Article
Cell Biology
Pouya Youseflee, Faezeh Esmaeili Ranjbar, Marjan Bahraminasab, Ali Ghanbari, Davood Rabiei Faradonbeh, Samaneh Arab, Akram Alizadeh, Vajihe Taghdiri Nooshabadi
Summary: This study synthesized and characterized hydroxyapatite (HA) scaffolds and investigated the osteogenic and angiogenic effects of HA scaffolds with or without endometrial mesenchymal stem stromal cells (hEnSCs) derived exosomes in a rat calvaria defect animal model. The results showed that the scaffolds had a rough and porous structure and continuously released exosomes. In vivo analysis confirmed the osteogenic and angiogenic characteristics of the implanted scaffolds.
CELL AND TISSUE BANKING
(2023)
Article
Engineering, Biomedical
Sangil Min, David Cleveland, In Kap Ko, Ji Hyun Kim, Hee Jo Yang, Anthony Atala, James J. Yoo
Summary: By incorporating vascular endothelial growth factor (VEGF) into the vascular scaffold, improved angiogenic capability was achieved, promoting vascularization, reducing apoptosis of implanted cells, and forming hybrid renal tubule-like structures.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Fushi Wang, Xinjie Cai, Ya Shen, Liuyan Meng
Summary: This review discusses the effects of various types of scaffold materials on cell-scaffold interaction in tissue engineering. It elaborates on the influence of the physical, chemical, mechanical, and biological characteristics of scaffold materials on cell-scaffold interaction. The review also examines the role of scaffold components, degradation process, and degraded products in cell-scaffold interactions. Furthermore, it summarizes the latest research progress on cell-scaffold interactions among various engineered tissues or organs in the oral and craniofacial region.
BIOACTIVE MATERIALS
(2023)
Review
Polymer Science
Mohammad Javad Javid-Naderi, Javad Behravan, Negar Karimi-Hajishohreh, Shirin Toosi
Summary: Damage or loss of bone tissue is a major issue affecting human well-being, and tissue engineering is used to recover and regenerate bone fractures and damage. Polymer biomaterials are the most commonly required materials for synthetic bone scaffolds due to their suitable mechanical properties and degradation rates. Synthetic polymers offer advantages in bone replacement because they can be designed and changed easily, and their biocompatibility has been widely accepted in tissue engineering. This article updates on materials and application usage of scaffolds in bone tissue engineering for hard tissue regeneration.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Review
Engineering, Biomedical
Kenichi Arai, Takahiro Kitsuka, Koichi Nakayama
Summary: The safety and efficacy of new drugs are typically tested in animals, but differences in drug responses and potential cardiac side effects have led to many drug development projects being discontinued. Alternative methods to animal testing are needed. Tissue engineering techniques can create three-dimensional cardiac constructs from hiPSC-CMs, providing a new approach for drug screening.
Review
Biotechnology & Applied Microbiology
Jiang-Nan Fu, Xing Wang, Meng Yang, You-Rong Chen, Ji-Ying Zhang, Rong-Hui Deng, Zi-Ning Zhang, Jia-Kuo Yu, Fu-Zhen Yuan
Summary: This article reviews the advances in osteochondral tissue engineering and discusses various strategies including scaffold design, material types, fabrication techniques, and functional properties. Although there are still challenges and difficulties, research in this field is of great importance for repairing OC defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Tierong Bian, Ni Pang, Hongyun Xing
Summary: A parallel-aligned beta-tricalcium phosphate/collagen composite nanofiber scaffold with a microstructure similar to natural bone matrix membrane was fabricated, and crosslinked with glutaraldehyde to enhance its stability. The scaffold not only promotes biomimetic apatite-like mineral deposition and bone integration during repair, but also exhibits compatibility with bone marrow mesenchymal stem cells and strong antibacterial activity against E.coli. This composite nanofiber scaffold provides a new bioactive bone scaffold material for bone defect repair with antibacterial properties.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Review
Biochemistry & Molecular Biology
Jonard Corpuz Valdoz, Benjamin C. Johnson, Dallin J. Jacobs, Nicholas A. Franks, Ethan L. Dodson, Cecilia Sanders, Collin G. Cribbs, Pam M. Van Ry
Summary: ECM in tissue engineering plays a crucial role, with scaffold-based and scaffold-free techniques each having their own advantages and limitations. Scaffold-free techniques are suitable for high-throughput cell aggregates preparation, while scaffold-based techniques are more suitable for modeling organotypic models that mimic the native ECM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Zhou Jian, Tian Zhuang, Tian Qinyu, Peng Liqing, Li Kun, Luo Xujiang, Wang Diaodiao, Yang Zhen, Jiang Shuangpeng, Sui Xiang, Huang Jingxiang, Liu Shuyun, Hao Libo, Tang Peifu, Yao Qi, Guo Quany
Summary: By optimizing the preparation of meniscus-derived bioink and utilizing a custom 3D bioprinting system, a biomimetic meniscal scaffold with optimal features in terms of morphology and components was successfully created. Comprehensive evaluations were conducted on cell viability, mechanics, biodegradation, and tissue formation to ensure the scaffold's feasibility and functionality for application in tissue engineering.
BIOACTIVE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Jie Xu, Huan Fang, Ya Su, Yue Kang, Deli Xu, Yuen Yee Cheng, Yi Nie, Hong Wang, Tianqing Liu, Kedong Song
Summary: Finding a bioink suitable for 3D bioprinting that can mimic the microenvironment of native skin and prevent bacterial infection remains a major challenge in skin tissue engineering. In this study, a tissue-specific extracellular matrix-based bioink was prepared, and a novel scaffold was obtained using an extrusion 3D bioprinting technology and dynamic hydrogen bonding method. The hybrid scaffold exhibited excellent properties including antibacterial activity, hemostatic effect, and biocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Polymer Science
Antony V. V. Samrot, Mahendran Sathiyasree, Sadiq Batcha Abdul Rahim, Robinson Emilin Renitta, Kasirajan Kasipandian, Sivasuriyan Krithika Shree, Deenadhayalan Rajalakshmi, Nagarajan Shobana, Shanmugaboopathi Dhiva, Sasi Abirami, Sridevi Visvanathan, Basanta Kumar Mohanty, Gokul Shankar Sabesan, Suresh V. Chinni
Summary: Biological macromolecules, such as polysaccharides, proteins, and glycoproteins, have been widely used in tissue engineering due to their ability to mimic the extracellular matrix and their biocompatibility. Scaffolds made from these macromolecules have properties like tensile strength, biodegradability, and flexibility. This review discusses the fabrication methods and applications of scaffolds using various biological macromolecules and emphasizes the importance of natural polymers over synthetic ones due to their unique properties.
Article
Biotechnology & Applied Microbiology
Samira Tajvar, Afra Hadjizadeh, Saeed Saber Samandari
Summary: Successful bone tissue engineering requires 3D scaffolds with controllable properties tailored to specific clinical applications. Scaffold degradation, which must match the rate of host tissue regeneration, has been identified as a major challenge. This review focuses on the degradation mechanisms and approaches used to control the degradation rate of bone scaffold materials.
INTERNATIONAL BIODETERIORATION & BIODEGRADATION
(2023)
Article
Biochemistry & Molecular Biology
Hsu-Hsiang Lin, Pen-Hsiu Grace Chao, Wei-Chiu Tai, Po-Chun Chang
Summary: This study successfully developed a biomimetic microfibrous system to assist PDL regeneration and withstand functional load. Collagen-based microfibers were fabricated and PDL cells seeded on waveform microfibers showed enhanced growth and gene expression levels, indicating potential for promoting healing and regeneration under shear stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biophysics
Banafsheh Safari, Ayuob Aghanejad, Jamileh Kadkhoda, Marziyeh Aghazade, Leila Roshangar, Soodabeh Davaran
Summary: This study successfully fabricated a biofunctional magnetic scaffold with well-developed porous morphology and stable structure, showing no toxicity on dental pulp stem cells and improved osteoconductivity. The use of phosphorylated polymer and magnetic nanoparticles enhanced bone mineralization and expression of osteogenic biomarkers in the scaffold. The phosphorylation also increased the osteoinductivity of the scaffold and upregulated specific genes related to bone formation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Engineering, Biomedical
Rui-Chian Tang, Lily Shang, Philip O. Scumpia, Dino Di Carlo
Summary: Researchers have developed a novel crescent-shaped hydrogel scaffold with a microporous structure that allows for improved cell infiltration and expansion. With the use of microfluidic fabrication, the size of the cavities in the scaffold can be adjusted, leading to enhanced cellular network formation in vitro and in vivo. The results suggest that this new scaffold has the potential for superior functionality in tissue engineering applications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Microbiology
Namarta Kalia, Jatinder Singh, Manpreet Kaur
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2020)
Article
Materials Science, Multidisciplinary
Pardeep Kaur, K. J. Singh, Sandeep Kaur, Satwinderjeet Kaur, Amrit Pal Singh
MATERIALS CHEMISTRY AND PHYSICS
(2020)
Article
Biochemistry & Molecular Biology
Navdeep Kaur, Daljit Singh Arora, Namarta Kalia, Manpreet Kaur
MOLECULAR BIOLOGY REPORTS
(2020)
Article
Endocrinology & Metabolism
Raminderjit Kaur, Jatinder Singh, Rohit Kapoor, Manpreet Kaur
BMC ENDOCRINE DISORDERS
(2020)
Article
Multidisciplinary Sciences
Namarta Kalia, Jatinder Singh, Akash Kumar Rauniyar, Manpreet Kaur
SCIENTIFIC REPORTS
(2020)
Article
Materials Science, Ceramics
Parminder Kaur, K. J. Singh, Sonika Thakur, Murat Kurudirek
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2020)
Article
Microbiology
Preeti Sharma, Sumanpreet Kaur, Bhupinder Singh Chadha, Raminderjit Kaur, Manpreet Kaur, Sukhraj Kaur
Summary: Enterocin 12a is a novel bacteriocin with anticancer properties against human cancer cell lines. It selectively inhibits the proliferation of cancer cells in a dose-dependent manner and induces apoptosis-like morphological changes, while having negligible activity towards non-malignant cells. Further evaluation in animal models is recommended to explore its potential as an anticancer agent.
Article
Engineering, Electrical & Electronic
Shailja, K. J. Singh, Ravi Chand Singh
Summary: The study showed that Ga doping can improve the sensing properties of NiO nanoparticles, including increasing surface area, changing surface morphology, and enhancing defect concentration. Additionally, the catalytic effect of Ga can lower the activation energy of NiO and improve its sensing performance for ethanol.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2021)
Article
Materials Science, Biomaterials
Kulwinder Kaur, Silvia Sa' Paiva, David Caffrey, Brenton L. Cavanagh, Ciara M. Murphy
Summary: This study successfully developed injectable and thermoresponsive hydrogels with enhanced mechanical strength and bioactivity by integrating COOH-SWCNTs into chitosan and collagen, showing great potential in bone tissue engineering and regenerative medicine.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Dermatology
Unnikrishnan M. Chandrasekharan, Raminderjit Kaur, Jennifer E. Harvey, Chad Braley, Vandana Rai, MacKenzie Lee, Nicholas de Windt, Jason Hsieh, Ritika Jaini, Defne Bayik, Rachel G. Scheraga, Anthony P. Fernandez, Paul E. DiCorleto, M. Elaine Husni
Summary: TNF-alpha is a crucial mediator in the development of psoriasis. Inhibition of TNF can be an effective treatment, but it may also cause adverse effects. Studies have shown that the TNFR2 pathway plays a key role in psoriatic inflammation. Therefore, targeting the TNFR2 pathway could be a potential new approach for treating psoriatic diseases.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mustafa Mohammad Rafiei, Sara Parsaei, Parminder Kaur, K. J. Singh, Mehmet Buyukyildiz, Murat Kurudirek
Summary: The attenuation coefficients of water and several human tissues at low energy photons were estimated using the MCNP6.1 code. The results were compared with literature data and showed good agreement. Additionally, various parameters such as mean free path, half value layer, and effective atomic number were calculated using the obtained attenuation coefficients. The study also compared human tissues with tissue equivalent materials to identify the best match, with the muscle-equivalent liquid with sucrose found to be the best for certain tissues.
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
(2022)
Article
Rheumatology
April W. Armstrong, Rasika M. Reddy, Keith Colaco, Pamela A. Diaz, Raminderjit Kaur, David Simon, Matteo Vecellio, M. Elaine Husni
Summary: GRAPPA held a trainee symposium at its 2021 virtual meeting, featuring research on psoriasis and psoriatic arthritis. The report includes 5 oral presentations and 22 poster discussions.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Shailja, K. J. Singh, Sandeep Sharma
Summary: This study synthesized pure NiO and Eu-doped NiO using the coprecipitation method for xylene sensing applications. Europium doping was found to increase the surface area of nickel oxide, with the 3% Eu-doped NiO sensor exhibiting selectivity towards xylene at 200 degrees C. The improved sensing performance was attributed to factors such as high surface area, presence of defects, and nickel vacancies in the doped samples.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2022)
Article
Chemistry, Physical
Jasvir Singh, Gurdev Preet Singh, Sunil Kumar, Ravish Kumar Jain, Sahil Gasso, Brahmjot Singh, K. J. Singh, Anupinder Singh, Ravi Chand Singh
Summary: Pristine and Sm3+-doped ZnO nanostructures were prepared using an eco-friendly ball milling technique and their physical properties were investigated. Sm-doping resulted in a reduction in crystallite size, an increase in structural defects, a decrease in band gap, and an enhancement of magnetic properties. The photocatalytic degradation and antibacterial activity of the samples were improved with Sm3+ doping, showing potential for applications in these areas.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Organic
Nitin Srivastava, Devdutt Chaturvedi, Ram Kishore, Manpreet Kaur, Raminderjit Kaur
Summary: This communication presents a novel method for synthesizing substituted thioureas using readily available, less toxic and cost-effective chemicals under normal temperature and pressure. The reaction between various aliphatic and aromatic amines and CS2, methyl iodide with Triton-B as a phase transfer catalyst resulted in the formation of substituted thioureas. This new method offers a one-flask reaction at room temperature and pressure, providing high yield and easy separation of the compound from the reaction mixture.
INDIAN JOURNAL OF CHEMISTRY
(2022)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
