Article
Cell Biology
Ruilian Li, Fangyan Jia, Kaixuan Ren, Mai Luo, Xiaoyun Min, Shengxiang Xiao, Yumin Xia
Summary: The study shows that TWEAK and anti-dsDNA IgG enhance the cellular internalization of antibodies and induce the production of fibrotic factors in mesangial cells. Moreover, TWEAK regulates HMGB1, NF-κB, and PI3K/Akt pathways, promoting the penetration of antibodies.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Mai Luo, Mengmeng Liu, Wei Liu, Xiao Cui, Siyue Zhai, Hanjiang Gu, Huixia Wang, Kunyi Wu, Wen Zhang, Ke Li, Yumin Xia
Summary: Fn14 deficiency alleviates pathological changes in renal fibrosis, including inflammatory cell infiltration and cell proliferation, accompanied by reduced production of profibrotic factors and extracellular matrix deposition. TWEAK/Fn14 signals contribute to tubulointerstitial fibrosis by acting on proximal tubular epithelial cells.
INFLAMMATION RESEARCH
(2021)
Article
Pathology
Abbe R. Clark, Jamie Marshall, Yiming Zhou, Monica S. Montesinos, Haiqi Chen, Lan Nguyen, Fei Chen, Anna Greka
Summary: Communication among podocytes, endothelial cells, and mesangial cells is crucial for the health of the kidney filtration barrier. Disruption of these interactions contributes to disease progression in chronic kidney diseases (CKDs). A study using single-cell RNA sequencing revealed the earliest transcriptional effects of podocyte injury on cell-cell interactions within the kidney filter, highlighting potential therapeutic targets for CKDs.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Masumi Namba, Tomoe Kobayashi, Mayumi Kohno, Takayuki Koyano, Takuo Hirose, Masaki Fukushima, Makoto Matsuyama
Summary: Alport syndrome is a genetic chronic kidney disease characterized by abnormalities in glomerular basement membrane. A novel rat model with Col4 alpha 5 deficiency was created to study this disease, showing characteristic symptoms and disruptions in collagen chains, providing a reliable candidate for investigating kidney disease mechanisms and potential therapeutic targets.
SCIENTIFIC REPORTS
(2021)
Article
Urology & Nephrology
Riko Sato, Tadaatsu Imaizumi, Tomomi Aizawa, Shojiro Watanabe, Koji Tsugawa, Shogo Kawaguchi, Kazuhiko Seya, Tomoh Matsumiya, Hiroshi Tanaka
Summary: Anti-malarial agents chloroquine and hydroxychloroquine exert a protective effect against TLR3 signaling-induced chemokine expression, with chloroquine showing stronger inhibition compared to hydroxychloroquine. Further studies are needed to confirm these preliminary findings and support the theory that hydroxychloroquine may be safer than chloroquine in a clinical setting.
Article
Cell Biology
Baris Afsar, Mehmet Kanbay, Rengin Elsurer Afsar
Summary: Bone marrow hematopoiesis is regulated by various factors, including bone components, EPO, and FGF23. The interaction between these factors involves HIF pathway, direct stimulation of FGF23 synthesis, and cleavage of FGF23. Recent evidence suggests a complex relationship between FGF23, klotho, EPO, and HIF in hematopoiesis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Nobuyuki Yoshizawa, Muneharu Yamada, Masayuki Fujino, Takashi Oda
Summary: Nephritis-associated plasmin receptor (NAPlr) is a receptor found in group A Streptococci that is associated with nephritis. It has functions such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity, plasmin-binding capacity, and direct activation of the complement alternative pathway. NAPlr deposition triggers inflammation in the glomeruli, leading to glomerulonephritis. This finding expands the understanding of infection-related glomerulonephritis (IRGN) and suggests that glomerular NAPlr and plasmin activity could be used as biomarkers for IRGN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sum Lam, David Tak Wai Lui, Sammy Wing Ming Shiu, Ying Wong, Kathryn Choon Beng Tan
Summary: IDOL acts as a post-transcriptional degrader of the LDL receptor. In individuals with type 2 diabetes, the expression of IDOL is decreased and associated with glycemia and serum FGF21 concentration. Downregulation of IDOL may affect cytokine production in monocyte-derived macrophages.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Medicine, General & Internal
Hanna Nosek, Dorota Jankowska, Karolina Brzozowska, Katarzyna Kazberuk, Anna Wasilewska, Katarzyna Taranta-Janusz
Summary: This study indicates that TWEAK and RANTES may serve as potential markers of renal impairment in children with solitary functioning kidney.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Zhi-Hui Wang, Zi-Wei Dai, Yuan-Yuan Dong, Hong Wang, Fei-Fei Yuan, Bin Wang, Dong-Qing Ye
Summary: This meta-analysis evaluated the diagnostic value of uTWEAK for lupus nephritis (LN) and found that uTWEAK has moderate sensitivity and specificity for diagnosing and evaluating activity in LN, indicating its potential as a helpful biomarker for LN.
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2021)
Review
Ophthalmology
Tayler F. L. Wishart, Frank J. Lovicu
Summary: HSPGs are present in various parts of the eye and play a role in regulating the activity of signaling molecules involved in eye development and homeostasis. The specific functions of individual HSPG family members and their associated sulfated HS chains are not yet fully understood. The crystalline lens, a well-studied ocular tissue, is used as a model to explore the expression and unique roles of HSPGs. Changes in HSPG expression and function in the lens can lead to pathology or tissue repair, and may have broader implications for the development of therapeutics for eye and systemic diseases.
PROGRESS IN RETINAL AND EYE RESEARCH
(2023)
Review
Genetics & Heredity
Stephanie U-Shane Huang, Oneli Kulatunge, Kim Maree O'Sullivan
Summary: Autoimmune kidney diseases occur due to the loss of self-antigen tolerance, leading to inflammation and pathological damage to the kidneys. This review focuses on the genetic associations of major autoimmune kidney diseases, including lupus nephritis, anti-neutrophil cytoplasmic associated vasculitis, anti-glomerular basement disease, IgA nephropathy, and membranous nephritis. Genetic associations are not only linked to polymorphisms in the human leukocyte antigen II region, but also to genes regulating inflammation. The article also discusses genome-wide association studies to uncover similarities and differences in gene polymorphisms among different ethnicities. Finally, the role of neutrophil extracellular traps in inflammation and autoimmune kidney diseases is reviewed.
Article
Biochemistry & Molecular Biology
Takahiro Shimizu, Norihito Takahashi, Vincent J. Huber, Yasunobu Asawa, Hiroki Ueda, Atsushi Yoshimori, Yukiko Muramatsu, Hiroyuki Seimiya, Hiroyuki Kouji, Hiroyuki Nakamura, Hiroki Oguri
Summary: This study utilized a novel synthetic approach to generate modulators of protein-protein interactions by exploiting alkaloidal macrocyclic scaffolds, mimicking hot-spot residues in alpha-helices responsible for transcriptional regulation. Experimental results demonstrated the effectiveness of this synthesis approach in inhibiting the activity of relevant proteins and impacting cell proliferation.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Gastroenterology & Hepatology
Jennifer M. Noto, M. Blanca Piazuelo, Judith Romero-Gallo, Alberto G. Delgado, Giovanni Suarez, Konstantina Akritidou, Miguel Girod Hoffman, Juan Carlos Roa, Cormac T. Taylor, Richard M. Peek Jr
Summary: HIF-1α plays a crucial role in Helicobacter pylori-induced gastric injury and is involved in protecting against inflammation and bacterial virulence.
Article
Pharmacology & Pharmacy
A. Celikkol, A. Demirkiran, C. Aydin
Summary: The study suggests that plasma TWEAK levels are elevated earlier in the acute phase and decrease earlier after PPCI in patients with STEMI, compared to other classic myocardial biomarkers.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)