Article
Polymer Science
Yifei Guo, Yiping Shen, Bo Yu, Lijuan Ding, Zheng Meng, Xiaotong Wang, Meihua Han, Zhengqi Dong, Xiangtao Wang
Summary: Poly(amino acids) with unique characteristics are suitable as drug delivery nanocarriers for tumor therapy. In this study, two kinds of pH-sensitive isoforms were used to prepare a nanodrug delivery system, which showed sustained drug release and enhanced antitumor efficacy both in vitro and in vivo.
Article
Instruments & Instrumentation
Zhuang Hu, Gongshu Wang, Rui Zhang, Yingyu Yang, Jiwei Wang, Jianshe Hu, Aikebaier Reheman
Summary: By constructing a drug-loaded triblock copolymer nano-delivery system, targeted drug aggregation can be achieved in the tumor microenvironment, thereby improving the efficacy of tumor therapy.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Polymer Science
Ya-Bin Meng, Jun Wu
Summary: This study synthesized and optimized a polypeptide with good biodegradability and biocompatibility using a one-step and direct synthesis strategy. The polypeptide was used to prepare drug-loaded nanoparticles, which exhibited high drug-loading capacity and strong cytotoxicity against cancer cells. The drug release was accelerated in the acidic environment inside cells, leading to enhanced anticancer effects. In vivo experiments demonstrated that the nanoparticles had long blood circulation time, high tumor accumulation and penetration, and good therapeutic performance without causing obvious adverse effects on major organs. These findings suggest that the polypeptide-based nanoplatform can serve as an effective drug delivery tool for clinical breast cancer therapy.
CHINESE JOURNAL OF POLYMER SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Matthias Rohmer, Jan Freudenberg, Wolfgang Hubertus Binder
Summary: The secondary structure of poly(amino acids) is a useful tool for studying proteins. This article discusses the secondary structures of homopolymers made from glutamic acid, aspartic acid, and alpha-aminoisobutyric acid, and reviews factors such as side groups, solvent interactions, and chain interactions. The folding of hybrid-polymers, which consist of both oligo(amino acids) and synthetic polymers, is also explored. This overview is part of a larger study on protein fibrillation and supramolecular polymers, and provides insights into amyloid fibrillation, which is crucial for the design of biomolecules.
MACROMOLECULAR BIOSCIENCE
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Xiujuan Qian, Min Jiang, Weiliang Dong
Summary: Upcycling processes using tandem chemical deconstruction and bio-logical transformation show promise in managing poly(ethylene tere-phthalate) (PET) waste. This framework utilizes postconsumer PET as a low-cost and abundant starting material for the synthesis of high-value chemicals.
TRENDS IN BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Morvarid Borhaninia, Mahsa Zahiri, Khalil Abnous, Seyed Mohammad Taghdisi, Mohammad Ramezani, Mona Alibolandi
Summary: In this study, a pH-sensitive polymersome incorporating doxorubicin (DOX) was prepared using a hyaluronic acid-beta-poly (beta-amino ester) (HA-PBAE) diblock copolymer. The DOX was loaded into the aqueous compartment of the HA-PBAE polymersome with high entrapment efficiency and loading content. The DOX-HA-PBAE platform showed accelerated drug release under acidic conditions and exhibited higher cytotoxicity and cellular internalization compared to free DOX in CD44 positive cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Sun Woo Jin, Gi Ho Lee, Ji Yeon Kim, Chae Yeon Kim, Young Moo Choo, Whajung Cho, Jae Ho Choi, Eun Hee Han, Yong Pil Hwang, Hye Gwang Jeong
Summary: This study demonstrates the potential of porcine whole-blood protein hydrolysate (PWBPH) in enhancing exercise endurance and promoting muscle differentiation. PWBPH can be utilized as an effective resource to improve exercise function and muscle development.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Meifang Wang, Jing Lin, Jiawei Gong, Mingchen Ma, Hongliang Tang, Jiyang Liu, Fei Yan
Summary: The study demonstrates the rapid and sensitive electrochemical detection of doxorubicin using electrochemically pretreated glassy carbon electrodes modified with vertically-ordered mesoporous silica films. The sensor showed ultra-high sensitivity, low limit of detection, wide linear range, and the ability for direct and reliable detection of doxorubicin in human whole blood without complex sample pretreatments, thanks to the excellent anti-fouling and anti-interference properties of the VMSF.
Article
Biochemistry & Molecular Biology
Olga Michalak, Marcin Cybulski, Wojciech Szymanowski, Agnieszka Gornowicz, Marek Kubiszewski, Kinga Ostrowska, Piotr Krzeczynski, Krzysztof Bielawski, Bartosz Trzaskowski, Anna Bielawska
Summary: A series of new derivatives of ursolic acid (UA) were designed and synthesized by substituting various amino acids (AAs) or dipeptides (DP) at the C-3 position of the steroid skeleton. These conjugates exhibited cytotoxic activity against hormone-dependent and triple-negative breast cancer cells. Mechanistic studies revealed the activation of apoptotic pathways for some compounds and the induction of autophagy for others. Additionally, the synthesized compounds showed potential as anticancer agents based on their ADME properties and molecular docking to the estrogen receptor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Zhuang Hu, Jiwei Wang, Siyu Han, Shizhi Jiang, Jianshe Hu, Aikebaier Reheman
Summary: A series of amphiphilic poly(amino acid)s materials were synthesized by ring-opening polymerization, and drug-loaded nanoparticles were prepared by self-assembly. The nanoparticles showed different shapes such as cube/spherical/spindle in different pH environments, and their size was less than 200 nm. Cholesterol was grafted to the side chain, enabling the nanomicelles to effectively enter cancer cells through endocytosis. The nanomicelles exhibited dual temperature and pH responsiveness, and CCK-8 experiment confirmed their non-toxicity, laying the foundation for their use as new carriers in sustained drug release.
POLYMER-PLASTICS TECHNOLOGY AND MATERIALS
(2023)
Article
Cell Biology
Andrea Bianchetti, Clizia Chinello, Michele Guindani, Simona Braga, Arabella Neva, Rosanna Verardi, Giovanna Piovani, Lisa Pagani, Gina Lisignoli, Fulvio Magni, Domenico Russo, Camillo Almici
Summary: Human platelet lysate (hPL) is considered a valid substitute for fetal bovine serum in the expansion of mesenchymal stromal cells, and efforts to optimize and standardize its production process have led to improved growth factor content and reduced batch-to-batch variability. Increasing the number of freeze/thaw cycles from one to four has shown favorable effects on growth factor release and led to faster MSC expansion. The strict application of blood bank standards has resulted in a standardized, reproducible, safe, inexpensive, and ready-to-use product with reduced variability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Fang Wang, Xiaoyong Yue, Qi Ding, Hengwei Lin, Chuanlai Xu, Si Li
Summary: Chiral nanomaterials in biology are vital for maintaining various physiological processes and have potential applications in biosensing, drug delivery, early diagnosis, bio-imaging, and disease therapy. Chiral inorganic nanomaterials, with their unique properties, can be constructed similarly to natural chiral nanomaterials. This review summarizes the research on the bio-functions and bio-applications of chiral inorganic nanomaterials, including their construction methods, classification and properties, and highlights their potential in solving problems in living systems.
Article
Pharmacology & Pharmacy
Bo Yu, Yiping Shen, Xuejie Zhang, Lijuan Ding, Zheng Meng, Xiaotong Wang, Meihua Han, Yifei Guo, Xiangtao Wang
Summary: Poly(methacrylate citric acid) (PCA) can be used as a dual functional nanocarrier to construct a nanodelivery system due to its pH-sensitive property and chelating Cu2+ effect. PCA/DOX NPs show good stability, sustained release profile, and effective inhibition of tumor growth.
Article
Pharmacology & Pharmacy
Yamini Bobde, Milan Paul, Tarun Patel, Swati Biswas, Balaram Ghosh
Summary: Delivery of combination chemotherapeutic agents to tumors using nanovesicles shows promise for enhanced tumor suppression and reduced toxicity. These novel micelles exhibit improved anti-tumor efficacy and cytotoxicity, with higher induction of apoptosis and cellular arrest in G2 and S phase compared to traditional drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Polymer Science
Simona Campora, Reham Mohsen, Daniel Passaro, Howida Samir, Hesham Ashraf, Saif El-Din Al-Mofty, Ayman A. Diab, Ibrahim M. El-Sherbiny, Martin J. Snowden, Giulio Ghersi
Summary: The study successfully utilized a novel design of p(NIPAM) microgels to specifically target cancer cells while avoiding healthy cells, leading to successful drug release. Through a series of experiments and analyses, the feasibility and effectiveness of this approach were confirmed.
Article
Chemistry, Physical
Mohammad Barzegar-Jalali, Parisa Jafari, Salar Hemmati, Abolghasem Jouyban
Summary: This study investigated the solubilization power of PEGDME 250 for three poorly water-soluble drugs in water medium. The solubility of the drugs in PEGDME 250 + water solutions was found to increase with temperature and PEGDME 250 mass fraction. Various mathematical models were used to fit the obtained data and assess their accuracy. The thermodynamic properties of dissolution and mixing of the drugs in PEGDME 250 + water mixtures were determined and observed to vary depending on the specific drug.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Kambiz Ghaseminasab, Nastaran Aletaha, Mohammad Hasanzadeh
Summary: This study aims to develop a portable tool for the colorimetric and spectrophotometric detection of Hyd using silver nanoparticles. The method shows both qualitative and quantitative measurement of Hyd with high sensitivity, low cost, and fast analysis time, and can potentially be industrialized for quick detection of Hyd in aquatic real samples.
Article
Thermodynamics
Bizhan Honarvar, Seyed Ali Sajadian, Adrian Rojas, Maria Jose Galotto, Abolghasem Jouyban
Summary: The solubility of sildenafil citrate (SLC) in supercritical carbon dioxide (SC-CO2) was measured and modeled for the first time in this study. Experiments were conducted at different temperature and pressure values, and the solubility of SLC in SC-CO2 was quantified. Various models were used to correlate the measured solubility data, and the approximate values of enthalpies were computed.
FLUID PHASE EQUILIBRIA
(2023)
Article
Chemistry, Inorganic & Nuclear
Mir Saleh Hoseininezhad-Namin, Zahra Javanshir, Elaheh Rahimpour, Abolghasem Jouyban
Summary: Metal oxide nanoclusters (Zn12O12, Mg12O12, and Be12O12) were used to adsorb phenytoin (PHT) drug, and their adsorption energies were calculated using density functional theory. The Be12O12 nanocluster showed a significant change in electrical conductivity after PHT adsorption, making it a suitable candidate for PHT detection. The nanoclusters also exhibited an ideal recovery time for PHT desorption and could be used in biological samples. UV-vis calculation showed a red shift in the spectrum after PHT adsorption on Be12O12, further supporting its suitability for PHT detection.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Homa Rezaei, Maryam Khoubnasabjafari, Vahid Jouyban-Gharamaleki, Hamed Hamishehkar, Mohammad Reza Afshar Mogaddam, Elaheh Rahimpour, Reza Mehvar, Abolghasem Jouyban
Summary: This study tested the practical applicability of a previously proposed hypothesis on the bioequivalence of inhaled salbutamol formulations using two different types of pressurized metered dose inhalers (MDI-1 and MDI-2). The results showed that there was no significant bioequivalence between the two formulations based on the comparison of salbutamol concentration profiles in exhaled breath condensate (EBC) samples and the determination of aerodynamic particle size distribution.
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
(2023)
Article
Chemistry, Analytical
Faez Feyzi, Jafar Soleymani, Siavoush Dastmalchi, Fatemeh Ranjbar, Abolghasem Jouyban
Summary: A graphene oxide-based aerogel was synthesized and used as a dispersive solid-phase extraction sorbent for risperidone extraction from plasma samples. The method determined risperidone in plasma samples in a wide dynamic range with improved analytical performance. The developed approach could be employed as an accurate method for the quantification of risperidone in real plasma samples.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Biochemical Research Methods
Ahmad Mobed, Fereshteh Kohansal, Sanam Dolati, Mohammad Hasanzadeh
Summary: The aim of this study was to develop a label-free electrochemical biosensor for detecting telomerase in human biofluid. A green nanocomposite (poly[chitosan] decorated by gold nanoparticles) was used to immobilize the biotinylated antibody of telomerase and the immunocomplex of antigen-antibody. The constructed immunosensor showed a wide dynamic range (0.078-160 IU/ml(-1)) with a low limit of quantification of 0.078 IU/ml(-1), providing a unique approach for telomerase assays in early cancer prognosis.
Article
Thermodynamics
Ratna Surya Alwi, Adrian Rojas, Nadia Esfandiari, Seyed Ali Sajadian, Nedasadat Saadati Ardestani, Abolghasem Jouyban
Summary: The solubility of Clonazepam in supercritical carbon dioxide was measured at different temperatures and pressures. Various models, including density-based models, equations of state, and association theory based models, were used to correlate the experimental data. These models demonstrated good consistency in correlating the solubility of Clonazepam under different conditions. Gas antisolvent processes were suggested for micro or nano-sizing Clonazepam based on its dissolution behavior in supercritical carbon dioxide.
FLUID PHASE EQUILIBRIA
(2023)
Article
Biochemical Research Methods
Yasaman Sefid-Sefidehkhan, Mehdi Mokhtari, Abolghasem Jouyban, Maryam Khoshkam, Maryam Khoubnasabjafari, Vahid Jouyban-Gharamaleki, Elaheh Rahimpour
Summary: A colorimetric method using smartphone digital image analysis was developed for the quantification of lamotrigine. UV-visible spectroscopy and image analysis with the PhotoMetrix PRO & REG; app were used for optimization and validation. Parallel factor analysis was then employed for data analysis as a multivariate calibration method. The results demonstrated the potential of these methods in estimating lamotrigine concentrations in exhaled breath condensate, highlighting the value of combining digital images, smartphone applications, and chemometric tools.
Article
Chemistry, Multidisciplinary
Payam Shahbazi-Derakhshi, Mohammad Abbasi, Amirhossein Akbarzadeh, Ahad Mokhtarzadeh, Hamid Hosseinpour, Jafar Soleymani
Summary: A novel electrochemical probe was developed for quantification of apixaban in unprocessed plasma samples using electrochemically oxidized graphene oxide aerogels and nano-sized Bi2Fe4O9 particles. The probe employed a ratiometric electrochemical method for enhanced specificity in plasma samples and utilized K-3[Fe(CN)(6)]/K-4[Fe(CN)(6)] as the redox pair for indirect detection of apixaban. Differential pulse voltammetry was used to record the current alteration of the probe, and the response was proportional to apixaban concentrations from 10 ng mL(-1) to 10 μg mL(-1) with a low limit of quantification of 10 ng mL(-1). The fabricated chemosensor showed high selectivity for detecting apixaban concentrations in unprocessed plasma samples due to the physical filtering antifouling activity of aerogels.
Article
Chemistry, Medicinal
Vahid Jouyban-Gharamaleki, Fleming Martinez, Martin Kuentz, Elaheh Rahimpour, Abolghasem Jouyban
Summary: In this study, a laser monitoring technique was used to investigate the dissolution and solubility of CBX in mixtures of 2-propanol and propylene glycol. Mathematical models such as the van't Hoff model, mixture surface model, Jouyban-Acree and Jouyban-Acree-van't Hoff equations, and modified Wilson model were employed to fit the solubility data. The thermodynamic behavior of CBX dissolution was analyzed using the van't Hoff and Gibbs equations. The results showed that CBX had the highest solubility in 2-propanol at all temperatures, and its dissolution was an endothermic and enthalpy-driven process. The studied cosolvent mixtures have the potential to be used in pharmaceutical development or as intermediate bulk solutions for CBX products.
DISSOLUTION TECHNOLOGIES
(2023)
Article
Chemistry, Multidisciplinary
Yasaman Sefid-Sefidehkhan, Mehdi Mokhtari, Ata Mahmoodpoor, Yosra Vaez-Gharamaleki, Maryam Khoubnasabjafari, Mohammad Reza Afshar Moghaddam, Vahid Jouyban-Gharamaleki, Siavoush Dastmalchi, Elaheh Rahimpour, Abolghasem Jouyban
Summary: In this study, bismuth ferrite nano-sorbent was synthesized and used for the dispersive solid-phase extraction of methylprednisolone from exhaled breath samples. The size and morphology of the nano-sorbent were characterized, and methylprednisolone was quantified using high-performance liquid chromatography-ultraviolet detector. The optimized method showed a linear relationship between the analytical signals and methylprednisolone concentration, and achieved a pre-concentration factor of 6.4-fold.
Article
Pharmacology & Pharmacy
Fatemeh Mehdizadeh, Ramin Mohammadzadeh, Hossein Nazemiyeh, Mehran Mesgari-Abbasi, Mohammad Barzegar-Jalali, Morteza Eskandani, Khosro Adibkia
Summary: The aim of this study was to prepare electrosprayed nanoparticles (EP-Eudragit RS100 NPs) containing Echinacea purpurea extract to enhance its immunomodulatory effects. The results showed that EP-Eudragit RS100 NPs significantly increased the serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin 1-13 (IL1-13), as well as the white blood cell count (WBCs).
ADVANCED PHARMACEUTICAL BULLETIN
(2023)
Review
Biochemical Research Methods
Farahnaz Behzad, Azam Samadi, Elaheh Rahimpour, Mahdi Adabi, Abolghasem Jouyban
Summary: Aptasensors have gained popularity due to their excellent particularity, selectivity, and responsiveness. When combined with gold nanoparticles (AuNPs), these biosensors can detect various chemical and biological molecules. The changing color of AuNPs provides a simple explanation for the sensor's response. This review summarizes the recent developments in AuNP-based colorimetric aptasensors for sensing different analytes, discusses their uses, challenges, and prospects for forming new aptasensors.
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)