Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci
出版年份 2017 全文链接
标题
Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci
作者
关键词
-
出版物
NATURE GENETICS
Volume 49, Issue 4, Pages 625-634
出版商
Springer Nature
发表日期
2017-02-21
DOI
10.1038/ng.3793
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Customizing the genome as therapy for the β-hemoglobinopathies
- (2016) Matthew C. Canver et al. BLOOD
- Analyzing CRISPR genome-editing experiments with CRISPResso
- (2016) Luca Pinello et al. NATURE BIOTECHNOLOGY
- Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
- (2016) John G Doench et al. NATURE BIOTECHNOLOGY
- High-throughput mapping of regulatory DNA
- (2016) Nisha Rajagopal et al. NATURE BIOTECHNOLOGY
- CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions
- (2016) D. M. Munoz et al. Cancer Discovery
- Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting
- (2016) A. J. Aguirre et al. Cancer Discovery
- Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis
- (2015) Sidi Chen et al. CELL
- Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
- (2015) Bernd Zetsche et al. CELL
- Engineered CRISPR-Cas9 nucleases with altered PAM specificities
- (2015) Benjamin P. Kleinstiver et al. NATURE
- BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
- (2015) Matthew C. Canver et al. NATURE
- A global reference for human genetic variation
- (2015) Richard A. Gibbs et al. NATURE
- In vivo genome editing using Staphylococcus aureus Cas9
- (2015) F. Ann Ran et al. NATURE
- Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
- (2015) Benjamin P Kleinstiver et al. NATURE BIOTECHNOLOGY
- High-throughput functional genomics using CRISPR–Cas9
- (2015) Ophir Shalem et al. NATURE REVIEWS GENETICS
- Characterization of Genomic Deletion Efficiency Mediated by Clustered Regularly Interspaced Palindromic Repeats (CRISPR)/Cas9 Nuclease System in Mammalian Cells
- (2014) Matthew C. Canver et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- HBS1L-MYB intergenic variants modulate fetal hemoglobin via long-range MYB enhancers
- (2014) Ralph Stadhouders et al. JOURNAL OF CLINICAL INVESTIGATION
- Saturation editing of genomic regions by multiplex homology-directed repair
- (2014) Gregory M. Findlay et al. NATURE
- Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation
- (2014) John G Doench et al. NATURE BIOTECHNOLOGY
- Improved vectors and genome-wide libraries for CRISPR screening
- (2014) Neville E Sanjana et al. NATURE METHODS
- Genome Wide Association Study of Fetal Hemoglobin in Sickle Cell Anemia in Tanzania
- (2014) Siana Nkya Mtatiro et al. PLoS One
- Analysis of chromatin-state plasticity identifies cell-type-specific regulators of H3K27me3 patterns
- (2014) L. Pinello et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells
- (2014) Luhan Yang et al. Nature Communications
- Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
- (2013) Warren A. Whyte et al. CELL
- Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
- (2013) F. Ann Ran et al. CELL
- Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits
- (2013) O. Corradin et al. GENOME RESEARCH
- Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network
- (2013) Zhao Chen et al. HUMAN MOLECULAR GENETICS
- DNA targeting specificity of RNA-guided Cas9 nucleases
- (2013) Patrick D Hsu et al. NATURE BIOTECHNOLOGY
- Cas9 as a versatile tool for engineering biology
- (2013) Prashant Mali et al. NATURE METHODS
- Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
- (2013) Kevin M Esvelt et al. NATURE METHODS
- JASPAR 2014: an extensively expanded and updated open-access database of transcription factor binding profiles
- (2013) Anthony Mathelier et al. NUCLEIC ACIDS RESEARCH
- Establishment of Immortalized Human Erythroid Progenitor Cell Lines Able to Produce Enucleated Red Blood Cells
- (2013) Ryo Kurita et al. PLoS One
- An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level
- (2013) D. E. Bauer et al. SCIENCE
- RNA-Guided Human Genome Engineering via Cas9
- (2013) P. Mali et al. SCIENCE
- Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
- (2013) Ophir Shalem et al. SCIENCE
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans
- (2012) H. T. Bae et al. BLOOD
- HbA2levels in normal adults are influenced by two distinct genetic mechanisms
- (2012) Stephan Menzel et al. BRITISH JOURNAL OF HAEMATOLOGY
- Seventy-five genetic loci influencing the human red blood cell
- (2012) Pim van der Harst et al. NATURE
- Systematic Localization of Common Disease-Associated Variation in Regulatory DNA
- (2012) M. T. Maurano et al. SCIENCE
- FIMO: scanning for occurrences of a given motif
- (2011) Charles E. Grant et al. BIOINFORMATICS
- A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression
- (2011) J. J. Farrell et al. BLOOD
- Proof of principle for transfusion of in vitro-generated red blood cells
- (2011) M.-C. Giarratana et al. BLOOD
- MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13
- (2011) V. G. Sankaran et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation
- (2010) Geneviève Galarneau et al. NATURE GENETICS
- Genome-wide association study of hematological and biochemical traits in a Japanese population
- (2010) Yoichiro Kamatani et al. NATURE GENETICS
- Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster
- (2009) N. Solovieff et al. BLOOD
- Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
- (2009) Santhi K Ganesh et al. NATURE GENETICS
- A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
- (2009) Nicole Soranzo et al. NATURE GENETICS
- Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of -thalassemia
- (2008) M. Uda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DNA polymorphisms at the BCL11A, HBS1L-MYB, and -globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease
- (2008) G. Lettre et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started