Deletion of Type-2 Cannabinoid Receptor Induces Alzheimer’s Disease-Like Tau Pathology and Memory Impairment Through AMPK/GSK3β Pathway

CB2 Cannabinoid Receptor Agonist Ameliorates Alzheimer-Like Phenotype in AβPP/PS1 Mice

(2018) Ester Aso et al.   JOURNAL OF ALZHEIMERS DISEASE

AMPK Activation Ameliorates Alzheimer's Disease-Like Pathology and Spatial Memory Impairment in a Streptozotocin-Induced Alzheimer's Disease Model in Rats

(2018) Lai-Ling Du et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau and tauopathies

(2016) Thomas Arendt et al.   BRAIN RESEARCH BULLETIN

Decreased in vivo availability of the cannabinoid type 2 receptor in Alzheimer’s disease

(2016) Rawaha Ahmad et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Energy metabolism and inflammation in brain aging and Alzheimer’s disease

(2016) Fei Yin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cannabinoid Receptor 2 Participates in Amyloid-β Processing in a Mouse Model of Alzheimer’s Disease but Plays a Minor Role in the Therapeutic Properties of a Cannabis-Based Medicine

(2016) Ester Aso et al.   JOURNAL OF ALZHEIMERS DISEASE

Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK

(2016) Yan-jing Yang et al.   Journal of Neuroinflammation

Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer’s disease neuropathological deficits

(2016) S A Shah et al.   MOLECULAR PSYCHIATRY

CB2 Cannabinoid Receptor Knockout in Mice Impairs Contextual Long-Term Memory and Enhances Spatial Working Memory

(2016) Yong Li et al.   NEURAL PLASTICITY

CB2 Cannabinoid Receptor As Potential Target against Alzheimer's Disease

(2016) Ester Aso et al.   Frontiers in Neuroscience

Effects of long-term resveratrol-induced SIRT1 activation on insulin and apoptotic signalling in aged skeletal muscle

(2015) Thomas K. Sin et al.   ACTA DIABETOLOGICA

Aging-associated formaldehyde-induced norepinephrine deficiency contributes to age-related memory decline

(2015) Yufei Mei et al.   AGING CELL

Cannabinoid receptor 2 deficiency results in reduced neuroinflammation in an Alzheimer's disease mouse model

(2015) Anne-Caroline Schmöle et al.   NEUROBIOLOGY OF AGING

Alterations in synaptic plasticity coincide with deficits in spatial working memory in presymptomatic 3xTg-AD mice

(2015) Jason K. Clark et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Neuronal expression of CB2 cannabinoid receptor mRNAs in the mouse hippocampus

(2015) Y. Li et al.   NEUROSCIENCE

Mitochondrial Dysfunction Contributes to the Pathogenesis of Alzheimer’s Disease

(2015) Fabian A. Cabezas-Opazo et al.   Oxidative Medicine and Cellular Longevity

Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape

(2015) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease

(2014) Ignacio Pedrós et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Species Differences in Cannabinoid Receptor 2 and Receptor Responses to Cocaine Self-Administration in Mice and Rats

(2014) Hai-Ying Zhang et al.   NEUROPSYCHOPHARMACOLOGY

�-Caryophyllene Ameliorates the Alzheimer-Like Phenotype in APP/PS1 Mice through CB2 Receptor Activation and the PPARγ Pathway

(2014) Yujie Cheng et al.   PHARMACOLOGY

Cannabinoid CB2receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice

(2014) Hai-Ying Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Putative Role of AMPK in Fetal Adaptive Brain Shut-Down: Linking Metabolism and Inflammation in the Brain

(2014) Martin G. Frasch   Frontiers in Neurology

Activation of Cannabinoid CB2 Receptor–Mediated AMPK/CREB Pathway Reduces Cerebral Ischemic Injury

(2013) In-Young Choi et al.   AMERICAN JOURNAL OF PATHOLOGY

Disease-modified glycogen synthase kinase-3β intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model

(2013) Cai-Xia Peng et al.   NEUROBIOLOGY OF AGING

Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice

(2013) Christoph Köhler et al.   NEUROBIOLOGY OF AGING

Activation of AMP-Activated Protein Kinase Alleviates Homocysteine-Mediated Neurotoxicity in SH-SY5Y Cells

(2013) Youn-Jin Park et al.   NEUROCHEMICAL RESEARCH

Synaptic plasticity alterations associated with memory impairment induced by deletion of CB2 cannabinoid receptors

(2013) María S. García-Gutiérrez et al.   NEUROPHARMACOLOGY

Fear Learning Enhances Neural Responses to Threat-Predictive Sensory Stimuli

(2013) M. D. Kass et al.   SCIENCE

The Protein Phosphatase PP2A/Bα Binds to the Microtubule-associated Proteins Tau and MAP2 at a Motif Also Recognized by the Kinase Fyn

(2012) Jean-Marie Sontag et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CB2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients

(2012) Maite Solas et al.   NEUROBIOLOGY OF AGING

Activation of the CB2 receptor system reverses amyloid-induced memory deficiency

(2012) Jiang Wu et al.   NEUROBIOLOGY OF AGING

Methylglyoxal Induces Tau Hyperphosphorylation via Promoting AGEs Formation

(2012) Xiao-Hong Li et al.   NEUROMOLECULAR MEDICINE

Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and β-amyloid in neurons

(2011) Steven J. Greco et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure

(2011) Claire Thornton et al.   BIOCHEMICAL JOURNAL

Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABAA receptors

(2011) María S García-Gutiérrez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Modeling of ligand binding to G protein coupled receptors: cannabinoid CB1, CB2 and adrenergic β2AR

(2011) Dorota Latek et al.   JOURNAL OF MOLECULAR MODELING

Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression

(2011) Sifan Chen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Brain cannabinoid CB2 receptors modulate cocaine's actions in mice

(2011) Zheng-Xiong Xi et al.   NATURE NEUROSCIENCE

AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation

(2011) Xiao-Hong Li et al.   NEUROBIOLOGY OF AGING

Deletion of CB2 Cannabinoid Receptor Induces Schizophrenia-Related Behaviors in Mice

(2011) Antonio Ortega-Alvaro et al.   NEUROPSYCHOPHARMACOLOGY

AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies

(2010) Valérie Vingtdeux et al.   ACTA NEUROPATHOLOGICA

Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularis

(2010) José L Lanciego et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Redox Regulation of the AMP-Activated Protein Kinase

(2010) Yingying Han et al.   PLoS One

Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity

(2009) Javier Palazuelos et al.   BRAIN

AMP-Activated Protein Kinase-Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol

(2009) J.-H. Um et al.   DIABETES

Emerging role of the cannabinoid receptor CB2 in immune regulation: therapeutic prospects for neuroinflammation

(2009) Guy A. Cabral et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

AMP-activated Protein Kinase Activation Increases Phosphorylation of Glycogen Synthase Kinase 3β and Thereby Reduces cAMP-responsive Element Transcriptional Activity and Phosphoenolpyruvate Carboxykinase C Gene Expression in the Liver

(2008) Nanao Horike et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

(2008) Saravanan S. Karuppagounder et al.   NEUROCHEMISTRY INTERNATIONAL