标题
Genetics of coronary artery disease: discovery, biology and clinical translation
作者
关键词
-
出版物
NATURE REVIEWS GENETICS
Volume 18, Issue 6, Pages 331-344
出版商
Springer Nature
发表日期
2017-03-13
DOI
10.1038/nrg.2016.160
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Incorporating a Genetic Risk Score Into Coronary Heart Disease Risk EstimatesCLINICAL PERSPECTIVE
- (2016) Iftikhar J. Kullo et al. CIRCULATION
- Are Genetic Tests for Atherosclerosis Ready for Routine Clinical Use?
- (2016) Nina P. Paynter et al. CIRCULATION RESEARCH
- From Loci to Biology
- (2016) Sylvia T. Nurnberg et al. CIRCULATION RESEARCH
- The impact of genome‐wide association studies on the pathophysiology and therapy of cardiovascular disease
- (2016) Thorsten Kessler et al. EMBO Molecular Medicine
- Genomic prediction of coronary heart disease
- (2016) Gad Abraham et al. EUROPEAN HEART JOURNAL
- Innovation in the pharmaceutical industry: New estimates of R&D costs
- (2016) Joseph A. DiMasi et al. JOURNAL OF HEALTH ECONOMICS
- Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels
- (2016) Connor A. Emdin et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia
- (2016) Amit V. Khera et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
- (2016) Georg B Ehret et al. NATURE GENETICS
- The genetics of drug efficacy: opportunities and challenges
- (2016) Matthew R. Nelson et al. NATURE REVIEWS GENETICS
- Unravelling the human genome–phenome relationship using phenome-wide association studies
- (2016) William S. Bush et al. NATURE REVIEWS GENETICS
- Type 2 diabetes: genetic data sharing to advance complex disease research
- (2016) Jason Flannick et al. NATURE REVIEWS GENETICS
- Developing and evaluating polygenic risk prediction models for stratified disease prevention
- (2016) Nilanjan Chatterjee et al. NATURE REVIEWS GENETICS
- VariantASGR1Associated with a Reduced Risk of Coronary Artery Disease
- (2016) Paul Nioi et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Public and the Gene-Editing Revolution
- (2016) Robert J. Blendon et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease
- (2016) Amit V. Khera et al. NEW ENGLAND JOURNAL OF MEDICINE
- Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease
- (2016) NEW ENGLAND JOURNAL OF MEDICINE
- Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease
- (2016) Frederick E. Dewey et al. NEW ENGLAND JOURNAL OF MEDICINE
- Health and population effects of rare gene knockouts in adult humans with related parents
- (2016) V. M. Narasimhan et al. SCIENCE
- Knockout ofAdamts7, a Novel Coronary Artery Disease Locus in Humans, Reduces Atherosclerosis in MiceCLINICAL PERSPECTIVE
- (2015) Robert C. Bauer et al. CIRCULATION
- Heart Disease and Stroke Statistics—2016 Update
- (2015) Dariush Mozaffarian et al. CIRCULATION
- ADAMTS-7 Inhibits Re-endothelialization of Injured Arteries and Promotes Vascular Remodeling Through Cleavage of Thrombospondin-1CLINICAL PERSPECTIVE
- (2015) Thorsten Kessler et al. CIRCULATION
- Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history
- (2015) Hayato Tada et al. EUROPEAN HEART JOURNAL
- HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
- (2015) Daniel I Swerdlow et al. LANCET
- Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials
- (2015) Jessica L Mega et al. LANCET
- Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study
- (2015) Sotirios Tsimikas et al. LANCET
- A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
- (2015) Majid Nikpay et al. NATURE GENETICS
- Coronary Heart Disease and Genetic Variants with Low Phospholipase A2 Activity
- (2015) Linda M. Polfus et al. NEW ENGLAND JOURNAL OF MEDICINE
- Brave New Genome
- (2015) Eric S. Lander NEW ENGLAND JOURNAL OF MEDICINE
- Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events
- (2015) Jennifer G. Robinson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia
- (2015) Daniel Gaudet et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficacy and Safety of Evolocumab in Reducing Lipids and Cardiovascular Events
- (2015) Marc S. Sabatine et al. NEW ENGLAND JOURNAL OF MEDICINE
- Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes
- (2015) Christopher P. Cannon et al. NEW ENGLAND JOURNAL OF MEDICINE
- New loci and coding variants confer risk for age-related macular degeneration in East Asians
- (2015) Ching-Yu Cheng et al. Nature Communications
- Disproportionate Contributions of Select Genomic Compartments and Cell Types to Genetic Risk for Coronary Artery Disease
- (2015) Hong-Hee Won et al. PLoS Genetics
- Rare-Variant Association Analysis: Study Designs and Statistical Tests
- (2014) Seunggeung Lee et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing
- (2014) Qiurong Ding et al. CIRCULATION RESEARCH
- Effect of Darapladib on Major Coronary Events After an Acute Coronary Syndrome
- (2014) Michelle L. O’Donoghue et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Guidelines for investigating causality of sequence variants in human disease
- (2014) D. G. MacArthur et al. NATURE
- Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction
- (2014) Ron Do et al. NATURE
- Loss-of-Function Mutations in APOC3 and Risk of Ischemic Vascular Disease
- (2014) Anders Berg Jørgensen et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Form of the Metabolic Syndrome Associated with Mutations in DYRK1B
- (2014) Ali R. Keramati et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inactivating Mutations in NPC1L1 and Protection from Coronary Heart Disease
- (2014) NEW ENGLAND JOURNAL OF MEDICINE
- Darapladib for Preventing Ischemic Events in Stable Coronary Heart Disease
- (2014) NEW ENGLAND JOURNAL OF MEDICINE
- Loss-of-Function Mutations in APOC3, Triglycerides, and Coronary Disease
- (2014) NEW ENGLAND JOURNAL OF MEDICINE
- Searching for missing heritability: Designing rare variant association studies
- (2014) O. Zuk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ADAMTS7 Cleavage and Vascular Smooth Muscle Cell Migration Is Affected by a Coronary-Artery-Disease-Associated Variant
- (2013) Xiangyuan Pu et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society
- (2013) B. G. Nordestgaard et al. EUROPEAN HEART JOURNAL
- Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study
- (2013) Philippa J Talmud et al. LANCET
- Dysfunctional nitric oxide signalling increases risk of myocardial infarction
- (2013) Jeanette Erdmann et al. NATURE
- Common variants associated with plasma triglycerides and risk for coronary artery disease
- (2013) Ron Do et al. NATURE GENETICS
- Discovery and refinement of loci associated with lipid levels
- (2013) Cristen J Willer et al. NATURE GENETICS
- The Genotype-Tissue Expression (GTEx) project
- (2013) John Lonsdale et al. NATURE GENETICS
- Validating therapeutic targets through human genetics
- (2013) Robert M. Plenge et al. NATURE REVIEWS DRUG DISCOVERY
- RNA-Guided Human Genome Engineering via Cas9
- (2013) P. Mali et al. SCIENCE
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- Genetic Basis of Atherosclerosis: Insights From Mice and Humans
- (2012) Ioannis M. Stylianou et al. CIRCULATION RESEARCH
- Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism
- (2012) Alanna Strong et al. JOURNAL OF CLINICAL INVESTIGATION
- Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
- (2012) Benjamin F Voight et al. LANCET
- Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010
- (2012) Rafael Lozano et al. LANCET
- Bayesian refinement of association signals for 14 loci in 3 common diseases
- (2012) Julian B Maller et al. NATURE GENETICS
- Rare and common variants: twenty arguments
- (2012) Greg Gibson NATURE REVIEWS GENETICS
- Low Lipoprotein(a) Concentration Is Associated with Cancer and All-Cause Deaths: A Population-Based Cohort Study (The JMS Cohort Study)
- (2012) Motoji Sawabe et al. PLoS One
- Systematic Localization of Common Disease-Associated Variation in Regulatory DNA
- (2012) M. T. Maurano et al. SCIENCE
- Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases
- (2011) Hon-Cheong So et al. GENETIC EPIDEMIOLOGY
- Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies
- (2011) Muredach P Reilly et al. LANCET
- 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response
- (2011) Olivier Harismendy et al. NATURE
- A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
- (2011) John F Peden et al. NATURE GENETICS
- Full Coverage for Preventive Medications after Myocardial Infarction
- (2011) Niteesh K. Choudhry et al. NEW ENGLAND JOURNAL OF MEDICINE
- Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease
- (2011) PLoS Genetics
- ANRIL Expression Is Associated With Atherosclerosis Risk at Chromosome 9p21
- (2010) Lesca M. Holdt et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Genetic Heterogeneity in Human Disease
- (2010) Jon McClellan et al. CELL
- Angptl4 Protects against Severe Proinflammatory Effects of Saturated Fat by Inhibiting Fatty Acid Uptake into Mesenteric Lymph Node Macrophages
- (2010) Laeticia Lichtenstein et al. Cell Metabolism
- PLA2G7 Genotype, Lipoprotein-Associated Phospholipase A 2 Activity, and Coronary Heart Disease Risk in 10 494 Cases and 15 624 Controls of European Ancestry
- (2010) Juan P. Casas et al. CIRCULATION
- Lipoprotein(a) and Risk of Type 2 Diabetes
- (2010) S. Mora et al. CLINICAL CHEMISTRY
- A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses
- (2010) Samuli Ripatti et al. LANCET
- Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials
- (2010) Naveed Sattar et al. LANCET
- From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
- (2010) Kiran Musunuru et al. NATURE
- Biological, clinical and population relevance of 95 loci for blood lipids
- (2010) Tanya M. Teslovich et al. NATURE
- Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
- (2010) B. M. Neale et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration
- (2010) W. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functional Analysis of the Chromosome 9p21.3 Coronary Artery Disease Risk Locus
- (2009) Olga Jarinova et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Common Genetic Variants on Chromosome 9p21 Confers Risk of Ischemic Stroke
- (2009) J. Gustav Smith et al. Circulation-Cardiovascular Genetics
- New susceptibility locus for coronary artery disease on chromosome 3q22.3
- (2009) Jeanette Erdmann et al. NATURE GENETICS
- Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease
- (2009) Robert Clarke et al. NEW ENGLAND JOURNAL OF MEDICINE
- Association of Genetic Variation on Chromosome 9p21 With Susceptibility and Progression of Atherosclerosis
- (2008) Shu Ye et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
- (2008) Anna Helgadottir et al. NATURE GENETICS
- Newly identified loci that influence lipid concentrations and risk of coronary artery disease
- (2008) Cristen J Willer et al. NATURE GENETICS
- Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
- (2008) Sekar Kathiresan et al. NATURE GENETICS
- Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development
- (2008) Robert L Wilensky et al. NATURE MEDICINE
- Polymorphisms Associated with Cholesterol and Risk of Cardiovascular Events
- (2008) Sekar Kathiresan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genetic Mapping in Human Disease
- (2008) D. Altshuler et al. SCIENCE
- Lack of Association Between the MEF2A Gene and Myocardial Infarction
- (2007) Wolfgang Lieb et al. CIRCULATION
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started