Article
Biochemistry & Molecular Biology
Zhijun He, Xiaoqian Li, Zi Wang, Yingqi Cao, Shuangxue Han, Nan Li, Jie Cai, Shuiyuan Cheng, Qiong Liu
Summary: This study revealed the beneficial effects of luteolin on Alzheimer's disease through inhibiting Aβ generation, repairing mitochondrial damage, and reducing neuronal apoptosis. The mechanism involved the binding of luteolin to PPARγ to promote its expression and function.
Article
Biochemistry & Molecular Biology
Roberta Facchinetti, Marta Valenza, Chiara Gomiero, Giulia Federica Mancini, Luca Steardo, Patrizia Campolongo, Caterina Scuderi
Summary: This study investigates the effects of Aβ(1-42) toxicity on the maturation of astrocyte/oligodendrocyte co-cultured precursor cells and the potential beneficial effects of the anti-inflammatory and neuroprotective compound co-ultra PEALut. The results show that Aβ(1-42) induces astrocyte reactivity and inflammation, leading to reduced levels of growth factors important for OPCs maturation. Co-ultra PEALut counteracts these negative effects and preserves the morphology of co-cultured oligodendrocytes through mechanisms involving PPAR-α.
Article
Agriculture, Dairy & Animal Science
Yu Li, Zhong-Hao Zhang, Shao-Ling Huang, Zhong-Bao Yue, Xue-Song Yin, Zi-Qi Feng, Xu-Guang Zhang, Guo-Li Song
Summary: Whey protein powder (PP), derived from bovine milk, has been shown to improve the cognitive ability of AD mice, reduce amyloid peptide deposition and tau hyperphosphorylation in the brain, and inhibit neuroinflammation through the PPARγ-NF-κB signaling pathway. This study reveals a previously unknown role of PP in regulating the neuroinflammatory pathology of AD in a mouse model.
JOURNAL OF DAIRY SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Ya-Na Yang, Mao-Qing Zhang, Feng-Lin Yu, Bing Han, Ming-Yue Bao, Xing Li, Yuan Zhang
Summary: Neurodegenerative disorders (NDDs) are characterized by progressive loss of vulnerable neuronal populations and myelin sheath, leading to behavioral and cognitive dysfunction. Peroxisome proliferator-activated receptor-? coactivator-1a (PGC-1a) has shown a strong connection with NDDs and its understanding is important for the development of therapeutic strategies. This review provides an overview of PGC-1a, its role in various NDDs, and the mechanisms through which it exerts neuroprotective effects.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Chemistry, Medicinal
Ahmad Alhowail, Rawan Alsikhan, May Alsaud, Maha Aldubayan, Syed Imam Rabbani
Summary: Pioglitazone has potential in treating cognitive impairment, but its use is associated with cardiovascular risks and limited blood-brain barrier penetration. However, existing research demonstrates that pioglitazone improves inflammation, oxidative stress, amyloidogenesis, hypothyroidism, neurogenesis, synaptic plasticity, and mitochondrial function through activating PPAR receptors.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Zhen Wang, Shu Yang, Yan Li, Yongying Zhou, Daoquan Liu, Jianmin Liu, Michael E. DiSanto, Xinhua Zhang
Summary: BPH is a common disease in elderly men and is closely related to MetS. This study demonstrates that SV can modulate cell proliferation, apoptosis, tissue fibrosis, and the EMT process in the prostate through crosstalk between PPAR gamma and WNT/beta-catenin pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Ellinore R. Doroshenko, Paulina C. Drohomyrecky, Annette Gower, Heather Whetstone, Lindsay S. Cahill, Milan Ganguly, Shoshana Spring, Tae Joon Yi, John G. Sled, Shannon E. Dunn
Summary: The study found that PPAR-delta plays a crucial role in microglia in limiting bystander tissue damage during neuroinflammation. Deficiency of PPAR-delta may lead to exacerbated neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ashi Mannan, Nikhil Garg, Thakur Gurjeet Singh, Harmeet Kaur Kang
Summary: PPAR-gamma plays a neuroprotective role in cerebral ischemic injury by negatively controlling the expression of genes modulated by cerebral ischemic injury to prevent post-ischemic inflammation and neuronal damage. It also regulates lipid metabolism, improves insulin sensitivity, reduces oxidative stress, and inhibits inflammation in the brain. This review provides insights into the cellular and molecular mechanisms through which PPAR-gamma exerts its neuroprotective effects in cerebral ischemic injury.
NEUROCHEMICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Yanhao Qiu, Mailin Gan, Xingyu Wang, Tianci Liao, Qiuyang Chen, Yuhang Lei, Lei Chen, Jinyong Wang, Ye Zhao, Lili Niu, Yan Wang, Shunhua Zhang, Li Zhu, Linyuan Shen
Summary: Excessive expansion of adipocytes can lead to ectopic fat deposition, increasing the risk of metabolic diseases. Peroxisome proliferator-activated receptor gamma (PPARγ) plays a crucial role in fat cell differentiation and adipogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Medicinal
Claudia Sagheddu, Miriam Melis, Anna Lisa Muntoni, Marco Pistis
Summary: Shared pathophysiological mechanisms are found in different neurological and neuropsychiatric conditions. PPARs may play a neuroprotective role, suggesting that repurposing these drugs could be a potential treatment for diseases affecting the central nervous system.
Article
Biochemistry & Molecular Biology
Mahesha Gangadhariah, Triveni Pardhi, Jahnavi Ravilla, Subhash Chandra, Sridevi Annapurna Singh
Summary: PPAR gamma agonists are effective in treating type 2 diabetes but have severe side effects. Lemon contains eriocitrin, which may have potential as a PPAR gamma agonist.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Neurosciences
Riham M. Mansour, Nesrine S. El Sayed, Maha A. E. Ahmed, Ayman E. El-Sahar
Summary: This study aimed to explore the neuroprotective effect of telmisartan in 3-nitropropionic acid-induced neurotoxicity. The results showed that telmisartan improved motor and cognitive functioning, reduced neuronal inflammation and apoptosis, and promoted mitochondrial biogenesis through PPAR gamma activation.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Cell Biology
Iason Psilopatis, Kleio Vrettou, Florian Nima Fleckenstein, Stamatios Theocharis
Summary: Preeclampsia is a common hypertensive disorder in pregnancy, and PPARs play a significant role in its pathophysiology. Studies have shown contradictory conclusions regarding PPAR expression in preeclamptic placentae, but PPAR gamma agonists have been identified as a novel and potent anti-preeclamptic treatment option.
Article
Biochemistry & Molecular Biology
Rodrigo Zamith Cunha, Alberto Semprini, Giulia Salamanca, Francesca Gobbo, Maria Morini, Kirstie J. Pickles, Veronica Roberts, Roberto Chiocchetti
Summary: This study investigated the expression of cannabinoid receptors and related receptors in the trigeminal ganglia of horses and found that they are expressed in sensory neurons. The study suggests further investigation of these receptors in equine trigeminal neuronal disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hyejin Ko, Hongjun Jang, Seungchan An, In Guk Park, Sungjin Ahn, Junpyo Gong, Seok Young Hwang, Soyeon Oh, Soo Yeon Kwak, Won Jun Choi, Hyoungsu Kim, Minsoo Noh
Summary: The upregulation of adiponectin production is a potential therapeutic strategy for metabolic diseases. Galangin and its derivatives were found to promote adiponectin synthesis by binding to PPARγ and enhancing its activity while reducing the activity of ERβ. A novel galangin derivative, galangin 3-benzyl-5,7-dimethylether, showed the highest potency and selectively bound to PPARγ, suggesting its potential therapeutic use in various metabolic diseases.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)