Loss of host-derived osteopontin creates a glioblastoma-promoting microenvironment

Osteopontin has a protective role in prostate tumor development in mice

(2016) Keiko Danzaki et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human glioblastoma-associated microglia/monocytes express a distinct RNA profile compared to human control and murine samples

(2016) Frank Szulzewsky et al.   GLIA

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

Advances in the molecular genetics of gliomas — implications for classification and therapy

(2016) Guido Reifenberger et al.   Nature Reviews Clinical Oncology

Tumour-processed osteopontin and lactadherin drive the protumorigenic reprogramming of microglia and glioma progression

(2016) A Ellert-Miklaszewska et al.   ONCOGENE

New role of osteopontin in DNA repair and impact on human glioblastoma radiosensitivity

(2016) Aurélie Henry et al.   Oncotarget

Suppression of osteopontin inhibits chemically induced hepatic carcinogenesis by induction of apoptosis in mice

(2016) Su-Hyung Lee et al.   Oncotarget

The embryonic type of SPP1 transcriptional regulation is re-activated in glioblastoma

(2016) Magdalena Kijewska et al.   Oncotarget

Intracellular osteopontin stabilizes TRAF3 to positively regulate innate antiviral response

(2016) Kai Zhao et al.   Scientific Reports

Macrophage-derived osteopontin induces reactive astrocyte polarization and promotes re-establishment of the blood brain barrier after ischemic stroke

(2015) Michael Gliem et al.   GLIA

Targeting osteopontin suppresses glioblastoma stem-like cell character and tumorigenicityin vivo

(2015) Virginie Lamour et al.   INTERNATIONAL JOURNAL OF CANCER

Glioma-Associated Microglia/Macrophages Display an Expression Profile Different from M1 and M2 Polarization and Highly Express Gpnmb and Spp1

(2015) Frank Szulzewsky et al.   PLoS One

Intracellular Osteopontin Inhibits Toll-like Receptor Signaling and Impedes Liver Carcinogenesis

(2014) X. Fan et al.   CANCER RESEARCH

Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth

(2014) Alexander Pietras et al.   Cell Stem Cell

Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion

(2013) K. Vinnakota et al.   NEURO-ONCOLOGY

Functional Characterization of Stromal Osteopontin in Melanoma Progression and Metastasis

(2013) Santosh Kumar et al.   PLoS One

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Host-derived osteopontin maintains an acute inflammatory response to suppress early progression of extrinsic cancer cells

(2011) Yu-Hua Hsieh et al.   INTERNATIONAL JOURNAL OF CANCER

Osteopontin regulates human glioma cell invasiveness and tumor growth in mice

(2011) H.-J. Jan et al.   NEURO-ONCOLOGY

Osteopontin is up-regulated and associated with neutrophil and macrophage infiltration in glioblastoma

(2010) Nadia A. Atai et al.   IMMUNOLOGY

Osteopontin induces angiogenesis through activation of PI3K/AKT and ERK1/2 in endothelial cells

(2009) J Dai et al.   ONCOGENE