期刊
NATURAL PRODUCT RESEARCH
卷 33, 期 5, 页码 673-680出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1405407
关键词
Corylifol F; corylifol G; Psoralea corylifolia L; anti-radiation
资金
- National Natural Science Foundation of China [81403060, 81403059, 81402541]
- Science and Technology Program of Tianjin [15PTCYSY00030, 14TXZYJC00440]
- Tianjin Support Plans for the Top of the Notch Youth Talents
- National Basic Scientific and Technological Project [2014FY111100]
- Tianjin Applied Basic and Cutting-edge Technology Research Program [14JCYBJC42900]
Two new flavonoids, corylifol F (1) and corylifol G (2), together with 19 known compounds, were isolated from the fruits of Psoralea corylifolia L.. The structures of these compounds were determined by interpretation of spectroscopic data and comparison with literature properties. The radioprotective effects of the isolated compounds against ionising radiation damage were also evaluated in vitro. The results showed that corylifol A exhibited radioprotective effects in both HBL-100 and MCF-7 cells, while psoralen, isopsoralen, corylifol C and bakuchiol showed obvious selective action to protect HBL-100 cells against damage caused by ionising radiation. [GRAPHICS] .
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