Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons

(2016) Vsevolod Telezhkin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes

(2016) Ying Pei et al.   BRAIN RESEARCH

Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice

(2016) Peter Langfelder et al.   NATURE NEUROSCIENCE

PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo

(2016) Joseph Ochaba et al.   NEURON

Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington’s disease

(2016) Aldrin E. Molero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Tumour resistance in induced pluripotent stem cells derived from naked mole-rats

(2016) Shingo Miyawaki et al.   Nature Communications

Jmjd2C increases MyoD transcriptional activity through inhibiting G9a-dependent MyoD degradation

(2015) Eun-Shil Jung et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Basal ganglia-cortical structural connectivity in Huntington's disease

(2015) Marianne J.U. Novak et al.   HUMAN BRAIN MAPPING

HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity

(2015) Virginia B. Mattis et al.   HUMAN MOLECULAR GENETICS

Neuronal identity genes regulated by super-enhancers are preferentially down-regulated in the striatum of Huntington's disease mice

(2015) M. Achour et al.   HUMAN MOLECULAR GENETICS

Imbalanced Mechanistic Target of Rapamycin C1 and C2 Activity in the Cerebellum of Angelman Syndrome Mice Impairs Motor Function

(2015) J. Sun et al.   JOURNAL OF NEUROSCIENCE

Platinum (IV) coiled coil nanotubes selectively kill human glioblastoma cells

(2015) Thatchawan Thanasupawat et al.   Nanomedicine-Nanotechnology Biology and Medicine

Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington’s Disease Neural Stem Cells

(2015) Karen L. Ring et al.   Stem Cell Reports

Huntington disease

(2015) Gillian P. Bates et al.   Nature Reviews Disease Primers

RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression

(2015) Adam Labadorf et al.   PLoS One

Neurogenesis in the Striatum of the Adult Human Brain

(2014) Aurélie Ernst et al.   CELL

Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains

(2014) Guang Bai et al.   HUMAN MOLECULAR GENETICS

Mutant LRRK2 Toxicity in Neurons Depends on LRRK2 Levels and Synuclein But Not Kinase Activity or Inclusion Bodies

(2014) G. Skibinski et al.   JOURNAL OF NEUROSCIENCE

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models

(2014) Sami J Barmada et al.   Nature Chemical Biology

Molecular and functional definition of the developing human striatum

(2014) Marco Onorati et al.   NATURE NEUROSCIENCE

Huntington disease: natural history, biomarkers and prospects for therapeutics

(2014) Christopher A. Ross et al.   Nature Reviews Neurology

Tgfβ Signaling Regulates Temporal Neurogenesis and Potency of Neural Stem Cells in the CNS

(2014) José M. Dias et al.   NEURON

Talpid3-Binding Centrosomal Protein Cep120 Is Required for Centriole Duplication and Proliferation of Cerebellar Granule Neuron Progenitors

(2014) Chuanqing Wu et al.   PLoS One

Universal Count Correction for High-Throughput Sequencing

(2014) Tatsunori B. Hashimoto et al.   PLoS Computational Biology

Ataxia and hypogonadism caused by the loss of ubiquitin ligase activity of the U box protein CHIP

(2013) Chang-He Shi et al.   HUMAN MOLECULAR GENETICS

Modeling human neurological disorders with induced pluripotent stem cells

(2013) Yoichi Imaizumi et al.   JOURNAL OF NEUROCHEMISTRY

Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models

(2013) Sonia Marco et al.   NATURE MEDICINE

Glial cell line-derived neurotrophic factor-secreting human neural progenitors show long-term survival, maturation into astrocytes, and no tumor formation following transplantation into the spinal cord of immunocompromised rats

(2013) Geneviève Gowing et al.   NEUROREPORT

Targeting H3K4 trimethylation in Huntington disease

(2013) M. Vashishtha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural Stem Cells, Excited

(2013) J. Hsieh et al.   SCIENCE

EZ spheres: A stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs

(2013) Allison D. Ebert et al.   Stem Cell Research

Induced Pluripotent Stem Cells from Patients with Huntington's Disease Show CAG-Repeat-Expansion-Associated Phenotypes

(2012) The HD iPSC Consortium   Cell Stem Cell

REST regulates the pool size of the different neural lineages by restricting the generation of neurons and oligodendrocytes from neural stem/progenitor cells

(2012) M. V. Covey et al.   DEVELOPMENT

Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development

(2012) Junke Zheng et al.   NATURE

REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors

(2012) Alma Rodenas-Ruano et al.   NATURE NEUROSCIENCE

Development and neurodegeneration: Turning HD pathogenesis on its head

(2012) K. Marder et al.   NEUROLOGY

Measures of growth in children at risk for Huntington disease

(2012) J. K. Lee et al.   NEUROLOGY

Inhibition of Apoptosis Blocks Human Motor Neuron Cell Death in a Stem Cell Model of Spinal Muscular Atrophy

(2012) Dhruv Sareen et al.   PLoS One

MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets

(2012) Zhen Shao et al.   GENOME BIOLOGY

A Call for Standardized Naming and Reporting of Human ESC and iPSC Lines

(2011) Mai X. Luong et al.   Cell Stem Cell

Neurogenesis in humans

(2011) Maurice A. Curtis et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A bioinformatic assay for pluripotency in human cells

(2011) Franz-Josef Müller et al.   NATURE METHODS

A more efficient method to generate integration-free human iPS cells

(2011) Keisuke Okita et al.   NATURE METHODS

Microstructural changes observed with DKI in a transgenic Huntington rat model: Evidence for abnormal neurodevelopment

(2011) Ines Blockx et al.   NEUROIMAGE

Neuronal Activity-Regulated Gene Transcription in Synapse Development and Cognitive Function

(2011) A. E. West et al.   Cold Spring Harbor Perspectives in Biology

An assessment of histone-modification antibody quality

(2010) Thea A Egelhofer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease

(2010) Noel J. Buckley et al.   NEUROBIOLOGY OF DISEASE

Neurogenesis in the R6/2 mouse model of Huntington's disease is impaired at the level of NeuroD1

(2010) V. Fedele et al.   NEUROSCIENCE

Signaling from Axon Guidance Receptors

(2010) G. J. Bashaw et al.   Cold Spring Harbor Perspectives in Biology

Long-term plasticity of excitatory inputs to granule cells in the rat olfactory bulb

(2009) Yuan Gao et al.   NATURE NEUROSCIENCE

CpG-depleted promoters harbor tissue-specific transcription factor binding signals—implications for motif overrepresentation analyses

(2009) Helge G. Roider et al.   NUCLEIC ACIDS RESEARCH

Impairment of developmental stem cell-mediated striatal neurogenesis and pluripotency genes in a knock-in model of Huntington's disease

(2009) A. E. Molero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expanded CAG repeats in the murine Huntington's disease gene increases neuronal differentiation of embryonic and neural stem cells

(2008) Matthew T. Lorincz et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Small-molecule activation of neuronal cell fate

(2008) Jay W Schneider et al.   Nature Chemical Biology

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY