Coupled excitable Ras and F-actin activation mediates spontaneous pseudopod formation and directed cell movement

A Gα-Stimulated RapGEF Is a Receptor-Proximal Regulator of Dictyostelium Chemotaxis

(2016) Youtao Liu et al.   DEVELOPMENTAL CELL

The novel RacE-binding protein GflB sharpens Ras activity at the leading edge of migrating cells

(2016) Hiroshi Senoo et al.   MOLECULAR BIOLOGY OF THE CELL

A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells

(2016) Monica Skoge et al.   PLoS One

dictyBase 2015: Expanding data and annotations in a new software environment

(2015) Siddhartha Basu et al.   GENESIS

Locally excitable Cdc42 signals steer cells during chemotaxis

(2015) Hee Won Yang et al.   NATURE CELL BIOLOGY

Activator–inhibitor coupling between Rho signalling and actin assembly makes the cell cortex an excitable medium

(2015) William M. Bement et al.   NATURE CELL BIOLOGY

Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes

(2014) Yulia Artemenko et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Actin and PIP3 waves in giant cells reveal the inherent length scale of an excited state

(2014) Matthias Gerhardt et al.   JOURNAL OF CELL SCIENCE

Intrinsic activity in cells and the brain

(2014) Dennis Bray   MOLECULAR BIOLOGY OF THE CELL

Steering cell migration: lamellipodium dynamics and the regulation of directional persistence

(2014) Matthias Krause et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cellular memory in eukaryotic chemotaxis

(2014) Monica Skoge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis

(2014) Ming Tang et al.   Nature Communications

Rectified directional sensing in long-range cell migration

(2014) Akihiko Nakajima et al.   Nature Communications

The interaction between pseudopods and extracellular signalling during chemotaxis and directed migration

(2013) Robert Insall   CURRENT OPINION IN CELL BIOLOGY

Ras activation and symmetry breaking during Dictyostelium chemotaxis

(2013) A. Kortholt et al.   JOURNAL OF CELL SCIENCE

An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration

(2013) Chuan-Hsiang Huang et al.   NATURE CELL BIOLOGY

Distinct cell shapes determine accurate chemotaxis

(2013) Luke Tweedy et al.   Scientific Reports

Interaction of Motility, Directional Sensing, and Polarity Modules Recreates the Behaviors of Chemotaxing Cells

(2013) Changji Shi et al.   PLoS Computational Biology

Excitable Actin Dynamics in Lamellipodial Protrusion and Retraction

(2012) Gillian L. Ryan et al.   BIOPHYSICAL JOURNAL

A Gβγ Effector, ElmoE, Transduces GPCR Signaling to the Actin Network during Chemotaxis

(2012) Jianshe Yan et al.   DEVELOPMENTAL CELL

An Excitable Cortex and Memory Model Successfully Predicts New Pseudopod Dynamics

(2012) Robert M. Cooper et al.   PLoS One

Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification

(2011) Arjan Kortholt et al.   EMBO REPORTS

Chemotaxis: A Feedback-Based Computational Model Robustly Predicts Multiple Aspects of Real Cell Behaviour

(2011) Matthew P. Neilson et al.   PLOS BIOLOGY

Activated Membrane Patches Guide Chemotactic Cell Motility

(2011) Inbal Hecht et al.   PLoS Computational Biology

A Ras Signaling Complex Controls the RasC-TORC2 Pathway and Directed Cell Migration

(2010) Pascale G. Charest et al.   DEVELOPMENTAL CELL

Ras-mediated activation of the TORC2–PKB pathway is critical for chemotaxis

(2010) Huaqing Cai et al.   JOURNAL OF CELL BIOLOGY

Chemotaxis: insights from the extending pseudopod

(2010) P. J. M. Van Haastert   JOURNAL OF CELL SCIENCE

Involvement of the Cytoskeleton in Controlling Leading-Edge Function during Chemotaxis

(2010) Susan Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Transient Localized Patterns in Noise-Driven Reaction-Diffusion Systems

(2010) Inbal Hecht et al.   PHYSICAL REVIEW LETTERS

Quimp3, an automated pseudopod-tracking algorithm

(2010) Leonard Bosgraaf et al.   Cell Adhesion & Migration

A RasGTP-Induced Conformational Change in C-RAF Is Essential for Accurate Molecular Recognition

(2009) Kayo Hibino et al.   BIOPHYSICAL JOURNAL

The Three-Dimensional Dynamics of Actin Waves, a Model of Cytoskeletal Self-Organization

(2009) Till Bretschneider et al.   BIOPHYSICAL JOURNAL

The local cell curvature guides pseudopodia towards chemoattractants

(2009) Peter J. M. Van Haastert et al.   HFSP Journal

The Ordered Extension of Pseudopodia by Amoeboid Cells in the Absence of External Cues

(2009) Leonard Bosgraaf et al.   PLoS One

Food Searching Strategy of Amoeboid Cells by Starvation Induced Run Length Extension

(2009) Peter J. M. Van Haastert et al.   PLoS One

Navigation of Chemotactic Cells by Parallel Signaling to Pseudopod Persistence and Orientation

(2009) Leonard Bosgraaf et al.   PLoS One

Highlighting the role of Ras and Rap during Dictyostelium chemotaxis

(2008) Arjan Kortholt et al.   CELLULAR SIGNALLING

Four key signaling pathways mediating chemotaxis inDictyostelium discoideum

(2008) Douwe M. Veltman et al.   JOURNAL OF CELL BIOLOGY

PI3-kinase signaling contributes to orientation in shallow gradients and enhances speed in steep chemoattractant gradients

(2008) L. Bosgraaf et al.   JOURNAL OF CELL SCIENCE

Lifeact: a versatile marker to visualize F-actin

(2008) Julia Riedl et al.   NATURE METHODS

A new set of small, extrachromosomal expression vectors for Dictyostelium discoideum

(2008) Douwe M. Veltman et al.   PLASMID

Persistent Cell Motion in the Absence of External Signals: A Search Strategy for Eukaryotic Cells

(2008) Liang Li et al.   PLoS One