Suppressing allostery in epitope mapping experiments using millisecond hydrogen / deuterium exchange mass spectrometry

The role of dimer asymmetry and protomer dynamics in enzyme catalysis

(2017) Tae Hun Kim et al.   SCIENCE

Entropy Transfer between Residue Pairs and Allostery in Proteins: Quantifying Allosteric Communication in Ubiquitin

(2017) Aysima Hacisuleyman et al.   PLoS Computational Biology

Hydrogen deuterium exchange mass spectrometry in biopharmaceutical discovery and development – A review

(2016) Bin Deng et al.   ANALYTICA CHIMICA ACTA

Evidence of Allosteric Enzyme Regulation via Changes in Conformational Dynamics: A Hydrogen/Deuterium Exchange Investigation of Dihydrodipicolinate Synthase

(2016) Modupeola A. Sowole et al.   BIOCHEMISTRY

Therapeutic monoclonal antibodies and derivatives: Historical perspectives and future directions

(2016) Kyla R. Rodgers et al.   BIOTECHNOLOGY ADVANCES

Heavy lessons in protein allostery

(2016) Lars Konermann   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Broadly neutralizing epitopes in thePlasmodium vivaxvaccine candidate Duffy Binding Protein

(2016) Edwin Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heavy lessons in protein allostery

(2016) Lars Konermann   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Getting to the core of protein pharmaceuticals – Comprehensive structure analysis by mass spectrometry

(2015) Ulrike Leurs et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Epitope mapping by solution NMR spectroscopy

(2015) M. Bardelli et al.   JOURNAL OF MOLECULAR RECOGNITION

Hyperphosphorylation of Intrinsically Disordered Tau Protein Induces an Amyloidogenic Shift in Its Conformational Ensemble

(2015) Shaolong Zhu et al.   PLoS One

Applications of Hydrogen/Deuterium Exchange MS from 2012 to 2014

(2014) Gregory F. Pirrone et al.   ANALYTICAL CHEMISTRY

ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers

(2014) B. G. Pierce et al.   BIOINFORMATICS

Changes in Signal Transducer and Activator of Transcription 3 (STAT3) Dynamics Induced by Complexation with Pharmacological Inhibitors of Src Homology 2 (SH2) Domain Dimerization

(2014) Diana Resetca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

3D modeling and characterization of the human CD115 monoclonal antibody H27K15 epitope and design of a chimeric CD115 target

(2014) Benoît Grellier et al.   mAbs

Biopharmaceutical benchmarks 2014

(2014) Gary Walsh   NATURE BIOTECHNOLOGY

NMR methods for structural studies of large monomeric and multimeric proteins

(2013) Dominique P Frueh et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Characterizing rapid, activity-linked conformational transitions in proteins via sub-second hydrogen deuterium exchange mass spectrometry

(2013) Diana Resetca et al.   FEBS Journal

Mass spectrometry for the biophysical characterization of therapeutic monoclonal antibodies

(2013) Hao Zhang et al.   FEBS LETTERS

An electrospray ms-coupled microfluidic device for sub-second hydrogen/deuterium exchange pulse-labelling reveals allosteric effects in enzyme inhibition

(2013) Tamanna Rob et al.   LAB ON A CHIP

Measuring Dynamics in Weakly Structured Regions of Proteins Using Microfluidics-Enabled Subsecond H/D Exchange Mass Spectrometry

(2012) Tamanna Rob et al.   ANALYTICAL CHEMISTRY

Monoclonal antibody therapeutics: history and future

(2012) Nicholas APS Buss et al.   CURRENT OPINION IN PHARMACOLOGY

Mapping of discontinuous conformational epitopes by amide hydrogen/deuterium exchange mass spectrometry and computational docking

(2012) Deepangi Pandit et al.   JOURNAL OF MOLECULAR RECOGNITION

Hydrogen exchange mass spectrometry for studying protein structure and dynamics

(2010) Lars Konermann et al.   CHEMICAL SOCIETY REVIEWS

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation

(2010) Zhongqi Zhang et al.   PROTEIN SCIENCE

An integrated suite of fast docking algorithms

(2010) Efrat Mashiach et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The structural basis of allosteric regulation in proteins

(2009) Roman A. Laskowski et al.   FEBS LETTERS

Ezrin Induces Long-Range Interdomain Allostery in the Scaffolding Protein NHERF1

(2009) Jianquan Li et al.   JOURNAL OF MOLECULAR BIOLOGY

High-Speed and High-Resolution UPLC Separation at Zero Degrees Celsius

(2008) Thomas E. Wales et al.   ANALYTICAL CHEMISTRY