Methylglyoxal attenuates insulin signaling and downregulates the enzymes involved in cholesterol biosynthesis

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

(2017) Amand F Schmidt et al.   Lancet Diabetes & Endocrinology

Estimation of methylglyoxal in cow milk – an accurate electrochemical response time based approach

(2016) Bhat Lakshmishri Ramachandra et al.   Analytical Methods

Simvastatin induces insulin resistance in L6 skeletal muscle myotubes by suppressing insulin signaling, GLUT4 expression and GSK-3β phosphorylation

(2016) Nagendra Yaluri et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies

(2016) Yousif A. Shamsaldeen et al.   CURRENT DRUG METABOLISM

Methylglyoxal-Induced Endothelial Cell Loss and Inflammation Contribute to the Development of Diabetic Cardiomyopathy

(2016) Branka Vulesevic et al.   DIABETES

Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics

(2016) Naila Rabbani et al.   GLYCOCONJUGATE JOURNAL

Alzheimer’s Disease Risk Genes and Lipid Regulators

(2016) Farida El Gaamouch et al.   JOURNAL OF ALZHEIMERS DISEASE

Variation in PCSK9 and HMGCR and Risk of Cardiovascular Disease and Diabetes

(2016) Brian A. Ference et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort

(2015) Henna Cederberg et al.   DIABETOLOGIA

Reducing methylglyoxal as a therapeutic target for diabetic heart disease

(2014) Branka Vulesevic et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Statin treatment and new-onset diabetes: A review of proposed mechanisms

(2014) Marilyne Brault et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Measurement of methylglyoxal by stable isotopic dilution analysis LC-MS/MS with corroborative prediction in physiological samples

(2014) Naila Rabbani et al.   Nature Protocols

Dynamic GLUT4 sorting through a syntaxin-6 compartment in muscle cells is derailed by insulin resistance-causing ceramide

(2014) K. P. Foley et al.   Biology Open

Knockdown of both mitochondrial isocitrate dehydrogenase enzymes in pancreatic beta cells inhibits insulin secretion

(2013) Michael J. MacDonald et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Critical Role of Methylglyoxal and Glyoxalase 1 in Diabetic Nephropathy

(2013) N. Rabbani et al.   DIABETES

Exercise, GLUT4, and Skeletal Muscle Glucose Uptake

(2013) Erik A. Richter et al.   PHYSIOLOGICAL REVIEWS

Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis

(2012) Ludovic C. Gillet et al.   MOLECULAR & CELLULAR PROTEOMICS

Regulation of glucose transport by insulin: traffic control of GLUT4

(2012) Dara Leto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Angiogenesis Impairment in Diabetes: Role of Methylglyoxal-Induced Receptor for Advanced Glycation Endproducts, Autophagy and Vascular Endothelial Growth Factor Receptor 2

(2012) Hongtao Liu et al.   PLoS One

Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1

(2012) W. Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic Methylglyoxal Infusion by Minipump Causes Pancreatic β-Cell Dysfunction and Induces Type 2 Diabetes in Sprague-Dawley Rats

(2011) Arti Dhar et al.   DIABETES

The Role of Skeletal Muscle Glycogen Breakdown for Regulation of Insulin Sensitivity by Exercise

(2011) Jørgen Jensen et al.   Frontiers in Physiology

Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose

(2010) Arti Dhar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Proteomics analysis of methylglyoxal-induced neurotoxic effects in SH-SY5Y cells

(2010) Guoyi Li et al.   CELL BIOCHEMISTRY AND FUNCTION

Demonstration of a visual cell-based assay for screening glucose transporter 4 translocation modulators in real time

(2010) Maleppillil Vavachan Vijayakumar et al.   JOURNAL OF BIOSCIENCES

Inhibition of cholesterol biosynthesis disrupts lipid raft/caveolae and affects insulin receptor activation in 3T3-L1 preadipocytes

(2009) Jana Sánchez-Wandelmer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes

(2009) H. Hwang et al.   DIABETES

Hyperglycemia Impairs Proteasome Function by Methylglyoxal

(2009) M. A. Queisser et al.   DIABETES

Statin Therapy and Risk of Developing Type 2 Diabetes: A Meta-Analysis

(2009) S. N. Rajpathak et al.   DIABETES CARE

Effects of Atorvastatin and Pravastatin on Signal Transduction Related to Glucose Uptake in 3T3L1 Adipocytes

(2008) Akira Takaguri et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES