Unfolding the Interactions between Endoplasmic Reticulum Stress and Oxidative Stress

Activation of the UPR sensor ATF6α is regulated by its redox-dependent dimerization and ER retention by ERp18

(2022) Ojore Benedict Valentine Oka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer

(2022) Aitor Almanza et al.   Nature Communications

IP3R1/GRP75/VDAC1 complex mediates endoplasmic reticulum stress-mitochondrial oxidative stress in diabetic atrial remodeling

(2022) Ming Yuan et al.   Redox Biology

The endoplasmic reticulum kinase PERK interacts with the oxidoreductase ERO1 to metabolically adapt mitochondria

(2022) Arthur Bassot et al.   Cell Reports

Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis

(2021) Alina Küper et al.   Cell Death & Disease

The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling

(2021) Kashi Raj Bhattarai et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Heat Shock Proteins in Oxidative Stress and Ischemia/Reperfusion Injury and Benefits from Physical Exercises: A Review to the Current Knowledge

(2021) Jakub Szyller et al.   Oxidative Medicine and Cellular Longevity

CYP2E1 in Alcoholic and Non-Alcoholic Liver Injury. Roles of ROS, Reactive Intermediates and Lipid Overload

(2021) Riina Harjumäki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of the eIF2α/ATF4 axis drives triple-negative breast cancer radioresistance by promoting glutathione biosynthesis

(2021) Xupeng Bai et al.   Redox Biology

ATF4-Dependent NRF2 Transcriptional Regulation Promotes Antioxidant Protection during Endoplasmic Reticulum Stress

(2020) Carmen Sarcinelli et al.   Cancers

Roles of Autophagy in Oxidative Stress

(2020) Hyeong Rok Yun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells

(2020) Monica Pibiri et al.   Scientific Reports

Up-regulation of PERK/Nrf2/HO-1 axis protects myocardial tissues of mice from damage triggered by ischemia-reperfusion through ameliorating endoplasmic reticulum stress

(2020) Jichun Wang et al.   Cardiovascular Diagnosis and Therapy

Modulation of CYP2C9 activity and hydrogen peroxide production by cytochrome b5

(2020) Javier Gómez-Tabales et al.   Scientific Reports

Regulation of the unfolded protein response in yeast by oxidative stress

(2019) Angel Guerra‐Moreno et al.   FEBS LETTERS

Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1

(2019) Takafumi Suzuki et al.   Cell Reports

Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications

(2019) Doyoung Kwon et al.   Acta Pharmaceutica Sinica B

Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate

(2018) Tsun-Kai Chang et al.   MOLECULAR CELL

XBP1-KLF9 Axis Acts as a Molecular Rheostat to Control the Transition from Adaptive to Cytotoxic Unfolded Protein Response

(2018) Emily E. Fink et al.   Cell Reports

Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells

(2017) Jui-Hung Yen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the HeartNovelty and Significance

(2016) Jung-Kang Jin et al.   CIRCULATION RESEARCH

Thapsigargin induces apoptosis when autophagy is inhibited in HepG2 cells and both processes are regulated by ROS-dependent pathway

(2016) Congcong Wang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

PDIA6 regulates insulin secretion by selectively inhibiting the RIDD activity of IRE1

(2016) Daniela Eletto et al.   FASEB JOURNAL

The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome

(2016) Sandra Reeg et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response

(2016) John M. Hourihan et al.   MOLECULAR CELL

The endoplasmic reticulum: structure, function and response to cellular signaling

(2015) Dianne S. Schwarz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ERO1-independent production of H2O2within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding

(2015) Tasuku Konno et al.   JOURNAL OF CELL BIOLOGY

Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease

(2014) Stewart Siyan Cao et al.   ANTIOXIDANTS & REDOX SIGNALING

Endoplasmic reticulum stress in insulin resistance and diabetes

(2014) Agustin Guerrero-Hernández et al.   CELL CALCIUM

GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum

(2014) Thomas Ramming et al.   FREE RADICAL BIOLOGY AND MEDICINE

Unspliced X-box-binding Protein 1 (XBP1) Protects Endothelial Cells from Oxidative Stress through Interaction with Histone Deacetylase 3

(2014) Daniel Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrf2- and ATF4-Dependent Upregulation of xCT Modulates the Sensitivity of T24 Bladder Carcinoma Cells to Proteasome Inhibition

(2014) P. Ye et al.   MOLECULAR AND CELLULAR BIOLOGY

A Synthetic Biology Approach Identifies the Mammalian UPR RNA Ligase RtcB

(2014) Yanyan Lu et al.   MOLECULAR CELL

Nrf2 Amplifies Oxidative Stress via Induction of Klf9

(2014) Shoshanna N. Zucker et al.   MOLECULAR CELL

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

(2014) M. Lu et al.   SCIENCE

Physiological roles of regulated Ire1 dependent decay

(2014) Dina S. Coelho et al.   Frontiers in Genetics

Glutathione Peroxidase 7 Utilizes Hydrogen Peroxide Generated by Ero1α to Promote Oxidative Protein Folding

(2013) Lei Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein kinase RNA- like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)- mediated endoplasmic reticulum stress- induced apoptosis in diabetic cardiomyopathy

(2013) Zhong-Wei Liu et al.   Cardiovascular Diabetology

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

Vitamin K epoxide reductase contributes to protein disulfide formation and redox homeostasis within the endoplasmic reticulum

(2012) Lori A. Rutkevich et al.   MOLECULAR BIOLOGY OF THE CELL

The ER stress transducer IRE1β is required for airway epithelial mucin production

(2012) M B Martino et al.   Mucosal Immunology

Activation of ER stress and apoptosis by hydrogen peroxide in HeLa cells: Protective role of mild heat preconditioning at 40°C

(2011) Pragathi Pallepati et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Different consequences of reactions with hydrogen peroxide and t-butyl hydroperoxide in the hyperoxidative inactivation of rat peroxiredoxin-4

(2011) Y. Ikeda et al.   JOURNAL OF BIOCHEMISTRY

Regulation of the Nrf2–Keap1 Antioxidant Response by the Ubiquitin Proteasome System: An Insight into Cullin-Ring Ubiquitin Ligases

(2010) Nicole F. Villeneuve et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative Protein Folding and the Quiescin–Sulfhydryl Oxidase Family of Flavoproteins

(2010) Vamsi K. Kodali et al.   ANTIOXIDANTS & REDOX SIGNALING

A structural overview of the PDI family of proteins

(2010) Guennadi Kozlov et al.   FEBS Journal

Emerging Roles for XBP1, a sUPeR Transcription Factor

(2010) YIN HE et al.   GENE EXPRESSION

Identification of a consensus element recognized and cleaved by IRE1α

(2010) Daisuke Oikawa et al.   NUCLEIC ACIDS RESEARCH

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

(2010) E Bobrovnikova-Marjon et al.   ONCOGENE

Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners

(2010) S. Schulman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms and Implications of Reactive Oxygen Species Generation During the Unfolded Protein Response: Roles of Endoplasmic Reticulum Oxidoreductases, Mitochondrial Electron Transport, and NADPH Oxidase

(2009) Célio X.C. Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

Preventing oxidative stress: a new role for XBP1

(2009) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum

(2008) Yusuke Adachi et al.   CELL STRUCTURE AND FUNCTION

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE