期刊
CHEMICAL ENGINEERING JOURNAL
卷 407, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2020.127076
关键词
Bacterial infection; Acidity-triggered aggregation; Gold nanoparticles; Charge-convertible; Photothermal therapy
资金
- National Natural Science Foundation of China [21807036, 21778020, 31750110464]
- Sci-tech Innovation Foundation of Huazhong Agriculture University [2662017PY042, 2662018PY024]
- Science and Technology Major Project of Guangxi [Gui Ke AA18118046]
- Huazhong Agricultural University, Talented Young Scientist Program (TYSP) [420004817]
The intelligent antibacterial platform developed here utilizes the acidic environment of bacterial infection to trigger the aggregation of gold nanoparticles on the bacterial surface, with a charge-convertible property for precise targeting. This acidity-triggered aggregation strategy provides an excellent therapeutic mode for treating focal bacterial infections, achieving accurate bacterial killing under NIR irradiation light without causing critical damage to healthy tissues.
Precisely striking the bacterially infected site and avoiding damage to healthy tissues is vital for bacterial infection therapy. Herein, an intelligent antibacterial platform that triggers the aggregation of gold nanoparticles (AuNPs) on bacterial surface based on the acidic environment of bacterial infection was developed. Also, the AuNPs functionalized with an acidity-triggered moiety (Pep-DA) exhibited a charge-convertible properties to target bacterial infection sites. The positively charged acidity-triggered AuNPs endowed the AuNPs aggregate on negatively charged bacterial surface in the infected site rather than in healthy tissues, achieving the threshold to interparticle plasmonic coupling effect among AuNPs, and killing bacteria accurately under NIR irradiation light. This acidity-triggered aggregation strategy provides an excellent therapeutic mode for treating focal bacterial infections with no critical damage to healthy tissues.
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