The CXCR4 inhibitor BL-8040 induces the apoptosis of AML blasts by downregulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression
出版年份 2017 全文链接
标题
The CXCR4 inhibitor BL-8040 induces the apoptosis of AML blasts by downregulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression
作者
关键词
-
出版物
LEUKEMIA
Volume 31, Issue 11, Pages 2336-2346
出版商
Springer Nature
发表日期
2017-03-10
DOI
10.1038/leu.2017.82
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Binding of Released Bim to Mcl-1 is a Mechanism of Intrinsic Resistance to ABT-199 which can be Overcome by Combination with Daunorubicin or Cytarabine in AML Cells
- (2016) X. Niu et al. CLINICAL CANCER RESEARCH
- Inhibition of CXCR4 by LY2624587, a Fully Humanized Anti-CXCR4 Antibody Induces Apoptosis of Hematologic Malignancies
- (2016) Sheng-Bin Peng et al. PLoS One
- ‘Acute myeloid leukemia: a comprehensive review and 2016 update’
- (2016) I De Kouchkovsky et al. Blood Cancer Journal
- Targeting MCL-1/BCL-XL Forestalls the Acquisition of Resistance to ABT-199 in Acute Myeloid Leukemia
- (2016) Kevin H. Lin et al. Scientific Reports
- Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy
- (2015) B.-S. Cho et al. BLOOD
- MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies
- (2015) G S Choudhary et al. Cell Death & Disease
- Role of miR-15/16 in CLL
- (2014) Y Pekarsky et al. CELL DEATH AND DIFFERENTIATION
- Internal Tandem Duplication Mutations inFLT3Gene Augment Chemotaxis to Cxcl12 Protein by Blocking the Down-regulation of the Rho-associated Kinase via the Cxcl12/Cxcr4 Signaling Axis
- (2014) Chie Onish et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Acute myeloid leukemia cells harboring MLL fusion genes or with the acute promyelocytic leukemia phenotype are sensitive to the Bcl-2-selective inhibitor ABT-199
- (2014) X Niu et al. LEUKEMIA
- Combination of Imatinib with CXCR4 Antagonist BKT140 Overcomes the Protective Effect of Stroma and Targets CML In Vitro and In Vivo
- (2014) K. Beider et al. MOLECULAR CANCER THERAPEUTICS
- CXCR4/CXCL12 Mediate Autocrine Cell- Cycle Progression in NF1-Associated Malignant Peripheral Nerve Sheath Tumors
- (2013) Wei Mo et al. CELL
- Targeting the CD20 and CXCR4 Pathways in Non-Hodgkin Lymphoma with Rituximab and High-Affinity CXCR4 Antagonist BKT140
- (2013) K. Beider et al. CLINICAL CANCER RESEARCH
- The High-Affinity CXCR4 Antagonist BKT140 Is Safe and Induces a Robust Mobilization of Human CD34+ Cells in Patients with Multiple Myeloma
- (2013) A. Peled et al. CLINICAL CANCER RESEARCH
- ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
- (2013) Andrew J Souers et al. NATURE MEDICINE
- Selective BCL-2 Inhibition by ABT-199 Causes On-Target Cell Death in Acute Myeloid Leukemia
- (2013) R. Pan et al. Cancer Discovery
- Role of CXCR4 in the Pathogenesis of Acute Myeloid Leukemia
- (2013) Amnon Peled et al. Theranostics
- Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process
- (2012) M. Rahmani et al. BLOOD
- BMS-936564/MDX-1338: A Fully Human Anti-CXCR4 Antibody Induces Apoptosis In Vitro and Shows Antitumor Activity In Vivo in Hematologic Malignancies
- (2012) M. R. Kuhne et al. CLINICAL CANCER RESEARCH
- Development of novel CXCR4-based therapeutics
- (2012) Amnon Peled et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Pure curcumin decreases the expression of WT1 by upregulation of miR-15a and miR-16-1 in leukemic cells
- (2012) Shen-meng Gao et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- In vitro and in vivo therapeutic efficacy of CXCR4 antagonist BKT140 against human non–small cell lung cancer
- (2012) Duha Fahham et al. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
- MicroRNA-16 Is Down-Regulated in Mutated FLT3 Expressing Murine Myeloid FDC-P1 Cells and Interacts with Pim-1
- (2012) Kyu-Tae Kim et al. PLoS One
- CXCR4 inhibitors selectively eliminate CXCR4-expressing human acute myeloid leukemia cells in NOG mouse model
- (2012) Y Zhang et al. Cell Death & Disease
- PET imaging of CXCR4 using copper-64 labeled peptide antagonist
- (2012) Orit Jacobson et al. Theranostics
- Low hepcidin accounts for the proinflammatory status associated with iron deficiency
- (2011) A. Pagani et al. BLOOD
- The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy
- (2011) P N Kelly et al. CELL DEATH AND DIFFERENTIATION
- miR-15a and miR-16-1 inhibit the proliferation of leukemic cells by down-regulating WT1 protein level
- (2011) Shen-meng Gao et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- miR-15a/16-1 enhances retinoic acid-mediated differentiation of leukemic cells and is up-regulated by retinoic acid
- (2011) Shen-Meng Gao et al. LEUKEMIA & LYMPHOMA
- Exploiting cellular pathways to develop new treatment strategies for AML
- (2010) Amir T. Fathi et al. CANCER TREATMENT REVIEWS
- CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth
- (2010) Katia Beider et al. EXPERIMENTAL HEMATOLOGY
- PET of Tumor CXCR4 Expression with 4-18F-T140
- (2010) O. Jacobson et al. JOURNAL OF NUCLEAR MEDICINE
- Dissection of PIM serine/threonine kinases in FLT3-ITD–induced leukemogenesis reveals PIM1 as regulator of CXCL12–CXCR4-mediated homing and migration
- (2009) Rebekka Grundler et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Contribution of bone microenvironment to leukemogenesis and leukemia progression
- (2009) F Ayala et al. LEUKEMIA
- The CXCR4 antagonist 4F-benzoyl-TN14003 stimulates the recovery of the bone marrow after transplantation
- (2009) M Abraham et al. LEUKEMIA
- A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response
- (2008) K. W. Pratz et al. BLOOD
- Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML
- (2008) Z. Zeng et al. BLOOD
- Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100
- (2008) B. Nervi et al. BLOOD
- The CXCR4 antagonist AMD3100 impairs survival of human AML cells and induces their differentiation
- (2008) S Tavor et al. LEUKEMIA
- Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway
- (2008) W Zhang et al. LEUKEMIA
- CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers
- (2008) J A Burger et al. LEUKEMIA
- The miR-15a–miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities
- (2008) Désirée Bonci et al. NATURE MEDICINE
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