The role of structural proteomics in vaccine development: recent advances and future prospects

Probing the Conformational and Functional Consequences of Disulfide Bond Engineering in Growth Hormone by Hydrogen–Deuterium Exchange Mass Spectrometry Coupled to Electron Transfer Dissociation

(2015) Signe T. Seger et al.   ANALYTICAL CHEMISTRY

Hydrogen Exchange Mass Spectrometry of Proteins at Langmuir Monolayers

(2015) Gregory F. Pirrone et al.   ANALYTICAL CHEMISTRY

Conformational Difference in Human IgG2 Disulfide Isoforms Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry

(2015) Aming Zhang et al.   BIOCHEMISTRY

Getting to the core of protein pharmaceuticals – Comprehensive structure analysis by mass spectrometry

(2015) Ulrike Leurs et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Neisseria meningitis GNA1030 is a ubiquinone-8 binding protein

(2015) Danilo Donnarumma et al.   FASEB JOURNAL

Protein Crystallography in Vaccine Research and Development

(2015) Enrico Malito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural and biochemical studies of HCMV gH/gL/gO and Pentamer reveal mutually exclusive cell entry complexes

(2015) Claudio Ciferri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical cross-linking and native mass spectrometry: A fruitful combination for structural biology

(2015) Andrea Sinz et al.   PROTEIN SCIENCE

Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies

(2015) Claudio Ciferri et al.   PLoS Pathogens

Proteomic Identification of Monoclonal Antibodies from Serum

(2014) Daniel R. Boutz et al.   ANALYTICAL CHEMISTRY

Applications of Hydrogen/Deuterium Exchange MS from 2012 to 2014

(2014) Gregory F. Pirrone et al.   ANALYTICAL CHEMISTRY

Identification of glycosylated regions in pneumococcal PspA conjugated to serotype 6B capsular polysaccharide

(2014) Giovana Cappio Barazzone et al.   GLYCOCONJUGATE JOURNAL

Nonbinding Site-Directed Mutants of Transferrin Binding Protein B Exhibit Enhanced Immunogenicity and Protective Capabilities

(2014) Rafael Frandoloso et al.   INFECTION AND IMMUNITY

Structural Conservation, Variability, and Immunogenicity of the T6 Backbone Pilin of Serotype M6 Streptococcus pyogenes

(2014) Paul G. Young et al.   INFECTION AND IMMUNITY

Characterization of immune response elicited by the recombinant outer membrane protein OmpF of Aeromonas hydrophila, a potential vaccine candidate in murine model

(2014) Sunita Kumari Yadav et al.   MOLECULAR BIOLOGY REPORTS

The power of ion mobility-mass spectrometry for structural characterization and the study of conformational dynamics

(2014) Francesco Lanucara et al.   Nature Chemistry

Antibody-driven design of a human cytomegalovirus gHgLpUL128L subunit vaccine that selectively elicits potent neutralizing antibodies

(2014) Anna Kabanova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes

(2014) Alexander Leitner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of differences in the conformational flexibility of hepatitis B virus core-antigen and e-antigen by hydrogen deuterium exchange-mass spectrometry

(2014) Jessica Z. Bereszczak et al.   PROTEIN SCIENCE

The Discovery and Development of a Novel Vaccine to Protect againstNeisseria meningitidisSerogroup B Disease

(2014) Gary W Zlotnick et al.   Human Vaccines & Immunotherapeutics

Studying 18 MDa Virus Assemblies with Native Mass Spectrometry

(2013) Joost Snijder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Broadly neutralizing antibodies against influenza viruses

(2013) Nick S. Laursen et al.   ANTIVIRAL RESEARCH

Effects of Salts from the Hofmeister Series on the Conformational Stability, Aggregation Propensity, and Local Flexibility of an IgG1 Monoclonal Antibody

(2013) Ranajoy Majumdar et al.   BIOCHEMISTRY

A Multi-Component Meningococcal Serogroup B Vaccine (4CMenB): The Clinical Development Program

(2013) Miguel O’Ryan et al.   DRUGS

Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties

(2013) Agnese Faleri et al.   FASEB JOURNAL

Nonfunctional Variant 3 Factor H Binding Proteins as Meningococcal Vaccine Candidates

(2013) Stijn van der Veen et al.   INFECTION AND IMMUNITY

Investigating Monoclonal Antibody Aggregation Using a Combination of H/DX-MS and Other Biophysical Measurements

(2013) Roxana E. Iacob et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Correlating Excipient Effects on Conformational and Storage Stability of an IgG1 Monoclonal Antibody with Local Dynamics as Measured by Hydrogen/Deuterium-Exchange Mass Spectrometry

(2013) Prakash Manikwar et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Rapid Screening for Potential Epitopes Reactive with a Polycolonal Antibody by Solution-Phase H/D Exchange Monitored by FT-ICR Mass Spectrometry

(2013) Qian Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Isolate-Specific Differences in the Conformational Dynamics and Antigenicity of HIV-1 gp120

(2013) T. M. Davenport et al.   JOURNAL OF VIROLOGY

Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG

(2013) Rebecca J. Rose et al.   mAbs

Probing the biophysical interplay between a viral genome and its capsid

(2013) J. Snijder et al.   Nature Chemistry

Molecular deconvolution of the monoclonal antibodies that comprise the polyclonal serum response

(2013) Y. Wine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains

(2013) J. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

(2013) J. S. McLellan et al.   SCIENCE

Intrinsically Disordered Protein Threads Through the Bacterial Outer-Membrane Porin OmpF

(2013) N. G. Housden et al.   SCIENCE

Twenty Years of Gas Phase Structural Biology

(2013) Julien Marcoux et al.   STRUCTURE

Microbials for the production of monoclonal antibodies and antibody fragments

(2013) Oliver Spadiut et al.   TRENDS IN BIOTECHNOLOGY

Targeted Amino Acid Substitutions Impair Streptolysin O Toxicity and Group A Streptococcus Virulence

(2013) E. Chiarot et al.   mBio

Comparative cross-linking and mass spectrometry of an intact F-type ATPase suggest a role for phosphorylation

(2013) Carla Schmidt et al.   Nature Communications

The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

(2013) Devin Sok et al.   PLoS Pathogens

Mechanism and Rates of Exchange of L7/L12 between Ribosomes and the Effects of Binding EF-G

(2012) Stéphanie Deroo et al.   ACS Chemical Biology

Immunogenic characterization of outer membrane porins OmpC and OmpF of porcine extraintestinal pathogenicEscherichia coli

(2012) Canying Liu et al.   FEMS MICROBIOLOGY LETTERS

Multi High-Throughput Approach for Highly Selective Identification of Vaccine Candidates: the Group A Streptococcus Case

(2012) Giuliano Bensi et al.   MOLECULAR & CELLULAR PROTEOMICS

False discovery rate estimation for cross-linked peptides identified by mass spectrometry

(2012) Thomas Walzthoeni et al.   NATURE METHODS

Dynamics of a bacterial multidrug ABC transporter in the inward- and outward-facing conformations

(2012) S. Mehmood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen Molecules

(2012) Steven Johnson et al.   PLoS Pathogens

Protein–excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development

(2011) Tim J. Kamerzell et al.   ADVANCED DRUG DELIVERY REVIEWS

Structural Mass Spectrometry of Proteins Using Hydroxyl Radical Based Protein Footprinting

(2011) Liwen Wang et al.   ANALYTICAL CHEMISTRY

A Meningococcal Factor H Binding Protein Mutant That Eliminates Factor H Binding Enhances Protective Antibody Responses to Vaccination

(2011) P. T. Beernink et al.   JOURNAL OF IMMUNOLOGY

Joining Forces: Integrating Proteomics and Cross-linking with the Mass Spectrometry of Intact Complexes

(2011) Florian Stengel et al.   MOLECULAR & CELLULAR PROTEOMICS

Distinct Aggregation Mechanisms of Monoclonal Antibody Under Thermal and Freeze-Thaw Stresses Revealed by Hydrogen Exchange

(2011) Aming Zhang et al.   PHARMACEUTICAL RESEARCH

Structure-based approach to rationally design a chimeric protein for an effective vaccine against Group B Streptococcus infections

(2011) A. Nuccitelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mass Spectrometry of Intact V-Type ATPases Reveals Bound Lipids and the Effects of Nucleotide Binding

(2011) M. Zhou et al.   SCIENCE

Rational Design of a Meningococcal Antigen Inducing Broad Protective Immunity

(2011) M. Scarselli et al.   Science Translational Medicine

Structural characterisation, stability and antibody recognition of chimeric NHBA-GNA1030: An investigational vaccine component against Neisseria meningitidis

(2011) Angela Martino et al.   VACCINE

Resolving Disulfide Structural Isoforms of IgG2 Monoclonal Antibodies by Ion Mobility Mass Spectrometry

(2010) Dhanashri Bagal et al.   ANALYTICAL CHEMISTRY

Loss of Ammonia during Electron-Transfer Dissociation of Deuterated Peptides as an Inherent Gauge of Gas-Phase Hydrogen Scrambling

(2010) Kasper D. Rand et al.   ANALYTICAL CHEMISTRY

Quantitative Cell Surface Proteome Profiling for SigB-Dependent Protein Expression in the Human PathogenStaphylococcus aureusvia Biotinylation Approach

(2010) Kristina Hempel et al.   JOURNAL OF PROTEOME RESEARCH

Post-translational Modifications Differentially Affect IgG1 Conformation and Receptor Binding

(2010) Damian Houde et al.   MOLECULAR & CELLULAR PROTEOMICS

Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells

(2010) Sai T Reddy et al.   NATURE BIOTECHNOLOGY

Identification of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenic Escherichia coli

(2010) D. G. Moriel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of a discontinuous epitope of the human immunodeficiency virus (HIV) core protein p24 by epitope excision and differential chemical modification followed by mass spectrometric peptide mapping analysis

(2010) Elisabeth O. Hochleitner et al.   PROTEIN SCIENCE

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation

(2010) Zhongqi Zhang et al.   PROTEIN SCIENCE

Conformational changes in oxidatively stressed monoclonal antibodies studied by hydrogen exchange mass spectrometry

(2010) William Burkitt et al.   PROTEIN SCIENCE

Profiling the surfacome of Staphylococcus aureus

(2010) Annette Dreisbach et al.   PROTEOMICS

Hydrogen/Deuterium Exchange Analysis of HIV-1 Capsid Assembly and Maturation

(2010) Eric B. Monroe et al.   STRUCTURE

Influence of serogroup B meningococcal vaccine antigens on growth and survival of the meningococcus in vitro and in ex vivo and in vivo models of infection

(2010) Kate L. Seib et al.   VACCINE

Characterization of IgG1 Conformation and Conformational Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry

(2009) Damian Houde et al.   ANALYTICAL CHEMISTRY

Protein Hydrogen Exchange Measured at Single-Residue Resolution by Electron Transfer Dissociation Mass Spectrometry

(2009) Kasper D. Rand et al.   ANALYTICAL CHEMISTRY

Conformational changes in p47phoxupon activation highlighted by mass spectrometry coupled to hydrogen/deuterium exchange and limited proteolysis

(2009) Julien Marcoux et al.   FEBS LETTERS

Intramolecular Isopeptide Bonds Give Thermodynamic and Proteolytic Stability to the Major Pilin Protein ofStreptococcus pyogenes

(2009) Hae Joo Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chaperonin Complexes Monitored by Ion Mobility Mass Spectrometry

(2009) Esther van Duijn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Surfome Analysis as a Fast Track to Vaccine Discovery

(2009) Francesco Doro et al.   MOLECULAR & CELLULAR PROTEOMICS

Elucidatingin VivoStructural Dynamics in Integral Membrane Protein by Hydroxyl Radical Footprinting

(2009) Yi Zhu et al.   MOLECULAR & CELLULAR PROTEOMICS

Structural organization of NadAΔ351–405, a recombinant MenB vaccine component, by its physico-chemical characterization at drug substance level

(2009) Claudia Magagnoli et al.   VACCINE

Electron Transfer Dissociation Facilitates the Measurement of Deuterium Incorporation into Selectively Labeled Peptides with Single Residue Resolution

(2008) Martin Zehl et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electron Capture Dissociation of Electrosprayed Protein Ions for Spatially Resolved Hydrogen Exchange Measurements

(2008) Jingxi Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electron Capture Dissociation Proceeds with a Low Degree of Intramolecular Migration of Peptide Amide Hydrogens

(2008) Kasper D. Rand et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Probing protein structure by amino acid-specific covalent labeling and mass spectrometry

(2008) Vanessa Leah Mendoza et al.   MASS SPECTROMETRY REVIEWS

Micelles Protect Membrane Complexes from Solution to Vacuum

(2008) N. P. Barrera et al.   SCIENCE

Complementary Structural Mass Spectrometry Techniques Reveal Local Dynamics in Functionally Important Regions of a Metastable Serpin

(2008) Xiaojing Zheng et al.   STRUCTURE

Physicochemical characterisation of glycoconjugate vaccines for prevention of meningococcal diseases

(2008) Angela Bardotti et al.   VACCINE

Epitope mapping on bovine prion protein using chemical cross-linking and mass spectrometry

(2007) Tatiana Pimenova et al.   JOURNAL OF MASS SPECTROMETRY

Capsid structure and dynamics of a human rhinovirus probed by hydrogen exchange mass spectrometry

(2005) Lintao Wang et al.   PROTEIN SCIENCE