Article
Food Science & Technology
Chunyue Wang, Hongbo Jiang, Honghan Liu, Shanshan Chen, Hangyu Guo, Shuoshuo Ma, Weiwei Han, Yu Li, Di Wang
Summary: In this study, the researchers investigated the protective effects of isoforsythiaside (IFY) against ferroptosis and neuroinflammation. They found that IFY can alleviate the expression levels of pro-inflammatory factors and improve mitochondria morphology, and regulate the activation of Nrf2 and NF-xB signaling in erastin-damaged HT22 cells and APP/PS1 mice.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Review
Biochemistry & Molecular Biology
Qi Wang, Jingyi Sun, Tian Chen, Siyu Song, Yajun Hou, Lina Feng, Cundong Fan, Mingquan Li
Summary: Alzheimer's disease, the most common form of dementia, is characterized by progressive cognitive dysfunction in elderly individuals. Regulatory cell death, including ferroptosis, pyroptosis, and cuproptosis, has been found to be closely related to the occurrence and development of AD. Understanding the molecular mechanisms of these processes may lead to potential therapeutic targets for AD.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Qi Wang, Jingyi Sun, Tian Chen, Siyu Song, Yajun Hou, Lina Feng, Cundong Fan, Mingquan Li
Summary: Alzheimers disease is a neurodegenerative disorder with a rapidly increasing mortality rate. Regulation of cell death plays a crucial role in maintaining homeostasis, and studies have found that ferroptosis, pyroptosis, and cuproptosis are closely related to the development of Alzheimers disease.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Immunology
Shiqi Zhou, Yanyan Li, Zhao Zhang, Yuhe Yuan
Summary: The TAM receptors may have a role in delaying the progression of Alzheimer's disease (AD), the most common neurodegenerative disease associated with aging. These receptors are associated with immune responses, cellular differentiation and migration, and clearance of apoptotic cells and debris. Research suggests that the TAM system is involved in AD pathology and regulates microglia, the key sensors of disorder in the central nervous system (CNS).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Wangyu Bi, Tong Lei, Shanglin Cai, Xiaoshuang Zhang, Yanjie Yang, Zhuangzhuang Xiao, Lei Wang, Hongwu Du
Summary: This review summarizes the role of astrocytes in Alzheimer's disease (AD) and explores the potential therapeutic strategies targeting astrocytes. Astrocytes play an important role in the pathogenesis of AD, and therapies targeting astrocytes have shown high efficacy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Lusi Zhang, Jia Fang, Zhenchu Tang, Yingying Luo
Summary: The study identified significant gene expression differences in the hippocampus of AD patients, particularly in genes related to ferroptosis. These differences impact biological processes and pathways related to AD pathogenesis, and also regulate immune cell infiltration patterns in the hippocampus. The dysregulation of ferroptosis-related genes may accurately predict the occurrence of AD.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Miaomiao Wang, Gan Tang, Congfa Zhou, Hongmin Guo, Zihui Hu, Qixing Hu, Guilin Li
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by chronic neuroinflammation, amyloid beta-protein deposition, and hyperphosphorylated tau protein. Neuroinflammation and microglial activation play significant roles in AD, contributing to neuronal dysfunction and disease progression. Ferroptosis, an iron-dependent form of cell death, accelerates AD by promoting abnormal microglial activation and neuronal dysfunction. Iron dysregulation and neuronal ferroptosis aggravate neuroinflammation and abnormal microglial activation, creating a vicious cycle. This review explores the relationship between ferroptosis, microglia, and AD, emphasizing the role of ferroptosis in chronic neuroinflammation and providing new insights for potential therapeutic targets.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Pharmacology & Pharmacy
L. van Olst, L. Coenen, J. M. Nieuwland, C. Rodriguez-Mogeda, N. M. de Wit, A. Kamermans, J. Middeldorp, H. E. de Vries
Summary: Alzheimer's disease is the most common form of dementia, and currently there are only medications that can improve symptoms but not cure the disease. Recent studies have shown that T cells play an important role in the pathogenesis of Alzheimer's disease, and targeting T cells can combat the pathology and cognitive decline.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Immunology
Zhiyu Wang, Donald F. Weaver
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by the progressive deterioration of multiple cognitive functions. Microglial cells play a crucial role in the pathogenesis of Alzheimer's disease through the recognition and response to misfolded proteins like beta-amyloid and tau. These proteins contribute to neuroinflammation and neurotoxicity, while microglia's primary function is to maintain brain homeostasis and synaptic integrity. However, prolonged activation of microglia can be harmful. This review discusses the role of microglia in Alzheimer's disease pathogenesis and explores potential drug candidates targeting microglial receptors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Swetha Pavani Rao, Wei Xie, Ye In Christopher Kwon, Nicholas Juckel, Jiashu Xie, Venkateshwara Rao Dronamraju, Robert Vince, Michael K. Lee, Swati S. More
Summary: This study demonstrates the feasibility of managing AD by enhancing 3MST function in the brain and identifies sulfanegen as a potential AD therapeutic.
Article
Immunology
Panagiota Pagoni, Roxanna S. Korologou-Linden, Laura D. Howe, George Davey Smith, Yoav Ben-Shlomo, Evie Stergiakouli, Emma L. Anderson
Summary: This study suggests a causal role of cytokines in the pathogenesis of Alzheimer's disease and fluid intelligence.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Review
Cell Biology
Lee Wei Lim, Md . Sahab Uddin
Summary: Alzheimer's disease is a neurodegenerative disorder with unclear pathogenesis. Recent research suggests that microglia and astrocytes may play a role in the development of AD and could be potential therapeutic targets.
AGEING RESEARCH REVIEWS
(2022)
Review
Cell Biology
Yiran Sun, Chenchen Yan, Libo He, Shixie Xiang, Pan Wang, Zhonghua Li, Yuanzhao Chen, Jie Zhao, Ye Yuan, Wang Wang, Xiaowei Zhang, Pan Su, Yunfang Su, Jinlian Ma, Jiangyan Xu, Quekun Peng, Huifen Ma, Zhishen Xie, Zhenqiang Zhang
Summary: Alzheimer's disease (AD), a chronic and progressive neurodegenerative disease, poses a serious threat to the health of the elderly. The microscopic features of the AD brain are amyloid plaques and neurofibrillary tangles. Despite extensive research, there are still no effective drugs to halt the progression of AD. Ferroptosis, a type of programmed cell death, has been shown to promote the development of AD, and inhibiting neuronal ferroptosis can improve cognitive impairment. Calcium (Ca2+) dyshomeostasis has been found to be closely related to AD pathology, driving ferroptosis through various pathways. This paper reviews the roles of ferroptosis and Ca2+ in AD pathology and suggests that targeting the homeostasis of Ca2+ to restrain ferroptosis may be an innovative approach for AD treatment.
AGEING RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Joanna I. Lachowicz, Giusi Pichiri, Marco Piludu, Sara Fais, Germano Orru, Terenzio Congiu, Monica Piras, Gavino Faa, Daniela Fanni, Gabriele Dalla Torre, Xabier Lopez, Kousik Chandra, Kacper Szczepski, Lukasz Jaremko, Mitra Ghosh, Abdul-Hamid Emwas, Massimo Castagnola, Mariusz Jaremko, Ewald Hannappel, Pierpaolo Coni
Summary: Thymosin beta 4 (T beta 4) is a protein involved in blood clotting, tissue regeneration, angiogenesis, and anti-inflammatory processes. This study reveals the important role of T beta 4 in an iron-dependent form of cell death, and its potential therapeutic implications in cancer and neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Caterina Di Lauro, Carolina Bianchi, Alvaro Sebastian-Serrano, Lucia Soria-Tobar, Beatriz Alvarez-Castelao, Annette Nicke, Miguel Diaz-Hernandez
Summary: The upregulation of P2X7 in patients with tauopathies and a tauopathy mouse model suggests its involvement in neuroinflammation and potential as a target for treating tauopathies. Pharmacological or genetic blockade of P2X7 in P301S mice reversed microglial activation, reduced intraneuronal phosphorylated Tau levels, and improved cellular survival, motor and memory deficits, and anxiolytic profile. Conversely, overexpression of P2X7 worsened Tau-induced toxicity and exacerbated motor and memory deficits in P301S mice.
PROGRESS IN NEUROBIOLOGY
(2022)
Correction
Biochemistry & Molecular Biology
Mohamed Marzouk, Shimaa M. Khalifa, Amal H. Ahmed, Ahmed M. Metwaly, Hala Sh. Mohammed, Hanan A. A. Taie
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Gerardo Andres Libreros-Zuniga, Danilo Pava e Pavao, Vinicius de Morais Barroso, Nathalya Cristina de Moraes Roso Mesquita, Saulo Fehelberg Pinto Braga, Glaucius Oliva, Rafaela Salgado Ferreira, Kelly Ishida, Marcio Vinicius Bertacine Dias
Summary: Tuberculosis is a major global cause of death, and the emergence of drug-resistant strains has increased the burden of this disease. New alternative therapies are constantly needed, and recent research has identified small molecules as potential inhibitors of Ldts in M. tuberculosis, which have antimycobacterial activity.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xiao-Dong Wang, Yong-Si Liu, Ming-Hao Hu
Summary: In this study, a selffolded fluorescent probe was designed to selectively illuminate G4s by unfolding its intramolecular aggregation mediated by G4 binding. This probe showed more controllable background emission and promising ability to track G4 forming dynamics compared to previous disaggregation-induced emission (DIE) probes.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Xiang, Zhuo Yuan, Qichuan Deng, Linshen Xie, Dongke Yu, Jianyou Shi
Summary: This review provides a brief description of the diagnosis, pathogenesis, and potential therapeutic inhibitors for renal fibrosis. Currently, there are no clear therapeutic targets or drugs for renal fibrosis; however, some natural products may have potential efficacy for treating renal fibrosis.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Simone Giovannuzzi, Anna Nikitjuka, Bruna Rafaela Pereira Resende, Michael Smietana, Alessio Nocentini, Claudiu T. Supuran, Jean-Yves Winum
Summary: Boron-based compounds have been extensively studied in medicinal chemistry, playing a crucial role in designing small molecule drugs for various diseases. Boron is particularly valuable in developing inhibitors for metalloenzymes carbonic anhydrases, and it can modulate ligand recognition ability and selectivity. Recent advancements have led to the discovery of novel boron-based inhibitors that can inhibit carbonic anhydrases through a Lewis acid-base mechanism. Further research is needed to fully explore the potential of boron-based inhibitors and advance their clinical applications.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinxin Liu, Lei Chen, Ze Chen
Summary: This study developed a nanostructured photosensitizer loaded with oxygen-throttling drug and demonstrated its enhanced cytotoxicity against tumor cells under hypoxic conditions. Animal experiments showed the enhanced tumor targeting capability of the photosensitizer and its inhibitory effect on tumor growth.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuai Jiang, Wen-Yan Li, Zai-Feng Yuan, Qin-Shi Zhao
Summary: This study isolated two new dimeric Lycopodium alkaloids and twelve previously undescribed Lycopodium alkaloids from Lycopodiastrum casuarinoides. The structures of these compounds were determined and their inhibitory activities on the Cav3.1 channel were evaluated.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yan Yang, Dong-Xiao Yan, Rui-Xue Rong, Bing-Ye Shi, Man Zhang, Jing Liu, Jie Xin, Tao Xu, Wen-Jie Ma, Xiao-Liu Li, Ke-Rang Wang
Summary: In this study, a series of nucleolar fluorescent probes based on naphthalimide derivatives were designed and synthesized, which could achieve clear nucleolar staining in living cells. The results showed that these probes exhibited good targeting to the cell nucleolus and could bind to RNA and enhance fluorescence. This has positive implications for the diagnosis and treatment of nucleolus-related diseases.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yongxi Dong, Fang Wang, Jinlan Wen, Yongqing Mao, Shanhui Zhang, Tiemei Long, Zhangxiang Yang, Lei Li, Jiquan Zhang, Li Dong, Gang Liu, Jianwei Xu
Summary: The hybrid molecules of Scutellarein and Tertramethylpyrazine show excellent neuroprotective and antiplatelet effects in the treatment of ischemic stroke. Compound 1e is particularly effective, enhancing cell membrane permeability and inhibiting cell uptake, as well as significantly reducing cerebral infarction volume.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Chen, Yuanyuan Ying, Jonathan Lalsiamthara, Yuheng Zhao, Saber Imani, Xin Li, Sijing Liu, Qingjing Wang
Summary: This paper examines the role and metabolic regulation of NAD+ in bacteria, highlighting its impact on physiology and virulence. It explores enzymes associated with NAD+ metabolism as potential targets for antibacterial drugs and vaccine candidates. Additionally, it scrutinizes the medical potential of NAD+ and provides insights for its application in biomedicine.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jon Macicior, Daniel Fernandez, Silvia Ortega-Gutierrez
Summary: Hutchinson-Gilford progeria syndrome (HGPS), also known as progeria, is a rare genetic disease that causes premature aging and significantly reduces life expectancy. Currently, there is only one approved drug for treating progeria, but its efficacy is limited. Progerin levels are believed to be the most important biomarker related to disease severity.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Fuko Hirano, Naoya Kondo, Yusuke Murata, Aya Sudani, Takashi Temma
Summary: Fluorinated alpha-methyl 3BPA derivatives showed improved water solubility, tumor targetability, and biodistribution compared to 3BPA and BPA, resulting in significantly improved tumor-to-normal tissue ratios.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ying Shi, Jiaqin Tang, Shumeng Zhi, Ruiqi Jiang, Qing Huang, Lei Sun, Zhizhong Wang, Yanran Wu
Summary: Necroptosis is a type of cell death associated with various diseases. In this study, we identified a small molecule inhibitor, SY-1, that effectively blocks necroptosis by inhibiting the phosphorylation of RIP1/RIP3/MLKL pathway. SY-1 also showed protective effects against TNF-induced hypothermia and improved survival in mice with SIRS. These findings highlight the potential therapeutic applications of SY-1.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Andrea Bagan, Sonia Abas, Judith Pala-Pujadas, Alba Irisarri, Christian Grinan-Ferre, Merce Pallas, Itziar Muneta-Arrate, Carolina Muguruza, Luis F. Callado, Belen Perez, Elies Molins, Jose A. Morales-Garcia, Carmen Escolano
Summary: Recent studies have identified the modulation of imidazoline I-2 receptors (I-2-IR) by selective ligands as a potential strategy for treating neurodegenerative diseases. This study reports a family of bicyclic alpha-iminophosphonates that show high affinity and selectivity for I-2-IR and demonstrates their neuroprotective and anti-inflammatory effects in in vitro and in vivo models. The findings emphasize the importance of exploring structurally novel I-2-IR ligands for therapeutic strategies in neurodegeneration.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qiuping Xiang, Tianbang Wu, Cheng Zhang, Chao Wang, Hongrui Xu, Qingqing Hu, Jiankang Hu, Guolong Luo, Xiaoxi Zhuang, Xishan Wu, Yan Zhang, Yong Xu
Summary: This study reports the discovery of a 1-(indolizin-3-yl)ethan-1-one derivative as a potent and selective CBP bromodomain inhibitor for AML drug development.
BIOORGANIC CHEMISTRY
(2024)