Role of exchange protein directly activated by cAMP (EPAC1) in breast cancer cell migration and apoptosis

Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1

(2016) Pooja Singhmar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G protein-coupled receptor GPR160 is associated with apoptosis and cell cycle arrest of prostate cancer cells

(2016) Caihong Zhou et al.   Oncotarget

Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression

(2015) Muayad Almahariq et al.   BIOCHEMICAL JOURNAL

Cancer metastases: challenges and opportunities

(2015) Xiangming Guan   Acta Pharmaceutica Sinica B

Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window”

(2015) Yingmin Zhu et al.   Scientific Reports

Protein Kinase C Activation Stimulates Mesenchymal Stem Cell Adhesion through Activation of Focal Adhesion Kinase

(2013) Byeong-Wook Song et al.   CELL TRANSPLANTATION

Compartmentalization of Distinct cAMP Signaling Pathways in Mammalian Sperm

(2013) Eva Wertheimer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways

(2013) Yasuhito Onodera et al.   JOURNAL OF CLINICAL INVESTIGATION

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Isoform-specific antagonists of exchange proteins directly activated by cAMP

(2012) T. Tsalkova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

7q21-rs6964587 and breast cancer risk: an extended case-control study by the Breast Cancer Association Consortium

(2011) R. L. Milne et al.   JOURNAL OF MEDICAL GENETICS

Epac: Defining a New Mechanism for cAMP Action

(2010) Martijn Gloerich et al.   Annual Review of Pharmacology and Toxicology

AKAP9 regulation of microtubule dynamics promotes Epac1-induced endothelial barrier properties

(2010) S. Sehrawat et al.   BLOOD

The Interaction of Epac1 and Ran Promotes Rap1 Activation at the Nuclear Envelope

(2010) C. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Spatial Regulation of Cyclic AMP-Epac1 Signaling in Cell Adhesion by ERM Proteins

(2010) M. Gloerich et al.   MOLECULAR AND CELLULAR BIOLOGY

Epac inhibits migration and proliferation of human prostate carcinoma cells

(2009) M Grandoch et al.   BRITISH JOURNAL OF CANCER

The cAMP/Epac1/Rap1 Pathway in Pancreatic Carcinoma

(2009) Richard Lorenz et al.   PANCREAS

Epac and PKA: a tale of two intracellular cAMP receptors

(2008) Xiaodong Cheng et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Microtubules: A dynamic target in cancer therapy

(2008) Eddy Pasquier et al.   IUBMB LIFE

Ras Is Required for the Cyclic AMP-Dependent Activation of Rap1 via Epac2

(2008) C. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of Epac1, an Exchange Factor for Rap GTPases, in Endothelial Microtubule Dynamics and Barrier Function

(2008) Seema Sehrawat et al.   MOLECULAR BIOLOGY OF THE CELL