期刊
MEDICINAL RESEARCH REVIEWS
卷 38, 期 1, 页码 101-146出版社
WILEY
DOI: 10.1002/med.21435
关键词
human antimicrobial peptides; antibacterial; antifungal; antiviral; human biological fluids; peptidomics
资金
- FCT (Fundacao para a Ciencia e a Tecnologia) [UID/BIM/04501/2013, UID/IC/00051/2013]
- Fundação para a Ciência e a Tecnologia [UID/IC/00051/2013] Funding Source: FCT
Antimicrobial peptides (AMPs) are an integral part of the innate immune defense mechanism of many organisms. Due to the alarming increase of resistance to antimicrobial therapeutics, a growing interest in alternative antimicrobial agents has led to the exploitation of AMPs, both synthetic and isolated from natural sources. Thus, many peptide-based drugs have been the focus of increasing attention by many researchers not only in identifying novel AMPs, but in defining mechanisms of antimicrobial peptide activity as well. Herein, we review the available strategies for the identification of AMPs in human body fluids and their mechanism(s) of action. In addition, an overview of the distribution of AMPs across different human body fluids is provided, as well as its relation with microorganisms and infectious conditions.
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