期刊
MOLECULAR & CELLULAR PROTEOMICS
卷 16, 期 12, 页码 2079-2097出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/mcp.M117.067116
关键词
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资金
- National Institutes of Health [NS082240, CA097093, AI115104, AI118891, GM110174]
- Institute for Immunology of the University of Pennsylvania
- Children's Hospital of Philadelphia
- Office of the Vice Provost for Research at the University of Pennsylvania
- NIH Research Supplement to Support Diversity [NS082240]
- [T32 NS007180]
- [T32 CA115299]
- [F32 GM112414]
Viral DNA genomes replicating in cells encounter a myriad of host factors that facilitate or hinder viral replication. Viral proteins expressed early during infection modulate host factors interacting with viral genomes, recruiting proteins to promote viral replication, and limiting access to antiviral repressors. Although some host factors manipulated by viruses have been identified, we have limited knowledge of pathways exploited during infection and how these differ between viruses. To identify cellular processes manipulated during viral replication, we defined proteomes associated with viral genomes during infection with adenovirus, herpes simplex virus and vaccinia virus. We compared enrichment of host factors between virus proteomes and confirmed association with viral genomes and replication compartments. Using adenovirus as an illustrative example, we uncovered host factors deactivated by early viral proteins, and identified a subgroup of nucleolar proteins that aid virus replication. Our data sets provide valuable resources of virus-host interactions that affect proteins on viral genomes.
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