Article
Neurosciences
Guang Han, Xiang Li, Chun-Hsien Wen, Shaogen Wu, Long He, Cynthia Tan, John Nivar, Alex Bekker, Steve Davidson, Yuan-Xiang Tao
Summary: This study investigates the role of Fused in sarcoma (FUS) protein in neuropathic pain. The researchers found that peripheral nerve injury increased the expression of FUS protein in injured dorsal root ganglion (DRG) neurons. Blocking this increase reduced nociceptive hypersensitivities and the levels of certain proteins involved in pain processing. On the other hand, mimicking this increase induced pain-like behaviors and increased pain-related protein levels. Mechanistically, the increased FUS activated the NF-KB signaling pathway. Overall, these findings suggest that DRG FUS contributes to neuropathic pain through the activation of NF-KB in primary sensory neurons.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Xiaoxia Zhang, Linling Li, Gan Huang, Li Zhang, Zhen Liang, Li Shi, Zhiguo Zhang
Summary: This study conducted a multisensory fMRI experiment on 80 healthy participants to investigate nociceptive-specific brain regions, distinguishing between nociceptive-specific regions and nociceptive-preferential regions. The results identified brain regions specifically or preferentially involved in nociceptive sensory input, such as different parts of cortical regions like insula and cingulate gyrus, shedding light on the functional integrations and segregations of nociceptive-related regions.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Pharmacology & Pharmacy
Kazuhide Inoue, Makoto Tsuda
Summary: Chronic pain, especially neuropathic pain, is a significant clinical issue due to the ineffectiveness of available drugs. Research on extracellular ATP and P2 receptors in pain signaling provides insight into the mechanisms underlying chronic pain and potential therapeutic targets.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Mario A. Acuna, Fernando Kasanetz, Paolo De Luna, Marta Falkowska, Thomas Nevian
Summary: The perception of pain is a complex experience and understanding how the brain distinguishes pain from other sensory stimuli has been a challenge. In this study, researchers used calcium imaging in mice to investigate the coding of pain in the anterior cingulate cortex. They found that population activity, rather than single-cell responses, allowed the discrimination of painful stimuli. Additionally, they discovered that chronic neuropathic pain led to changes in sensory processing, which were restored by analgesic treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Computer Science, Interdisciplinary Applications
Yuan Zhou, Sule Tinaz, Hemant D. Tagare
Summary: This study proposes a model for quantifying the heterogeneous progression of Parkinson's disease in DaTscan images, revealing different progression subtypes with varying speeds and trajectories. The model also identifies characteristic spatial progression patterns in the brain, which can serve as markers of disease progression, and the subtypes exhibit different rates of progression in clinical symptoms.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Clinical Neurology
J. Naisby, R. A. Lawson, B. Galna, L. Alcock, D. J. Burn, L. Rochester, A. J. Yarnall
Summary: Pain is a common non-motor symptom in Parkinson's disease, with unexplained pain being prevalent even in early stages. The frequency and type of pain fluctuates as symptoms progress, highlighting the importance of asking PD patients about their pain at clinical consultations and providing support in describing it.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Victor Rossetto Barboza, Gabriel Taricani Kubota, Valquiria Aparecida da Silva, Luciana Mendonca Barbosa, Debora Arnaut, Antonia Lilian de Lima Rodrigues, Ricardo Galhardoni, Rubens Gisbert Cury, Egberto Reis Barbosa, Andre Russowsky Brunoni, Manoel Jacobsen Teixeira, Daniel Ciampi de Andrade
Summary: This study found that Parkinson's disease patients with nociceptive chronic pain may have distinctive somatosensory and corticospinal excitability profiles compared to those with non-nociceptive pain subtypes.
Article
Medicine, General & Internal
G. Pagano, K. I. Taylor, J. Anzures-Cabrera, M. Marchesi, T. Simuni, K. Marek, R. B. Postuma, N. Pavese, F. Stocchi, J. -P. Azulay, B. Mollenhauer, L. Lopez-Manzanares, D. S. Russell, J. T. Boyd, A. P. Nicholas, M. R. Luquin, R. A. Hauser, T. Gasser, W. Poewe, B. Ricci, A. Boulay, A. Vogt, F. G. Boess, J. Dukart, G. D'Urso, R. Finch, S. Zanigni, A. Monnet, N. Pross, A. Hahn, H. Svoboda, M. Britschgi, F. Lipsmeier, E. Volkova-Volkmar, M. Lindemann, S. Dziadek, S. Holiga, D. Rukina, T. Kustermann, G. A. Kerchner, P. Fontoura, D. Umbricht, R. Doody, T. Nikolcheva, A. Bonni
Summary: The study found that prasinezumab had no meaningful effect on global or imaging measures of Parkinson's disease progression and was associated with infusion reactions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Engineering, Biomedical
Sana M. Keloth, Sridhar P. Arjunan, Sanjay Raghav, Dinesh Kant Kumar
Summary: The study found that people with early-stage PD exhibit high asymmetry, reduced modulation, and higher co-activation during walking. They have reduced muscle activity, ability to inhibit antagonist, and modulate their muscle activities, which suggests a potential for diagnosing and regularly assessing gait impairments in PD patients using wearable sensors.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Article
Geriatrics & Gerontology
Yi Xiao, Qianqian Wei, Ruwei Ou, Yanbing Hou, Lingyu Zhang, Kuncheng Liu, Junyu Lin, Tianmi Yang, Qirui Jiang, Huifang Shang
Summary: The study aimed to evaluate the consistency of motor-nonmotor subtypes across five years of follow-up in patients with early-stage Parkinson's disease, and found that many patients experienced changes in their subtypes during the follow-up period.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Frederic Sampedro, Saul Martinez-Horta, Andrea Horta-Barba, Michel J. Grothe, Miguel A. Labrador-Espinosa, Silvia Jesus, Astrid Adarmes-Gomez, Fatima Carrillo, Arnau Puig-Davi, Florinda Roldan-Lora, Miquel Aguilar-Barbera, Pau Pastor, Sonia Escalante Arroyo, Berta Solano Vila, Anna Cots-Foraster, Javier Ruiz-Martinez, Francisco Carrillo-Padilla, Mercedes Pueyo-Morlans, Isabel Gonzalez-Aramburu, Jon Infante-Ceberio, Jorge Hernandez-Vara, Oriol de Fabregues-Boixar, Teresa de Deus Fonticoba, Asuncion Avila, Juan Carlos Martinez-Castrillo, Helena Bejr-Kasem, Antonia Campolongo, Berta Pascual-Sedano, Pablo Martinez-Martin, Diego Santos-Garcia, Pablo Mir, Pedro J. Garcia-Ruiz, Jaime Kulisevsky
Summary: This study explores the neural correlates of reduced facial expression and its relationship with other non-motor symptoms in Parkinson's disease. The severity of hypomimia was found to be closely associated with rigidity and bradykinesia, and significantly related to the severity of apathy. At the neural level, hypomimia was related to several brain regions involved in the recognition and production of facial expressions.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Diego Santos-Garcia, Fonticoba T. De Deus, Bartolome C. Cores, Aymerich L. Valdes, Castro E. Suarez, Angel Aneiros, Silvia Jesus, Miquel Aguilar, Pau Pastor, Lluis Planellas, Marina Cosgaya, Caldente J. Garcia, Nuria Caballol, Ines Legarda, Vara J. Hernandez, Iria Cabo, Manzanares L. Lopez, Aramburu I. Gonzalez, Rivera M. A. Avila, Catalan M. Jose, Victor Nogueira, Victor Puente, Moreno J. M. Garcia, Carmen Borrue, Vila B. Solano, Sauco M. Alvarez, Lydia Vela, Sonia Escalante, Esther Cubo, Padilla F. Carrillo, Castrillo J. C. Martinez, Alonso P. Sanchez, Losada M. G. Alonso, Ariztegui N. Lopez, Itziar Gaston, Jaime Kulisevsky, Estrada M. Blazquez, Manuel Seijo, Martinez J. Ruiz, Caridad Valero, Monica Kurtis, Oriol de Fabregues-Boixar, Ardura J. Gonzalez, Jurczynska C. Prieto, Diaz L. Lopez, Darrian McAfee, Pablo Mir
Summary: This study investigated the frequency of depression, mood related factors, and the contribution of mood to a Parkinson's disease patient's quality of life perception. It found that the impact of mood on QoL perception is greater in patients with longer disease duration.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Clinical Neurology
Massimo Leandri, Giulia Di Stefano, Andrea Truini, Lucio Marinelli
Summary: This study investigated early cortical responses to nociceptive stimulation, confirming the presence of the N40 component possibly conducted by fast A delta fibers. It is the first report of such early responses in humans, with important implications for future experimental and clinical neurophysiology.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Anatomy & Morphology
Xueling Suo, Du Lei, Nannan Li, Wenbin Li, Graham J. Kemp, John A. Sweeney, Rong Peng, Qiyong Gong
Summary: This study found disruptions in the topological organization of GM networks in early-stage PD, suggesting greater segregation of information processing. These findings have potential application in early imaging diagnosis.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Joana Maria dos Santos Alves, Khalil Fernandes Viana, Anamaria Falcao Pereira, Roberto Cesar Pereira Lima Junior, Mariana Lima Vale, Karuza Maria Alves Pereira, Delane Viana Gondim
Summary: The objective of this study was to identify changes in the trigeminal pathway in oral cancer and establish an effective approach to pain control. The results showed that 4-NQO induced macroscopic lesions consistent with neoplastic tumors, and histopathological analysis confirmed the presence of oral squamous cell carcinoma. Changes in nociceptive behavior, as indicated by nociceptive expression scores and increased grooming and exploratory activity, were observed. Alterations in c-Fos expression further supported the findings.
Article
Geriatrics & Gerontology
Chao-Wen Lin, Tzu-Ting Lai, Szu-Ju Chen, Chin-Hsien Lin
Summary: The levels of alpha-synuclein and NfL in tears as well as retinal microvascular densities are associated with the risk and progression of Parkinson's disease.
Article
Clinical Neurology
Ming-Che Kuo, Ying-Che Lu, Chun-Hwei Tai, Bing-Wen Soong, Fu-Chang Hu, Meng-Ling Chen, Chin-Hsien Lin, Ruey-Meei Wu
Summary: This study investigated the integrated effect of genetic and environmental factors on the etiology of multiple system atrophy (MSA). The results showed that certain genetic variations and environmental factors interact to modulate the risk and subtype disposition of MSA. Further investigation is needed to understand the underlying mechanisms of these gene-environment interactions in MSA etiopathogenesis.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Cheng-Hsuan Li, Ta-Fu Chen, Pei-Ling Peng, Chin-Hsien Lin
Summary: Cognitive decline in Parkinson's disease patients is correlated with neuroimaging and plasma biomarkers in specific cognitive domains.
JOURNAL OF NEUROLOGY
(2022)
Review
Medicine, General & Internal
Chin-Hsien Lin, Hsin-Chih Lai, Ming-Shiang Wu
Summary: Neuropathology studies have found that Parkinson's disease may originate in the gut enteric nervous system and spread to the central dopaminergic neurons through the gut-brain axis. The gut microbiomes and metabolites of PD patients have been found to be different from unaffected controls. Targeting the gut microbiota as a potential disease-modifying therapy for PD has been suggested, especially for patients whose disease begins in the gut.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Letter
Clinical Neurology
Pin-Shiuan Chen, Meng-Chen Wu, Chun-Hwei Tai, Yung-Yee Chang, Min-Yu Lan, Ying-Fa Chen, Han- Lin, Ni-Chung Lee, Chin-Hsien Lin
Summary: We investigated 245 Taiwanese patients with dystonia and found no evidence to suggest a link between the inosine monophosphate dehydrogenase gene (IMPDH2) and the disease, suggesting that IMPDH2 may not play a major role in dystonia.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Cheng-Hsuan Li, Ni-Chung Lee, Kun-Ju Lin, Ing-Tsung Hsiao, Yi-Hsin Weng, Chin-Hsien Lin
Summary: This article reported a 49-year-old Taiwanese woman with a three-year history of progressive right-hand dystonia and slowness of gait, who also had a family history of autosomal-dominant parkinsonism. Genetic analysis revealed a pathogenic heterozygous missense variant on exon 10 of the MAPT gene, expanding the phenotypic spectrum of the MAPT p.P301L mutation. Our findings highlighted the heterogeneity of this rare genetic variant and suggested that MAPT mutations should be considered in Asian patients with early-onset or familial CBS.
Article
Clinical Neurology
Yi-Cheng Tai, Peng-Hsiang Liao, Valentina Leta, Chin-Hsien Lin, K. Ray Chaudhuri
Summary: This study investigated the prevalence of functional gastrointestinal disorders in Parkinson's disease (PD) patients and its correlation with the clinical severity of PD. The results showed that constipation and irritable bowel syndrome (IBS) were more common in PD patients than controls. The severity of IBS was associated with non-motor symptom burden, especially mood symptoms, while the severity of constipation was correlated with motor symptom severity.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Huan-Yun Chen, Han- Lin, Chia-Lang Hsu, Pei-Lung Chen, Cheng-Yen Huang, Shu-Chun Teng, Chin-Hsien Lin
Summary: A novel heterozygous mutation in the C19orf12 gene, c273_274 insA (p.P92Tfs*9), was identified in a Taiwanese family with autosomal dominant MPAN. This study provided clinical, genetic, and mechanistic insights into the pathogenesis of MPAN, highlighting the importance of mitochondrial dysfunction.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Sung -Pin Fan, Yih-Chih Kuo, Ni-Chung Lee, Yin-Hsiu Chien, Wuh-Liang Hwu, Yu-Hsuan Huang, Han- Lin, Tai -Chung Tseng, Tung -Hung Su, Shiou-Ru Tzeng, Chien -Ting Hsu, Huey -Ling Chen, Chin-Hsien Lin, Yen-Hsuan Ni
Summary: In this retrospective analysis, the clinical characteristics and long-term outcomes of a large cohort of WD patients were determined. Differences were observed between the neuro-psychiatric group and the hepatic group in terms of presentation, neuroimaging, genetic information, and prognosis. The findings suggest that the clinical characteristics and prognosis of WD are influenced by ethnic differences.
JOURNAL OF MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Priya Jagota, Shen-Yang Lim, Pramod Kumar Pal, Jee-Young Lee, Prashanth Lingappa Kukkle, Shinsuke Fujioka, Huifang Shang, Onanong Phokaewvarangkul, Roongroj Bhidayasiri, Norlinah Mohamed Ibrahim, Yoshikazu Ugawa, Zakiyah Aldaajani, Beomseok Jeon, Cid Diesta, Cholpon Shambetova, Chin-Hsien Lin
Summary: The increasing availability of molecular genetic testing has changed the landscape of both genetic research and clinical practice. These advancements lead to the awareness that some genetic movement disorders may cluster in certain ethnic populations and genetic pleiotropy may result in unique clinical presentations in specific ethnic groups. Recognition of a particular clinical phenotype, combined with information about the ethnic origin of patients could lead to early and correct diagnosis and assist the development of future personalized medicine for patients with these disorders.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Meng-Chen Wu, Yung-Yee Chang, Min-Yu Lan, Ying-Fa Chen, Chun-Hwei Tai, Szu-Ju Chen, Chin-Hsien Lin
Summary: This study aimed to investigate whether plasma NfL levels were elevated and associated with disease severity in patients with dystonia. The results showed that plasma NfL levels were significantly higher in those with generalized dystonia compared to those with focal dystonia or controls, while the level was comparable between the focal dystonia group and controls. Furthermore, the dystonia combined with parkinsonism group had higher NfL levels than the isolated dystonia group. This suggests that neurodegeneration is involved in the disease process of this subgroup of patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Yung-Tsai Chu, Chin-Feng Yu, Sung-Pin Fan, Ta-Fu Chen, Ming-Jang Chiu, Jyh-Shing Roger Jang, Shu- Chiu, Chin-Hsien Lin
Summary: This study found that the size of nigrosome-1 is significantly smaller in PD patients compared to controls. The loss and size of nigrosome-1 may potentially assist in the diagnosis of PD and reflect the motor severity of the disease.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Hsiu-Hui Tsai, Hsiao-Jung Kao, Ming-Wei Kuo, Chin-Hsien Lin, Chun-Min Chang, Yi-Yin Chen, Hsiao-Huei Chen, Pui-Yan Kwok, Alice L. Yu, John Yu
Summary: CRISPR-Cas9 genome editing has potential therapeutic applications, but safety concerns arise. Whole genomic analysis reveals large chromosomal deletions at non-homologous off-target sites, limiting the usefulness of CRISPR-Cas9 editing in disease modeling and gene therapy. Ensuring genome integrity after editing is crucial for minimizing unintended effects in research and clinical applications.
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Szu-Ju Chen, Chin-Hsien Lin
Summary: Parkinson's disease is the second most common neurodegenerative disease, influenced by both genetic risk and environmental factors. While motor dysfunction is the main characteristic, the disease process involves multiple systems and shows heterogenous clinical presentation and progression. Genetic predisposition to Parkinson's disease includes abnormal immune responses, protein aggregation, autophagolysosomal impairment, and mitochondrial dysfunction, leading to vulnerable neurons that are sensitive to environmental triggers. Changes in the gut microenvironment may potentially act as a trigger in genetically susceptible individuals.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Computer Science, Information Systems
Chin-Hsien Lin, Fu-Cheng Wang, Tien-Yun Kuo, Po-Wei Huang, Szu-Fu Chen, Li-Chen Fu
Summary: This study developed neural network models that can identify Parkinson's disease (PD) and differentiate patients at different severity stages. The models achieved high accuracy in recognizing advanced-stage PD patients and distinguishing early-stage PD patients from normal elderly subjects.