Article
Multidisciplinary Sciences
Yanlin Lv, Feng Li, Shuang Wang, Guihong Lu, Weier Bao, Yugang Wang, Zhiyuan Tian, Wei Wei, Guanghui Ma
Summary: The anticancer platelet-based biomimetic formulation developed in this study integrates photothermal nanoparticles and immunostimulator into platelets to target tumor cells effectively. By accumulating at tumor sites and releasing active components, this formulation induces a strong immune response against residual, metastatic, and recurrent tumors, showing exceptionally high therapeutic efficacy across various murine models.
Article
Chemistry, Multidisciplinary
Philipp Neidinger, Joshua Davis, Dominik Voll, Esa A. Jaatinen, Sarah L. Walden, Andreas N. Unterreiner, Christopher Barner-Kowollik
Summary: This study introduces a gold nanorod-driven methodology to induce free radical polymerization in water using near infrared light. The process utilizes photothermal conversion and heat transfer to generate radicals, allowing control over the molecular weight and reaction conversion of the polymers. The results demonstrate the potential of this initiation mechanism for inducing polymerization in biological environments.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Analytical
Kuanzhi Qu, Jing Xu, Yuanfei Xue, Junli Guo, Zhida Gao, Yan-Yan Song, Ye Mei
Summary: An enantioselective desorption strategy based on homochiral Au/TiO2 nanotubes was developed using a photothermal effect, enabling the selective separation of chiral molecules. Molecular docking simulations confirmed the role of hydrogen bonding in the origin of enantioselective desorption, offering a green and alternative approach for chiral molecule separation.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Cheng Xu, Yuyan Jiang, Jingsheng Huang, Jiaguo Huang, Kanyi Pu
Summary: Immunometabolic modulation through a second near-infrared (NIR-II) photothermally activatable semiconducting polymeric nanoantagonist (ASPA) provides a new approach for synergistic photothermal immunometabolic therapy of cancer. This remotely controlled immunometabolic regulation enhances cytotoxic T cell functions, suppresses regulatory T cell activities, and leads to efficient primary tumor inhibition, pulmonary metastasis prevention, and long-term immunological memory. This work offers a generic polymeric approach for precise spatiotemporal regulation of cancer immunometabolism.
ADVANCED MATERIALS
(2021)
Review
Chemistry, Applied
Wen Zhou, Mingzhi Du, Jinghui Wang, Xuheng Zhang, Tingting Liang, Chen Xie, Quli Fan
Summary: Photothermal therapy (PTT) has shown outstanding efficacy in cancer treatment, but the overexpression of heat shock proteins (HSPs) within tumor cells can reduce the damage caused by high temperature, thereby limiting the therapeutic efficacy. To improve the efficacy, researchers are exploring the combination of PTT with other therapeutic modalities such as chemotherapy and immunotherapy. Recently, the oxygen-independent thermodynamic therapy (TDT) has shown great promise in combination with PTT, as it can enhance the efficacy without inducing additional side effects.
Article
Polymer Science
Qi Wang, Xuefeng Yan, Ping Liu, Yiyan Xu, Qingbao Guan, Zhengwei You
Summary: A new near-infrared light-triggered shape memory polymer (PDA/EA) is developed by combining photothermal conversion agent polydopamine (PDA) nanoparticles and epoxy acrylate polymer (EA) effectively. The introduction of PDA improves the dynamic mechanical properties and thermal resistance compared to EA, making PDA/EA a promising environmentally friendly and highly efficient photoactive SMP.
Review
Chemistry, Multidisciplinary
Cheng Xu, Kanyi Pu
Summary: Second near-infrared photothermal therapy (NIR-II PTT) has advantages of deeper penetration and less toxicity, but faces challenges of suboptimal photothermal conversion and limited therapeutic efficacy. To improve efficacy, multifunctional NIR-II photothermal inorganic or organic materials have been developed for combination with other therapeutic modalities.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Chemistry, Physical
Qichen Chen, Zilin Li, Jiangyuan Yu, Qing Xie, Haizhen Lu, Yiqiao Deng, Jinghua Chen, Wenjia Zhu, Li Huo, Yizhou Zhang, Wei Song, Jianqiang Lan, Jianqiang Cai, Zhen Huang, Zixi Wang, Hong Zhao
Summary: This study combines nanomaterials and targeted therapy for neuroendocrine tumors, showing good photothermal conversion efficiency and significant antitumor effects, with potential for further applications.
Article
Biochemistry & Molecular Biology
Gayoung Jo, Eun Jeong Kim, Min Ho Park, Hoon Hyun
Summary: In this study, a tumor-targetable NIR fluorophore conjugate with rapid body clearance was developed for accurate tumor imaging and effective photothermal therapy. The conjugate showed high tumor accumulation and rapid background clearance, and its photothermal energy induced necrotic cell death in the targeted tumor site.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chang Xu, Jiachen Sun, Miaomiao Tian, Jingwen Cui, Dingyuan Jiang, Hao Deng, Dan Li, Xifan Mei
Summary: Spinal cord injury is a complex neurological disorder with serious socioeconomic implications. Near-Infrared light-assisted therapy for SCI shows great promise in anti-inflammation and tissue regeneration effects. By summarizing the reported strategies, we can advance the research on NIR adjuvant therapy for SCI.
PROCESS BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Gayoung Jo, Eun Jeong Kim, Hoon Hyun
Summary: This study developed a feasible strategy for improving tumor targeting, in vivo biodistribution, and photothermal therapy (PTT) performance by conjugating a water-insoluble anticancer drug with a highly water-soluble zwitterionic near-infrared (NIR) fluorophore. The results demonstrated high tumor accumulation and rapid body clearance behavior, as well as effective photothermal therapy for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Chaoqun Li, Sai Shi, Dong Gao, Boying Li, Guoqiang Song, Yafei Chen, Chengfen Xing, Hailong An
Summary: In this study, a natural compound procyanidin (PC) was identified as an efficacious and selective inhibitor of TMEM16A, and near-infrared (NIR)-light-responsive photothermal conjugated polymer nanoparticles encapsulating PC (CPNs-PC) were developed to target and regulate TMEM16A anion channel. It was found that CPNs-PC could downregulate the signaling pathway downstream of TMEM16A, arrest cancer cell cycle progression, and enhance the bioavailability of PC. CPNs-PC exhibited superior tumor inhibition compared to PC.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Chaoqun Li, Sai Shi, Dong Gao, Boying Li, Guoqiang Song, Yafei Chen, Hailong An, Chengfen Xing
Summary: In this study, a natural compound procyanidin (PC) was identified as a selective inhibitor of TMEM16A and its precise electrostatic interactions with TMEM16A were characterized. Near-infrared (NIR)-light-responsive photothermal conjugated polymer nanoparticles encapsulating PC (CPNs-PC) were developed for remote targeting and regulation of TMEM16A. The findings provided a strategy to promote tumor regression by accurately and remotely regulating anion channels using NIR-light-responsive polymer nanoparticles containing specific inhibitors of TMEM16A.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Shaojing Zhao, Li Yan, Mingyue Cao, Li Huang, Ke Yang, Shuilin Wu, Minhuan Lan, Guangle Niu, Wenjun Zhang
Summary: Carbon dots (CDs) prepared by hydrothermal treatment of coronene derivatives exhibit a high photothermal conversion efficiency at 808 nm, making them suitable as an efficient NIR light-triggered photothermal agent for effective photothermal therapy against cancer.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Jingyi Zhu, Xiangning Li, Wenling Gao, Jian Jing
Summary: In this study, a new antimelanoma tumor peptide, LbtA5, was successfully developed and synthesized. LbtA5 showed strong biological effects in inhibiting tumor cell viability and tumor tissue angiogenesis. This study provides a potential strategy for the treatment of various cancers, including malignant melanoma, using the recombinant fusion protein LbtA5.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Electrochemistry
Reda Bababrik, Daniel Santhanaraj, Daniel E. Resasco, Bin Wang
Summary: This study compares the selectivity in aqueous-phase thermal catalytic and electrocatalytic conversion of furfural and reveals fundamental differences in elementary steps in the two reaction systems. In electrocatalysis, 2-methylfuran dominates as the product, while in thermal catalysis, furfural alcohol and its derivatives are the major products.
JOURNAL OF APPLIED ELECTROCHEMISTRY
(2021)
Article
Chemistry, Physical
Gengnan Li, Bin Wang, Daniel E. Resasco
Article
Chemistry, Physical
Felipe Anaya, Daniel E. Resasco
Article
Chemistry, Physical
Gengnan Li, Bin Wang, Daniel E. Resasco
JOURNAL OF CATALYSIS
(2020)
Article
Engineering, Chemical
Nuttapong Makmeesub, Chonlada Ritvirulh, Kittisak Choojun, Teng-Hao Chen, Yingyot Poo-arporn, Daniel E. Resasco, Tawan Sooknoi
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2020)
Article
Chemistry, Physical
Gengnan Li, Duong T. Ngo, Yu Yan, Qiaohua Tan, Bin Wang, Daniel E. Resasco
Article
Chemistry, Physical
Feifei Yang, Mallikharjuna Rao Komarneni, Nicole J. Libretto, Liwen Li, Wei Zhou, Jeffrey T. Miller, Qingfeng Ge, Xinli Zhu, Daniel E. Resasco
Summary: This study reports a bimetallic NiW/SiO2 catalyst that exhibits high efficiency in HDO reaction and inhibition of CH4 formation, with a unique structure that shows excellent performance in aromatic synthesis. Detailed characterization of the catalyst structure was conducted using multiple techniques.
Article
Chemistry, Physical
Gengnan Li, Zheng Zhao, Tong Mou, Qiaohua Tan, Bin Wang, Daniel Resasco
Summary: The study evaluates the effects of different solvents on the hydrogenation reactions catalyzed by Pd/alumina, revealing that the solvent can shift the rate determining step of the reaction by competitive adsorption. The results show that non-polar solvents decrease surface coverage of reactants and intermediates, leading to different hydrogenation rates for different solvents.
JOURNAL OF CATALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Camila Abreu Teles, Priscilla Magalhaes de Souza, Raimundo Crisostomo Rabelo-Neto, Alejandra Teran, Gary Jacobs, Daniel E. Resasco, Fabio B. Noronha
Summary: The study on the catalytic upgrading of biomass pyrolysis products emphasizes the importance of understanding competitive adsorption in the process. Different catalyst supports influence the rate of elimination of hydroxyl and methoxy groups, leading to the formation of various oxygenated products. Preferential reactions of hydroxyl groups were observed in binary mixtures, highlighting the impact of competitive adsorption on product selectivity.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Physical
Kuizhi Chen, Anya Zornes, Reda Bababrik, Jacob Crouch, Walter Alvarez, Matt Wulfers, Daniel Resasco, Bin Wang, Steven Crossley, Jeffery L. White
Summary: Modification of Zeolite ZSM-5 catalysts with varying amounts of H3PO4 results in increased structural heterogeneity of phosphates with higher loadings, while similar experiments on silicalite show formation of only free phosphates.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Physical
Gengnan Li, Nebojsa Marinkovic, Bin Wang, Mallikharjuna Rao Komarneni, Daniel E. Resasco
Summary: Precise tuning of the local environment surrounding the active site is crucial for engineering catalytic materials. This study explores a nanoconfined catalytic system in which organic surfactants anchored on metal surfaces not only modify catalytic performance but also regulate solvent distribution at the liquid-solid interface. The combination of catalyst synthesis, spectroscopic characterization, reaction kinetics analysis, and computational techniques provides a quantitative description of a catalyst with a tunable local environment near the active site.
Article
Chemistry, Physical
Laura A. Gomez, Caleb Q. Bavlnka, Tianhao E. Zhang, Daniel E. Resasco, Steven P. Crossley
Summary: The study investigates the selective deoxygenation of carboxylic acid on promoted MoO3, revealing the potential for synthesizing valuable renewable products. The results suggest that the deoxygenation of pentanoic acid on an oxygen vacancy of MoO3 can be explained by a Langmuir-Hinshelwood mechanism. The incorporation of Pt shifts the reaction order with respect to hydrogen and alters the rate-determining step.
Article
Chemistry, Multidisciplinary
Gengnan Li, Mallikharjuna Rao Komarneni, Bin Wang, Nebojsa Marinkovic, Daniel E. Resasco
Summary: In this study, the role of water in the selective hydrogenation of cinnamaldehyde was investigated. It was found that boron species exsolve from the bulk phase and become enriched on the surface, forming acidic species that enhance the activity and selectivity of carbonyl bond hydrogenation. Metal-support interactions result in smaller particles and a drop in selectivity towards unsaturated alcohol. The presence of boron species and strong metal-support interactions protect the catalysts from water attack, resulting in enhanced stability.
CELL REPORTS PHYSICAL SCIENCE
(2023)
Article
Engineering, Chemical
Nilson F. L. de Paula, Tuong V. Bui, Daniel E. Resasco
Summary: This study presents a method using titration technique and reaction-diffusion model to quantify mass-transfer limitations in microporous acid zeolites. The method allows for the determination of the extent of mass-transport limitations in the system by observing the variation in reaction rate and manipulating site density. The results also indicate that the degree of mass transfer limitations can influence the selectivity of product formation in the reaction.
CHEMICAL ENGINEERING SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Patrick McKernan, Needa A. Virani, Gabriela N. F. Faria, Clement G. Karch, Ricardo Prada Silvy, Daniel E. Resasco, Linda F. Thompson, Roger G. Harrison
Summary: The study demonstrates that a novel treatment combining photothermal therapy with targeted single-walled carbon nanotubes and immunostimulation can significantly increase the survival rate of patients with metastatic breast cancer, showing a remarkable anti-cancer immune effect.
NANOSCALE RESEARCH LETTERS
(2021)