Disruption of SIRPα signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts

Is targeting of CD47-SIRP  enough for treating hematopoietic malignancy?

(2012) X. W. Zhao et al.   BLOOD

Bone marrow CD169+macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

(2011) Andrew Chow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells

(2011) Faiyaz Notta et al.   NATURE

Stem cell gene expression programs influence clinical outcome in human leukemia

(2011) Kolja Eppert et al.   NATURE MEDICINE

CD47-signal regulatory protein-  (SIRP ) interactions form a barrier for antibody-mediated tumor cell destruction

(2011) X. W. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

(2011) G. L. Beatty et al.   SCIENCE

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

(2011) David G. DeNardo et al.   Cancer Discovery

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

(2010) I. G. Winkler et al.   BLOOD

Self inhibition of phagocytosis: The affinity of ‘marker of self’ CD47 for SIRPα dictates potency of inhibition but only at low expression levels

(2010) Richard K. Tsai et al.   BLOOD CELLS MOLECULES AND DISEASES

β-Catenin Mediates the Establishment and Drug Resistance of MLL Leukemic Stem Cells

(2010) Jenny Yeung et al.   CANCER CELL

Therapeutic Antibody Targeting of CD47 Eliminates Human Acute Lymphoblastic Leukemia

(2010) Mark P. Chao et al.   CANCER RESEARCH

Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma

(2010) Mark P. Chao et al.   CELL

Genetic variegation of clonal architecture and propagating cells in leukaemia

(2010) Kristina Anderson et al.   NATURE

A double agent in cancer: Deciphering macrophage roles in human tumors

(2010) Christiana Ruhrberg et al.   NATURE MEDICINE

Tumor-Associated Macrophages and Survival in Classic Hodgkin's Lymphoma

(2010) Christian Steidl et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

(2009) Siddhartha Jaiswal et al.   CELL

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

(2009) Ravindra Majeti et al.   CELL

Monoclonal Antibody-Mediated Targeting of CD123, IL-3 Receptor α Chain, Eliminates Human Acute Myeloid Leukemic Stem Cells

(2009) Liqing Jin et al.   Cell Stem Cell

M2 Macrophages Phagocytose Rituximab-Opsonized Leukemic Targets More Efficiently than M1 Cells In Vitro

(2009) M. Leidi et al.   JOURNAL OF IMMUNOLOGY

Endothelial CD47 interaction with SIRP  is required for human T-cell transendothelial migration under shear flow conditions in vitro

(2008) M. Stefanidakis et al.   BLOOD

CD47 in the Immune Response: Role of Thrombospondin and SIRP-α Reverse Signaling

(2008) Marika Sarfati et al.   CURRENT DRUG TARGETS