficits in decision-making under innate forms of approach-avoidance conflict.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Aldo Rustichini, Katherine E. Conen, Xinying Cai, Camillo Padoa-Schioppa
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Xinying Cai, Camillo Padoa-Schioppa
NATURE COMMUNICATIONS
(2019)
Article
Neurosciences
Katherine E. Conen, Camillo Padoa-Schioppa
JOURNAL OF NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Sebastien Ballesta, Camillo Padoa-Schioppa
Article
Neurosciences
Ahmad Jezzini, Camillo Padoa-Schioppa
JOURNAL OF NEUROSCIENCE
(2020)
Article
Biology
Masaru Kuwabara, Ningdong Kang, Timothy E. Holy, Camillo Padoa-Schioppa
Article
Neurosciences
Weikang Shi, Sebastien Ballesta, Camillo Padoa-Schioppa
Summary: A series of studies has identified different groups of neurons in the orbitofrontal cortex (OFC) that encode the value of individual options, the choice outcome, and the chosen value. Recent research showed that these neuronal responses are similar under simultaneous and sequential offers, indicating that economic choices rely on the same neural circuit regardless of presentation order.
JOURNAL OF NEUROSCIENCE
(2022)
Editorial Material
Neurosciences
Katherine E. Conen, Theresa M. Desrochers
Summary: In this study, Chiang et al. investigate the population coding of self-ordered sequences in the prefrontal cortex. They find that consistent ordering leads to better decoding, more distributed information, and less variability, which may contribute to planning and memory.
Article
Biology
Xinying Cai, Camillo Padoa-Schioppa
Summary: The role of the dorsal anterior cingulate cortex (ACCd) in decision making remains somewhat unclear. While it encodes post-decision variables, it does not represent pre-decision variables like the individual offer values. Thus, ongoing decisions are unlikely guided by ACCd, but its neuronal activity may inform subsequent actions.
Article
Biology
Weikang Shi, Sebastien Ballesta, Camillo Padoa-Schioppa
Summary: Economic choices are influenced by various biases, including order bias and preference bias. These biases emerge at different computational stages.
Article
Multidisciplinary Sciences
Sebastien Ballesta, Weikang Shi, Camillo Padoa-Schioppa
Summary: The authors demonstrate the role of the orbitofrontal cortex in value comparison during economic choices, providing new insights into the decision-making process.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Sebastien Ballesta, Weikang Shi, Katherine E. Conen, Camillo Padoa-Schioppa
Article
Multidisciplinary Sciences
Wenlong Tang, Jacob D. Davidson, Guoqiang Zhang, Katherine E. Conen, Jian Fang, Fabrizio Serluca, Jingyao Li, Xiaorui Xiong, Matthew Coble, Tingwei Tsai, Gregory Molind, Caroline H. Fawcett, Ellen Sanchez, Peixin Zhu, Iain D. Couzin, Mark C. Fishman