Article
Agriculture, Dairy & Animal Science
Ling Yang, Zimo Zhao, Maosheng Cui, Leying Zhang, Qianjun Li
Summary: Heat stress negatively affects the quality and in vitro maturation of oocytes, but melatonin treatment can counteract these effects and reduce damage. Heat stress alters gene expression, while melatonin can partially restore this effect.
Article
Cell Biology
Elisa Mariano Pioltine, Camila Bortoliero Costa, Lais Barbosa Latorraca, Fernanda Fagali Franchi, Priscila Helena dos Santos, Gisele Zoccal Mingoti, Fabiola Freitas de Paula-Lopes, Marcelo Fabio Gouveia Nogueira
Summary: The study showed that adding 200μM of TUDCA to IVM medium reduced ROS production and increased the abundance of transcripts related to antioxidant activity in oocytes and embryos. However, a high concentration of TUDCA (1,000μM) was toxic to oocytes, decreasing nuclear maturation rate, mitochondrial activity, and increasing ER stress and cellular apoptosis related transcripts. Treatment with 200μM of TUDCA was associated with greater resistance to oxidative stress and indirectly with ER stress relief in bovine oocytes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sanaz Dastghaib, P. Sravan Kumar, Sajjad Aftabi, Gautam Damera, Azadeh Dalvand, Adel Sepanjnia, Mohammad Kiumarsi, Mohamad-Reza Aghanoori, Sukhwinder Singh Sohal, Sudharsana R. Ande, Javad Alizadeh, Pooneh Mokarram, Saeid Ghavami, Pawan Sharma, Amir A. Zeki
Summary: Lung cells are exposed to internal and external stressors, leading to disruption of protein homeostasis and activation of the UPR. Dysregulation of the UPR is associated with disease development and various human conditions. Compounds targeting the UPR pathway show potential for future therapeutic interventions.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Cell Biology
Sicong Yu, Lepeng Gao, Chang Zhang, Yumeng Wang, Hainan Lan, Qianran Chu, Suo Li, Xin Zheng
Summary: This study demonstrated that glycine can improve ER stress induced by TG treatment and enhance oocyte quality and developmental potential by regulating intracellular calcium levels, mitochondrial function, and ER stress response pathways. Glycine supplementation alleviated ER stress, reduced ROS levels, maintained mitochondrial function, and restored calcium equilibrium in porcine oocytes exposed to ER stress inducers. Glycine also modulated apoptosis-related factors and gene expression, suggesting its potential for enhancing oocyte maturation in vitro.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Toxicology
Min-Ah Gwon, Min Ju Kim, Hyo-Gu Kang, Ye Eun Joo, Se-Been Jeon, Pil-Soo Jeong, Sun-Uk Kim, Bo-Woong Sim, Deog-Bon Koo, Bong-Seok Song
Summary: This study investigated the effect of Cd exposure on porcine oocyte maturation and found that it inhibited cumulus cell expansion and meiotic maturation, increased oocyte degeneration, and induced ER stress. Cd-induced ER stress impaired oocyte quality by disrupting mitochondrial function and elevating intracellular reactive oxygen species levels while decreasing ER function. However, supplementation with TUDCA significantly decreased the expression of ER stress-related genes and increased the quantity of ER, rescuing excessive levels of ROS and restoring normal mitochondrial function. Additionally, TUDCA greatly ameliorated Cd-mediated detrimental effects on meiotic maturation and oocyte quality.
TOXICOLOGY IN VITRO
(2023)
Article
Agriculture, Dairy & Animal Science
Chunhua Xing, Shun Chen, Yue Wang, Zhennan Pan, Yuanjing Zou, Shaochen Sun, Zili Ren, Yu Zhang
Summary: Exposure to glyphosate disrupts porcine oocyte maturation by affecting gene expression and organelle functions, such as mitochondrial distribution, ER stress, lysosome function, Golgi apparatus distribution, and ribosome function.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Muhammad Rosyid Ridlo, Geon A. Kim, Anukul Taweechaipaisankul, Eui Hyun Kim, Byeong Chun Lee
Summary: Research showed that zinc supplementation during in vitro maturation can alleviate ER stress, improve nuclear maturation of oocytes, and enhance normal embryonic development.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Seul-Gi Yang, Seung-Yeon Joe, Jin-Wook Bae, Gyeong-Deok Heo, Hyo-Jin Park, Deog-Bon Koo
Summary: The study found a close relationship between mitochondrial function and oocyte maturation in pigs, with melatonin being able to rehabilitate meiotic maturation disrupted by Mdivi-1. Melatonin also has direct beneficial effects on meiotic maturation through tubulin formation factors during porcine oocyte maturation, reducing DNA damage and improving spindle assembly.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Genetics & Heredity
Xin Kang, Jing Wang, Liying Yan
Summary: The storage and release of calcium ions in oocyte maturation and fertilization are important functions of the endoplasmic reticulum (ER). The ER, composed of rough ER, smooth ER, and nuclear envelope, plays a crucial role in protein synthesis, transport and folding, and lipid and steroid synthesis. This review summarizes the functions, structures, interactions with other organelles, and spatiotemporal localization of the ER in mammalian oocytes. It also discusses the mechanisms of maintaining ER homeostasis and its relevance to assisted reproductive technology (ART) research.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Yeong-Min Yoo, Seong Soo Joo
Summary: As people age, their risks of developing degenerative diseases such as cancer, diabetes, Parkinson's Disease (PD), Alzheimer's Disease (AD), rheumatoid arthritis, and osteoporosis increase. Neurodegenerative diseases are recognized as the leading cause of affliction in the elderly worldwide. Research suggests that endoplasmic reticulum (ER) stress is associated with some neurological diseases like PD and AD. Melatonin, a hormone synthesized in the pineal gland, has various biological functions including circadian rhythm control, immune enhancement, and antioxidant, anti-aging, and anti-tumor effects. This paper aims to summarize the effects of melatonin on neurons and neurodegenerative diseases related to ER stress, highlighting its role in protecting neurons and treating neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yu-Shen Luo, Quan-Kuo He, Ming-Xin Sun, Feng-Xin Qiao, Yue-Cen Liu, Chang-Long Xu, Zhi-Ran Xu, Si-Cheng Zhao, Hai-Long Wang, Zhong-Quan Qi, Yu Liu
Summary: Acrylonitrile treatment disrupts ovarian homeostasis, leading to impaired follicular development and reduced offspring. This is associated with inflammation, apoptosis, DNA damage, oxidative stress, endoplasmic reticulum abnormalities, and lysosomal aggregation caused by acrylonitrile exposure.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Medicinal
Samira Aouichat, Miguel Navarro-Alarcon, Pablo Alarcon-Guijo, Diego Salagre, Marwa Ncir, Lazhar Zourgui, Ahmad Agil
Summary: The study demonstrated that melatonin can play a renoprotective role by suppressing ER stress and the pro-apoptotic IRE1α/JNK signaling pathway.
Review
Biochemistry & Molecular Biology
Gideon Ong, Susan E. Logue
Summary: Oxidative stress is caused by an imbalance in cellular redox state due to the accumulation of reactive oxygen species (ROS). It can lead to negative effects such as damage to biological macromolecules and disruption of organelle function. The unfolded protein response (UPR), a stress response initiated by cells to combat endoplasmic reticulum (ER) stress, is well characterized, but its response and influence on oxidative stress are less defined. This review evaluates the interplay between oxidative stress, ER stress, and UPR signaling networks, particularly focusing on how UPR signaling mediators can influence antioxidant responses.
Article
Environmental Sciences
Senlin Li, Renjie Wang, Zhaolai Dai, Chao Wang, Zhenlong Wu
Summary: The study found that adding Yucca schidigera extract significantly alleviated the growth arrest, intestinal dysfunction, and oxidative damage caused by heat stress in tilapia. This effect may be related to the regulation of the ubiquitin-proteasome system and inflammatory factors by Yucca supplementation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Jing-Tao Sun, Jin-Dong Yuan, Qi Zhang, Xin Luo, Xin-Yue Qi, Jia-Hui Liu, Xi-Qing Jiang, Sanghoon Lee, Anukul Taweechaipaisankul, Zhong-Hua Liu, Jun-Xue Jin
Summary: This study demonstrates that supplementation of 10(-11) M ramelteon during in vitro maturation (IVM) can significantly improve oocyte maturation and subsequent embryo development in pigs by reducing oxidative stress and maintaining lipid homeostasis.