Review
Biochemistry & Molecular Biology
Katarzyna Logon, Gabriela Swirkosz, Monika Nowak, Martyna Wrzesniewska, Aleksandra Szczygiel, Krzysztof Gomulka
Summary: The role of the microbiome in asthma pathology and treatment is significant, as highlighted in this article. The interplay between asthma and the microbiome is complex, and further research is needed to clarify the factors that moderate this relationship. The pre-treatment bronchial microbiome in asthmatic patients influences their response to treatment. The gut microbiota and its dysbiosis can contribute to immune system modulation and the development of asthma. An appropriate gut microbiome and its intestinal metabolites are protective factors for asthma development. Prebiotics and specific dietary strategies may have prophylactic or therapeutic effects, but further research is needed for definitive conclusions. While evidence regarding probiotics is inconclusive, recent studies have shown promising effects. Future studies should focus on investigating specific strains and examining their mechanisms and genetic aspects.
Article
Biochemistry & Molecular Biology
Chris Callewaert, Nastassia Knodlseder, Ante Karoglan, Marc Guell, Bernhard Paetzold
Summary: Manipulating the skin microbiome has become a hot topic for both therapeutic and cosmetic purposes. Various strategies, such as skin microbiome transplantation and the use of prebiotics, probiotics, and postbiotics, have been explored. The skin microbiome represents a novel platform for therapy, with the transplantation of a complete microbiome or application of single strains showing beneficial therapeutic applications.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Editorial Material
Biochemistry & Molecular Biology
Xin Li, Deepak Saxena
Summary: Two new studies provide a comprehensive understanding of tumor-associated fungal communities in human cancers, revealing their ubiquity and potential prognostic value.
Article
Neuroimaging
Kejal Kantarci, Bradley F. Boeve, Scott A. Przybelski, Timothy G. Lesnick, Qin Chen, Julie Fields, Christopher G. Schwarz, Matthew L. Senjem, Jeffrey L. Gunte, Clifford R. Jack, Paul Min, Manoj Jain, Toji Migayawa, Rodolfo Savica, Jonathan Graff-Radford, Hugo Botha, David T. Jones, David S. Knopman, Neill Graff-Radford, Tanis J. Ferman, Ronald C. Petersen, Val J. Lowe
Summary: Patients with mild cognitive impairment (MCI) who progressed to probable dementia with Lewy bodies (DLB) show hypometabolism in the parieto-occipital cortex extending into temporal lobes, substantia nigra, and thalamus. In comparison to those who progressed to Alzheimer's disease (AD) dementia, MCI-DLB patients exhibit preserved medial temporal and posterior cingulate metabolism, along with greater hypometabolism in the substantia nigra. The CIS ratio and medial temporal to substantia nigra ratio are identified as useful in distinguishing prodromal DLB from AD.
NEUROIMAGE-CLINICAL
(2021)
Article
Biochemistry & Molecular Biology
Hui-Hua Zheng, Chong-Tao Du, Chao Yu, Xin-Yue Tang, Rong-Lei Huang, Yu-Zhu Zhang, Wei Gao, Guang-Hong Xie
Summary: Early diagnosis of canine mammary tumor (CMT) is crucial for prognosis. This study examined the bacterial community in tumor tissues, oral and gut samples from dogs with CMTs, and found significant differences compared to healthy dogs. Bacteroides was identified as a significant microbial biomarker in the oral and gut bacterium community, suggesting a potential route for microbiota to travel from the mouth to the intestine and to distant mammary tumor tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Oncology
Kornelia Polyak
Summary: In this study, the researchers discovered that intracellular bacteria in a breast cancer model can enhance resistance to mechanical stress by reorganizing the cytoskeleton, leading to promotion of tumor metastasis and survival in the circulation.
Article
Psychiatry
Ming-Chyi Pai, Chiu-Jun Yang, Sheng-Yu Fan
Summary: This study investigated the differences in time perception performance between prodromal AD and prodromal DLB patients. The findings revealed that prodromal AD patients exhibited imprecision and overestimation of time, while prodromal DLB patients tended to underestimate time intervals. The study suggests that the clinical and pathological severity of these two prodromal dementia stages may differ.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Microbiology
Esther Ndungo, Johanna B. Holm, Syze Gama, Andrea G. Buchwald, Sharon M. Tennant, Miriam K. Laufer, Marcela F. Pasetti, David A. Rasko
Summary: Shigella continues to be a major contributor to diarrheal illness and dysentery in children under 5 in low- and middle-income countries. This study explored the impact of Shigella infection on the developing gastrointestinal microbiome in infants and found temporal changes in the microbiota associated with the infection. These findings highlight the need for further research on the microbial communities associated with disease susceptibility and resolution.
Article
Multidisciplinary Sciences
Manuel Ochoa-Sanchez, Eliana Paola Acuna Gomez, Lia Ramirez-Fenandez, Luis E. Eguiarte, Valeria Souza
Summary: Host-microbe interactions play a crucial role in host biology, ecology, and evolution. However, research on marine hosts and their associated microbes in the Southern Hemisphere, particularly in developing countries, is limited. This review explores the current knowledge of marine host microbiomes in the Southern Hemisphere, highlighting biases towards certain species such as sponges and marine mammals. The results reveal variations in sponge-associated microbes across regions and species, while geography and aging are important factors driving marine mammal microbiomes. Additional research is needed on seabirds, macroalgae, invertebrates, and fish microbiomes. The predominant approach to studying these microbiomes has been the sequencing of the 16S rRNA gene. Holobiont studies, which analyze both host and microbial traits, have been conducted on African and Australian marine invertebrates and macroalgae. The review concludes by introducing an ongoing project on the surface microbiome of key species in the Strait of Magellan, which aims to provide novel insights into microbial diversity and host-microbial responses to climate change.
Article
Microbiology
Florencia Velez-Cortes, Harris Wang
Summary: Bacterially secreted proteins are crucial for the functioning of bacterial cells and communities. In this study, a computational pipeline was used to predict and analyze the bacterial metasecretome of the human gut, revealing the presence of diverse families of secreted carbohydrate-active enzymes and their distribution across taxonomic groups. By mapping secreted proteins to metagenomic data from endoscopic sampling of the human gastrointestinal tract, specific regions were identified where resident microbes secrete glycosidases. The comprehensive analysis of the metasecretome provides valuable insights for microbiome research and understanding the impact of gut bacteria on human health.
Article
Immunology
Ylaine Gerardin, Sonia Timberlake, Jessica R. Allegretti, Mark B. Smith, Zain Kassam
Summary: The transfer of live gut microbes may revolutionize the treatment of various diseases, with fecal microbiota transplantation showing early success in certain infections. The development of microbiome drugs is now being driven by these clinical advances, although challenges remain in terms of safety, consistency, and delivery.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Esraah Alharris, Amira Mohammed, Hasan Alghetaa, Juhua Zhou, Mitzi Nagarkatti, Prakash Nagarkatti
Summary: Resveratrol (RES), a plant-based polyphenol, can attenuate allergic asthma by modulating gut and lung microbiome and promoting normal barrier functions of the lung.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Microbiology
Inmyoung Park, Young-Su Seo, Mohamed Mannaa
Summary: The viable community of microorganisms in the rhizosphere significantly affects plant development and vitality. This review discusses the factors that influence the composition and function of the rhizosphere microbiome and how they facilitate the recruitment of specific microbes by the host plant to support plant growth and resilience under stress. The review also explores current methods for manipulating the rhizosphere microbiome and highlights promising techniques and avenues for future research.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Oncology
Courtney Hoskinson, Rachel Yutong Jiang, Leah T. Stiemsma
Summary: The mammary microbiome and gut microbiome are associated with breast cancer, with unique microbial signatures and dysbiosis occurring in these areas. Specific breast and gut microbes can influence host immune responses and chemotherapies affect the microbiome. Understanding the role of the microbiome using multi-omic approaches and animal models is important for improving strategies for breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Jin-A Lim, Jihye Cha, Soyoung Choi, Jae-Hwan Kim, Dahye Kim
Summary: This study investigated changes in piglet fecal microbiomes from birth through weaning and their associations with sows. The results revealed that certain bacterial groups dominated early piglet microbiomes during nursing, and an increase in specific bacteria was observed in weaned piglets fed solid feed. The study also suggested that the piglet intestinal microbiome is vertically transmitted from the mother. Further research is needed to better understand the early establishment of piglet intestinal microbiomes by considering factors related to sows, piglets, and the environment.
Article
Clinical Neurology
Elina Makinen, Juho Joutsa, Elina Jaakkola, Tommi Noponen, Jarkko Johansson, Miia Pitkonen, Reeta Levo, Tuomas Mertsalmi, Filip Scheperjans, Valtteri Kaasinen
JOURNAL OF NEUROLOGY
(2019)
Article
Clinical Neurology
Rebekka M. Ortiz, Filip Scheperjans, Eero Pekkonen
Article
Clinical Neurology
Elina Jaakkola, Juho Joutsa, Elina Makinen, Tommi Noponen, Miia Pitkonen, Reeta Levo, Tuomas Mertsalmi, Filip Scheperjans, Valtteri Kaasinen
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2019)
Review
Neurosciences
Jeffrey M. Boertien, Pedro A. B. Pereira, Velma T. E. Aho, Filip Scheperjans
JOURNAL OF PARKINSONS DISEASE
(2019)
Article
Clinical Neurology
Tuomas H. Mertsalmi, Eero Pekkonen, Filip Scheperjans
MOVEMENT DISORDERS
(2020)
Article
Neurosciences
Velma T. E. Aho, Madelyn C. Houser, Pedro A. B. Pereira, Jianjun Chang, Knut Rudi, Lars Paulin, Vicki Hertzberg, Petri Auvinen, Malu G. Tansey, Filip Scheperjans
Summary: This study found that intestinal inflammatory responses and reductions in fecal SCFAs occur in Parkinson's disease (PD), are related to the microbiota and to disease onset, and are not reflected in plasma inflammatory profiles. Some of these relationships are distinct in PD and are sex-dependent. This study revealed potential alterations in microbiota-host interactions and links between earlier PD onset and intestinal inflammatory responses and reduced SCFA levels.
MOLECULAR NEURODEGENERATION
(2021)
Article
Neurosciences
Sebastiaan P. van Kessel, Petri Auvinen, Filip Scheperjans, Sahar El Aidy
Summary: The gut microbiota plays a role in the clinical response of orally administered drugs, particularly in the case of tyrosine decarboxylating (TDC) bacteria and Parkinson's disease medication. Exposure to anti-PD medication may affect the abundance of bacterial TDC gene, potentially impacting drug efficacy. Further research is needed to understand the effects of anti-PD medication on microbial changes and gastrointestinal function.
NPJ PARKINSONS DISEASE
(2021)
Article
Neurosciences
Pedro A. B. Pereira, Drupad K. Trivedi, Justin Silverman, Ilhan Cem Duru, Lars Paulin, Petri Auvinen, Filip Scheperjans
Summary: This study investigated the link between serum metabolites, gut bacterial community composition, and clinical variables in Parkinson's disease (PD) and healthy control subjects (HC). The results showed alterations in serum metabolite profiles in PD, and suggested that several bacterial taxa are associated with altered lipid and energy metabolism in PD.
NPJ PARKINSONS DISEASE
(2022)
Article
Health Care Sciences & Services
Maija Koivu, Filip Scheperjans, Johanna Eerola-Rautio, Nuutti Vartiainen, Julio Resendiz-Nieves, Riku Kivisaari, Eero Pekkonen
Summary: Directional deep brain stimulation (dDBS) is effective in reducing both motor and non-motor symptoms in advanced Parkinson's disease patients, with minimal adverse effects in real-life clinical care.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Clinical Neurology
Sven Kleine Bardenhorst, Emanuele Cereda, Marco Severgnini, Michela Barichella, Gianni Pezzoli, Ali Keshavarzian, Alessandro Desideri, Daniele Pietrucci, Velma T. E. Aho, Filip Scheperjans, Falk Hildebrand, Severin Weis, Markus Egert, Andre Karch, Marius Vital, Nicole Ruebsamen
Summary: The aim of this study is to reduce methodological heterogeneity in Parkinson's disease (PD) research and perform a pooled analysis. The results show that harmonizing workflows minimizes differences between statistical methods and reveals a small set of taxa associated with PD. Increased shares of Akkermansia and Bifidobacterium and decreased shares of Roseburia and Faecalibacterium are characteristic of PD-associated microbiota.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Meeting Abstract
Clinical Neurology
K. Murtomaki, T. Mertsalmi, E. Jaakkola, E. Makinen, J. Joutsa, R. Levo, E. Pekkonen, V. Kaasinen, F. Scheperjans
MOVEMENT DISORDERS
(2019)
Meeting Abstract
Clinical Neurology
S. Nuuttila, J. Joutsa, M. Eklund, E. Jaakkola, E. Makinen, T. Noponen, T. Ihalainen, F. Scheperjans, V. Kaasinen
MOVEMENT DISORDERS
(2019)
Meeting Abstract
Clinical Neurology
R. Ortiz, T. Mertsalmi, F. Scheperjans, E. Pekkonen
MOVEMENT DISORDERS
(2019)
Meeting Abstract
Clinical Neurology
M. Koivu, J. Resendiz-Nieves, J. Eerola-Rautio, F. Scheperjans, R. Kivisaari, E. Pekkonen
MOVEMENT DISORDERS
(2019)
Meeting Abstract
Clinical Neurology
M. Eklund, J. Joutsa, S. Nuuttila, E. Makinen, E. Jaakkola, T. Noponen, T. Ihalainen, M. Koivisto, S. Teperi, F. Scheperjans, V. Kaasinen
MOVEMENT DISORDERS
(2019)
