标题
Cellular senescence in gastrointestinal diseases: from pathogenesis to therapeutics
作者
关键词
-
出版物
Nature Reviews Gastroenterology & Hepatology
Volume 15, Issue 2, Pages 81-95
出版商
Springer Nature
发表日期
2017-11-29
DOI
10.1038/nrgastro.2017.146
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
- (2017) Birgit Ritschka et al. GENES & DEVELOPMENT
- Targeting metabolism in cellular senescence, a role for intervention
- (2017) Timothy Nacarelli et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Cellular senescence mediates fibrotic pulmonary disease
- (2017) Marissa J. Schafer et al. Nature Communications
- Cellular senescence drives age-dependent hepatic steatosis
- (2017) Mikolaj Ogrodnik et al. Nature Communications
- Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression
- (2016) Tobias Eggert et al. CANCER CELL
- Induction of Therapeutic Senescence in Vemurafenib-Resistant Melanoma by Extended Inhibition of CDK4/6
- (2016) A. Yoshida et al. CANCER RESEARCH
- NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer
- (2016) Iok In Christine Chio et al. CELL
- Increased expression of SIRT2 is a novel marker of cellular senescence and is dependent on wild type p53 status
- (2016) Tarique Anwar et al. CELL CYCLE
- From Ancient Pathways to Aging Cells—Connecting Metabolism and Cellular Senescence
- (2016) Christopher D. Wiley et al. Cell Metabolism
- Clinical patterns of hepatocellular carcinoma in nonalcoholic fatty liver disease: A multicenter prospective study
- (2016) Fabio Piscaglia et al. HEPATOLOGY
- Senescence in chronic liver disease: Is the future in aging?
- (2016) Aloysious D. Aravinthan et al. JOURNAL OF HEPATOLOGY
- A molecular biology and phase II study of imetelstat (GRN163L) in children with recurrent or refractory central nervous system malignancies: a pediatric brain tumor consortium study
- (2016) Ralph Salloum et al. JOURNAL OF NEURO-ONCOLOGY
- CD20-Targeting Immunotherapy Promotes Cellular Senescence in B-Cell Lymphoma
- (2016) J. H. M. Da britz et al. MOLECULAR CANCER THERAPEUTICS
- The Mitochondrial Basis of Aging
- (2016) Nuo Sun et al. MOLECULAR CELL
- Trade talk: Neuro connector
- (2016) Monya Baker NATURE
- A New Cell-Cycle Target in Cancer — Inhibiting Cyclin D–Dependent Kinases 4 and 6
- (2016) Charles J. Sherr NEW ENGLAND JOURNAL OF MEDICINE
- The Human Intestinal Microbiome in Health and Disease
- (2016) Susan V. Lynch et al. NEW ENGLAND JOURNAL OF MEDICINE
- Tissue damage and senescence provide critical signals for cellular reprogramming in vivo
- (2016) Lluc Mosteiro et al. SCIENCE
- Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer
- (2016) Diletta Di Mitri et al. TRENDS IN CELL BIOLOGY
- TERT promoter mutations in primary liver tumors
- (2016) Jean-Charles Nault et al. Clinics and Research in Hepatology and Gastroenterology
- Therapeutic Targeting of Telomerase
- (2016) Kathrin Jäger et al. Genes
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- Functional Role of Cellular Senescence in Biliary Injury
- (2015) Luke Meng et al. AMERICAN JOURNAL OF PATHOLOGY
- VEGFR2 Signaling Prevents Colorectal Cancer Cell Senescence to Promote Tumorigenesis in Mice With Colitis
- (2015) Sebastian Foersch et al. GASTROENTEROLOGY
- Immune Checkpoint Blockade in Cancer Therapy
- (2015) Michael A. Postow et al. JOURNAL OF CLINICAL ONCOLOGY
- Autophagy and senescence in fibrosing cholangiopathies
- (2015) Yasuni Nakanuma et al. JOURNAL OF HEPATOLOGY
- UBTD1 induces cellular senescence through an UBTD1-Mdm2/p53 positive feedback loop
- (2015) Xiao-Wei Zhang et al. JOURNAL OF PATHOLOGY
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- (2015) Jianhui Chang et al. NATURE MEDICINE
- Cellular senescence in aging and age-related disease: from mechanisms to therapy
- (2015) Bennett G Childs et al. NATURE MEDICINE
- A Pilot Study of the Telomerase Inhibitor Imetelstat for Myelofibrosis
- (2015) Ayalew Tefferi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia
- (2015) Gabriela M. Baerlocher et al. NEW ENGLAND JOURNAL OF MEDICINE
- Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma
- (2015) James Larkin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cancer and the gut microbiota: An unexpected link
- (2015) Laurence Zitvogel et al. Science Translational Medicine
- Senescence-associated inflammatory responses: aging and cancer perspectives
- (2015) Audrey Lasry et al. TRENDS IN IMMUNOLOGY
- Obesity, inflammation, and the gut microbiota
- (2015) Amanda J Cox et al. Lancet Diabetes & Endocrinology
- Obesity and Cancer: A Gut Microbial Connection
- (2014) N. Ohtani et al. CANCER RESEARCH
- Senescence Helps Regeneration
- (2014) Manuel Serrano DEVELOPMENTAL CELL
- An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
- (2014) Marco Demaria et al. DEVELOPMENTAL CELL
- Cellular senescence and its effector programs
- (2014) R. Salama et al. GENES & DEVELOPMENT
- Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype
- (2014) Antony Cougnoux et al. GUT
- Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis
- (2014) James H. Tabibian et al. HEPATOLOGY
- Arrested development and the great escape – The role of cellular senescence in pancreatic cancer
- (2014) John AG Moir et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression
- (2014) Maïté Rielland et al. JOURNAL OF CLINICAL INVESTIGATION
- Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial
- (2014) Gary Middleton et al. LANCET ONCOLOGY
- Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer
- (2014) Diletta Di Mitri et al. NATURE
- The role of senescent cells in ageing
- (2014) Jan M. van Deursen NATURE
- Cellular senescence: from physiology to pathology
- (2014) Daniel Muñoz-Espín et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Characterization of novel markers of senescence and their prognostic potential in cancer
- (2014) M Althubiti et al. Cell Death & Disease
- Histone H3.3 and its proteolytically processed form drive a cellular senescence programme
- (2014) Luis F. Duarte et al. Nature Communications
- Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity
- (2014) Alberto Toso et al. Cell Reports
- Precursor Lesions for Sporadic Pancreatic Cancer: PanIN, IPMN, and MCN
- (2014) M. Distler et al. Biomed Research International
- Biliary Epithelial Senescence and Plasticity in Acute Cellular Rejection
- (2013) J. G. Brain et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Recent progress in pancreatic cancer
- (2013) Christopher L. Wolfgang et al. CA-A CANCER JOURNAL FOR CLINICIANS
- A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism
- (2013) Ariel Pribluda et al. CANCER CELL
- A multi-peptide, dual-adjuvant telomerase vaccine (GX301) is highly immunogenic in patients with prostate and renal cancer
- (2013) Daniela Fenoglio et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- A New Development in Senescence
- (2013) Ana Banito et al. CELL
- Non-Cell-Autonomous Tumor Suppression by p53
- (2013) Amaia Lujambio et al. CELL
- Programmed Cell Senescence during Mammalian Embryonic Development
- (2013) Daniel Muñoz-Espín et al. CELL
- Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
- (2013) Mekayla Storer et al. CELL
- Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma
- (2013) J. Rader et al. CLINICAL CANCER RESEARCH
- Senescence in pancreatic carcinogenesis: from signalling to chromatin remodelling and epigenetics
- (2013) Shiv K Singh et al. GUT
- Enhanced killing of therapy-induced senescent tumor cells by oncolytic measles vaccine viruses
- (2013) Timo Weiland et al. INTERNATIONAL JOURNAL OF CANCER
- High-fat diet alters gut microbiota physiology in mice
- (2013) Hannelore Daniel et al. ISME Journal
- Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
- (2013) Tamara Tchkonia et al. JOURNAL OF CLINICAL INVESTIGATION
- Differential Induction of Apoptosis and Senescence by the DNA Methyltransferase Inhibitors 5-Azacytidine and 5-Aza-2'-Deoxycytidine in Solid Tumor Cells
- (2013) S. Venturelli et al. MOLECULAR CANCER THERAPEUTICS
- Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
- (2013) Peng Jiang et al. NATURE
- Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
- (2013) Shin Yoshimoto et al. NATURE
- A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
- (2013) Joanna Kaplon et al. NATURE
- T-helper-1-cell cytokines drive cancer into senescence
- (2013) Heidi Braumüller et al. NATURE
- Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
- (2013) Jan R. Dörr et al. NATURE
- A complex secretory program orchestrated by the inflammasome controls paracrine senescence
- (2013) Juan Carlos Acosta et al. NATURE CELL BIOLOGY
- Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions
- (2013) Felipe De Sousa E Melo et al. NATURE MEDICINE
- Targeting homologous recombination and telomerase in Barrett’s adenocarcinoma: impact on telomere maintenance, genomic instability and tumor growth
- (2013) R Lu et al. ONCOGENE
- Biology of telomeres: importance in etiology of esophageal cancer and as therapeutic target
- (2013) Jagannath Pal et al. Translational Research
- Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development
- (2013) Binh Vu et al. ACS Medicinal Chemistry Letters
- Primary sclerosing cholangitis: a review and update on therapeutic developments
- (2013) James H Tabibian et al. Expert Review of Gastroenterology & Hepatology
- Aging, Cellular Senescence, and Cancer
- (2012) Judith Campisi Annual Review of Physiology
- A phase II open label trial evaluating safety and efficacy of a telomerase peptide vaccination in patients with advanced hepatocellular carcinoma
- (2012) Tim F Greten et al. BMC CANCER
- Cancer cell senescence: a new frontier in drug development
- (2012) Claire J. Cairney et al. DRUG DISCOVERY TODAY
- Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer
- (2012) Carlo Schneider et al. GUT
- Hepatocyte senescence predicts progression in non-alcohol-related fatty liver disease
- (2012) Aloysious Aravinthan et al. JOURNAL OF HEPATOLOGY
- Acceleration of Gastric Tumorigenesis Through MKRN1-Mediated Posttranslational Regulation of p14ARF
- (2012) Aram Ko et al. JNCI-Journal of the National Cancer Institute
- Lamin B1 loss is a senescence-associated biomarker
- (2012) Adam Freund et al. MOLECULAR BIOLOGY OF THE CELL
- Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation
- (2012) Marzia Fumagalli et al. NATURE CELL BIOLOGY
- Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota
- (2012) J. C. Arthur et al. SCIENCE
- Senescence: a new weapon for cancer therapy
- (2012) Juan Carlos Acosta et al. TRENDS IN CELL BIOLOGY
- Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence
- (2011) Carmen Guerra et al. CANCER CELL
- Deletion of Rb Accelerates Pancreatic Carcinogenesis by Oncogenic Kras and Impairs Senescence in Premalignant Lesions
- (2011) Catherine Carrière et al. GASTROENTEROLOGY
- The role of nuclear lamin B1 in cell proliferation and senescence
- (2011) T. Shimi et al. GENES & DEVELOPMENT
- CKIα ablation highlights a critical role for p53 in invasiveness control
- (2011) Ela Elyada et al. NATURE
- Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
- (2011) Gina M. DeNicola et al. NATURE
- Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
- (2011) Tae-Won Kang et al. NATURE
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- Oncogene- and tumor suppressor gene-mediated suppression of cellular senescence
- (2011) Lars-Gunnar Larsson SEMINARS IN CANCER BIOLOGY
- Bile Ductular Cells Undergoing Cellular Senescence Increase in Chronic Liver Diseases Along With Fibrous Progression
- (2010) Motoko Sasaki et al. AMERICAN JOURNAL OF CLINICAL PATHOLOGY
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- Cellular senescence predicts treatment outcome in metastasised colorectal cancer
- (2010) A M Haugstetter et al. BRITISH JOURNAL OF CANCER
- Ink4a/Arf and Oncogene-Induced Senescence Prevent Tumor Progression during Alternative Colorectal Tumorigenesis
- (2010) Moritz Bennecke et al. CANCER CELL
- V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation ofp16INK4a
- (2010) Linda A. S. Carragher et al. EMBO Molecular Medicine
- Role of the Serrated Pathway in Colorectal Cancer Pathogenesis
- (2010) Barbara Leggett et al. GASTROENTEROLOGY
- The essence of senescence
- (2010) T. Kuilman et al. GENES & DEVELOPMENT
- Dual antitumour effect of 5-azacytidine by inducing a breakdown of resistance-mediating factors and epigenetic modulation
- (2010) S. Venturelli et al. GUT
- Update on the serrated pathway to colorectal carcinoma
- (2010) Dale C. Snover HUMAN PATHOLOGY
- Conversion ofHelicobacter pyloriCagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21
- (2010) Yasuhiro Saito et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Therapy-Induced Senescence in Cancer
- (2010) Jonathan A. Ewald et al. JNCI-Journal of the National Cancer Institute
- Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells
- (2010) G. Cuevas-Ramos et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sin3B Expression Is Required for Cellular Senescence and Is Up-regulated upon Oncogenic Stress
- (2009) K. B. Grandinetti et al. CANCER RESEARCH
- Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
- (2009) Francis Rodier et al. NATURE CELL BIOLOGY
- Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
- (2009) Dunyaporn Trachootham et al. NATURE REVIEWS DRUG DISCOVERY
- Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
- (2009) J. P. Morton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Senescence of Activated Stellate Cells Limits Liver Fibrosis
- (2008) Valery Krizhanovsky et al. CELL
- Telomere Maintenance in Laser Capture Microdissection-Purified Barrett's Adenocarcinoma Cells and Effect of Telomerase Inhibition In vivo
- (2008) M. A. Shammas et al. CLINICAL CANCER RESEARCH
- Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence
- (2008) Motoko Sasaki et al. HEPATOLOGY
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