Article
Biochemistry & Molecular Biology
Peng Wang, Silvia Moreno, Andreas Janke, Susanne Boye, Dishi Wang, Simona Schwarz, Brigitte Voit, Dietmar Appelhans
Summary: This article introduces a simple method for constructing clusters of polymeric vesicles to simulate complex intracellular biological functions. The permeability of the clusters can be regulated by tuning the pH values. Compared to traditional blending methods, the complex microstructure of the clusters significantly increases the rate of enzymatic cascade reactions. The clusters, connecting catalytic nanocompartments of different enzymes, provide an excellent platform for the development of artificial systems.
Review
Chemistry, Multidisciplinary
Rong Zhu, Juan Li, Lisen Lin, Jibin Song, Huanghao Yang
Summary: Plasmonic gold nanocrystals exhibit unique optical enhancement, catalytic activity, and photothermal properties, and when combined with DNA technology, novel functional Au nanomaterials can be created for biosensing, imaging, drug delivery, and therapy applications.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Samuel Okyem, Olatunde Awotunde, Tosin Ogunlusi, McKenzie B. Riley, Jeremy D. Driskell
Summary: Gold nanoparticles (AuNPs) offer unique physicochemical properties for the development of novel biomedical technologies, with the ability to be functionalized through the immobilization of biomolecules for various purposes. The interaction between proteins and AuNPs involves electrostatic bridging, leading to reversible aggregation within the first few hours and irreversible aggregation after 24 hours. This study provides insights into antibody-nanoparticle interactions and suggests a method to prevent protein-induced AuNP aggregation over a wide pH range.
Article
Chemistry, Analytical
Yuqiu Zi, Dawei Xu, Cong Li, Fei Qu, Xian-En Zhao
Summary: A new strategy was developed to induce the aggregation of glutathione-capped gold nanoclusters (GSHAuNCs) by self-assembly of peptide. The resulting dual-emission probe, FF-N@GSH-AuNCs, showed one emission from the selfassembled FF-N at 470 nm and another from the aggregation-induced enhanced emission (AIEE) of GSH-AuNCs at 575 nm. The probe was used to screen and evaluate chymotrypsin inhibitors, showing significant inhibitory effects of epigallocatechin gallate (EGCG) and tannic acid on CHT activity.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Physical
Jacopo Cardellini, Andrea Ridolfi, Melissa Donati, Valentina Giampietro, Mirko Severi, Marco Brucale, Francesco Valle, Paolo Bergese, Costanza Montis, Lucrezia Caselli, Debora Berti
Summary: The clinical application of inorganic nanoparticles (NPs) in biomedicine is hindered by their low biocompatibility and stability. To address this issue, researchers have coated the NPs with a lipid bilayer to redefine their chemical and biological identity. However, there is currently no reliable method to quantify the integrity of the bilayer coverage. In this study, SiO2 nanoparticles with different membrane coverage degrees were prepared, and their interaction with AuNPs was monitored. The results showed a linear correlation between the membrane coverage and a spectral descriptor for the AuNPs' plasmonic resonance, providing a fast and cost-effective assay for evaluating the compatibility of NPs with biological environments.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Engineering, Environmental
Huajuan Wang, Jin Zhang, Zhiyong Song, Yongli Mu, Mohamed F. Foda, Yang Wu, Heyou Han
Summary: The intelligent antibacterial platform developed here utilizes the acidic environment of bacterial infection to trigger the aggregation of gold nanoparticles on the bacterial surface, with a charge-convertible property for precise targeting. This acidity-triggered aggregation strategy provides an excellent therapeutic mode for treating focal bacterial infections, achieving accurate bacterial killing under NIR irradiation light without causing critical damage to healthy tissues.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Zeyaul Islam, Mohamed H. Ali, Anton Popelka, Raghvendra Mall, Ehsan Ullah, Janarthanan Ponraj, Prasanna R. Kolatkar
Summary: Amyloid fibrillation, related to various neurological disorders, was studied by examining lysozyme fibrillation using nano-infrared spectroscopy (nanoIR). The study showed that lysozyme transformed into mainly parallel beta-sheets in its fibrillar structure, and nanoIR can complement other biophysical studies in analyzing the aggregation process for potential therapeutic design against amyloid disorders.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Multidisciplinary
Qiulian Mao, Jing Fang, Anna Wang, Yuqi Zhang, Chaoxiang Cui, Shuyue Ye, Yan Zhao, Yali Feng, Jiachen Li, Haibin Shi
Summary: Developing endogenous photo-activated theranostic platforms is crucial for cancer diagnosis and treatment. A chemiluminescence-triggered nanoparticle aggregation strategy was developed to activate the theranostic functions of gold nanoparticles, enhancing tumor imaging and therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Kailash P. Prajapati, Ayoushna Panigrahi, Sampreeta Purohit, Masihuzzaman Ansari, Kriti Dubey, Rajendra Kumar Behera, Bibin G. Anand, Karunakar Kar
Summary: The study synthesized gold nanoparticles coated with osmolytes, which were found to inhibit temperature-induced amyloid aggregation of insulin. The nanoparticles interacted directly with insulin, protecting it from aggregation-prone domains under extreme conditions, suggesting potential for antiamyloid nanoformulations.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Xiaoshuang Ma, Fang Sun, Lubing Qin, Yonggang Liu, Xiongwu Kang, Likai Wang, De-en Jiang, Qing Tang, Zhenghua Tang
Summary: This study systematically investigated the catalytic performance of alkynyl-protected Au7Ag8, Ag9Cu6, and Au2Ag8Cu5 nanoclusters towards CO2 reduction reaction (CO2RR). The results showed that the three clusters exhibited drastically different CO2RR performance, and the exposed, undercoordinated metal atoms played a critical role in formate formation. The study demonstrated the usefulness of tuning the metal centers of ultrasmall metal nanoclusters via metal exchange for exploring the structure-selectivity relationships for CO2RR.
Article
Chemistry, Multidisciplinary
Bingyan Han, Qifang Yan, Ze Xin, Qingdong Liu, Dan Li, Jiao Wang, Gaohong He
Summary: In this study, L-cysteine-mediated copper nanoclusters were reported to undergo an assembly-to-monodispersion switching triggered by pH modulation. At pH = 3, aggregated red emissive CuNCs changed to monodispersed blue emissive CuNCs at pH = 10, with the shift attributed to the transition from weak electrostatic interactions to strong Cu-N bonds.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Environmental Sciences
Haiyang Xian, Hongping He, Jianxi Zhu, Kunfeng Qiu, Yang Li, Yiping Yang, Jieqi Xing, Wei Tan, Akira Tsuchiyama, Masahiro Yastake, Satomi Enju, Akira Miyake, Runliang Zhu
Summary: A self-purification model explains the hyperenrichment of gold from nanoparticles to veinlets in deformed pyrite. The transformation from nanoparticles to veinlets is a thermodynamically favorable process driven by deformation and thermodynamics. This process effectively concentrates gold to a high grade and may have broad implications in ore-forming and beneficiation processes.
COMMUNICATIONS EARTH & ENVIRONMENT
(2022)
Article
Chemistry, Multidisciplinary
Yuchen Fu, Sai Zhao, Yulong Fan, Yannis Yan Lum Ho, Yufeng Wang, Dangyuan Lei, Peiyang Gu, Thomas P. Russell, Yu Chai
Summary: Nanoparticles can undergo phase transfer from the aqueous phase to the organic phase via a single-aggregation-single pathway, challenging the conventional idea that aggregation inhibits NP transfer. Charged amphiphilic polymers effectively act as chaperons for the NP transfer and offer a unique way to manipulate the dispersion and distribution of NPs in two immiscible liquids. In addition, intentionally jamming the NP-polymer assembly at the liquid/liquid interface can inhibit the transfer process.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Jitka Petrlova, Firdaus Samsudin, Peter J. Bond, Artur Schmidtchen
Summary: This study demonstrates that lipopolysaccharide (LPS) can induce aggregation of the spike (S) protein of SARS-CoV-2 at high concentrations. Through various experiments, the researchers confirmed that LPS enhances the formation of S protein aggregates and validated the role of LPS using an inhibitor. Additionally, they predicted that aggregation-prone sequences in the S protein are located near LPS binding sites and conducted molecular simulations to support this finding.
Article
Chemistry, Analytical
Tian Zhang, Chaoqing Dong, Jicun Ren
Summary: A novel measurement strategy was proposed to investigate the protein corona formed in nanoparticles using a dual-wavelength laser-irradiated differenced resonance light scattering correlation spectroscopy (D-RLSCS) technique. The binding constants and rates between proteins and gold nanoparticles (GNPs) were determined using the ratiometric diffusion change of NPs. The study also investigated the dynamic behavior of the protein corona in a fluid flow mimicking biological vessels using a microfluidic channel.
ANALYTICAL CHEMISTRY
(2023)
Article
Polymer Science
Wei-cai Wang, Kai Shi, Yan-xiong Pan, Chao Peng, Zi-liang Zhao, Wei Liu, Yong-gang Liu, Xiang-ling Ji
CHINESE JOURNAL OF POLYMER SCIENCE
(2016)
Article
Endocrinology & Metabolism
Mei-Qin Zhuo, Yan-Xiong Pan, Kun Wu, Yi-Huan Xu, Zhi Luo
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2017)
Article
Chemistry, Analytical
Kwaku Baryeh, Sunitha Takalkar, Michelle Lund, Guodong Liu
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2017)
Article
Polymer Science
Yanxiong Pan, Sunanda Neupane, Jasmin Farmakes, Bingqing Liu, Wenfang Sun, Zhongyu Yang
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS
(2017)
Article
Chemistry, Analytical
Yan Huang, Yongqiang Wen, Kwaku Baryeh, Sunitha Takalkar, Michelle Lund, Xueji Zhang, Guodong Liu
Article
Chemistry, Multidisciplinary
Yanxiong Pan, Sunanda Neupane, Jasmin Farmakes, Michael Bridges, James Froberg, Jiajia Rao, Steven Y. Qian, Guodong Liu, Yongki Choi, Zhongyu Yang
Article
Chemistry, Physical
Yanxiong Pan, Sunanda Neupane, Jasmin Farmakes, Myungkeun Oh, Kylie Bentz, Yongki Choi, Zhongyu Yang
Article
Nanoscience & Nanotechnology
Yanxiong Pan, Bingrui Li, Zhi Liu, Zhongyu Yang, Xu Yang, Kai Shi, Wei Li, Chao Peng, Weicai Wang, Xiangling Ji
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Chemistry, Physical
Yanxiong Pan, Oksana Zholobko, Andriy Voronov, Zhongyu Yang
JOURNAL OF PHYSICAL CHEMISTRY C
(2018)
Article
Chemistry, Multidisciplinary
Yanxiong Pang, Hui Li, Jasmin Farmakes, Feng Xiao, Bingcan Chen, Shengqian Ma, Zhongyu Yang
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Biophysics
Sunitha Takalkar, Kwaku Baryeh, Guodong Liu
BIOSENSORS & BIOELECTRONICS
(2017)
Article
Chemistry, Analytical
Yan Huang, Yongqiang Wen, Kwaku Baryeh, Sunitha Takalkar, Michelle Lund, Xueji Zhang, Guodong Liu
ANALYTICA CHIMICA ACTA
(2017)
Article
Chemistry, Multidisciplinary
Liu Zhi, Li Bingrui, Pan Yanxiong, Shi Kai, Wang Weicai, Peng Chao, Wang Zhe, Ji Xiangling
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
(2017)