Article
Multidisciplinary Sciences
Jue Zhang, Jackie Chang, Mirza Ahmar Beg, Wenxin Huang, Yiqiong Zhao, Wen Dai, Xiaopeng Wu, Weiguo Cui, Sneha S. Pillai, Hari Vishal Lakhani, Komal Sodhi, Joseph I. Shapiro, Daisy Sahoo, Ze Zheng, Roy L. Silverstein, Yiliang Chen
Summary: This study found that NKA alpha 1 plays a role in suppressing LPS-induced pro-inflammatory signaling through the inhibition of Lyn.
Review
Endocrinology & Metabolism
Ben F. Brian, Tanya S. Freedman
Summary: Effective regulation of immune-cell activation is crucial to minimize tissue damage caused by unrestrained inflammation and immune response. Lyn kinase plays a critical role in regulating immunoreceptor signaling, and defects in Lyn signaling can lead to autoimmune disease.
Article
Cell Biology
Yuanyuan Zhao, Hefen Sun, Xuan Li, Qiqi Liu, Yang Liu, Yifeng Hou, Wei Jin
Summary: This study identified DGKZ as a potential prometastatic gene in breast cancer. It was found that high expression of DGKZ was correlated with tumor progression and poor prognosis. Mechanistic studies showed that DGKZ might regulate cell metastasis by promoting epithelial-mesenchymal transition via the TGF-β signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
John Abousawan, Laura A. Orofiamma, Gregory D. Fairn, Costin N. Antonescu
Summary: The epidermal growth factor receptor (EGFR) controls many cellular functions by undergoing dimerization, phosphorylation, and activation of signals including the PI3K-Akt pathway upon ligand binding. The role of flotillin nanodomains in EGFR signaling remains unclear, as some studies suggest their involvement while others show limited effect. This study reveals that HER2 expression alters EGFR signaling duration and requires flotillin-1 and c-Src for Akt activation and cell proliferation.
JOURNAL OF CELL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Zilei Chen, Pedro Carpio Malia, Riko Hatakeyama, Raffaele Nicastro, Zehan Hu, Marie-Pierre Peli-Gulli, Jieqiong Gao, Taki Nishimura, Elja Eskes, Christopher J. Stefan, Joris Winderickx, Jorn Dengjel, Claudio De Virgilio, Christian Ungermann
Summary: The study reveals a regulatory feedback loop between TORC1 and the Fab1 complex that controls signaling at endolysosomes.
Article
Biochemistry & Molecular Biology
Erik Wahlen, Frida Olsson, Doroteya Raykova, Ola Soderberg, Johan Heldin, Johan Lennartsson
Summary: This study investigates the internalization process of EGFR and PDGFR-β using immunofluorescent microscopy. The results show that these two receptors utilize separate internalization routes, but merge in a common endosomal compartment after 45 minutes of stimulation. The association between EGFR and caveolin-1 is stronger compared to PDGFR-β, and disruption of lipid rafts affects the signaling of EGFR and PDGFR-β differently.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Hong -Yin Wang, Sze Ham Chan, Simli Dey, Ivan Castello-Serrano, Michael K. Rosen, Jonathon A. Ditlev, Kandice R. Levental, Ilya Levental
Summary: During T cell activation, LAT forms condensates with Grb2 and Sos1, inducing lipid domains and stabilizing raft-like membrane domains. The coupling of lipid and protein assembly is functionally important, as uncoupling them abrogates T cell activation.
Article
Hematology
Roger Belizaire, Sebastian H. J. Koochaki, Namrata D. Udeshi, Alexis Vedder, Lei Sun, Tanya Svinkina, Christina Hartigan, Marie McConkey, Veronica Kovalcik, Amanuel Bizuayehu, Caroline Stanclift, Monica Schenone, Steven A. Carr, Eric Padron, Benjamin L. Ebert
Summary: Mutations in CBL affect cellular signaling, leading to aberrant activation of the CBL-PI3K/AKT pathway and promoting cell proliferation. Activation of LYN and its interaction with mutated CBL are key drivers in this process. Inhibiting LYN can reduce CBL phosphorylation and decrease the activity of the PI3K/AKT signaling pathway.
Article
Oncology
Beiyuan Hu, Tiantian Zou, Wei Qin, Xiaotian Shen, Yinghan Su, Jianhua Li, Yang Chen, Ze Zhang, Haoting Sun, Yan Zheng, Chao-Qun Wang, Zhengxin Wang, Tian-En Li, Shun Wang, Le Zhu, Xufeng Wang, Yan Fu, Xudong Ren, Qiongzhu Dong, Lun-Xiu Qin
Summary: Lenvatinib, a first-line treatment for hepatocellular carcinoma (HCC), has limited clinical benefits. This study reveals that HCC cells develop resistance to Lenvatinib by activating the EGFR-STAT3-ABCB1 pathway. Combined treatment with erlotinib, an EGFR inhibitor, may overcome acquired resistance and improve the clinical benefit of Lenvatinib.
Article
Multidisciplinary Sciences
Nirmalya Bag, Alice Wagenknecht-Wiesner, Allan Lee, Sophia M. Shi, David A. Holowka, Barbara A. Baird
Summary: This study evaluated the relative contributions and functional importance of different types of interactions leading to suprathreshold phosphorylation of Ag-crosslinked IgE-FceRI in live rat basophilic leukemia mast cells. The results establish a synergy of lipid-based, protein-based, and steric interactions underlying functional TM signaling in mast cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Erik Wahlen, Frida Olsson, Ola Soderberg, Johan Lennartsson, Johan Heldin
Summary: Lipid rafts play a crucial role in connecting cell surface receptors to intracellular signaling pathways. This study investigates the involvement of lipid rafts in receptor tyrosine kinase signaling through the analysis of PDGFR-beta signaling in different cell lines depleted of cholesterol. The results suggest that cell type-specific wiring of signaling pathways can lead to differential sensitivity to cholesterol depletion.
CELLULAR SIGNALLING
(2022)
Article
Cell Biology
Xiaolian Li, Mingkun Xu, Jiaojiao Shen, Yuqin Li, Shaoping Lin, Min Zhu, Qiongni Pang, Xiujuan Tan, Jing Tang
Summary: Sorafenib is a drug used for anti-tumor treatment. It has been found to inhibit inflammatory reactions and reduce the expression of inflammatory factors possibly by inhibiting the phosphorylation of specific enzymes.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Jose Carlos Bozelli, Jenny Yune, Daisuke Takahashi, Fumio Sakane, Richard M. Epand
Summary: The physical properties of membranes determine the substrate acyl chain specificity of human DGK alpha, affecting its enzymatic activity and ability to differentiate between DAG molecular species. Changes in membrane morphology, particularly the presence of physically curved membrane structures, impact the specificity of DGK alpha for certain DAG pools, adding a layer of regulation to the interconversion between DAG and PA. This suggests a fine-tuned signaling system dependent on the levels and molecular species of DAG and PA regulated by the interplay between membrane physical and chemical properties.
Review
Biochemistry & Molecular Biology
Anna Ciesielska, Marta Matyjek, Katarzyna Kwiatkowska
Summary: This article discusses the role of TLR4 in promoting inflammatory responses, including internalization and intracellular trafficking of exogenous endotoxin and bacteria. The authors emphasize the significant impact of internalization rate and endo-lysosomal compartment transport rate on inflammatory responses.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Chemistry, Medicinal
Rui Liu, Yonghui Zhang, Yuejin Wang, Yihan Huang, Jiapan Gao, Xi Tian, Tianyou Ma, Tao Zhang
Summary: Herb-derived dictamnine has pharmacological effects on IgE-induced MC activation and OVA-induced murine AR model, reducing local allergic reactions and systemic anaphylaxis. Dictamnine inhibits MC activation via the LYN kinase-mediated molecular signaling pathway, making it a promising treatment for AR.
PHYTOTHERAPY RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Anna Ciesielska, Marta Matyjek, Katarzyna Kwiatkowska
Summary: This article discusses the role of TLR4 in promoting inflammatory responses, including internalization and intracellular trafficking of exogenous endotoxin and bacteria. The authors emphasize the significant impact of internalization rate and endo-lysosomal compartment transport rate on inflammatory responses.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ewelina Ziemlinska, Justyna Sobocinska, Anna Swiatkowska, Aneta Hromada-Judycka, Gabriela Traczyk, Agata Malinowska, Bianka Swiderska, Anna Mietelska-Porowska, Anna Ciesielska, Katarzyna Kwiatkowska
Summary: The research suggests that a diet rich in palm oil may affect protein S-palmitoylation in the liver and contribute to issues like obesity, hypercholesterolemia, and hyperglycemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Anna Ciesielska, Marta Krawczyk, Hanna Sas-Nowosielska, Aneta Hromada-Judycka, Katarzyna Kwiatkowska
Summary: TLR4 is activated by LPS and CD14 plays a crucial role in its signaling by controlling its endocytosis. This study demonstrates that CD14 can recycle back to the plasma membrane after endocytosis, a process regulated by SNXs. Silencing of these SNXs attenuates CD14-dependent endosomal signaling of TLR4.
Article
Immunology
Tomasz Jedrzejewski, Justyna Sobocinska, Malgorzata Pawlikowska, Artur Dzialuk, Sylwia Wrotek
Summary: This study investigated the effects of extract from Coriolus versicolor on the production of pro-inflammatory cytokines in macrophages. The results showed that the extract can stimulate the secretion of IL-6 and TNF-α, and alter the expression of related signaling pathway components. The effects of the extract on cytokine production can be antagonistic or additive depending on the concentration of LPS.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Traczyk, Anna Swiatkowska, Aneta Hromada-Judycka, Justyna Janikiewicz, Katarzyna Kwiatkowska
Summary: This study analyzed the role of the zinc finger motif in the C1B domain of DGKe. A novel fluorescent assay was introduced to determine DGKe activity, and it was found that four amino acids in the C1B domain are crucial for the activity and stability of DGKe-Myc.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tomasz Jedrzejewski, Malgorzata Pawlikowska, Justyna Sobocinska, Sylwia Wrotek
Summary: This paper analyzes the research advances in the anti-cancer and anti-viral effects of Coriolus versicolor (CV), a common species used in traditional Chinese herbal medicine. The direct effects of CV on cancer cells and angiogenesis are discussed based on in vitro and in vivo studies, as well as clinical research trials. The potential use of CV compounds in anti-viral treatment, including COVID-19 therapy, is also analyzed. Additionally, the significance of fever in viral infection and cancer is debated, with evidence suggesting that CV affects this phenomenon.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Konkonika Roy, Henryk Mikolaj Kozlowski, Tomasz Jedrzejewski, Justyna Sobocinska, Bartosz Maciejewski, Artur Dzialuk, Sylwia Wrotek
Summary: Our study reveals that under endotoxin tolerance (ET) conditions, macrophages undergo reprogramming and release factors that promote a cancer-favourable environment. This research uncovers the potential role of ET as a mechanism in cancer progression, offering novel avenues for cancer prevention and treatment by targeting ET.