标题
Applications of mass spectrometry in drug metabolism: 50 years of progress
作者
关键词
-
出版物
DRUG METABOLISM REVIEWS
Volume 47, Issue 1, Pages 71-87
出版商
Informa UK Limited
发表日期
2015-02-02
DOI
10.3109/03602532.2014.1001029
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Integrated Quantification and Identification of Aldehydes and Ketones in Biological Samples
- (2014) David Siegel et al. ANALYTICAL CHEMISTRY
- LC–MS-based metabolomics: an update
- (2014) Zhong-Ze Fang et al. ARCHIVES OF TOXICOLOGY
- Metabolomic and Genomic Evidence for Compromised Bile Acid Homeostasis by Senecionine, a Hepatotoxic Pyrrolizidine Alkaloid
- (2014) Aizhen Xiong et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Liquid Chromatography High-Resolution TOF Analysis: Investigation of MSE for Broad-Spectrum Drug Screening
- (2014) N. S. Chindarkar et al. CLINICAL CHEMISTRY
- Rapid Identification of Polymethoxylated Flavonoids in Traditional Chinese Medicines with a Practical Strategy of Stepwise Mass Defect Filtering Coupled to Diagnostic Product Ions Analysis based on a Hybrid LTQ-Orbitrap Mass Spectrometer
- (2014) Jia-Yu Zhang et al. PHYTOCHEMICAL ANALYSIS
- Reflecting on a decade of metabolite screening and monitoring
- (2014) Anne-Françoise Aubry et al. Bioanalysis
- Qualitative metabolism assessment and toxicological detection of xylazine, a veterinary tranquilizer and drug of abuse, in rat and human urine using GC–MS, LC–MS n , and LC–HR-MS n
- (2013) Golo M. J. Meyer et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Detection and characterization of ticlopidine conjugates in rat bile using high-resolution mass spectrometry: applications of various data acquisition and processing tools
- (2013) Fuying Du et al. JOURNAL OF MASS SPECTROMETRY
- Data acquisition and data mining techniques for metabolite identification using LC coupled to high-resolution MS
- (2013) Shuguang Ma et al. Bioanalysis
- Analysis of Synthetic Cannabinoids Using High-Resolution Mass Spectrometry and Mass Defect Filtering: Implications for Nontargeted Screening of Designer Drugs
- (2012) Megan Grabenauer et al. ANALYTICAL CHEMISTRY
- Recent Development in Liquid Chromatography/Mass Spectrometry and Emerging Technologies for Metabolite Identification
- (2012) Yan Liang et al. CURRENT DRUG METABOLISM
- Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates
- (2012) Ben-Quan Shen et al. NATURE BIOTECHNOLOGY
- Application of LC–high-resolution MS with ‘intelligent’ data mining tools for screening reactive drug metabolites
- (2012) Shuguang Ma et al. Bioanalysis
- Recent advances in metabolite identification and quantitative bioanalysis by LC–Q-TOF MS
- (2012) Cen Xie et al. Bioanalysis
- High-resolution mass spectrometry for integrated qualitative and quantitative analysis of pharmaceuticals in biological matrices
- (2011) Gérard Hopfgartner et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Xenobiotic Metabolomics: Major Impact on the Metabolome
- (2011) Caroline H. Johnson et al. Annual Review of Pharmacology and Toxicology
- Drug Metabolite Profiling and Identification by High-resolution Mass Spectrometry
- (2011) Mingshe Zhu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural identification of the metabolites for strictosamide in rats bile by an ion trap-TOF mass spectrometer and mass defect filter technique
- (2011) Yan Liang et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- The resurgence of covalent drugs
- (2011) Juswinder Singh et al. NATURE REVIEWS DRUG DISCOVERY
- Metabolite identification of artemether by data-dependent accurate mass spectrometric analysis using an LTQ-Orbitrap hybrid mass spectrometer in combination with the online hydrogen/deuterium exchange technique
- (2011) Tian Liu et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- High-resolution chromatography/time-of-flight MSE with in silico data mining is an information-rich approach to reactive metabolite screening
- (2011) Joanna E. Barbara et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- From definition to implementation: a cross-industry perspective of past, current and future MIST strategies
- (2011) Angus N.R. Nedderman et al. XENOBIOTICA
- Pooled Sample Strategy in Conjunction with High-Resolution Liquid Chromatography−Mass Spectrometry-Based Background Subtraction to Identify Toxicological Markers in Dogs Treated with Ibipinabant
- (2010) Haiying Zhang et al. ANALYTICAL CHEMISTRY
- Investigation of Bioactivation of Ticlopidine Using Linear Ion Trap/Orbitrap Mass Spectrometry and an Improved Mass Defect Filtering Technique
- (2010) Qian Ruan et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Determination of Exposure Multiples of Human Metabolites for MIST Assessment in Preclinical Safety Species without Using Reference Standards or Radiolabeled Compounds
- (2010) Shuguang Ma et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Xenobiotic Metabolism: A View through the Metabolometer
- (2010) Andrew D. Patterson et al. CHEMICAL RESEARCH IN TOXICOLOGY
- An Accurate-Mass-Based Spectral-Averaging Isotope-Pattern-Filtering Algorithm for Extraction of Drug Metabolites Possessing a Distinct Isotope Pattern from LC-MS Data
- (2009) Peijuan Zhu et al. ANALYTICAL CHEMISTRY
- Integrated strategies for assessment of metabolite exposure in humans during drug development: analytical challenges and clinical development considerations
- (2009) Mingshe Zhu et al. BIOPHARMACEUTICS & DRUG DISPOSITION
- Rapid Detection and Characterization of in Vitro and UrinaryN-Acetyl-l-cysteine Conjugates Using Quadrupole-Linear Ion Trap Mass Spectrometry and Polarity Switching
- (2009) Wenying Jian et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Approaches to the Assessment of Stable and Chemically Reactive Drug Metabolites in Early Clinical Trials
- (2009) Thomas A. Baillie CHEMICAL RESEARCH IN TOXICOLOGY
- Metabolite Identification and Profiling in Drug Design: Current Practice and Future Directions
- (2009) Zhoupeng Zhang et al. CURRENT PHARMACEUTICAL DESIGN
- ADME Optimization and Toxicity Assessment in Early- and Late-Phase Drug Discovery
- (2009) Gary Caldwell et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Metabolic Activation of Nevirapine in Human Liver Microsomes: Dehydrogenation and Inactivation of Cytochrome P450 3A4
- (2009) B. Wen et al. DRUG METABOLISM AND DISPOSITION
- Analytical strategies for the screening and evaluation of chemically reactive drug metabolites
- (2009) Bo Wen et al. Expert Opinion on Drug Metabolism & Toxicology
- Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry
- (2009) Haiying Zhang et al. JOURNAL OF MASS SPECTROMETRY
- Rapid screening and characterization of drug metabolites using multiple ion monitoring dependent product ion scan and postacquisition data mining on a hybrid triple quadrupole-linear ion trap mass spectrometer
- (2009) Ming Yao et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- Generic dealkylation: a tool for increasing the hit-rate of metabolite rationalization, and automatic customization of mass defect filters
- (2009) Russell J. Mortishire-Smith et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- A retention-time-shift-tolerant background subtraction and noise reduction algorithm (BgS-NoRA) for extraction of drug metabolites in liquid chromatography/mass spectrometry data from biological matrices
- (2009) Peijuan Zhu et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- High-Throughput Screening and Characterization of Reactive Metabolites Using Polarity Switching of Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry
- (2008) Bo Wen et al. ANALYTICAL CHEMISTRY
- Unbiased High-Throughput Screening of Reactive Metabolites on the Linear Ion Trap Mass Spectrometer Using Polarity Switch and Mass Tag Triggered Data-Dependent Acquisition
- (2008) Zhengyin Yan et al. ANALYTICAL CHEMISTRY
- Rapid Screening of Glutathione-Trapped Reactive Metabolites by Linear Ion Trap Mass Spectrometry with Isotope Pattern-Dependent Scanning and Postacquisition Data Mining
- (2008) Li Ma et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Comparison of in Vitro Bioactivation of Flutamide and Its Cyano Analogue: Evidence for Reductive Activation by Human NADPH:Cytochrome P450 Reductase
- (2008) Bo Wen et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s
- (2008) Bo Wen et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Recent advances in applications of liquid chromatography–tandem mass spectrometry to the analysis of reactive drug metabolites
- (2008) Shuguang Ma et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Metabolic Stability: Main Enzymes Involved and Best Tools To Assess It
- (2008) Romuald Laine CURRENT DRUG METABOLISM
- Liquid chromatography–mass spectrometry in in vitro drug metabolite screening
- (2008) Ari Tolonen et al. DRUG DISCOVERY TODAY
- Detection of Novel Reactive Metabolites of Trazodone: Evidence for CYP2D6-Mediated Bioactivation of m-Chlorophenylpiperazine
- (2008) B. Wen et al. DRUG METABOLISM AND DISPOSITION
- A Metabolomic Perspective of Melatonin Metabolism in the Mouse
- (2008) Xiaochao Ma et al. ENDOCRINOLOGY
- An algorithm for thorough background subtraction from high-resolution LC/MS data: application for detection of glutathione-trapped reactive metabolites
- (2008) Haiying Zhang et al. JOURNAL OF MASS SPECTROMETRY
- Rapid screening and characterization of drug metabolites using a multiple ion monitoring-dependent MS/MS acquisition method on a hybrid triple quadrupole-linear ion trap mass spectrometer
- (2008) Ming Yao et al. JOURNAL OF MASS SPECTROMETRY
- An algorithm for thorough background subtraction from high-resolution LC/MS data: application to the detection of troglitazone metabolites in rat plasma, bile, and urine
- (2008) Haiying Zhang et al. JOURNAL OF MASS SPECTROMETRY
- Screening and characterization of reactive metabolites using glutathione ethyl ester in combination with Q-trap mass spectrometry
- (2008) Bo Wen et al. JOURNAL OF MASS SPECTROMETRY
- Comprehensive two-dimensional gas chromatography-mass spectrometry: A review
- (2008) Luigi Mondello et al. MASS SPECTROMETRY REVIEWS
- Fractional mass filtering as a means to assess circulating metabolites in early human clinical studies
- (2008) Philip R. Tiller et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- Mass defect profiles of biological matrices and the general applicability of mass defect filtering for metabolite detection
- (2008) Haiying Zhang et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- Dual negative precursor ion scan approach for rapid detection of glutathione conjugates using liquid chromatography/tandem mass spectrometry
- (2008) Mukesh K. Mahajan et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- High-throughput, accurate mass liquid chromatography/tandem mass spectrometry on a quadrupole time-of-flight system as a ‘first-line’ approach for metabolite identification studies
- (2008) Philip R. Tiller et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- Extracting metabolite ions out of a matrix background by combined mass defect, neutral loss and isotope filtration
- (2008) Filip Cuyckens et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- An integrated method for metabolite detection and identification using a linear ion trap/Orbitrap mass spectrometer and multiple data processing techniques: application to indinavir metabolite detection
- (2007) Qian Ruan et al. JOURNAL OF MASS SPECTROMETRY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started