Tricellular junctions: how to build junctions at the TRICkiest points of epithelial cells

Automated mitotic spindle tracking suggests a link between spindle dynamics, spindle orientation, and anaphase onset in epithelial cells

(2017) Matthew E. Larson et al.   MOLECULAR BIOLOGY OF THE CELL

Visualizing the dynamic coupling of claudin strands to the actin cytoskeleton through ZO-1

(2017) Christina M. Van Itallie et al.   MOLECULAR BIOLOGY OF THE CELL

ILDR1 is important for paracellular water transport and urine concentration mechanism

(2017) Yongfeng Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity

(2017) Julie Salomon et al.   Nature Communications

Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex

(2017) Martijn Gloerich et al.   Nature Communications

Maintenance of the Epithelial Barrier and Remodeling of Cell-Cell Junctions during Cytokinesis

(2016) Tomohito Higashi et al.   CURRENT BIOLOGY

Cell Boundary Elongation by Non-autonomous Contractility in Cell Oscillation

(2016) Yusuke Hara et al.   CURRENT BIOLOGY

Emergence of an Apical Epithelial Cell Surface In Vivo

(2016) Jakub Sedzinski et al.   DEVELOPMENTAL CELL

Tricellular Tight Junction Protein Tricellulin Is Targeted by the Enteropathogenic Escherichia coli Effector EspG1, Leading to Epithelial Barrier Disruption

(2016) Vijay Morampudi et al.   INFECTION AND IMMUNITY

Remodeling the zonula adherens in response to tension and the role of afadin in this response

(2016) Wangsun Choi et al.   JOURNAL OF CELL BIOLOGY

Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis

(2016) Denise K. Reaves et al.   MOLECULAR CANCER RESEARCH

Epithelial tricellular junctions act as interphase cell shape sensors to orient mitosis

(2016) Floris Bosveld et al.   NATURE

Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis

(2016) Martin Resnik-Docampo et al.   NATURE CELL BIOLOGY

Tight junctions: from simple barriers to multifunctional molecular gates

(2016) Ceniz Zihni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epidermal cell turnover across tight junctions based on Kelvin's tetrakaidecahedron cell shape

(2016) Mariko Yokouchi et al.   eLife

Group A Streptococcus exploits human plasminogen for bacterial translocation across epithelial barrier via tricellular tight junctions

(2016) Tomoko Sumitomo et al.   Scientific Reports

The Triple-Repeat Protein Anakonda Controls Epithelial Tricellular Junction Formation in Drosophila

(2015) Sunitha Byri et al.   DEVELOPMENTAL CELL

Actin-Delimited Adhesion-Independent Clustering of E-Cadherin Forms the Nanoscale Building Blocks of Adherens Junctions

(2015) Yao Wu et al.   DEVELOPMENTAL CELL

LSR/angulin-1 is a tricellular tight junction protein involved in blood–brain barrier formation

(2015) Fabien Sohet et al.   JOURNAL OF CELL BIOLOGY

Model for the Architecture of Claudin-Based Paracellular Ion Channels through Tight Junctions

(2015) Hiroshi Suzuki et al.   JOURNAL OF MOLECULAR BIOLOGY

Deficiency of Angulin-2/ILDR1, a Tricellular Tight Junction-Associated Membrane Protein, Causes Deafness with Cochlear Hair Cell Degeneration in Mice

(2015) Tomohito Higashi et al.   PLoS One

Downsloping High-Frequency Hearing Loss Due to Inner Ear Tricellular Tight Junction Disruption by a Novel ILDR1 Mutation in the Ig-Like Domain

(2015) Nayoung K. D. Kim et al.   PLoS One

Deletion of Tricellulin Causes Progressive Hearing Loss Associated with Degeneration of Cochlear Hair Cells

(2015) Toru Kamitani et al.   Scientific Reports

ILDR1 deficiency causes degeneration of cochlear outer hair cells and disrupts the structure of the organ of Corti: a mouse model for human DFNB42

(2015) Q. Sang et al.   Biology Open

Tension-Sensitive Actin Assembly Supports Contractility at the Epithelial Zonula Adherens

(2014) Joanne M. Leerberg et al.   CURRENT BIOLOGY

Anillin Regulates Cell-Cell Junction Integrity by Organizing Junctional Accumulation of Rho-GTP and Actomyosin

(2014) Ciara C. Reyes et al.   CURRENT BIOLOGY

Subcellular localisations of the CPTI collection of YFP-tagged proteins in Drosophila embryos

(2014) C. M. Lye et al.   DEVELOPMENT

JNK1/2-dependent phosphorylation of angulin-1/LSR is required for the exclusive localization of angulin-1/LSR and tricellulin at tricellular contacts in EpH4 epithelial sheet

(2014) Daiki Nakatsu et al.   GENES TO CELLS

ILDR1 null mice, a model of human deafness DFNB42, show structural aberrations of tricellular tight junctions and degeneration of auditory hair cells

(2014) Eva L. Morozko et al.   HUMAN MOLECULAR GENETICS

Cell division and the maintenance of epithelial order

(2014) Katerina Ragkousi et al.   JOURNAL OF CELL BIOLOGY

Tricellulin regulates junctional tension of epithelial cells at tricellular contacts through Cdc42

(2014) Y. Oda et al.   JOURNAL OF CELL SCIENCE

Androgen-Dependent Sertoli Cell Tight Junction Remodeling Is Mediated by Multiple Tight Junction Components

(2014) Papia Chakraborty et al.   MOLECULAR ENDOCRINOLOGY

The minimal cadherin-catenin complex binds to actin filaments under force

(2014) C. D. Buckley et al.   SCIENCE

Molecular organization and function of invertebrate occluding junctions

(2014) Yasushi Izumi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Tight junction, selective permeability, and related diseases

(2014) Susanne M. Krug et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Architecture of tight junctions and principles of molecular composition

(2014) Christina M. Van Itallie et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Deafness in occludin-deficient mice with dislocation of tricellulin and progressive apoptosis of the hair cells

(2014) S.-i. Kitajiri et al.   Biology Open

Localization of Angulin-1/LSR and Tricellulin at Tricellular Contacts of Brain and Retinal Endothelial Cells in vivo

(2013) Noriko Iwamoto et al.   CELL STRUCTURE AND FUNCTION

NMII Forms a Contractile Transcellular Sarcomeric Network to Regulate Apical Cell Junctions and Tissue Geometry

(2013) Seham Ebrahim et al.   CURRENT BIOLOGY

Septins Regulate the Contractility of the Actomyosin Ring to Enable Adherens Junction Remodeling during Cytokinesis of Epithelial Cells

(2013) Nabila Founounou et al.   DEVELOPMENTAL CELL

Adhesion Disengagement Uncouples Intrinsic and Extrinsic Forces to Drive Cytokinesis in Epithelial Tissues

(2013) Charlène Guillot et al.   DEVELOPMENTAL CELL

Interplay between the Dividing Cell and Its Neighbors Regulates Adherens Junction Formation during Cytokinesis in Epithelial Tissue

(2013) Sophie Herszterg et al.   DEVELOPMENTAL CELL

Tricellulin deficiency affects tight junction architecture and cochlear hair cells

(2013) Gowri Nayak et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell intercalation from top to bottom

(2013) Elise Walck-Shannon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanics of Epithelial Tissue Homeostasis and Morphogenesis

(2013) C. Guillot et al.   SCIENCE

Tricellulin expression in brain endothelial and neural cells

(2012) Cibelle Mariano et al.   CELL AND TISSUE RESEARCH

Shigella Targets Epithelial Tricellular Junctions and Uses a Noncanonical Clathrin-Dependent Endocytic Pathway to Spread Between Cells

(2012) Makoto Fukumatsu et al.   Cell Host & Microbe

Identification of the Cellular Receptor of Clostridium spiroforme Toxin

(2012) Panagiotis Papatheodorou et al.   INFECTION AND IMMUNITY

Analysis of the 'angulin' proteins LSR, ILDR1 and ILDR2 - tricellulin recruitment, epithelial barrier function and implication in deafness pathogenesis

(2012) T. Higashi et al.   JOURNAL OF CELL SCIENCE

In tight junctions, claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate claudin oligomerization

(2012) J. Cording et al.   JOURNAL OF CELL SCIENCE

A bigger picture: classical cadherins and the dynamic actin cytoskeleton

(2012) Aparna Ratheesh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bringing balance by force: live cell extrusion controls epithelial cell numbers

(2012) George T. Eisenhoffer et al.   TRENDS IN CELL BIOLOGY

Multi-Cellular Rosettes in the Mouse Visceral Endoderm Facilitate the Ordered Migration of Anterior Visceral Endoderm Cells

(2012) Georgios Trichas et al.   PLOS BIOLOGY

Loss-of-Function Mutations of ILDR1 Cause Autosomal-Recessive Hearing Impairment DFNB42

(2011) Guntram Borck et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Tight Junction Pore and Leak Pathways: A Dynamic Duo

(2011) Le Shen et al.   Annual Review of Physiology

A mechanism of mechanotransduction at the cell-cell interface

(2011) Shigenobu Yonemura   BIOESSAYS

Cadherin–actin interactions at adherens junctions

(2011) Shigenobu Yonemura   CURRENT OPINION IN CELL BIOLOGY

Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function

(2011) David R. Raleigh et al.   JOURNAL OF CELL BIOLOGY

LSR defines cell corners for tricellular tight junction formation in epithelial cells

(2011) S. Masuda et al.   JOURNAL OF CELL SCIENCE

The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled

(2011) Wangsun Choi et al.   MOLECULAR BIOLOGY OF THE CELL

A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension

(2011) Jessica K. Sawyer et al.   MOLECULAR BIOLOGY OF THE CELL

Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT)

(2011) P. Papatheodorou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Productive tension: force-sensing and homeostasis of cell–cell junctions

(2011) Guillermo A. Gomez et al.   TRENDS IN CELL BIOLOGY

Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner

(2010) Quint le Duc et al.   JOURNAL OF CELL BIOLOGY

Occludin is required for cytokine-induced regulation of tight junction barriers

(2010) C. M. Van Itallie et al.   JOURNAL OF CELL SCIENCE

c-Jun N-terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells

(2010) Takashi Kojima et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tight Junction–associated MARVEL Proteins MarvelD3, Tricellulin, and Occludin Have Distinct but Overlapping Functions

(2010) David R. Raleigh et al.   MOLECULAR BIOLOGY OF THE CELL

α-Catenin as a tension transducer that induces adherens junction development

(2010) Shigenobu Yonemura et al.   NATURE CELL BIOLOGY

Mechanical tugging force regulates the size of cell-cell junctions

(2010) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family

(2009) Emily Steed et al.   BMC CELL BIOLOGY

Myosin II Dynamics Are Regulated by Tension in Intercalating Cells

(2009) Rodrigo Fernandez-Gonzalez et al.   DEVELOPMENTAL CELL

Liver-Specific Loss of Lipolysis-Stimulated Lipoprotein Receptor Triggers Systemic Hyperlipidemia in Mice

(2009) P. Narvekar et al.   DIABETES

Involvement of the Interaction of Afadin with ZO-1 in the Formation of Tight Junctions in Madin-Darby Canine Kidney Cells

(2009) Takako Ooshio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers

(2009) Akiharu Kubo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tricellulin Forms a Barrier to Macromolecules in Tricellular Tight Junctions without Affecting Ion Permeability

(2009) Susanne M. Krug et al.   MOLECULAR BIOLOGY OF THE CELL

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

Transepithelial Projections from Basal Cells Are Luminal Sensors in Pseudostratified Epithelia

(2008) Winnie Wai Chi Shum et al.   CELL

The density of small tight junction pores varies among cell types and is increased by expression of claudin-2

(2008) C. M. Van Itallie et al.   JOURNAL OF CELL SCIENCE

Molecular Basis for Cation Selectivity in Claudin-2–based Paracellular Pores: Identification of an Electrostatic Interaction Site

(2008) Alan S.L. Yu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Loss of Occludin Affects Tricellular Localization of Tricellulin

(2008) Junichi Ikenouchi et al.   MOLECULAR BIOLOGY OF THE CELL

Nature and anisotropy of cortical forces orienting Drosophila tissue morphogenesis

(2008) Matteo Rauzi et al.   NATURE CELL BIOLOGY

Positional Cloning of “Lisch-like”, a Candidate Modifier of Susceptibility to Type 2 Diabetes in Mice

(2008) Marija Dokmanovic-Chouinard et al.   PLoS Genetics