Article
Multidisciplinary Sciences
Mariana Borsa, Niculo Barandun, Fabienne Graebnitz, Isabel Barnstorf, Nicolas S. Baumann, Katharina Pallmer, Samira Baumann, Dominique Stark, Miroslav Balaz, Nathalie Oetiker, Franziska Wagen, Christian Wolfrum, Anna Katharina Simon, Nicole Joller, Yves Barral, Roman Spoerri, Annette Oxenius
Summary: Impaired asymmetric cell division in CD8(+) T cells during aging can be rescued by transient mTOR inhibition, restoring expansion and memory potential of cellular progenies. Virtual memory T cells (T-VM cells) in aged individuals display unique proliferation and metabolic profiles, retaining the ability to divide asymmetrically and having increased memory potential.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Brandilyn A. Peters, Lila A. Sheira, David B. Hanna, Qibin Qi, Anjali Sharma, Adebola Adedimeji, Tracey Wilson, Daniel Merenstein, Phyllis C. Tien, Mardge Cohen, Eryka L. Wentz, Jennifer Kinslow, Alan L. Landay, Sheri D. Weiser
Summary: Food insecurity is associated with increased immune activation, senescence, and decreased co-stimulation in women with HIV on antiretroviral therapy. The relationship remains significant regardless of HIV viral load control status. Reducing food insecurity may be crucial in decreasing non-AIDS-related disease risk in this population.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, Research & Experimental
Cara E. Porsche, Jennifer B. Delproposto, Lynn Geletka, Robert O'Rourke, Carey N. Lumeng
Summary: Obese visceral white adipose tissue ATTs exhibited impaired inflammatory characteristics upon stimulation, potentially influenced by both environmental and cell-intrinsic factors, suggesting functional abnormalities in obesity-induced ATTs.
Review
Immunology
Quentin Le Hingrat, Irini Sereti, Alan L. Landay, Ivona Pandrea, Cristian Apetrei
Summary: CD4(+) T-cell depletion is a key feature of AIDS in both HIV and SIV infections, occurring early and being most significant at mucosal sites. The clinical outcome is associated with mucosal CD4(+) T-cell recovery during chronic infection, while immune activation and inflammation play critical roles in CD4(+) T-cell depletion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Julie Lajoie, Monika M. Kowatsch, Lucy W. Mwangi, Genevieve Boily-Larouche, Julius Oyugi, Yufei Chen, Makobu Kimani, Emmanuel A. Ho, Joshua Kimani, Keith R. Fowke
Summary: The study reveals that the use of ASA impacts the immune response in both systemic and genital tract compartments, with higher concentrations of ASA in the blood compared to the female genital tract. ASA use in the blood was inversely correlated with certain T cell expressions, while at the genital tract, it correlated with a decrease in activated CD4(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Lucy Kundura, Renaud Cezar, Manuela Pastore, Christelle Reynes, Jeremy Deverdun, Emmanuelle Le Bars, Albert Sotto, Jacques Reynes, Alain Makinson, Pierre Corbeau
Summary: HIV infection is associated with immune activation markers that correlate with neurocognitive impairment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Mengyan Li, Scott J. Garforth, Kaitlyn E. O'Connor, Hang Su, Danica M. Lee, Alev Celikgil, Rodolfo J. Chaparro, Ronald D. Seidel, R. Brad Jones, Ravit Arav-Boger, Steven C. Almo, Harris Goldstein
Summary: In this study, synTacs were used to expand highly functional HIV- and CMV-specific CD8(+) T cells, which showed potent antiviral activities in vivo. The results suggest that synTac-based approaches could be a promising therapeutic strategy for HIV cure and treatment of CMV and other viral infections.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Hematology
Masahiro Chiba, Joji Shimono, Takashi Ishio, Norio Takei, Kohei Kasahara, Reiki Ogasawara, Takahide Ara, Hideki Goto, Koh Izumiyama, Satoko Otsuguro, Liyanage P. Perera, Hiroo Hasegawa, Michiyuki Maeda, Satoshi Hashino, Katsumi Maenaka, Takanori Teshima, Thomas A. Waldmann, Yibin Yang, Masao Nakagawa
Summary: Adult T-cell leukemia/lymphoma (ATLL) is an aggressive peripheral T-cell neoplasm with poor prognosis. This study reveals that CD48 expression in ATLL cells determines the sensitivity for NK-cell-mediated cytotoxicity against ATLL cells, suggesting CD48 as a potential molecular biomarker in NK-cell-associated immunotherapies.
Article
Infectious Diseases
Javier Martinez-Sanz, Sergio Serrano-Villar, Maria Jesus Vivancos, Rafael Rubio, Santiago Moreno
Summary: Modern ART has successfully achieved HIV RNA suppression and reduced drug-related toxicities. The main health concerns for HIV-positive individuals in high-income settings are now non-HIV related diseases. These comorbidities, common in the general population but with unique features in HIV patients, present a significant challenge in managing and normalizing the health of PLWH. In this study, HIV specialists review the literature and discuss the major challenges in HIV-associated comorbidities, providing insights and future strategies.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Review
Cell Biology
Sepiso K. Masenga, Bislom C. Mweene, Emmanuel Luwaya, Lweendo Muchaili, Makondo Chona, Annet Kirabo
Summary: The development of antiretroviral drugs (ARVs) is a significant achievement in managing HIV infections by suppressing viral activity and extending lifespan. However, the success of HIV in evading the immune system has hindered the discovery of an effective treatment for four decades. Understanding the molecular interaction between HIV and host cells is crucial for developing preventive and curative therapies. This review highlights the inherent mechanisms of HIV, such as targeting CD4(+) lymphocytes, downregulating MHC class I and II, antigenic variation, and minimizing antibody access, which collectively render the immune system ineffective.
Review
Immunology
Julia Campe, Evelyn Ullrich
Summary: Allogenic hematopoietic stem cell transplantation is a potent treatment for hematologic disorders, but can also lead to graft-versus-host disease. CD4 T cell subtypes and transcription factor inhibitors play an important role in the pathogenesis and regulation of acute graft-versus-host disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Leidan Zhang, Yuqing Wei, Di Wang, Juan Du, Xinyue Wang, Bei Li, Meiqing Jiang, Mengyuan Zhang, Na Chen, Meiju Deng, Chuan Song, Danying Chen, Liang Wu, Jiang Xiao, Hongyuan Liang, Hongxin Zhao, Yaxian Kong
Summary: Persistent immune activation plays a crucial role in CD4(+) T cell depletion and AIDS progression during HIV infection. Foxp3(+) DNT cells accumulate in untreated HIV-infected individuals and are correlated with CD4(+) T cell count, immune activation, and systemic inflammation. These findings suggest that Foxp3(+) DNT cells may serve as a potential target for controlling immune activation during HIV infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Cheleka A. M. Mpande, Virginie Rozot, Boitumelo Mosito, Munyaradzi Musvosvi, One B. Dintwe, Nicole Bilek, Mark Hatherill, Thomas J. Scriba, Elisa Nemes
Summary: Recent M.tb infection is associated with highly activated and moderately differentiated functional M.tb-specific T cell subsets, which can be used as biomarkers to distinguish recent from remote infection. This study provides new insights into the immunobiology of M.tb infection and potential diagnostic tools.
Article
Virology
Maria Carolina Dos Santos Guedes, Wlisses Henrique Veloso Carvalho-Silva, Jose Leandro Andrade-Santos, Maria Carolina Accioly Brelaz-de-Castro, Fabricio Oliveira Souto, Rafael Lima Guimaraes
Summary: The mechanisms causing impaired immunological recovery in HIV-positive patients receiving antiretroviral therapy (ART) have not been fully understood yet. A study was conducted on 44 ART-treated HIV-positive patients to analyze T-lymphocytes immunophenotyping and cytokines levels. The patients were classified as immunological non-responders (INR) and immunological responders (IR) based on their CD4+ T cell levels. The study found that thymic exhaustion and increased immune activation are two significant mechanisms contributing to the impaired immune recovery in ART-treated HIV patients.
Article
Immunology
Laureline Roger, Kelly Miners, Louise Leonard, Julia Grimstead, David Price, Duncan Baird, Kristin Ladell
Summary: This study used specific markers to separate different subsets of CD8+ memory T cells and measured their telomere lengths. The expression of CD45RA was found to be positively correlated with telomere length, while there was a disconnect between replicative history and cellular differentiation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Boun Kim Tan, Mathieu Chalouni, Dominique Salmon Ceron, Alexandre Cinaud, Laure Esterle, Marc Arthur Loko, Christine Katlama, Isabelle Poizot-Martin, Didier Neau, Julie Chas, Philippe Morlat, Eric Rosenthal, Karine Lacombe, Alissa Naqvi, Karl Barange, Olivier Bouchaud, Anne Gervais, Caroline Lascoux-Combe, Daniel Garipuy, Laurent Alric, Cecile Goujard, Patrick Miailhes, Hugues Aumaitre, Claudine Duvivier, Anne Simon, Jose-Luis Lopez-Zaragoza, David Zucman, Francois Raffi, Estibaliz Lazaro, David Rey, Lionel Piroth, Francois Boue, Camille Gilbert, Firouze Bani-Sadr, Francois Dabis, Philippe Sogni', Linda Wittkop, Franck Boccara
Summary: HIV-HCV coinfected patients have a high incidence of ASCVD events, with traditional cardiovascular risk factors playing a significant role. Controlling cholesterol abnormalities and maintaining undetectable HIV RNA levels are essential in reducing cardiovascular risk.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Gastroenterology & Hepatology
Mathieu Chalouni, Stanislas Pol, Philippe Sogni, Helene Fontaine, Karine Lacombe, Jean Marc-Lacombe, Laure Esterle, Celine Dorival, Marc Bourliere, Firouze Bani-Sadr, Victor de Ledinghen, David Zucman, Dominique Larrey, Dominique Salmon, Fabrice Carrat, Linda Wittkop
Summary: The study showed that after DAA treatment, individuals coinfected with HIV/HCV had similar SVR rates and risks of liver-related deaths and events compared to those infected with HCV alone, but had a higher risk of all-cause deaths, non-liver-related deaths, and non-liver-related cancers.
JOURNAL OF HEPATOLOGY
(2021)
Review
Geriatrics & Gerontology
Virgilio Hernandez-Ruiz, Emmanuel Forestier, Gaetan Gavazzi, Tristan Ferry, Nicolas Gregoire, Dominique Breilh, Marc Paccalin, Sylvain Goutelle, Claire Roubaud-Baudron
Summary: Some studies suggest that the subcutaneous route could be an alternative to intravenous administration of antibiotics, particularly for time dependent antibiotics and certain patient populations. However, clinical evidence regarding the benefits and risks of subcutaneous antibiotic administration is still scarce and of low level. Further clinical studies are needed to assess the pharmacokinetic/pharmacodynamic properties of subcutaneous antibiotic administration.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Immunology
N. Legrand, G. David, A. Rodallec, A. Gaultier, D. Salmon, A. Cesbron, L. Wittkop, F. Raffi, K. Gendzekhadze, C. Retiere, C. Allavena, K. Gagne
Summary: The genetic combinations of KIR/HLA affect the clearance and chronic infection conditions of NK and T cells in HIV-HCV co-infected individuals, with European subjects with spontaneous clearance characterized by specific KIR/HLA genetic features.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Infectious Diseases
Eva Teruel, Marie-Anne Vandenhende, Didier Neau, Estibaliz Lazaro, Pierre Duffau, Marc-Olivier Vareil, Charles Cazanave, Adelaide Perrier, Fabien le Marec, Olivier Leleux, Fabrice Bonnet, Linda Wittkop
Summary: The study aimed to evaluate the effect of statin use on the occurrence of severe bacterial infections in people living with HIV. The results showed no effect of statins on the risk of developing severe bacterial infections or pneumonia.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Infectious Diseases
Tangui Barre, Teresa Rojas Rojas, Karine Lacombe, Camelia Protopopescu, Isabelle Poizot-Martin, Marie Liberee Nishimwe, David Zucman, Laure Esterle, Eric Billaud, Hugues Aumaitre, Olivier Bouchaud, David Rey, Lionel Piroth, Dominique Salmon-Ceron, Linda Wittkop, Philippe Sogni, Maria Patrizia Carrieri, Lawrence Serfaty, Fabienne Marcellin
Summary: The study suggests that regular or daily cannabis use is associated with a reduced risk of elevated fatty liver index (FLI) in HIV-HCV co-infected patients.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Article
Gastroenterology & Hepatology
Francis Megraud, Robin Bruyndonckx, Samuel Coenen, Linda Wittkop, Te-Din Huang, Martin Hoebeke, Lucie Benejat, Philippe Lehours, Herman Goossens, Youri Glupczynski
Summary: The study confirmed a positive correlation between macrolide and quinolone consumption in the community and corresponding H. pylori resistance in European countries. Therefore, treatment of H. pylori with clarithromycin and levofloxacin should involve susceptibility testing in most European countries before starting the treatment.
Article
Virology
Caroline Passaes, Heloise M. Delagreverie, Veronique Avettand-Fenoel, Annie David, Valerie Monceaux, Asma Essat, Michaela Mueller-Trutwin, Darragh Duffy, Nathalie De Castro, Linda Wittkop, Christine Rouzioux, Jean-Michel Molina, Laurence Meyer, Constance Delaugerre, Asier Saez-Cirion
Summary: This study evaluated the feasibility of using ultra-sensitive protein detection technologies to quantify p24 in plasma samples from people with HIV-1 infection. The results showed that ultra-sensitive p24 levels correlated with HIV RNA, DNA, and CD4(+) T cells, and provided an effective means of monitoring p24 during antiretroviral treatment.
JOURNAL OF VIROLOGY
(2021)
Letter
Biochemistry & Molecular Biology
Paul Loubet, Linda Wittkop, Eric Tartour, Beatrice Parfait, Benoit Barrou, Jean-Yves Blay, Maryvonne Hourmant, Marie Lachatre, David-Axel Laplaud, Martine Laville, Bruno Laviolle, Jean-Daniel Lelievre, Jacques Morel, Stephanie Nguyen, Jean-Philippe Spano, Benjamin Terrier, Anne Thiebaut, Jean-Francois Viallard, Francois Vrtovsnik, Xavier de Lamballerie, Odile Launay
Article
Immunology
Helene Chaussade, Fabien Le Marec, Gaelle Coureau, Olivier Leleux, Didier Neau, Estibaliz Lazaro, Brice Amadeo, Pierre Duffau, Helene Ferrand, Carine Courtault, Anne-Sophie Foucan, Linda Wittkop, Fabrice Bonnet
Summary: The objective of this study was to compare the incidence oflung and human papilloma virus (HPV)-related cancers between patients with HIV and the general population. The results showed that despite the advent of antiretroviral therapies, patients with HIV still have a higher risk of lung and HPV-related cancers, especially in the age group of 40-49 years.
Review
Infectious Diseases
Simon Galmiche, Liem Binh Luong Nguyen, Eric Tartour, Xavier de Lamballerie, Linda Wittkop, Paul Loubet, Odile Launay
Summary: This article systematically reviews the immunogenicity, efficacy, and effectiveness of COVID-19 vaccines in immunocompromised populations. The results highlight the risk of low immunogenicity in solid organ transplant recipients and patients with hematological malignancy. Enhanced vaccine regimens may be necessary despite the lack of vaccine effectiveness data.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Infectious Diseases
Elsa Nyamankolly, Pantxika Bellecave, Linda Wittkop, Fabien Le Marec, Pierre Duffau, Estibaliz Lazaro, Marc-Olivier Vareil, Camille Tumiotto, Mojgan Hessamfar, Charles Cazanave, Adelaide Perrier, Olivier Leleux, Fabrice Bonnet, Didier Neau
Summary: The efficacy of the TRIO regimen in treatment-experienced HIV-1 patients was evaluated in this study. The proportion of patients experiencing virological failure at Week 24 was described, and baseline plasma viral load and genotypic susceptibility score were found to be associated with virological failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Editorial Material
Gastroenterology & Hepatology
Linda Wittkop, Tobias Boettler
Article
Immunology
Fabienne Caby, Marguerite Guiguet, Laurence Weiss, Alan Winston, Jose M. Miro, Deborah Konopnicki, Vincent Le Moing, Fabrice Bonnet, Peter Reiss, Cristina Mussini, Isabelle Poizot-Martin, Ninon Taylor, Athanasios Skoutelis, Laurence Meyer, Cecile Goujard, Barbara Bartmeyer, Christoph Boesecke, Andrea Antinori, Eugenia Quiros-Roldan, Linda Wittkop, Casper Frederiksen, Antonella Castagna, Maria Christine Thurnheer, Veronica Svedhem, Sophie Jose, Dominique Costagliola, Murielle Mary-Krause, Sophie Grabar
Summary: The study found that in people living with HIV who were efficiently treated with combination antiretroviral therapy, a low CD4/CD8 ratio and high CD8 count were associated with an increased risk of Kaposi sarcoma and non-Hodgkin lymphoma. This association was particularly prominent in patients with a CD4 count greater than or equal to 500/mm3.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Tangui Barre, Patrick Mercie, Fabienne Marcellin, Laure Esterle, Claudine Duvivier, Elina Teicher, Morgane Bureau, Julie Chas, Dominique Salmon-Ceron, Philippe Sogni, Maria Patrizia Carrieri, Linda Wittkop, Camelia Protopopescu
Summary: Tobacco smoking is highly prevalent among patients co-infected with HIV and hepatitis C virus (HCV). HCV cure is associated with increased chances of tobacco smoking quit attempts (TSQA) in HIV-HCV co-infected patients, while cannabis use is linked with decreased chances of TSQA. Therefore, screening for smoking and cannabis use, as well as providing comprehensive counseling and referral to addiction services, is important for these patients.
