Article
Pharmacology & Pharmacy
Ping Bai, Prasenjit Mondal, Frederick A. Bagdasarian, Nisha Rani, Yan Liu, Ashley Gomm, Darcy R. Tocci, Se Hoon Choi, Hsiao-Ying Wey, Rudolph E. Tanzi, Can Zhang, Changning Wang
Summary: This study investigates the role of HDAC6 in Alzheimer's disease (AD) and suggests that HDAC6 may contribute to AD by affecting brain regions susceptible to AD through an association with amyloid pathology.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Food Science & Technology
Chunyue Wang, Hongbo Jiang, Honghan Liu, Shanshan Chen, Hangyu Guo, Shuoshuo Ma, Weiwei Han, Yu Li, Di Wang
Summary: In this study, the researchers investigated the protective effects of isoforsythiaside (IFY) against ferroptosis and neuroinflammation. They found that IFY can alleviate the expression levels of pro-inflammatory factors and improve mitochondria morphology, and regulate the activation of Nrf2 and NF-xB signaling in erastin-damaged HT22 cells and APP/PS1 mice.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Brian J. Burkett, Jeffrey C. Babcock, Val J. Lowe, Jonathan Graff-Radford, Rathan M. Subramaniam, Derek R. Johnson
Summary: PET imaging plays an essential role in the earlier and more specific diagnoses of dementia syndromes, especially with the development of pathology-specific disease-modifying therapy for Alzheimer disease. Amyloid and tau PET techniques have entered clinical use, making nuclear medicine physicians and radiologists crucial members of the care team. This review discusses recent changes in the understanding of dementia and examines the roles of nuclear medicine imaging in clinical practice.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Immunology
Shiqi Zhou, Yanyan Li, Zhao Zhang, Yuhe Yuan
Summary: The TAM receptors may have a role in delaying the progression of Alzheimer's disease (AD), the most common neurodegenerative disease associated with aging. These receptors are associated with immune responses, cellular differentiation and migration, and clearance of apoptotic cells and debris. Research suggests that the TAM system is involved in AD pathology and regulates microglia, the key sensors of disorder in the central nervous system (CNS).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Wangyu Bi, Tong Lei, Shanglin Cai, Xiaoshuang Zhang, Yanjie Yang, Zhuangzhuang Xiao, Lei Wang, Hongwu Du
Summary: This review summarizes the role of astrocytes in Alzheimer's disease (AD) and explores the potential therapeutic strategies targeting astrocytes. Astrocytes play an important role in the pathogenesis of AD, and therapies targeting astrocytes have shown high efficacy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
L. van Olst, L. Coenen, J. M. Nieuwland, C. Rodriguez-Mogeda, N. M. de Wit, A. Kamermans, J. Middeldorp, H. E. de Vries
Summary: Alzheimer's disease is the most common form of dementia, and currently there are only medications that can improve symptoms but not cure the disease. Recent studies have shown that T cells play an important role in the pathogenesis of Alzheimer's disease, and targeting T cells can combat the pathology and cognitive decline.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Immunology
Livia J. De Picker, Manuel Morrens, Igor Branchi, Bartholomeus C. M. Haarman, Tatsuhiro Terada, Min Su Kang, Delphine Boche, Marie-Eve Tremblay, Claire Leroy, Michel Bottlaender, Julie Ottoy
Summary: This study is a transdiagnostic systematic review and meta-analysis of case-control TSPO PET studies in humans for various CNS disorders. The results show robust increases in the TSPO signal for specific types of disorders, which can be widespread or focal. These findings can contribute to future studies in optimizing experimental design and power calculations.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Neurosciences
Pawel J. Markiewicz, Julian C. Matthews, John Ashburner, David M. Cash, David L. Thomas, Enrico De Vita, Anna Barnes, M. Jorge Cardoso, Marc Modat, Richard Brown, Kris Thielemans, Casper Da Costa-Luis, Isadora Lopes Alves, Juan Domingo Gispert, Mark E. Schmidt, Paul Marsden, Alexander Hammers, Sebastien Ourselin, Frederik Barkhof
Summary: The precision of MR-PET image registration is mainly driven by the registration implementation and the quality of PET images, with different software packages and reconstruction parameters having varying impacts on the uncertainty. This analysis provides insights into the factors influencing the accuracy of PET data obtained from different scanning techniques.
Article
Immunology
Zhiyu Wang, Donald F. Weaver
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by the progressive deterioration of multiple cognitive functions. Microglial cells play a crucial role in the pathogenesis of Alzheimer's disease through the recognition and response to misfolded proteins like beta-amyloid and tau. These proteins contribute to neuroinflammation and neurotoxicity, while microglia's primary function is to maintain brain homeostasis and synaptic integrity. However, prolonged activation of microglia can be harmful. This review discusses the role of microglia in Alzheimer's disease pathogenesis and explores potential drug candidates targeting microglial receptors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Swetha Pavani Rao, Wei Xie, Ye In Christopher Kwon, Nicholas Juckel, Jiashu Xie, Venkateshwara Rao Dronamraju, Robert Vince, Michael K. Lee, Swati S. More
Summary: This study demonstrates the feasibility of managing AD by enhancing 3MST function in the brain and identifies sulfanegen as a potential AD therapeutic.
Article
Immunology
Panagiota Pagoni, Roxanna S. Korologou-Linden, Laura D. Howe, George Davey Smith, Yoav Ben-Shlomo, Evie Stergiakouli, Emma L. Anderson
Summary: This study suggests a causal role of cytokines in the pathogenesis of Alzheimer's disease and fluid intelligence.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Review
Cell Biology
Lee Wei Lim, Md . Sahab Uddin
Summary: Alzheimer's disease is a neurodegenerative disorder with unclear pathogenesis. Recent research suggests that microglia and astrocytes may play a role in the development of AD and could be potential therapeutic targets.
AGEING RESEARCH REVIEWS
(2022)
Review
Chemistry, Analytical
Xingyun Liu, Yibiao Liu, Qiong Liu
Summary: Alzheimer's disease (AD) is a neurodegenerative disease characterized by memory loss and cognitive impairment. Early diagnosis is crucial for intervention and treatment effectiveness assessment, but current clinical methods are costly and inaccessible. Blood sample detection offers a less invasive and more accessible alternative, with various assays developed for the detection of AD biomarkers. Fluorescence-sensing techniques, with their low toxicity and high sensitivity, can not only detect biomarker levels in blood but also image them in the brain in real time. This review summarizes the recent development of fluorescent sensing platforms and their potential clinical applications.
Article
Radiology, Nuclear Medicine & Medical Imaging
Joseph Therriault, Andrea L. Benedet, Tharick A. Pascoal, Melissa Savard, Nicholas J. Ashton, Mira Chamoun, Cecile Tissot, Firoza Lussier, Min Su Kang, Gleb Bezgin, Tina Wang, Jaime Fernandes-Arias, Gassan Massarweh, Paolo Vitali, Henrik Zetterberg, Kaj Blennow, Paramita Saha-Chaudhuri, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Neto
Summary: This study assessed multiple methods for determining an optimal cutoff for F-18-AZD4694 PET positivity, with good convergence among different approaches. The findings suggest that a threshold of 1.55 SUVR may have reliable discriminative accuracy for amyloid-beta positivity on PET imaging.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Li-Lin Chen, Yong-Gang Fan, Ling-Xiao Zhao, Qi Zhang Zhan-You
Summary: Alzheimer's disease (AD) is the most common dementia with uncertain etiology, characterized by the deposition of beta-amyloid protein (A beta) and tau hyperphosphorylation. Metal ions dysmetabolism and chronic neuroinflammation are alternative etiological hypotheses for AD. This review comprehensively summarizes the effects of metal ions on A beta dynamics and tau phosphorylation in the progression of AD, and highlights the potential of metal ion chelators as agents to alleviate neuroinflammation in AD. More investigations on the effects of metal ions on neuroinflammation and metal ion chelators on neuroinflammation should be conducted. Title: Metal chelators against neuroinflammation.
BIOORGANIC CHEMISTRY
(2023)
Article
Clinical Neurology
Angelina J. Polsinelli, Ryan J. Wonderlin, Dustin B. Hammers, Alex Pena Garcia, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Laurel Beckett, Sujuan Gao, Sophia Wang, Kala Kirby, Paige E. Logan, Paul Aisen, Jeffrey L. Dage, Tatiana Foroud, Percy Griffin, Leonardo Iaccarino, Joel H. Kramer, Robert Koeppe, Walter A. Kukull, Renaud La Joie, Nidhi S. Mundada, Melissa E. Murray, Kelly Nudelman, David N. Soleimani-Meigooni, Malia Rumbaugh, Arthur W. Toga, Alexandra Touroutoglou, Prashanthi Vemuri, Alireza Atri, Gregory S. Day, Ranjan Duara, Neill R. Graff-Radford, Lawrence S. Honig, David T. Jones, Joseph Masdeu, Mario F. Mendez, Kyle Womack, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Steven Salloway, Sharon J. Sha, Raymond S. Turner, Thomas S. Wingo, David A. Wolk, Maria C. Carrillo, Bradford C. Dickerson, Gil D. Rabinovici, Liana G. Apostolova
Summary: We investigated NPS and psychotropic medication use in individuals with EOAD using data from LEADS. Affective behaviors were most common in EOAD, while tension and impulse control behaviors were more common in EOnonAD. Psychotropic medication use was higher in EOnonAD. Overall, NPS burden and psychotropic medication use were higher in EOnonAD compared to EOAD participants.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Dustin Hammers, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Laurel Beckett, Sujuan Gao, Kala Kirby, Paul L. Aisen, Jeffrey Dage, Tatiana Foroud, Percy T. Griffin, Lea R. Grinberg, Clifford Jack Jr, Joel Kramer, Robert A. Koeppe, Walter Kukull, Nidhi S. Mundada, Renaud N. La Joie, David Soleimani-Meigooni, Leonardo E. Iaccarino, Melissa Murray, Kelly J. Nudelman, Angelina Polsinelli, Malia Rumbaugh, Arthur Toga, Alexandra Touroutoglou, Prashanthi Vemuri, Alireza S. Atri, Gregory Day, Ranjan R. Duara, Neill S. Graff-Radford, Lawrence T. Honig, David Jones, Joseph F. Masdeu, Mario Mendez, Kyle Womack, Erik U. Musiek, Chiadi Onyike, Meghan Riddle, Emily Rogalski, Steven J. Salloway, Sharon Sha, Raymond Scott S. Turner, Thomas A. Wingo, David C. Wolk, Maria C. Carrillo, Bradford D. Dickerson, Gil G. Rabinovici, Liana Apostolova
Summary: This study provides a comprehensive understanding of early-onset Alzheimer's disease (EOAD) by profiling the baseline characteristics of EOAD patients. The study found that EOAD patients had worse cognitive performance and higher rates of APOE epsilon 4 carrier status. Amnestic presentation was common among EOAD patients, along with other clinical phenotypes.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Dustin Hammers, Sara Nemes, Taylor Diedrich, Ani Eloyan, Kala Kirby, Paul Aisen, Joel Kramer, Kelly Nudelman, Tatiana Foroud, Malia Rumbaugh, Alireza S. Atri, Gregory Day, Ranjan R. Duara, Neill S. Graff-Radford, Lawrence T. Honig, David C. Jones, Joseph F. Masdeu, Mario Mendez, Erik U. Musiek, Chiadi Onyike, Meghan Riddle, Emily Rogalski, Steve J. Salloway, Sharon J. Sha, Raymond Scott Turner, Sandra S. Weintraub, Thomas A. Wingo, David Wolk, Bonnie C. Wong, Maria C. Carrillo, Bradford D. Dickerson, Gil G. Rabinovici, Liana Apostolova
Summary: This study investigated the limitations of learning slopes in early-onset dementias and aimed to highlight the sensitivity of learning slopes in discriminating disease severity in cognitively normal participants and those diagnosed with early-onset dementia. The results showed that learning slopes are highly sensitive to early-onset dementias, even when controlling for the effect of total learning and cognitive severity. The rating for the importance of this study is 8 out of 10.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Han-Kyeol Kim, Tae Won Kim, Min Seok Baek, Eung Yeop Kim, Young Hee Sung, Jae Hoon Lee, Young Hoon Ryu, Sung Jun Ahn, Han Soo Yoo, Chul Hyoung Lyoo
Summary: In this study, the visibility of NG1 in SMwI was found to be associated with the degree of nigrostriatal degeneration in PD patients. It was concluded that SMwI can be used for diagnosing PD only after the onset of motor symptoms.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Immunology
Max Stevenson, Rency Varghese, Michaeline L. Hebron, Xiaoguang Liu, Nick Ratliff, Amelia Smith, R. Scott Turner, Charbel Moussa
Summary: Treatment with nilotinib in patients with mild-moderate Alzheimer's disease for 12 months can reduce amyloid plaque and cerebrospinal fluid amyloid levels, as well as attenuate hippocampal volume loss. This is achieved by inhibiting DDR-1 gene expression and activity, leading to a reduction in inflammation. Nilotinib may not only clear amyloid and tau but also reduce cerebrovascular fibrosis.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Clinical Neurology
Yoon-Sang Oh, Joong-Seok Kim, Chul Hyoung Lyoo, Hosung Kim
Summary: This study found that Parkinson's disease patients with obstructive sleep apnea had significantly lower dopamine availability in the caudate nucleus compared to those without obstructive sleep apnea. This association was more pronounced in female patients. However, there was no difference in dopamine availability in other structures (putamen, globus pallidus, thalamus) between the two groups.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Jeffrey Dage, Ani Eloyan, Maryanne Thangarajah, Dustin B. Hammers, Anne M. Fagan, Julia D. Gray, Suzanne E. Schindler, Casey Snoddy, Kelly N. H. Nudelman, Kelley M. Faber, Tatiana Foroud, Paul Aisen, Percy T. Griffin, Lea T. Grinberg, Leonardo Iaccarino, Kala Kirby, Joel Kramer, Robert A. Koeppe, Walter A. Kukull, Renaud La Joie, Nidhi S. Mundada, Melissa E. Murray, Malia Rumbaugh, David N. Soleimani-Meigooni, Arthur W. Toga, Alexandra Touroutoglou, Prashanthi Vemuri, Alireza A. Atri, Laurel A. Beckett, Gregory S. Day, Neill R. Graff-Radford, Ranjan S. Duara, Lawrence S. Honig, David T. Jones, Joseph C. Masdeu, Mario F. Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon J. Sha, Raymond S. Turner, Thomas S. Wingo, David A. Wolk, Kyle B. Womack, Maria C. Carrillo, Bradford C. Dickerson, Gil D. Rabinovici, Liana G. Apostolova
Summary: This study provides a comprehensive analysis of cerebrospinal fluid biomarkers in early-onset Alzheimer's disease (EOAD) and identifies significant differences in biomarker concentrations between different groups. Most biomarkers are found to be correlated with cognition. These findings have important implications for the design of clinical trials for EOAD.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Hanna Cho, Nidhi S. Mundada, Liana G. Apostolova, Maria C. Carrillo, Ranjani Shankar, Alinda N. Amuiri, Ehud Zeltzer, Charles C. Windon, David N. Soleimani-Meigooni, Jeremy A. Tanner, Courtney Lawhn Heath, Orit H. Lesman-Segev, Paul Aisen, Ani Eloyan, Hye Sun Lee, Dustin B. Hammers, Kala Kirby, Jeffrey L. Dage, Anne Fagan, Tatiana Foroud, Lea T. Grinberg, Clifford R. Jack, Joel Kramer, Walter A. Kukull, Melissa E. Murray, Kelly Nudelman, Arthur Toga, Prashanthi Vemuri, Alireza Atri, Gregory S. Day, Ranjan Duara, Neill R. Graff-Radford, Lawrence S. Honig, David T. Jones, Joseph Masdeu, Mario Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily J. Rogalski, Stephen Salloway, Sharon Sha, Raymond Scott Turner, Thomas S. Wingo, David A. Wolk, Robert Koeppe, Leonardo Iaccarino, Bradford C. Dickerson, Renaud La Joie, Gil D. Rabinovici
Summary: This study describes the baseline amyloid-beta and tau-PET results in early-onset Alzheimer's disease. The results show that amyloid-PET can help distinguish early-onset Alzheimer's disease from other cognitive impairments, and tau-PET signal is elevated in a parietal-predominant pattern with higher burden in younger female patients.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Sara Nemes, Paige E. Logan, Mohit K. Manchella, Nidhi S. Mundada, Renaud La Joie, Angelina J. Polsinelli, Dustin B. Hammers, Robert A. Koeppe, TatianaM. Foroud, Kelly N. Nudelman, Ani Eloyan, Leonardo Iaccarino, Valerie Dorsant-Ardon, Alexander Taurone, Maryanne Thangarajah, Jeffery L. Dage, Paul Aisen, Lea T. Grinberg, Clifford R. Jack, Joel Kramer, Walter A. Kukull, Melissa E. Murray, Malia Rumbaugh, David N. Soleimani-Meigooni, Arthur Toga, Alexandra Touroutoglou, Prashanthi Vemuri, Alireza Atri, Gregory S. Day, Ranjan Duara, Neill R. Graff-Radford, Lawrence S. Honig, David T. Jones, Joseph Masdeu, Mario F. Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon J. Sha, Raymond S. Turner, Thomas S. Wingo, Kyle B. Womack, David A. Wolk, Gil D. Rabinovici, Maria C. Carrillo, Bradford C. Dickerson, Liana G. Apostolova
Summary: This study investigated the predictive ability of sex and APOE epsilon 4 carrier status on the pathological burden in early-onset Alzheimer's disease. The results showed that EOAD females had higher amyloid and tau PET burdens compared to males, and EOAD female APOE epsilon 4 non-carriers had higher amyloid PET burdens and greater gray matter atrophy compared to carriers.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Justin Bushnell, Dustin B. Hammers, Paul Aisen, Jeffrey L. Dage, Ani Eloyan, Tatiana Foroud, Lea T. Grinberg, Leonardo Iaccarino, Clifford R. Jack Jr, Kala Kirby, Joel Kramer, Robert Koeppe, Walter A. Kukull, Renaud La Joie, Nidhi S. Mundada, Melissa E. Murray, Kelly Nudelman, Malia Rumbaugh, David N. Soleimani-Meigooni, Arthur Toga, Alexandra Touroutoglou, Prashanthi Vemuri, Alireza Atri, Gregory S. Day, Ranjan Duara, Neill R. Graff-Radford, Lawrence S. Honig, David T. Jones, Joseph Masdeu, Mario Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Steven Salloway, Sharon Sha, Raymond S. Turner, Thomas S. Wingo, David A. Wolk, Maria C. Carrillo, Bradford C. Dickerson, Gil D. Rabinovici, Liana G. Apostolova, David G. Clark
Summary: This study assessed the influence of amyloid and diagnostic syndrome on memory scores in early-onset Alzheimer's disease (EOAD) using the Rey Auditory Verbal Learning Test (RAVLT). The results showed that the RAVLT measures were sensitive to the effects of amyloid and syndrome in EOAD.
ALZHEIMERS & DEMENTIA
(2023)
Review
Clinical Neurology
Alexandra Touroutoglou, Yuta Katsumi, Michael Brickhouse, Alexander Zaitsev, Ryan Eckbo, Paul Aisen, Laurel Beckett, Jeffrey L. Dage, Ani Eloyan, Tatiana Foroud, Bernardino Ghetti, Percy Griffin, Dustin Hammers, Clifford R. Jack, Joel H. Kramer, Leonardo Iaccarino, Renaud La Joie, Nidhi S. Mundada, Robert Koeppe, Walter A. Kukull, Melissa E. Murray, Kelly Nudelman, Angelina J. Polsinelli, Malia Rumbaugh, David N. Soleimani-Meigooni, Arthur Toga, Prashanthi Vemuri, Alireza Atri, Gregory S. Day, Ranjan Duara, Neill R. Graff-Radford, Lawrence S. Honig, David T. Jones, Joseph C. Masdeu, Mario F. Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon Sha, R. Scott Turner, Thomas S. Wingo, David A. Wolk, Kyle Womack, Maria C. Carrillo, Gil D. Rabinovici, Liana G. Apostolova, Bradford C. Dickerson, LEADS Consortium
Summary: MRI research has advanced understanding of neurodegeneration in sporadic early-onset Alzheimer's disease, with the EOAD-signature atrophy replicated across different cohorts and associated with the severity of cognitive impairment. This suggests that EOAD-signature atrophy could be a reliable biomarker for AD-related neurodegeneration in clinical trials for EOAD.
ALZHEIMERS & DEMENTIA
(2023)
Review
Clinical Neurology
Ani Eloyan, Maryanne Thangarajah, Na J. An, Bret J. L. Borowski, Ashritha L. Reddy, Paul L. Aisen, Jeffrey L. Dage, Tatiana Foroud, Bernardino Ghetti, Percy Griffin, Dustin Hammers, Leonardo R. Iaccarino, Clifford R. Jack, Kala Kirby, Joel Kramer, Robert A. Koeppe, Walter A. Kukull, Renaud La Joie, Nidhi S. E. Mundada, Melissa E. Murray, Kelly Nudelman, Malia N. Rumbaugh, David N. Soleimani-Meigooni, Arthur Toga, Alexandra Touroutoglou, Alireza S. Atri, Gregory S. Day, Ranjan R. Duara, Neill R. S. Graff-Radford, Lawrence S. T. Honig, David T. Jones, Joseph F. Masdeu, Mario F. Mendez, Erik U. Musiek, Chiadi U. Onyike, Emily Rogalski, Stephen Salloway, Sharon S. Sha, Raymond S. S. Turner, Thomas S. A. Wingo, David A. Wolk, Kyle Womack, Laurel Beckett, Sujuan C. Gao, Maria C. Carrillo, Gil G. Rabinovici, Liana G. Apostolova, Brad Dickerson, Prashanthi Vemuri, LEADS Consortium
Summary: This study compared white matter hyperintensities (WMHs) in early-onset Alzheimer's disease (EOAD) with cognitively normal (CN) and early-onset amyloid-negative cognitively impaired (EOnonAD) groups. The results showed that EOAD patients had higher WMH volumes compared to CN and EOnonAD patients, and WMH volume was positively correlated with cognitive impairment and tau burden.
ALZHEIMERS & DEMENTIA
(2023)
Review
Clinical Neurology
Kelly N. H. Nudelman, Trever Jackson, Malia Rumbaugh, Ani Eloyan, Marco Abreu, Jeffrey L. Dage, Casey Snoddy, Kelley M. Faber, Tatiana Foroud, Dustin B. Hammers, Alexander Taurone, Maryanne Thangarajah, Paul Aisen, Laurel Beckett, Joel Kramer, Robert Koeppe, Walter A. Kukull, Melissa E. Murray, Arthur W. Toga, Prashanthi Vemuri, Alireza Atri, Gregory S. Day, Ranjan Duara, Neill R. Graff-Radford, Lawrence S. Honig, David T. Jones, Joseph C. Masdeu, Mario Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon J. Sha, R. Scott Turner, Thomas S. Wingo, David A. Wolk, Maria C. Carrillo, Bradford C. Dickerson, Gil D. Rabinovici, Liana G. Apostolova
Summary: The Longitudinal Early-onset Alzheimer's Disease Study aims to investigate the genetic causes of early onset cognitive impairment. The study found that the participants had a low frequency of common pathogenic variants.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Mark Monane, Kim G. Johnson, B. Joy Snider, Raymond S. Turner, Jonathan D. Drake, Demetrius M. Maraganore, James L. Bicksel, Daniel H. Jacobs, Julia L. Ortega, Joni Henderson, Yan Jiang, Shuguang Huang, Justine Coppinger, Ilana Fogelman, Tim West, Joel B. Braunstein
Summary: The objective of this study was to examine the patient selection and result interpretation of the PrecivityAD (R) blood test in clinicians evaluating symptomatic patients for Alzheimer's disease or other causes of cognitive decline. The study found that the test had clinical utility in patient care and could be particularly relevant with the introduction of new Alzheimer's disease therapies.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Neurosciences
Sang-Won Yoo, Seunggyun Ha, Chul Hyoung Lyoo, Yuna Kim, Ji-Yeon Yoo, Joong-Seok Kim
Summary: This study explores the interaction between essential tremor (ET) and Parkinson's disease (PD), finding that patients with PD preceded by ET may exhibit different characteristics from those with pure ET or PD. Patients with PD preceded by ET show typical striatal pathology, but with a delay in noradrenergic impairment. ET patients have similar patterns of presynaptic dopamine transporter deficits as PD patients.
NPJ PARKINSONS DISEASE
(2023)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)