Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK

Using magnets and magnetic beads to dissect signaling pathways activated by mechanical tension applied to cells

(2016) R.J. Marjoram et al.   METHODS

Dynamic Visualization of α-Catenin Reveals Rapid, Reversible Conformation Switching between Tension States

(2015) Tae-Jin Kim et al.   CURRENT BIOLOGY

Synaptopodin couples epithelial contractility to α-actinin-4–dependent junction maturation

(2015) Nivetha Kannan et al.   JOURNAL OF CELL BIOLOGY

Vinculin phosphorylation differentially regulates mechanotransduction at cell–cell and cell–matrix adhesions

(2014) Jennifer L. Bays et al.   JOURNAL OF CELL BIOLOGY

 -Catenin cytomechanics - role in cadherin-dependent adhesion and mechanotransduction

(2014) A. K. Barry et al.   JOURNAL OF CELL SCIENCE

Mechanobiology and Developmental Control

(2013) Tadanori Mammoto et al.   Annual Review of Cell and Developmental Biology

From tissue mechanics to transcription factors

(2013) Paul A. Janmey et al.   DIFFERENTIATION

ZO-1 recruitment to  -catenin - a novel mechanism for coupling the assembly of tight junctions to adherens junctions

(2013) J. L. Maiers et al.   JOURNAL OF CELL SCIENCE

Epithelial barrier assembly requires coordinated activity of multiple domains of the tight junction protein ZO-1

(2013) L. S. Rodgers et al.   JOURNAL OF CELL SCIENCE

Localized Tensional Forces on PECAM-1 Elicit a Global Mechanotransduction Response via the Integrin-RhoA Pathway

(2012) Caitlin Collins et al.   CURRENT BIOLOGY

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch

(2012) N. Borghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

(2011) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner

(2010) Quint le Duc et al.   JOURNAL OF CELL BIOLOGY

Vinculin regulates cell-surface E-cadherin expression by binding to  -catenin

(2010) X. Peng et al.   JOURNAL OF CELL SCIENCE

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Mechanical tugging force regulates the size of cell-cell junctions

(2010) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Cell-Cycle Control by Physiological Matrix Elasticity and In Vivo Tissue Stiffening

(2009) Eric A. Klein et al.   CURRENT BIOLOGY

Regulation of LKB1/STRAD Localization and Function by E-Cadherin

(2008) Michael Sebbagh et al.   CURRENT BIOLOGY