Alzheimer’s Disease Risk Genes and Lipid Regulators

Wild Type and Tangier Disease ABCA1 Mutants Modulate Cellular Amyloid-β Production Independent of Cholesterol Efflux Activity

(2018) Woojin S. Kim et al.   JOURNAL OF ALZHEIMERS DISEASE

Increase in Cerebrospinal Fluid F2-Isoprostanes is Related to Cognitive Decline in APOE ε4 Carriers

(2018) Flora H. Duits et al.   JOURNAL OF ALZHEIMERS DISEASE

Cardiolipin Profile Changes are Associated to the Early Synaptic Mitochondrial Dysfunction in Alzheimer's Disease

(2018) Vera F. Monteiro-Cardoso et al.   JOURNAL OF ALZHEIMERS DISEASE

ABCA5 Regulates Amyloid-β Peptide Production and is Associated with Alzheimer's Disease Neuropathology

(2018) YuHong Fu et al.   JOURNAL OF ALZHEIMERS DISEASE

Lipid Alterations in Lipid Rafts from Alzheimer's Disease Human Brain Cortex

(2017) Virginia Martín et al.   JOURNAL OF ALZHEIMERS DISEASE

The Alzheimer's Disease Mitochondrial Cascade Hypothesis

(2017) Russell H. Swerdlow et al.   JOURNAL OF ALZHEIMERS DISEASE

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Rare Variants inPLD3Do Not Affect Risk for Early-Onset Alzheimer Disease in a European Consortium Cohort

(2015) Rita Cacace et al.   HUMAN MUTATION

PLD3 in non-familial Alzheimer's disease

(2015) Stefanie Heilmann et al.   NATURE

Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer’s disease pathogenesis

(2015) Li Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is synaptic loss a unique hallmark of Alzheimer's disease?

(2014) Stephen W. Scheff et al.   BIOCHEMICAL PHARMACOLOGY

Cerebrospinal fluid biomarkers for neuropsychological symptoms in early stage of late-onset Alzheimer's disease

(2014) Hung-Chou Kuo et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Apolipoprotein E isoforms and lipoprotein metabolism

(2014) Michael C. Phillips   IUBMB LIFE

Membrane–Protein Interactions Are Key to Understanding Amyloid Formation

(2014) John E. Straub et al.   Journal of Physical Chemistry Letters

Amyloid Aggregation: Role of Biological Membranes and the Aggregate–Membrane System

(2014) Monica Bucciantini et al.   Journal of Physical Chemistry Letters

PLD3 in Alzheimer’s Disease

(2014) Jun Wang et al.   MOLECULAR NEUROBIOLOGY

Plasma phospholipids identify antecedent memory impairment in older adults

(2014) Mark Mapstone et al.   NATURE MEDICINE

Soluble Aβ Oligomers Are Rapidly Sequestered from Brain ISF In Vivo and Bind GM1 Ganglioside on Cellular Membranes

(2014) Soyon Hong et al.   NEURON

Deletion of Abca7 Increases Cerebral Amyloid-  Accumulation in the J20 Mouse Model of Alzheimer's Disease

(2013) W. S. Kim et al.   JOURNAL OF NEUROSCIENCE

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease

(2013) Carlos Cruchaga et al.   NATURE

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The stability and activity of respiratory Complex II is cardiolipin-dependent

(2012) Christine T. Schwall et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Abca1 Deficiency Affects Alzheimer's Disease-Like Phenotype in Human ApoE4 But Not in ApoE3-Targeted Replacement Mice

(2012) N. F. Fitz et al.   JOURNAL OF NEUROSCIENCE

Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury

(2012) Jing Ji et al.   NATURE NEUROSCIENCE

Lipid rafts, synaptic transmission and plasticity: Impact in age-related neurodegenerative diseases

(2012) Ana M. Sebastião et al.   NEUROPHARMACOLOGY

Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis

(2011) Catherine Marquer et al.   FASEB JOURNAL

Roles of ATP-Binding Cassette Transporter A7 in Cholesterol Homeostasis and Host Defense System

(2011) Nobukiyo Tanaka et al.   Journal of Atherosclerosis and Thrombosis

Docosahexaenoic Acid Reduces Amyloid β Production via Multiple Pleiotropic Mechanisms

(2011) Marcus O. W. Grimm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Making heads or tails of phospholipids in mitochondria

(2011) Christof Osman et al.   JOURNAL OF CELL BIOLOGY

Cholesterol Promotes the Interaction of Alzheimer β-Amyloid Monomer with Lipid Bilayer

(2011) Xiang Yu et al.   JOURNAL OF MOLECULAR BIOLOGY

Apolipoprotein E in Alzheimer's disease and other neurological disorders

(2011) Philip B Verghese et al.   LANCET NEUROLOGY

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Lipid composition influences the release of Alzheimer's amyloid β-peptide from membranes

(2011) Justin A. Lemkul et al.   PROTEIN SCIENCE

Mass Spectrometry of Intact V-Type ATPases Reveals Bound Lipids and the Effects of Nucleotide Binding

(2011) M. Zhou et al.   SCIENCE

Lipid rafts: Keys to neurodegeneration

(2010) Cara-Lynne Schengrund   BRAIN RESEARCH BULLETIN

Cardiolipin: characterization of distinct oxidized molecular species

(2010) Junhwan Kim et al.   JOURNAL OF LIPID RESEARCH

Phospholipase D2 Ablation Ameliorates Alzheimer's Disease-Linked Synaptic Dysfunction and Cognitive Deficits

(2010) T. G. Oliveira et al.   JOURNAL OF NEUROSCIENCE

Omega-3 fatty acids: potential role in the management of early Alzheimer’s disease

(2010) Greg Jicha   Clinical Interventions in Aging

Cardiolipin, a critical determinant of mitochondrial carrier protein assembly and function

(2009) Steven M. Claypool   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cholesterol Modulates the Interaction of β-Amyloid Peptide with Lipid Bilayers

(2009) Liming Qiu et al.   BIOPHYSICAL JOURNAL

Cytochrome c/cardiolipin relations in mitochondria: a kiss of death

(2009) Valerian E. Kagan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mild cholesterol depletion reduces amyloid-β production by impairing APP trafficking to the cell surface

(2009) Cristina Guardia-Laguarta et al.   JOURNAL OF NEUROCHEMISTRY

ApoE isoform-dependent changes in hippocampal synaptic function

(2009) Kimberly M Korwek et al.   Molecular Neurodegeneration

Alzheimer’s disease beyond APOE

(2009) Michael A van Es et al.   NATURE GENETICS

Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

(2009) Jungsu Kim et al.   NEURON

Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE

(2008) Lars Bertram et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Role of the Cell Surface LRP and Soluble LRP in Blood-Brain Barrier Aβ Clearance in Alzheimers Disease

(2008) R. Deane et al.   CURRENT PHARMACEUTICAL DESIGN

Cellular cholesterol efflux to serum is impaired in diabetic nephropathy

(2008) Huali Zhou et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

HDL is the major lipoprotein carrier of plasma F2-isoprostanes

(2008) Julie M. Proudfoot et al.   JOURNAL OF LIPID RESEARCH

Formation of Toxic Aβ(1–40) Fibrils on GM1 Ganglioside-Containing Membranes Mimicking Lipid Rafts: Polymorphisms in Aβ(1–40) Fibrils

(2008) Takuma Okada et al.   JOURNAL OF MOLECULAR BIOLOGY

ATP-binding cassette transporter A7 regulates processing of amyloid precursor proteinin vitro

(2008) Sharon L. Chan et al.   JOURNAL OF NEUROCHEMISTRY

Role of ATP-binding cassette transporters in brain lipid transport and neurological disease

(2008) Woojin Scott Kim et al.   JOURNAL OF NEUROCHEMISTRY

Lipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria

(2008) Michael A. Kiebish et al.   JOURNAL OF NEUROCHEMISTRY

Thromboxane Receptor Activation Mediates Isoprostane-Induced Increases in Amyloid Pathology in Tg2576 Mice

(2008) D. W. Shineman et al.   JOURNAL OF NEUROSCIENCE

Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease

(2008) Rene O Sanchez-Mejia et al.   NATURE NEUROSCIENCE

Oligomeric amyloid-β peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism

(2008) Diego E Berman et al.   NATURE NEUROSCIENCE

Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model

(2008) Saravanan S. Karuppagounder et al.   NEUROBIOLOGY OF AGING

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON

New therapeutic targets in the neurovascular pathway in Alzheimer’s disease

(2008) Berislav V. Zlokovic   Neurotherapeutics

Efficient Inhibition of the Alzheimer's Disease  -Secretase by Membrane Targeting

(2008) L. Rajendran et al.   SCIENCE

Hypometabolism and Altered Cerebrospinal Fluid Markers in Normal Apolipoprotein E E4 Carriers with Subjective Memory Complaints

(2007) Lisa Mosconi et al.   BIOLOGICAL PSYCHIATRY

The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease

(2007) Lidia Glodzik-Sobanska et al.   NEUROBIOLOGY OF AGING

Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment

(2007) Miroslaw Brys et al.   NEUROBIOLOGY OF AGING

Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production

(2007) Huaqi Xiong et al.   NEUROBIOLOGY OF DISEASE