Article
Ophthalmology
Renita Maria Martis, Bo Li, Paul James Donaldson, Julie Ching-Hsia Lim
Summary: The study found that loss of xCT resulted in depletion of glutathione in the epithelium and an oxidative shift in the cysteine/cystine ratio of the aqueous humor, accelerating the development of an anterior cataract in knockout mice.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Nutrition & Dietetics
Hai Jia, Yunchang Zhang, Xuemeng Si, Yuhang Jin, Da Jiang, Zhaolai Dai, Zhenlong Wu
Summary: This study demonstrates that quercetin can alleviate diquat-induced cell injury in enterocytes by upregulating the protein abundance of Nrf2 and regulating GSH-related redox homeostasis.
Article
Pharmacology & Pharmacy
G. Sevin, Z. Kerry, N. Sozer, G. Ozsarlak-Sozer
Summary: Age is a major risk factor for cataracts, and oxidative stress is a key factor in cataract formation. This study suggests that supplementing taurine may play an important role in slowing down the process of cataract formation.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yexin Liu, Ritsumi Saito, Naomi Matsukawa, Eiji Hishinuma, Daisuke Saigusa, Hong Liu, Masayuki Yamamoto, Akira Uruno
Summary: This study reveals that the transcription factor Nrf2 plays a critical role in protecting the body against oxidative stress and inflammation in diabetic kidney disease. The results demonstrate that Nrf2 deficiency exacerbates the symptoms of diabetic kidney disease, while Nrf2 induction helps alleviate kidney damage.
Article
Biochemistry & Molecular Biology
Ramachandran Kaliaperumal, Ramesh Venkatachalam, Prithiviraj Nagarajan, Satheesh Kumar Sabapathy
Summary: Magnesium deficiency is associated with oxidative stress and early development of cataracts, particularly in patients with type 2 diabetes mellitus. This study found significantly decreased levels of magnesium, GSH, GPX-3, and increased levels of MDA in diabetic cataract patients compared to non-diabetic senile cataract patients and healthy individuals, indicating a potential pathogenic role of hypomagnesemia in triggering oxidative stress and cataractogenesis in diabetes.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Medicine, Research & Experimental
Xiao Li, Doudou Chen, Bowen Ouyang, Shengnan Wang, Yawei Li, Li Li, Siquan Zhu, Guangying Zheng
Summary: This study investigated the role of KLF5 in diabetic cataract (DC) and its underlying mechanism. The expression of KLF5 was significantly increased in DC lens, diabetic rat lens, and high glucose-stimulated human lens epithelial cells (HLECs). Knockdown of KLF5 inhibited EMT, migration, oxidative stress, and inflammation in high glucose-stimulated HLECs. KLF5 was found to bind the MDM2 promoter and enhance the transcriptional activity of MDM2. The study suggests that targeting KLF5 could be a potential therapeutic strategy for DC.
LABORATORY INVESTIGATION
(2023)
Article
Neurosciences
Sara Petrillo, Massimo Santoro, Piergiorgio La Rosa, Alessia Perna, Maria Giovanna Gallo, Enrico Silvio Bertini, Gabriella Silvestri, Fiorella Piemonte
Summary: The study found a potential protective mechanism in two asymptomatic family members that may modulate the phenotype of FRDA, which is associated with the high reactivity of the GSH system and NRF2 activation.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Cell Biology
Weikun Jia, Tao Bai, Jiang Zeng, Zijing Niu, Daogui Fan, Xin Xu, Meiling Luo, Peijian Wang, Qingliang Zou, Xiaozhen Dai
Summary: The combination therapy of metformin and atorvastatin showed superior protective effects against diabetic cardiomyopathy by inhibiting oxidative stress and inflammation, as well as reducing apoptosis of cardiomyocytes. This effect may be related to the activation of AMPK/SIRT1 signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Neoma T. Boardman, Baher Migally, Chantal Pileggi, Gaganvir S. Parmar, Jian Ying Xuan, Keir Menzies, Mary-Ellen Harper
Summary: GRX2 and SIRT3 play important roles in controlling cardiac mitochondrial redox and oxidative processes. However, their combined absence does not exacerbate effects, consistent with the overall conclusion that they function together in the complex redox and antioxidant systems in the heart.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Nutrition & Dietetics
Annamaria D'Alessandro, Giovina Di Felice, Melania Manco, Anna Pastore, Simona Pezzi, Michela Mariani, Danilo Fintini, Andrea Onetti Muda, Ottavia Porzio
Summary: Obesity is a serious public health challenge that is closely linked to oxidative stress and metabolic disorders. This study analyzed serum samples from children with obesity and found abnormal levels of oxidative stress markers, which were positively correlated with obesity-related indices. Age was also found to be associated with oxidative stress.
Article
Pharmacology & Pharmacy
Felipe Zecchinati, Maria Manuela Barranco, Guillermo Nicolas Tocchetti, Camila Juliana Dominguez, Maite Rocio Arana, Virginia Gabriela Perdomo, Aldo Domingo Mottino, Fabiana Garcia, Silvina Stella Maris Villanueva
Summary: This study demonstrated that oxidative stress negatively regulates the intestinal barrier protein Mrp2 posttranslationally, leading to impaired barrier function. The altered distribution and function of Mrp2 caused by oxidative stress may have implications in xenobiotic absorption and toxicity in various human diseases associated with oxidative stress, affecting the safety and efficacy of therapeutic agents.
Article
Nutrition & Dietetics
Grazyna Swiderska-Kolacz, Malgorzata Jefimow, Jolanta Klusek, Norbert Raczka, Szymon Zmorzynski, Anna Wojciechowska, Iwona Stanislawska, Marek Lyp, Joanna Czerwik-Marcinkowska
Summary: This study found that diet supplementation with Pinnularia borealis could lower cholesterol and triacylglycerol concentrations in the liver and kidneys of mice, indicating the protective properties of algae. Additionally, even a low concentration of Pinnularia borealis was sufficient to improve antioxidant capacity.
Article
Nutrition & Dietetics
Yung-Fang Hsiao, Shao-Bin Cheng, Chia-Yu Lai, Hsiao-Tien Liu, Shih-Chien Huang, Yi-Chia Huang
Summary: This study compared the changes in oxidative stress and GSH-related antioxidant capacities before and after tumor resection in HCC patients, showing a decrease in plasma malondialdehyde level and varying increases in GSH and related enzyme activities. The findings suggest a potential therapeutic use of GPx or GR as targets for reducing HCC recurrence.
Review
Cell Biology
Manuel Ruiss, Oliver Findl, Martin Kronschlaeger
Summary: Cataract is a leading cause of blindness globally, and surgery is currently the only treatment option. However, complications and limited access to ophthalmic care may arise. With a growing and aging population, there will be an increase in cataract prevalence, presenting a challenge to society. As oxidative stress is a major pathological process in cataract formation, antioxidant supplementation may be a strategy to delay or prevent its progression. Caffeine, a widely consumed antioxidant, shows potential for preventing cataract.
AGEING RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Itaru Monno, Yoshio Ogura, Jing Xu, Daisuke Koya, Munehiro Kitada
Summary: This study found that 8 weeks of treadmill exercise training significantly reduced kidney injuries in type 2 diabetic obese rats, suppressing tubulointerstitial fibrosis, inflammation, and oxidative stress, promoting autophagy, and restoring mitochondrial abnormalities.
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
