Epitope characterization of anti-JAM-A antibodies using orthogonal mass spectrometry and surface plasmon resonance approaches

Analytical ultracentrifugation with fluorescence detection system reveals differences in complex formation between recombinant human TNF and different biological TNF antagonists in various environments

(2017) Elena Krayukhina et al.   mAbs

Strategies and challenges for the next generation of antibody–drug conjugates

(2017) Alain Beck et al.   NATURE REVIEWS DRUG DISCOVERY

Application of amide hydrogen/deuterium exchange mass spectrometry for epitope mapping in human cystatin C

(2016) Martyna Prądzińska et al.   AMINO ACIDS

Exploiting chimeric human antibodies to characterize a protective epitope of Neisseria adhesin A, one of the Bexsero vaccine components

(2016) Isabella Bertoldi et al.   FASEB JOURNAL

Antibodies to watch in 2017

(2016) Janice M. Reichert   mAbs

Biophysics in drug discovery: impact, challenges and opportunities

(2016) Jean-Paul Renaud et al.   NATURE REVIEWS DRUG DISCOVERY

High Resolution Mapping of Bactericidal Monoclonal Antibody Binding Epitopes on Staphylococcus aureus Antigen MntC

(2016) Alexey V. Gribenko et al.   PLoS Pathogens

Tandem Native Mass-Spectrometry on Antibody–Drug Conjugates and Submillion Da Antibody–Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selector

(2015) Andrey Dyachenko et al.   ANALYTICAL CHEMISTRY

Conformational Difference in Human IgG2 Disulfide Isoforms Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry

(2015) Aming Zhang et al.   BIOCHEMISTRY

Mapping the interaction between factor VIII and von Willebrand factor by electron microscopy and mass spectrometry

(2015) P.-L. Chiu et al.   BLOOD

The role of structural proteomics in vaccine development: recent advances and future prospects

(2015) Danilo Donnarumma et al.   Expert Review of Proteomics

Uncovering the Early Assembly Mechanism for Amyloidogenic β2-Microglobulin Using Cross-linking and Native Mass Spectrometry

(2015) Zoe Hall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-resolution epitope mapping by HX MS reveals the pathogenic mechanism and a possible therapy for autoimmune TTP syndrome

(2015) Veronica C. Casina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Conformational Impact of Chemical Modifications on Monoclonal Antibodies with Diverse Sequence Variation Using Hydrogen/Deuterium Exchange Mass Spectrometry and Structural Modeling

(2014) Aming Zhang et al.   ANALYTICAL CHEMISTRY

Current approaches to fine mapping of antigen-antibody interactions

(2014) W. Mark Abbott et al.   IMMUNOLOGY

Insight into cyanobacterial circadian timing from structural details of the KaiB-KaiC interaction

(2014) J. Snijder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein painting reveals solvent-excluded drug targets hidden within native protein–protein interfaces

(2014) Alessandra Luchini et al.   Nature Communications

Time Resolved Native Ion-Mobility Mass Spectrometry to Monitor Dynamics of IgG4 Fab Arm Exchange and “Bispecific” Monoclonal Antibody Formation

(2013) François Debaene et al.   ANALYTICAL CHEMISTRY

Physicochemical and Functional Comparability Between the Proposed Biosimilar Rituximab GP2013 and Originator Rituximab

(2013) Jan Visser et al.   BIODRUGS

Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications

(2013) Hui Wei et al.   DRUG DISCOVERY TODAY

Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties

(2013) Agnese Faleri et al.   FASEB JOURNAL

Mass spectrometry for the biophysical characterization of therapeutic monoclonal antibodies

(2013) Hao Zhang et al.   FEBS LETTERS

Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab

(2013) Mark Ultsch et al.   JOURNAL OF MOLECULAR BIOLOGY

Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG

(2013) Rebecca J. Rose et al.   mAbs

Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen

(2013) Enrico Malito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isotype and glycoform selection for antibody therapeutics

(2012) Roy Jefferis   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

In Vitro Stoichiometry of Complexes between the Soluble RANK Ligand and the Monoclonal Antibody Denosumab

(2012) Kelly K. Arthur et al.   BIOCHEMISTRY

A novel role for junctional adhesion molecule-A in tumor proliferation: Modulation by an anti-JAM-A monoclonal antibody

(2012) Liliane Goetsch et al.   INTERNATIONAL JOURNAL OF CANCER

Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars

(2012) Steven A. Berkowitz et al.   NATURE REVIEWS DRUG DISCOVERY

The Molecular Architecture of the Eukaryotic Chaperonin TRiC/CCT

(2012) Alexander Leitner et al.   STRUCTURE

Epitope Mapping of a 95 kDa Antigen in Complex with Antibody by Solution-Phase Amide Backbone Hydrogen/Deuterium Exchange Monitored by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

(2011) Qian Zhang et al.   ANALYTICAL CHEMISTRY

Advances and challenges in analytical characterization of biotechnology products: Mass spectrometry-based approaches to study properties and behavior of protein therapeutics

(2011) Igor A. Kaltashov et al.   BIOTECHNOLOGY ADVANCES

Structural and Functional Characterization of an Agonistic Anti-Human EphA2 Monoclonal Antibody

(2011) Li Peng et al.   JOURNAL OF MOLECULAR BIOLOGY

Extending Mass Spectrometry Contribution to Therapeutic Monoclonal Antibody Lead Optimization: Characterization of Immune Complexes Using Noncovalent ESI-MS

(2009) Cédric Atmanene et al.   ANALYTICAL CHEMISTRY