Article
Physiology
Yu Xu, Xuejie Fei, Hangjiang Fu, Aidong Chen, Xinrui Zhu, Feng Zhang, Ying Han
Summary: This study aimed to determine the roles of salusin-beta in the paraventricular nucleus (PVN) in modulating enhanced cardiac sympathetic afferent reflex (CSAR) and sympathetic hyperactivation in rats with chronic heart failure (CHF). The results showed that salusin-beta expression in the PVN was upregulated in CHF rats, and the injection of salusin-beta into the PVN increased blood pressure, renal sympathetic nerve activity, and CSAR. In addition, the use of anti-salusin-beta IgG produced opposite effects.
Article
Medicine, General & Internal
Takahiro Doi, Tomoaki Nakata, Takahiro Noto, Tomohiro Mita, Daigo Nagahara, Satoshi Yuda, Akiyoshi Hashimoto
Summary: This study analyzed the relationship between left ventricular mechanical dyssynchrony, left ventricular hypertrophy, cardiac sympathetic innervation, and lethal cardiac events in heart failure patients. The results showed that patients with greater phase SD, greater LVMI, and lower MIBG HMR were more likely to experience lethal cardiac events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Marc W. Heidorn, Stefanie Steck, Felix Mueller, Sven-Oliver Troebs, Gregor Buch, Andreas Schulz, Soeren Schwuchow-Thonke, Alexander Schuch, Konstantin Strauch, Irene Schmidtmann, Karl J. Lackner, Tommaso Gori, Thomas Muenzel, Philipp S. Wild, Jurgen H. Prochaska
Summary: This study aimed to investigate the relationship between pulmonary function and the progression of chronic heart failure (HF). The findings showed that FEV1 was independently associated with deteriorated left ventricle function and hypertrophy, and it was a strong predictor of worsening of HF.
Review
Cell Biology
Zhanhao Su, Yiwei Liu, Hao Zhang
Summary: Chronic hypoxia plays a crucial role in many cardiac diseases, affecting the heart's metabolic processes. However, the exact mechanisms of adaptive cardiac metabolism in response to chronic hypoxia are still not fully understood. New findings from animal and human studies are summarized to illustrate these mechanisms and potential treatment strategies in patients with chronic hypoxia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Mark B. B. Badrov, Daniel A. A. Keir, George Tomlinson, Catherine F. F. Notarius, Philip J. J. Millar, Derek S. S. Kimmerly, J. Kevin Shoemaker, Evan Keys, John S. S. Floras
Summary: This study compared patients with heart failure and healthy controls to identify factors that contribute to augmented muscle sympathetic nerve activity. The results showed that in heart failure patients, muscle sympathetic nerve activity was proportional to heart rate and body mass index, but not related to age, blood pressure, or drug therapy. This study has important implications for personalized therapy.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Zhiqiu Xia, Neetha Nanoth Vellichirammal, Li Han, Lie Gao, Erika Boesen, Alicia M. Schiller, Peter R. Pellegrino, Steven J. Lisco, Chittibabu Guda, Irving H. Zucker, Han-Jun Wang
Summary: Cardiorenal syndrome type 2 (CRS2) is a chronic cardiovascular disease that usually leads to chronic kidney disease due to chronic heart failure (CHF). The cardiac spinal afferent reflex (CSAR) plays a critical role in the development of CRS2. Our study demonstrates that cardiac afferent ablation and renal denervation improve cardiac function, protect the kidneys, and increase long-term survival in a myocardial infarction model of CHF. This research is of significance in the development of a unique neuromodulation therapy for CHF patients.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Hidenori Tani, Taketaro Sadahiro, Yu Yamada, Mari Isomi, Hiroyuki Yamakawa, Ryo Fujita, Yuto Abe, Tatsuya Akiyama, Koji Nakano, Yuta Kuze, Masahide Seki, Yutaka Suzuki, Manabu Fujisawa, Mamiko Sakata-Yanagimoto, Shigeru Chiba, Keiichi Fukuda, Masaki Ieda
Summary: Adult cardiomyocytes have limited regenerative ability, and the synthesis of extracellular matrix by cardiac fibroblasts (CFs) results in fibrosis and heart dysfunction after myocardial infarction (MI). The overexpression of cardiac transcription factors, MGTH, can directly reprogram CFs into induced cardiomyocytes (iCMs) and improve cardiac function in acute MI. However, it is unclear whether in vivo cardiac reprogramming can repair chronic MI with established scars.
Article
Cardiac & Cardiovascular Systems
Hidenori Tani, Taketaro Sadahiro, Yu Yamada, Mari Isomi, Hiroyuki Yamakawa, Ryo Fujita, Yuto Abe, Tatsuya Akiyama, Koji Nakano, Yuta Kuze, Masahide Seki, Yutaka Suzuki, Manabu Fujisawa, Mamiko Sakata-Yanagimoto, Shigeru Chiba, Keiichi Fukuda, Masaki Ieda
Summary: By conducting experiments on mice, this study found that cardiac reprogramming can repair chronic myocardial infarction, promote myocardial regeneration, and reduce fibrosis. The results of this study provide new insights for the treatment of chronic myocardial infarction and heart failure.
Article
Cardiac & Cardiovascular Systems
Soeren J. Backhaus, Torben Lange, Elisabeth F. George, Kristian Hellenkamp, Roman J. Gertz, Marcus Billing, Rolf Wachter, Michael Steinmetz, Shelby Kutty, Uwe Raaz, Joachim Lotz, Tim Friede, Martin Uecker, Gerd Hasenfuss, Tim Seidler, Andreas Schuster
Summary: Real-time cardiac magnetic resonance (RT-CMR) exercise imaging can accurately diagnose HFpEF, providing a suitable noninvasive diagnostic alternative, which may be beneficial for routine clinical use pending further multicenter studies.
Article
Cardiac & Cardiovascular Systems
Wayne L. Miller, Hidemi Sorimachi, Diane E. Grill, Karen Fischer, Barry A. Borlaug
Summary: The study showed that elevated cardiac filling pressures in heart failure patients may be related to abnormalities in cardiac diastolic function and intravascular volume. Some patients with increased volume still displayed normal hemodynamic parameters, while others with normal volume showed elevated filling pressures.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Review
Cardiac & Cardiovascular Systems
Justin D. Sprick, Jinhee Jeong, Jeann L. Sabino-Carvalho, Sabrina Li, Jeanie Park
Summary: Chronic kidney disease (CKD) is associated with exercise intolerance and elevated blood pressure response during exercise. The classic mechanisms contributing to exercise intolerance in CKD include uremic myopathy, chronic inflammation, malnutrition, and anemia. However, alterations in cardiovascular and autonomic regulation also play a key role in explaining the exercise intolerance experienced in CKD.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yu-Long Li
Summary: Heart failure is a significant global public health issue, with coronary heart disease-induced HF being the most common type, accounting for over 50%. Cardiac sympathetic overactivation is a major cause of mortality in HF patients and involves complex regulatory mechanisms at multiple levels of the nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Zhiyuan Guan, Wanqiong Yuan, Jialin Jia, Chenggui Zhang, Junxiong Zhu, Jie Huang, Wang Zhang, Dongwei Fan, Huijie Leng, Zijian Li, Yingsheng Xu, Chunli Song
Summary: The present study supports the relationship between heart failure and bone loss, and suggests that excessive activation of sympathetic nerves contributes to this pathophysiological process. It provides a potential pathological mechanism of heart failure-related osteoporosis and new perspectives for developing strategies to address bone loss associated with heart failure.
Review
Biochemistry & Molecular Biology
Fosca Quarti-Trevano, Raffaella Dell'Oro, Cesare Cuspidi, Pasquale Ambrosino, Guido Grassi
Summary: Vascular and sympathetic abnormalities are characteristic of chronic heart failure (CHF). These alterations have significant effects on disease prognosis and can promote disease progression and the development of cardiovascular complications. This review will discuss various therapeutic interventions targeting these vascular/sympathetic abnormalities in CHF, including non-pharmacological, pharmacological, and device-based treatments, and also address the unmet goals in treatment related to endothelial and adrenergic targets.
Review
Cardiac & Cardiovascular Systems
Guido Grassi, Giuseppe Mancia, Murray Esler
Summary: The overdrive of the sympathetic nervous system in heart failure has been reported for over half a century. Recent advancements in methodological approaches have provided a better understanding of various aspects of neuroadrenergic alterations, including regional differences, the role of the central nervous system, and the involvement of reflex mechanisms. Additionally, the impact of sympathetic activation on cardiovascular organs and potential therapeutic interventions have been highlighted.
CARDIOVASCULAR RESEARCH
(2022)