Evidence for widespread, severe brain copper deficiency in Alzheimer's dementia

Effect of Cerebral Amyloid Angiopathy on Brain Iron, Copper, and Zinc in Alzheimer's Disease

(2018) Matthew Schrag et al.   JOURNAL OF ALZHEIMERS DISEASE

Association of Selenoprotein P with Alzheimer's Pathology in Human Cortex

(2017) Frederick P. Bellinger et al.   JOURNAL OF ALZHEIMERS DISEASE

Graded perturbations of metabolism in multiple regions of human brain in Alzheimer's disease: Snapshot of a pervasive metabolic disorder

(2016) Jingshu Xu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer's disease frontal cortex

(2016) Dominic J. Hare et al.   NEUROIMAGE

Rubidium and potassium levels are altered in Alzheimer’s disease brain and blood but not in cerebrospinal fluid

(2016) Blaine R. Roberts et al.   Acta Neuropathologica Communications

Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer’s disease: metabolic basis for dementia

(2016) Jingshu Xu et al.   Scientific Reports

Manganese ions induce H2O2 generation at the ubiquinone binding site of mitochondrial complex II

(2015) Erik Bonke et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease

(2015) Stephanie J. Church et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Physicochemical studies on the copper(ii) binding by glycated collagen telopeptides

(2015) Meder Kamalov et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Brain-Specific Superoxide Dismutase 2 Deficiency Causes Perinatal Death with Spongiform Encephalopathy in Mice

(2015) Naotaka Izuo et al.   Oxidative Medicine and Cellular Longevity

Anatomical Region Differences and Age-Related Changes in Copper, Zinc, and Manganese Levels in the Human Brain

(2014) Patrícia Ramos et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Homeostasis of metals in the progression of Alzheimer’s disease

(2014) Raúl González-Domínguez et al.   BIOMETALS

Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation

(2014) Shaoping Zhang et al.   Cardiovascular Diabetology

Metabolism and functions of copper in brain

(2014) Ivo F. Scheiber et al.   PROGRESS IN NEUROBIOLOGY

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

Complex II of the Mitochondrial Respiratory Chain Is the Key Mediator of Divalent Manganese-Induced Hydrogen Peroxide Production in Microglia

(2013) Yue Liu et al.   TOXICOLOGICAL SCIENCES

Na+ and K+ ion imbalances in Alzheimer's disease

(2012) Victor M. Vitvitsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Selenium level and depressive symptoms in a rural elderly Chinese cohort

(2012) Sujuan Gao et al.   BMC Psychiatry

Selective Divalent Copper Chelation for the Treatment of Diabetes Mellitus

(2012) G. J.S. Cooper   CURRENT MEDICINAL CHEMISTRY

Metal-associated amyloid-β species in Alzheimer's disease

(2012) Amit S Pithadia et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Metallostasis in Alzheimer's disease

(2012) Scott Ayton et al.   FREE RADICAL BIOLOGY AND MEDICINE

Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders

(2012) Peter K. Stys et al.   JOURNAL OF PHYSIOLOGY-LONDON

Localization of copper and copper transporters in the human brain

(2012) Katherine M. Davies et al.   Metallomics

The Zinc Dyshomeostasis Hypothesis of Alzheimer's Disease

(2012) Travis J. A. Craddock et al.   PLoS One

Transition metal abnormalities in progressive dementias

(2011) Hiroyasu Akatsu et al.   BIOMETALS

Therapeutic Potential of Copper Chelation with Triethylenetetramine in Managing Diabetes Mellitus and Alzheimerʼs Disease

(2011) Garth J.S. Cooper   DRUGS

Metals in alzheimer's disease: a systemic perspective

(2011) Rosanna Squitti   Frontiers in Bioscience-Landmark

The role of metallobiology and amyloid-β peptides in Alzheimer’s disease

(2011) Blaine R. Roberts et al.   JOURNAL OF NEUROCHEMISTRY

Iron, zinc and copper in the Alzheimer's disease brain: A quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion

(2011) Matthew Schrag et al.   PROGRESS IN NEUROBIOLOGY

Mechanisms of Manganese-Induced Neurotoxicity in Primary Neuronal Cultures: The Role of Manganese Speciation and Cell Type

(2011) R. B. Hernández et al.   TOXICOLOGICAL SCIENCES

Alterations of plasma magnesium, copper, zinc, iron and selenium concentrations and some related erythrocyte antioxidant enzyme activities in patients with Alzheimer’s disease

(2010) Huseyin Vural et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

Magnesium induces neuronal apoptosis by suppressing excitability

(2010) W H Dribben et al.   Cell Death & Disease

Sodium MR Imaging Detection of Mild Alzheimer Disease: Preliminary Study

(2009) E.A. Mellon et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Nutritional status of selenium in Alzheimer's disease patients

(2009) Bárbara Rita Cardoso et al.   BRITISH JOURNAL OF NUTRITION

Agents Complexing Copper as a Therapeutic Strategy for the Treatment of Alzheimers Disease

(2009) Rosanna Squitti et al.   Current Alzheimer Research

A copper(II)-selective chelator ameliorates left-ventricular hypertrophy in type 2 diabetic patients: a randomised placebo-controlled study

(2009) G. J. S. Cooper et al.   DIABETOLOGIA

Acquired Copper Deficiency: A Potentially Serious and Preventable Complication Following Gastric Bypass Surgery

(2009) Daniel P. Griffith et al.   Obesity

The collection and processing of human brain tissue for research

(2008) H. J. Waldvogel et al.   CELL AND TISSUE BANKING

Manganese Neurotoxicity: Lessons Learned from Longitudinal Studies in Nonhuman Primates

(2008) Neal C. Burton et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Intake of copper has no effect on cognition in patients with mild Alzheimer’s disease: a pilot phase 2 clinical trial

(2008) Holger Kessler et al.   JOURNAL OF NEURAL TRANSMISSION

Neonatal Diagnosis and Treatment of Menkes Disease

(2008) Stephen G. Kaler et al.   NEW ENGLAND JOURNAL OF MEDICINE