CD47 receptor as a primary target for cancer therapy

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

Molecular Pathways: Activating T Cells after Cancer Cell Phagocytosis from Blockade of CD47 "Don't Eat Me" Signals

(2015) M. N. McCracken et al.   CLINICAL CANCER RESEARCH

CD47 blockade triggers T cell–mediated destruction of immunogenic tumors

(2015) Xiaojuan Liu et al.   NATURE MEDICINE

The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target

(2013) A. Neil Barclay et al.   Annual Review of Immunology

Intravenous Delivery of siRNA Targeting CD47 Effectively Inhibits Melanoma Tumor Growth and Lung Metastasis

(2013) Yuhua Wang et al.   MOLECULAR THERAPY

Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response

(2013) D. Tseng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered SIRP  Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies

(2013) K. Weiskopf et al.   SCIENCE

CD47 functions as a molecular switch for erythrocyte phagocytosis

(2012) P. Burger et al.   BLOOD

CD47 update: a multifaceted actor in the tumour microenvironment of potential therapeutic interest

(2012) E Sick et al.   BRITISH JOURNAL OF PHARMACOLOGY

The CD47–SIRPα pathway in cancer immune evasion and potential therapeutic implications

(2012) Mark P Chao et al.   CURRENT OPINION IN IMMUNOLOGY

Cancer stem cells

(2012) Zuoren Yu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement

(2012) Francis J. Alenghat et al.   JOURNAL OF CELL SCIENCE

Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts

(2012) Alexandre P.A. Theocharides et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells

(2012) D Kim et al.   LEUKEMIA

Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma

(2012) B. Edris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

(2012) S. B. Willingham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRPα Controls the Activity of the Phagocyte NADPH Oxidase by Restricting the Expression of gp91phox

(2012) Ellen M. van Beek et al.   Cell Reports

Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy

(2011) M. P. Chao et al.   BLOOD

Heparan Sulfate Modification of the Transmembrane Receptor CD47 Is Necessary for Inhibition of T Cell Receptor Signaling by Thrombospondin-1

(2011) Sukhbir Kaur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An essential role for the association of CD47 to SHPS-1 in skeletal remodeling

(2011) Laura A Maile et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Signal Regulatory Protein   Regulates the Homeostasis of T Lymphocytes in the Spleen

(2011) M. Sato-Hashimoto et al.   JOURNAL OF IMMUNOLOGY

Functional CD47/signal regulatory protein alpha (SIRPα) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo

(2011) Nicolas Legrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation by SIRP  of dendritic cell homeostasis in lymphoid tissues

(2010) Y. Saito et al.   BLOOD

Therapeutic Antibody Targeting of CD47 Eliminates Human Acute Lymphoblastic Leukemia

(2010) Mark P. Chao et al.   CANCER RESEARCH

Nanoparticles Modified With Tumor-targeting scFv Deliver siRNA and miRNA for Cancer Therapy

(2010) Yunching Chen et al.   MOLECULAR THERAPY

Dominant role of CD47-thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease

(2009) A. Kukreja et al.   BLOOD

MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47

(2009) Andreas Junker et al.   BRAIN

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

(2009) Ravindra Majeti et al.   CELL

Signal regulatory protein alpha (SIRPα)/CD47 interaction and function

(2009) A Neil Barclay   CURRENT OPINION IN IMMUNOLOGY

SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels

(2009) Ulrike Lorenz   IMMUNOLOGICAL REVIEWS

Functions and molecular mechanisms of the CD47–SIRPα signalling pathway

(2009) Takashi Matozaki et al.   TRENDS IN CELL BIOLOGY

Inhibition of “self” engulfment through deactivation of myosin-II at the phagocytic synapse between human cells

(2008) Richard K. Tsai et al.   JOURNAL OF CELL BIOLOGY

Paired Receptor Specificity Explained by Structures of Signal Regulatory Proteins Alone and Complexed with CD47

(2008) Deborah Hatherley et al.   MOLECULAR CELL

CD47 associates with alpha 5 integrin and regulates responses of human articular chondrocytes to mechanical stimulation in an in vitro model

(2008) Mahmoud Orazizadeh et al.   ARTHRITIS RESEARCH & THERAPY