Glucose-responsive insulin by molecular and physical design

Chemical synthesis of peptides within the insulin superfamily

(2016) Fa Liu et al.   JOURNAL OF PEPTIDE SCIENCE

Smart approaches to glucose-responsive drug delivery

(2015) Matthew J. Webber et al.   JOURNAL OF DRUG TARGETING

Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery

(2015) Jicheng Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates

(2015) Danny Hung-Chieh Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Synthetic Route to Human Insulin Using Isoacyl Peptides

(2014) Fa Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bio-Inspired Synthetic Nanovesicles for Glucose-Responsive Release of Insulin

(2014) Wanyi Tai et al.   BIOMACROMOLECULES

2-Nitroveratryl as a Photocleavable Thiol-Protecting Group for Directed Disulfide Bond Formation in the Chemical Synthesis of Insulin

(2014) John A. Karas et al.   CHEMISTRY-A EUROPEAN JOURNAL

Changes in Glucose and Fat Metabolism in Response to the Administration of a Hepato-Preferential Insulin Analog

(2014) Dale S. Edgerton et al.   DIABETES

Cell factories for insulin production

(2014) Nabih A Baeshen et al.   Microbial Cell Factories

Managing diabetes with nanomedicine: challenges and opportunities

(2014) Omid Veiseh et al.   NATURE REVIEWS DRUG DISCOVERY

Protective hinge in insulin opens to enable its receptor engagement

(2014) J. G. Menting et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Pharmacokinetic Model of a Tissue Implantable Insulin Sensor

(2014) Gili Bisker et al.   Advanced Healthcare Materials

Chemical Synthesis of Insulin Analogs through a Novel Precursor

(2013) Alexander N. Zaykov et al.   ACS Chemical Biology

Injectable Nano-Network for Glucose-Mediated Insulin Delivery

(2013) Zhen Gu et al.   ACS Nano

Glucose-Responsive Microgels Integrated with Enzyme Nanocapsules for Closed-Loop Insulin Delivery

(2013) Zhen Gu et al.   ACS Nano

Substituent Effects and pH Profiles for Stability Constants of Arylboronic Acid Diol Esters

(2013) Mayte A. Martínez-Aguirre et al.   JOURNAL OF ORGANIC CHEMISTRY

Fully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X-ray Structure by Racemic Protein Crystallography

(2013) Michal Avital-Shmilovici et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Glucose Sensing via Aggregation and the Use of “Knock-Out” Binding To Improve Selectivity

(2013) Yan-Jun Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

How insulin engages its primary binding site on the insulin receptor

(2013) John G. Menting et al.   NATURE

Concise Synthetic Routes to Human Insulin

(2013) Fa Liu et al.   ORGANIC LETTERS

Exploiting the Reversible Covalent Bonding of Boronic Acids: Recognition, Sensing, and Assembly

(2012) Steven D Bull et al.   ACCOUNTS OF CHEMICAL RESEARCH

Insulin analogs for the treatment of diabetes mellitus: therapeutic applications of protein engineering

(2012) Daniel F. Berenson et al.   Annals of the New York Academy of Sciences

Synthesis: A constructive debate

(2012) Jay D. Keasling et al.   NATURE

Design of the Novel Protraction Mechanism of Insulin Degludec, an Ultra-long-Acting Basal Insulin

(2012) Ib Jonassen et al.   PHARMACEUTICAL RESEARCH

A Synthetic Approach Toward a Self-Regulated Insulin Delivery System

(2011) Akira Matsumoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Receptor-isoform-selective insulin analogues give tissue-preferential effects

(2011) Sara G. Vienberg et al.   BIOCHEMICAL JOURNAL

Artificial Pancreas: Past, Present, Future

(2011) Claudio Cobelli et al.   DIABETES

A review of modern insulin analogue pharmacokinetic and pharmacodynamic profiles in type 2 diabetes: improvements and limitations

(2011) M. Evans et al.   DIABETES OBESITY & METABOLISM

Perfluoroalkyl Chains Direct Novel Self-Assembly of Insulin

(2011) Leila Malik et al.   LANGMUIR

Arylboronic acids: A diabetic eye on glucose sensing

(2011) Jon Stefan Hansen et al.   SENSORS AND ACTUATORS B-CHEMICAL

Ortho-substituted aryl monoboronic acids have improved selectivity for d-glucose relative to d-fructose and l-lactate

(2010) J.S. Hansen et al.   TETRAHEDRON

Total Synthesis of desB30 Insulin Analogues by Biomimetic Folding of Single-Chain Precursors

(2008) A. Pernille Tofteng et al.   CHEMBIOCHEM

Insulin analogues: an example of applied medical science

(2008) B. Sheldon et al.   DIABETES OBESITY & METABOLISM

Design of an Active Ultrastable Single-chain Insulin Analog

(2008) Qing-xin Hua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY